Supplement
Supports essential micronutrient pathways and deficiency-related physiology.[3445,3516,3540, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
-7
Mixed / Neutral • confidence Moderate
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 13 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Immune Support, Bone Health, Energy, Longevity.[95,262,306, etc.]
Dose guide: Human-study daily dose: 1 mg-150 mg/day (higher-confidence extraction from PubMed abstracts)..[95,262,306, etc.]
Category
Vitamin
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 1 mg-150 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 7,573 • RCTs: 921 • Meta: 210
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 1,748 • Interactions: 1,717
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
10598 total studies · 2 recent
Timeline
Animal-only studies
11,395
Total indexed
10,598
Human studies
7,573
In vitro / tissue
2,543
Safety adverse signals
1,748
Interaction signals
1,717
Weighted direction score: -7 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
11,395
Total indexed
10,598
Human studies
7,573
In vitro / tissue
2,543
Safety adverse signals
1,748
Interaction signals
1,717
Randomized trials
921
Meta-analyses
210
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 35365361 • 2022 Jun
ESPEN micronutrient guideline.
Clin Nutr
Open PubMedPMID 37644533 • 2023 Aug 29
Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis.
Reprod Biol Endocrinol
Open PubMedPMID 38140375 • 2023 Dec 15
Improving Cognitive Function with Nutritional Supplements in Aging: A Comprehensive Narrative Review of Clinical Studies Investigating the Effects of Vitamins, Minerals, Antioxidants, and Other Dietary Supplements.
Nutrients
Open PubMedPMID 35294044 • 2022 Mar 16
Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
Cochrane Database Syst Rev
Open PubMedPMID 31973225 • 2020 Jan 21
Micronutrient Supplementation and Fortification Interventions on Health and Development Outcomes among Children Under-Five in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 32075071 • 2020 Feb 14
Vitamin and Mineral Supplementation During Pregnancy on Maternal, Birth, Child Health and Development Outcomes in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 39275230 • 2024 Sep 1
Effects of Supplementation with Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Antioxidant Vitamins, Combined with High-Intensity Functional Training, on Exercise Performance and Body Composition: A Randomized, Double-Blind, Placebo-Controlled Trial.
Nutrients
Open PubMedPMID 32858063 • 2021 Mar
Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
Ophthalmology
Open PubMedPMID 37447400 • 2023 Jul 7
Pharmacokinetic Analyses of Liposomal and Non-Liposomal Multivitamin/Mineral Formulations.
Nutrients
Open PubMedPMID 33439085 • 2021 Jan 2
Hard-to-heal wounds: a randomised trial of an oral proline-containing supplement to aid repair.
J Wound Care
Open PubMedPMID 33409923 • 2021 Nov
Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism.
Biol Trace Elem Res
Open PubMedPMID 33615992 • 2021 Jan-Dec
Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome- a pilot study.
Gut Microbes
Open PubMedPMID 38256329 • 2023 Dec 29
Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
Medicina (Kaunas)
Open PubMedPMID 31697447 • 2019 Dec
Vitamin A and Wound Healing.
Nutr Clin Pract
Open PubMedPMID 38276540 • 2024 Jan 19
Nutritional Status of Breastfeeding Mothers and Impact of Diet and Dietary Supplementation: A Narrative Review.
Nutrients
Open PubMedBenefit reports: 5
Adverse reports: 5
No-effect reports: 0
Mixed reports: 3
Unclear reports: 0
Signal confidence: 0.41
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 7 mentions (confidence 0.41) across Supplements, Biohackers.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
ODS fact sheet linked for safety review.
Human-study daily dose signal: 1 mg-150 mg/day (confidence HIGH).
Extracted from 4 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$6.00.
Legacy community note: Universally recognized as a basic essential. Users report better skin, faster recovery from illness, and improved energy. Some biohackers use higher doses (IV vitamin C) for specific purposes.
post • r/Supplements • unclear
Does taking a selenium supplement for selenium deficiency depletes vitamin A stores? I have selenium deficiency and will start supplementing with 100mcg of daily selenium. However, I read that selenium depletes Vitamin A stores in the live…
Open mentionpost • r/Biohackers • unclear
Fixing folate deficiency completely changed my life Edit: I woke up this morning and played a song from my childhood, and I felt such a flood of nostalgic and emotion I cried lol. It's so emotional because everything has been so ROBOTIC an…
Open mentionpost • r/Supplements • unclear
Micellized Vitamin A supplement without castor oil, citrus or gums? The title pretty much covers it. I need to sometimes aggressively supplement Vitamin A, and the micellized drops seem like the answer, but I have bad reactions to castor o…
Open mentionpost • r/Supplements • adverse
Does Vitamin A depletes any nutrients like d3 if taken in supplement? Im having acne, dry skin, keratosis, atopic dermatitis. Im thinking to get vit a supplement (retinyl palmitate) for 1 month. I also have b12, b9 and magnesium deficiency…
Open mentionpost • r/Supplements • mixed
Your Body Gives You Clues When You're Low on Certain Nutrients I came across a list about how certain everyday symptoms might be linked to possible nutrient gaps, and it was actually pretty interesting. Obviously not medical advice, but it…
Open mentionpost • r/Supplements • benefit
Stopped My Multivitamin - 3 Days Later My Symptoms Vanished About five months ago, I started taking a highly-rated multivitamin. Great formulation, nothing crazy, at least that’s what I thought. Everything seemed “just right”: no megadoses…
Open mentionpost • r/Biohackers • mixed
Supplements that have worked for you and one's that didn't or you find overrated? Helped: 1) Vitamin D: supplementing helped get rid of a recurrent skin rash issue 2) Magnesium glycinate: Took away my exercise intolerance and heart palpita…
Open mentionpost • r/Supplements • mixed
Help, I think I overdosed! Hi, I don't mean to panic, my dumbass has recently acquired a lot of vitamin supplements for my daily diet, but I think it was a huge mistake. 34 year old male. I admit upfront that I'm an utter idiot for not thi…
Open mentioncomment • r/Supplements • benefit
Liver has tons of Vitamin A, either eat it if you can or take liver pills. Its not an isolate so better for you in the long run, easier for body to absorb and has other nutrients your body desperately needs. Blue berry liver shakes are act…
Open mentioncomment • r/Supplements • benefit
Selenium can affect vitamin A metabolism but in typical supplementation (100mcg/day), significant depletion is unlikely if your diet provides vitamin A-rich foods like you described. You don't necessarily need a vitamin A supplement alongs…
Open mentionamazon
Amazon search for Vitamin A
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 7573, RCTs 921, meta-analyses 210.[3445,3516,3540, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35365361 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37644533 from Reprod Biol Endocrinol.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38140375 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35294044 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31973225 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32075071 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39275230 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 32858063 from Ophthalmology.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37447400 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33439085 from J Wound Care.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33409923 from Biol Trace Elem Res.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33615992 from Gut Microbes.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38256329 from Medicina (Kaunas).
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31697447 from Nutr Clin Pract.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38276540 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3445,3516,3540, etc.]
Open source