Supplement
Supports broad cellular function with category-specific mechanisms.[1349,1542,1677, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
58/100
Moderate depth from human/RCT/meta counts
Community Direction
-10
Mixed / Neutral • confidence Moderate
Safety Friction
89/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 9 • mentions 15 • links 20
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[296,445,446, etc.]
Dose guide: Human-study daily dose: 600 mg/day (moderate-confidence extraction from PubMed abstracts)..[296,445,446, etc.]
Category
Other
Evidence Tier
MEDIUM
Daily Guide
Human-study daily dose: 600 mg/day (moderate-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 11 • RCTs: 2 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 12 • Interactions: 12
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
24 total studies
Timeline
Total indexed
24
Animal-only studies
21
Safety adverse signals
12
Interaction signals
12
Human studies
11
In vitro / tissue
10
Weighted direction score: -10 (Mixed / Neutral)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
Total indexed
24
Animal-only studies
21
Safety adverse signals
12
Interaction signals
12
Human studies
11
In vitro / tissue
10
Randomized trials
2
Meta-analyses
1
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 33086877 • 2020 Jan-Dec
Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
J Evid Based Integr Med
Open PubMedPMID 30632220 • 2019 Apr
Valerian extract alters functional brain connectivity: A randomized double-blind placebo-controlled trial.
Phytother Res
Open PubMedPMID 10599933 • 1999 Nov
The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers.
Pharmacopsychiatry
Open PubMedPMID 34370563 • 2021 Nov
Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review.
J Altern Complement Med
Open PubMedPMID 16554287 • 2006 Apr 1
Metal content of ephedra-containing dietary supplements and select botanicals.
Am J Health Syst Pharm
Open PubMedPMID 32719085 • 2020 Oct
Application of Cryopreserved Human Intestinal Mucosa and Cryopreserved Human Enterocytes in the Evaluation of Herb-Drug Interactions: Evaluation of CYP3A Inhibitory Potential of Grapefruit Juice and Commercial Formulations of Twenty-Nine Herbal Supplements.
Drug Metab Dispos
Open PubMedPMID 13129992 • 2003 Sep 17
Internet marketing of herbal products.
JAMA
Open PubMedPMID 23885542 • 2013 May-Jun
[Interactions between synthetic drugs used in treatment of selected central nervous system disorders and dietary supplements and herbal drugs].
Psychiatr Pol
Open PubMedPMID 33510252 • 2021 Jan 28
Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications.
Sci Rep
Open PubMedBenefit reports: 5
Adverse reports: 5
No-effect reports: 0
Mixed reports: 5
Unclear reports: 0
Signal confidence: 0.47
Benefits
Adverse
No Effect
Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 8 mentions (confidence 0.47) across sleep, Supplements, HubermanLab.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 600 mg/day (confidence MEDIUM).
Extracted from 2 dosing mentions across 1 PubMed studies (mg/day).
post • r/sleep • mixed
Spent 2 Years Fixing My Insomnia. Here Is My Honest Tier List of Supplements. I’ve had "wake up at 3 AM and stare at the wall" insomnia for years. I got sick of reading articles written by bots, so I spent way too much money testing this s…
Open mentionpost • r/Supplements • benefit
I Tried 15+ Supplements for Better Sleep & Recovery - Here's What Actually Moved the Needle Hey r/supplements, wanted to share my experience after spending way too much money experimenting with sleep and recovery supplements over the past …
Open mentionpost • r/sleep • benefit
Has anyone else experienced this "wired but exhausted" thing where you're dead tired but your brain won't shut off? I don't even know how to explain this properly but I'm going to try because I'm at my wit's end and I don't know where else…
Open mentionpost • r/sleep • benefit
After years of not being able to fall asleep I finally found something. What a nightmare this has all been, I was put on powerful benzos, I tried magnesium, gaba, ashwaganda, CBD, a blend of sleepy tea including valerian root, you name it,…
Open mentionpost • r/Supplements • mixed
Desperate for Sleep - What Supplements Actually Work? Lately, my sleep has been absolutely garbage. I'm tossing and turning for hours, and even when I do fall asleep, I wake up feeling completely unrested. I've tried all the usual advice (…
Open mentionpost • r/HubermanLab • mixed
What sleep supplements do you take? I have insomnia and started facing mood swings, hair loss, irritability, isolation and low motivation for past 8 months. I sleep 10 hours and would wake up often. I am now taking ashwagandha 650 mg, l th…
Open mentionpost • r/Supplements • mixed
My massive stack as a hardcore drug addict/alcoholic So I literally take all of these in a day to be the healthiest little druggie I can be. And I know what I take works cause I should be withdrawaling hard af currently from alcohol and I …
Open mentionpost • r/Supplements • mixed
Does Taurine REALLY work this well for sleep? Or is this placebo? I've had problems with my sleep quality for many years now, and have tried a plethora of various supplements that are supposed to help (ie; Valerian Root, Magnesium, L Thean…
Open mentioncomment • r/Supplements • unclear
Same for me, as Taurine, Valerian Root, Glycine. Took P5P due to a deficiency marked in an OAT test and now they all relax me!
Open mentionamazon
Amazon search for Valerian Root
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 11, RCTs 2, meta-analyses 1.[1349,1542,1677, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33086877 from J Evid Based Integr Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1349,1542,1677, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30632220 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1349,1542,1677, etc.]
Open sourcePUBMED • 1999 • Human evidence curation set
PMID 10599933 from Pharmacopsychiatry.
Outcome: See linked PubMed abstract for methods and outcomes.[1349,1542,1677, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34370563 from J Altern Complement Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1349,1542,1677, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 16554287 from Am J Health Syst Pharm.
Outcome: See linked PubMed abstract for methods and outcomes.[1349,1542,1677, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32719085 from Drug Metab Dispos.
Outcome: See linked PubMed abstract for methods and outcomes.[1349,1542,1677, etc.]
Open sourcePUBMED • 2003 • Human evidence curation set
PMID 13129992 from JAMA.
Outcome: See linked PubMed abstract for methods and outcomes.[1349,1542,1677, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 23885542 from Psychiatr Pol.
Outcome: See linked PubMed abstract for methods and outcomes.[1349,1542,1677, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33510252 from Sci Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1349,1542,1677, etc.]
Open source