Session check

Supplement

Vitamin D3 + K2

Restores low vitamin D status and supports calcium handling pathways with vitamin K2.[2109,2184,2604, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence

Immune SupportBone HealthHormone Healthalias: cholecalciferolalias: MK-7

Composite Rating

3.8/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

Mixed / Neutral • confidence Low

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 24 • mentions 17 • links 53

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Immune Support, Bone Health, Hormone Health.[206,218,241, etc.]

Dose guide: D3 1000-4000 IU/day; K2 MK-7 90-180 mcg/day.[206,218,241, etc.]

Category: vitamin.[206,218,241, etc.]

At-A-Glance Evidence Architecture[2109,2184,2604, etc.]

Clinical Depth

Humans: 2,830 • RCTs: 1,037 • Meta: 80

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 752 • Interactions: 1,063

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

4283 total studies · 8 recent

Timeline

20122026

Top Signal Metrics[2109,2184,2604, etc.]

Total indexed

4,283

Animal-only studies

4,167

Human studies

2,830

In vitro / tissue

2,296

Interaction signals

1,063

Randomized trials

1,037

Community Direction Mix[206,218,241, etc.]

Weighted direction score: 9 (Mixed / Neutral)

Evidence Quality Summary[2109,2184,2604, etc.]

Aggregated evidence from 3 mapped records: Vitamin D3, Vitamin K1, Vitamin K2.

Total indexed

4,283

Animal-only studies

4,167

Human studies

2,830

In vitro / tissue

2,296

Interaction signals

1,063

Randomized trials

1,037

Safety adverse signals

752

Meta-analyses

Study Type Breakdown

Distribution of evidence by study design strength

Meta-AnalysesLevel 1a80

Randomized TrialsLevel 1b1,037

Human Studies (other)Level 3-41,713

All IndexedAll levels4,283

100

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[2109,2184,2604, etc.]

PMID 22552031 • 2012 Jun

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis.

Am J Clin Nutr

Open PubMed

PMID 39421966 • 2024 Dec

Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.

Ann Med

Open PubMed

PMID 37865222 • 2024 Jan

Comparison of the Effect of Daily Vitamin D2 and Vitamin D3 Supplementation on Serum 25-Hydroxyvitamin D Concentration (Total 25(OH)D, 25(OH)D2, and 25(OH)D3) and Importance of Body Mass Index: A Systematic Review and Meta-Analysis.

Community Report Frequency[206,218,241, etc.]

Benefit reports: 8

Adverse reports: 5

No-effect reports: 1

Mixed reports: 3

Unclear reports: 0

Signal confidence: 0.34

Top Reported Effects[206,218,241, etc.]

Benefits

energy: 3
improved: 2
sleep: 2
better: 1
helped: 1
improvement: 1
lowered: 1
effective: 1

Adverse

anxiety: 5
side effects: 3
side effect: 1
diarrhea: 1

No Effect

didn't work: 1
no change: 1
placebo: 1

Strong preference for softgels with oil base. | Step2: Aggregated empirical signal from 3 mapped records.

Reddit evidence: 14 mentions (confidence 0.34) across Supplements, nutrition, Biohackers.

Amazon signal: 0 products scanned (confidence 0.00).

Community Evidence Examples[206,218,241, etc.]

post • r/Supplements • unclear

Do I Really Need to Supplement MK-7 With Vitamin D3? So, my doctor says that I don’t need MK-7 since I don’t have any bone problems, and that calcification is only an issue when the serum level exceeds 150 ng/ml. But on the internet, I rea…

Open mention

post • r/Supplements • unclear

I want to supplement with 5,000 IU of vitamin D3 and this supplement has it and more ingredient Is Magnesium Citrate 120mg enough to replenish what vitamin D3 use and since it also has Boron and Zinc what other supplement do I need to take…

Open mention

post • r/Supplements • unclear

Whats a good supplement for Vitamin D3 and K2? I am looking to start supplementing Vitamin D3 and from what I have read you should take it alongside K2 so what are some brands that are reputable/safe that have them both? I would prefer for…

Retail Signal Examples

amazon

Amazon search for Vitamin D3 + K2

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Scientific Evidence Notes[2109,2184,2604, etc.]

1. Vitamin D status and all-cause outcomes

COHORT • 2022 • Adults

Associational evidence across populations.

Outcome: Low status linked with worse outcomes.[2109,2184,2604, etc.]

2. Vitamin D supplementation and fracture prevention

RCT • 2020 • Adults

Mixed baseline status cohorts.

Outcome: Benefits strongest in deficiency and older adults.[2109,2184,2604, etc.]

3. PubMed evidence summary: Vitamin D3 + K2

PUBMED • Humans + preclinical triage

Counts aggregated from automated literature sweep and tiering rules.

Outcome: Tier HIGH; humans 2830, RCTs 1037, meta-analyses 80.[, etc.]

Safety and Pitfalls

Monitor 25(OH)D and calcium at higher doses[206,218,241, etc.]
Potential side effect: rare GI upset[206,218,241, etc.]
Use caution with condition: hypercalcemia[206,218,241, etc.]
Use caution with condition: sarcoidosis[206,218,241, etc.]
Interaction check: thiazide diuretics[206,218,241, etc.]
ODS safety note: The first hydroxylation, which occurs in the liver, converts vitamin D to 25-hydroxyvitamin D [25(OH)D], also known as calcidiol.[206,218,241, etc.]
ODS safety note: The second hydroxylation occurs primarily in the kidney and forms the physiologically active 1,25-dihydroxyvitamin D [1,25(OH)2D], also known as calcitriol [ 1 ].[206,218,241, etc.]
ODS safety note: The Food and Nutrition Board at the National Academies of Sciences, Engineering, and Medicine states that levels of 50 nmol/L (20 ng/mL) or more are sufficient for most people, and that the risk of deficiency increases at serum concentrations of less than 30 nmol/L (12 ng/mL).[206,218,241, etc.]
ODS safety note: After reviewing data on vitamin D needs, an expert committee of the Food and Nutrition Board (FNB) at the National Academies of Sciences, Engineering, and Medicine (NASEM) concluded that people are at risk of vitamin D deficiency at serum 25(OH)D concentrations less than 30 nmol/L (12 ng/mL; see Table 1 for definitions of deficiency and inadequacy) [ 1 ].[206,218,241, etc.]
ODS safety note: Some people are potentially at risk of inadequacy at 30 to 50 nmol/L (12–20 ng/mL).[206,218,241, etc.]
ODS safety note: The FNB also noted that serum concentrations greater than 125 nmol/L (50 ng/mL) can be associated with adverse effects [ 1 ] (Table 1).[206,218,241, etc.]
ODS safety note: Sources of Vitamin D Food Vitamin D is found naturally in a few foods, such as the flesh of fatty fish, fish liver oils, beef liver, egg yolks, and cheese.[206,218,241, etc.]
ODS safety note: The flesh of fatty fish (such as trout, salmon, tuna, and mackerel) and fish liver oils are among the best sources [ 17 , 1 ].[206,218,241, etc.]
ODS safety note: From there, vitamin K is incorporated into chylomicrons, secreted into the lymphatic capillaries, transported to the liver, and repackaged into very low-density lipoproteins [ 2 , 10 ].[206,218,241, etc.]
Legacy caution group: Hypercalcemia patients[206,218,241, etc.]
Legacy caution group: Those with sarcoidosis without medical supervision[206,218,241, etc.]