Supplement
Supports essential micronutrient pathways and deficiency-related physiology.[1450,2175,2715, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
47
Positive Lean • confidence Moderate
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 10 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Immune Support, Bone Health, Energy, Longevity.[103,251,304, etc.]
Dose guide: Human-study daily dose: 80 mg-7500 mg/day (higher-confidence extraction from PubMed abstracts)..[103,251,304, etc.]
Category
Vitamin
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 80 mg-7500 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 7,126 • RCTs: 915 • Meta: 243
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 1,818 • Interactions: 1,399
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
10169 total studies · 3 recent
Timeline
Total indexed
10,169
Human studies
7,126
Animal-only studies
5,439
In vitro / tissue
2,481
Safety adverse signals
1,818
Interaction signals
1,399
Weighted direction score: 47 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
10,169
Human studies
7,126
Animal-only studies
5,439
In vitro / tissue
2,481
Safety adverse signals
1,818
Interaction signals
1,399
Randomized trials
915
Meta-analyses
243
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 35365361 • 2022 Jun
ESPEN micronutrient guideline.
Clin Nutr
Open PubMedPMID 23440782 • 2013 Jan 31
Vitamin C for preventing and treating the common cold.
Cochrane Database Syst Rev
Open PubMedPMID 37644533 • 2023 Aug 29
Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis.
Reprod Biol Endocrinol
Open PubMedPMID 35311615 • 2022 Jul
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.
World J Biol Psychiatry
Open PubMedPMID 38345088 • 2024 Feb 12
Nutritional interventions for preventing and treating pressure ulcers.
Cochrane Database Syst Rev
Open PubMedPMID 38820340 • 2024
Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: A systematic review and meta-analysis of randomized controlled trials.
PLoS One
Open PubMedPMID 34122682 • 2021
The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial.
Pain Res Manag
Open PubMedPMID 31627309 • 2019 Oct 17
A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study.
Nutrients
Open PubMedPMID 38931263 • 2024 Jun 17
The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial.
Nutrients
Open PubMedPMID 33136134 • 2020 Nov 2
The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia: A Randomized Clinical Trial.
JAMA Netw Open
Open PubMedPMID 27852613 • 2017 Jan
Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis.
Am J Clin Nutr
Open PubMedPMID 11594942 • 2001 Oct
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
Arch Ophthalmol
Open PubMedPMID 34662692 • 2021 Dec
Micronutrients and athletic performance: A review.
Food Chem Toxicol
Open PubMedPMID 37417662 • 2023 Jul 1
Vitamin C Supplementation and Athletic Performance: A Review.
Curr Sports Med Rep
Open PubMedPMID 35268010 • 2022 Feb 28
Vitamin Supplementation and Dementia: A Systematic Review.
Nutrients
Open PubMedBenefit reports: 7
Adverse reports: 2
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.49
Benefits
Adverse
No Effect
Strong positive empirical sentiment with adequate confidence; boost recommendation priority.
Reddit evidence: 9 mentions (confidence 0.49) across Biohackers, Supplements, nutrition.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
ODS fact sheet linked for safety review.
Human-study daily dose signal: 80 mg-7500 mg/day (confidence HIGH).
Extracted from 11 dosing mentions across 6 PubMed studies (mg/day).
Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$6.00.
Legacy community note: Universally recognized as a basic essential. Users report better skin, faster recovery from illness, and improved energy. Some biohackers use higher doses (IV vitamin C) for specific purposes.
post • r/Biohackers • unclear
How's my morning supplement stack look? Mostly immune system focused, not getting sick. Garlic Vitamin C Fish oil Green tea extract Elderberry Vitamin D B complex Probiotics Zinc Creatine 39 y/o male
Open mentionpost • r/Supplements • unclear
Vitamin C supplements causing fatigue and blurry vision? I’ve noticed taking vitamin C at any dose, even as low as 50mg causes my vision to be more blurry and causes me to be fatigued. Why is this occurring? Could it be due to lowering cop…
Open mentionpost • r/Supplements • benefit
The Best Vitamin C Supplements at the Moment? I’ve been looking into vitamin C supplements lately and honestly, the more I read, the more confused I get. There are so many options out there, and everyone seems to have a different favorite.…
Open mentionpost • r/Supplements • benefit
The Best Vitamin C Supplement Right Now? Recommendation? My current vitamin C is almost finished, and I’m looking for a replacement. I want something high quality, clean, reliable not just cheap. Here are a few I've seen so far: * Thorne V…
Open mentionpost • r/Supplements • benefit
Astaxanthin changed my health I’ve been in the supplement space for a few years now, but like a lot of people, I wasn’t always consistent with my own health routine. So, earlier this year, I decided to fix my basics (diet, sleep, exercise …
Open mentionpost • r/nutrition • unclear
Why do all collegen supplements contain vitamin C? I realise that for collegen to be absorbed you need vitamin C. But for people who would like to start collegen but also have enough vitamin C surely the additional vitamin C in these suppl…
Open mentionpost • r/Biohackers • benefit
Do I need to take a vitamin C supplement? I usually eat anywhere from 1 to 3 oranges a day. Plus a small or big cup of grapes when grapes are in season in India. Or half a watermelon or several slices of watermelon when that's in season in…
Open mentionpost • r/Supplements • benefit
Is there evidence that vitamin C (liposomal) supplementation can improve skin quality? I'm currently supplementing with 1g of liposomal vitamin C per day (two 500mg doses, morning and night), and although I've noticed an improvement in my …
Open mentioncomment • r/Supplements • adverse
I don’t take vitamin c currently because of those symptoms. I have tried different types, dosages from 50-500mg and all have the same side effects. My blood test showed my vitamin c was at the bottom of the normal range so I don’t think my…
Open mentioncomment • r/Supplements • unclear
That's pretty weird, vitamin C usually doesn't cause those symptoms unless you're taking massive doses. Could be some kind of allergy or sensitivity, or maybe there's something else in the supplement you're reacting to. I'd honestly just s…
Open mentionamazon
Amazon search for Vitamin C
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 7126, RCTs 915, meta-analyses 243.[1450,2175,2715, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35365361 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 23440782 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37644533 from Reprod Biol Endocrinol.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35311615 from World J Biol Psychiatry.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38345088 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38820340 from PLoS One.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34122682 from Pain Res Manag.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31627309 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38931263 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33136134 from JAMA Netw Open.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 27852613 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11594942 from Arch Ophthalmol.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34662692 from Food Chem Toxicol.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37417662 from Curr Sports Med Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35268010 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1450,2175,2715, etc.]
Open source