Supplement
MK-7 activates osteocalcin (directing calcium to bones) and matrix Gla protein (preventing arterial calcification), complementing vitamin D for calcium homeostasis.[2184,2439,5977]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
49/100
Moderate depth from human/RCT/meta counts
Community Direction
24
Positive Lean • confidence High
Safety Friction
0/100
Sparse signal from adverse/interaction markers
Data Completeness
100%
Studies 3 • mentions 7 • links 4
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Bone Health, Heart Health.[2184,2439,5977, etc.]
Dose guide: 100-200 mcg MK-7 daily (often combined with D3).[2184,2439,5977, etc.]
Category
Vitamin
Evidence Tier
PRELIMINARY
Daily Guide
100-200 mcg MK-7 daily (often combined with D3)
Clinical Depth
Humans: 3 • RCTs: 3 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 0 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
· Limited trend data
Depth
3 total studies
Timeline
Total indexed
3
Human studies
3
Randomized trials
3
Meta-analyses
1
Cohort signals
0
Mechanistic signals
0
Weighted direction score: 24 (Positive Lean)
Total indexed
3
Human studies
3
Randomized trials
3
Meta-analyses
1
Cohort signals
0
Mechanistic signals
0
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 25694037 • 2015
Vitamin K2 and fracture risk: MA of RCTs and cohorts
META_ANALYSIS
Open PubMedPMID 25694037 • 2015
MK-7 supplementation and arterial stiffness in postmenopausal women
RCT
Open PubMedPMID 23525894 • 2013
MK-7 and bone mineral density in osteoporotic women
RCT
Open PubMedBenefit reports: 4
Adverse reports: 2
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 1.00
Benefits
Adverse
No Effect
Critical companion to vitamin D3. Directs calcium to bones instead of arteries. MK-7 form has longest half-life and best research.
Imported legacy community score: 10.0/10 (manual mapping confidence 1.00).
aggregate • benefit
Aggregate community signal: 7 directional mentions (benefit 4, adverse 2, no-effect 0, mixed 1).
Open mentionamazon
Amazon search for Vitamin K2 (MK-7, standalone)
Rating: n/a | Reviews: n/a
Open productPUBMED • 2015 • Human evidence curation set
PMID 25694037 from META_ANALYSIS.
Outcome: See linked PubMed abstract for methods and outcomes.[2184,2439,5977]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 25694037 from RCT.
Outcome: See linked PubMed abstract for methods and outcomes.[2184,2439,5977]
Open sourceLegacy community note: The most universally recommended supplement across all health communities. Users frequently report improved energy, mood, and reduced illness frequency. Consistently called "the one supplement everyone should take."
PUBMED • 2013 • Human evidence curation set
PMID 23525894 from RCT.
Outcome: See linked PubMed abstract for methods and outcomes.[2184,2439,5977]
Open source