Session check

Supplement

Vitamin E

Supports essential micronutrient pathways and deficiency-related physiology.[1450,1616,2068, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence

Immune SupportBone HealthEnergyLongevity

Composite Rating

3.8/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

Mixed / Neutral • confidence Moderate

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 15 • mentions 8 • links 26

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Immune Support, Bone Health, Energy, Longevity.[266,269,436, etc.]

Dose guide: Human-study daily dose: 15 mg-500 mg/day (higher-confidence extraction from PubMed abstracts)..[266,269,436, etc.]

Category: vitamin.[266,269,436, etc.]

At-A-Glance Evidence Architecture[1450,1616,2068, etc.]

Clinical Depth

Humans: 7,312 • RCTs: 1,283 • Meta: 269

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 3,163 • Interactions: 1,919

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

12808 total studies · 2 recent

Timeline

20012025

Top Signal Metrics[1450,1616,2068, etc.]

Animal-only studies

14,820

Total indexed

12,808

Human studies

7,312

In vitro / tissue

4,326

Safety adverse signals

3,163

Interaction signals

1,919

Community Direction Mix[266,269,436, etc.]

Weighted direction score: 14 (Mixed / Neutral)

Evidence Quality Summary[1450,1616,2068, etc.]

High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.

Animal-only studies

14,820

Total indexed

12,808

Human studies

7,312

In vitro / tissue

4,326

Safety adverse signals

3,163

Interaction signals

1,919

Randomized trials

1,283

Meta-analyses

269

Study Type Breakdown

Distribution of evidence by study design strength

Meta-AnalysesLevel 1a269

Randomized TrialsLevel 1b1,283

Human Studies (other)Level 3-45,760

All IndexedAll levels12,808

100

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1450,1616,2068, etc.]

PMID 35365361 • 2022 Jun

ESPEN micronutrient guideline.

Clin Nutr

Open PubMed

PMID 37644533 • 2023 Aug 29

Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis.

Reprod Biol Endocrinol

Open PubMed

PMID 38820340 • 2024

Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: A systematic review and meta-analysis of randomized controlled trials.

PLoS One

Open PubMed

Community Report Frequency[266,269,436, etc.]

Benefit reports: 4

Adverse reports: 2

No-effect reports: 1

Mixed reports: 1

Unclear reports: 0

Signal confidence: 0.41

Top Reported Effects[266,269,436, etc.]

Benefits

focus: 1
effective: 1
benefit: 1
better: 1

Adverse

insomnia: 1
acne: 1

No Effect

did nothing: 1

Insufficient empirical signal for a directional adjustment.

Reddit evidence: 6 mentions (confidence 0.41) across nutrition, Supplements, Biohackers.

Amazon signal: 0 products scanned (confidence 0.00).

GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].

PerimeterX / captcha block encountered.

Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.

Community Evidence Examples[266,269,436, etc.]

post • r/nutrition • unclear

Is vitamin E supplementation dangerous? Is vitamin e 200iu (plant derived)for 4 months dangerous?

Open mention

post • r/Supplements • benefit

Is it safe to just start supplementing with vitamin E? I heard it was good for improving immune health and I'm working towards that I'm not sure but I know theres certain things, you probably just can't take at all without a test. I though…

Open mention

post • r/Supplements • unclear

Is supplementing vitamin E a good idea? I've been supplementing vitamin E for some time. However, I saw a few posts saying it might not be that a good of an idea. I take only half of the recommended amount (0.25ml/50mg), and as a mixed com…

Retail Signal Examples

amazon

Amazon search for Vitamin E

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Scientific Evidence Notes[1450,1616,2068, etc.]

1. PubMed evidence summary: Vitamin E

PUBMED • Humans + preclinical triage

Counts aggregated from automated literature sweep and tiering rules.

Outcome: Tier HIGH; humans 7312, RCTs 1283, meta-analyses 269.[1450,1616,2068, etc.]

Open source

2. ESPEN micronutrient guideline.

PUBMED • 2022 • Human evidence curation set

PMID 35365361 from Clin Nutr.

Outcome: See linked PubMed abstract for methods and outcomes.[1450,1616,, etc.]

Safety and Pitfalls

Elevated adverse/interactions signal in literature; review medications and conditions before use.[266,269,436, etc.]
High interaction-signal count detected in literature search.[266,269,436, etc.]
Potential side effect: insomnia[266,269,436, etc.]
Potential side effect: acne[266,269,436, etc.]
ODS safety note: Ask ODS Join the ODS Email List Consumer Datos en español Health Professional Other Resources Table of Contents Introduction Recommended Intakes Sources of Vitamin E Vitamin E Intakes and Status Vitamin E Deficiency Vitamin E and Health Health Risks from Excessive Vitamin E Interactions with Medications Vitamin E and Healthful Diets References Disclaimer This is a fact sheet intended for health professionals.[266,269,436, etc.]
ODS safety note: Serum concentrations of vitamin E (alpha-tocopherol) depend on the liver, which takes up the nutrient after the various forms are absorbed from the small intestine.[266,269,436, etc.]
ODS safety note: The liver preferentially resecretes only alpha-tocopherol via the hepatic alpha-tocopherol transfer protein [ 1 ]; the liver metabolizes and excretes the other vitamin E forms [ 2 ].[266,269,436, etc.]
ODS safety note: Vitamin E supplementation in these infants might reduce the risk of some complications, such as those affecting the retina, but they can also increase the risk of infections [ 13 ].[266,269,436, etc.]
ODS safety note: People with Crohn's disease, cystic fibrosis, or an inability to secrete bile from the liver into the digestive tract, for example, often pass greasy stools or have chronic diarrhea; as a result, they sometimes require water-soluble forms of vitamin E, such as tocopheryl polyethylene glycol-1000 succinate [ 1 ].[266,269,436, etc.]
ODS safety note: Ataxia and vitamin E deficiency (AVED) is another rare, inherited disorder in which the liver's alpha-tocopherol transfer protein is defective or absent.[266,269,436, etc.]
ODS safety note: For example, the Heart Outcomes Prevention Evaluation (HOPE) study, which followed almost 10,000 patients at high risk of heart attack or stroke for 4.5 years [ 21 ], found that participants taking 400 IU/day of natural vitamin E (268 mg) experienced no fewer cardiovascular events or hospitalizations for heart failure or chest pain than participants taking a placebo.[266,269,436, etc.]
ODS safety note: The HOPE and HOPE-TOO trials provide compelling evidence that moderately high doses of vitamin E supplements do not reduce the risk of serious cardiovascular events among men and women >50 years of age with established heart disease or diabetes [ 23 ].[266,269,436, etc.]
ODS interaction note: Ask ODS Join the ODS Email List Consumer Datos en español Health Professional Other Resources Table of Contents Introduction Recommended Intakes Sources of Vitamin E Vitamin E Intakes and Status Vitamin E Deficiency Vitamin E and Health Health Risks from Excessive Vitamin E Interactions with Medications Vitamin E and Healthful Diets References Disclaimer This is a fact sheet intended for health professionals.[266,269,436, etc.]
ODS interaction note: Food and Drug Administration (FDA) required manufacturers to use these new labels starting in January 2020, but companies with annual sales of less than $10 million were allowed to use the old labels that list vitamin E in International Units (IUs) until January 2021 [ 8 ].[266,269,436, etc.]
Legacy caution group: Those on blood thinners without monitoring[266,269,436, etc.]
Legacy caution group: Avoid synthetic dl-alpha-tocopherol[266,269,436, etc.]