Supplement
Supports broad cellular function with category-specific mechanisms.[3837,4062,4318, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
90/100
High depth from human/RCT/meta counts
Community Direction
23
Positive Lean • confidence Moderate
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 9 • mentions 9 • links 20
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[96,279,315, etc.]
Dose guide: Human-study daily dose: 1000 mg/day (early-confidence extraction from PubMed abstracts)..[96,279,315, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 1000 mg/day (early-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 1000 mg/day (early-confidence extraction from PubMed abstracts).[3837,, etc.]
Clinical Depth
Humans: 57 • RCTs: 15 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 52 • Interactions: 65
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
109 total studies · 3 recent
Timeline
In vitro / tissue
199
Animal-only studies
146
Total indexed
109
Interaction signals
65
Human studies
57
Safety adverse signals
52
Weighted direction score: 23 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
In vitro / tissue
199
Animal-only studies
146
Total indexed
109
Interaction signals
65
Human studies
57
Safety adverse signals
52
Randomized trials
15
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 35050355 • 2022 Jan 4
Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial.
JAMA Netw Open
Open PubMedPMID 36175997 • 2022 Sep 30
The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial.
BMC Med
Open PubMedPMID 37743489 • 2023 Sep 25
The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial.
BMC Med
Benefit reports: 5
Adverse reports: 2
No-effect reports: 1
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.47
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 8 mentions (confidence 0.47) across Supplements, Biohackers, ketoscience.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
post • r/Supplements • adverse
Urolithin A supplement reverses anxiety in rats by repairing mitochondria in neurons [This article](https://www.neuroleman.ch/urolithin-a-repairs-brain-mitochondria-reverses-anxiety-in-rats/) details how in a [study](https://www.biological…
Open mentionpost • r/Biohackers • unclear
Distinct Roles of Urolithin A and Spermidine in Mitophagy and Autophagy: Implications for Dietary Supplementation | Nutrition Research Reviews (2025)
Open mentionpost • r/Supplements • unclear
Effect of the mitophagy inducer urolithin A on age-related immune decline
Open mentionamazon
Amazon search for Urolithin A
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 57, RCTs 15, meta-analyses 0.[3837,4062,4318, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35050355 from JAMA Netw Open.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
PMID 35021194 • 2022 May 1
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS).
Am J Clin Nutr
Open PubMedPMID 41174221 • 2025 Nov
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial.
Nat Aging
Open PubMedPMID 39487653 • 2024 Dec
Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study.
J Int Soc Sports Nutr
Open PubMedPMID 34030963 • 2021 Jul
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.
Trends Mol Med
Open PubMedPMID 33236953 • 2021 Mar 1
Sarcopenia in chronic liver disease: mechanisms and countermeasures.
Am J Physiol Gastrointest Liver Physiol
Open PubMedPMID 39060742 • 2024 Sep
Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing.
Sports Med
Open PubMedHuman-study daily dose signal: 1000 mg/day (confidence LOW).
Extracted from 1 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$60.00.
Legacy community note: Gaining rapid popularity in longevity and fitness communities. Users report improved energy and exercise endurance. Premium price point. MitoPure (Timeline) is the most studied brand.
post • r/ketoscience • no_effect
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial (2025)
Open mentionpost • r/Supplements • mixed
What Are the Best Anti Aging Supplements to Take in Your 30s for Long-Term Health? hey i’m in my 30s and been getting more into anti aging stuff lately. i already eat decent, stay active, try to sleep enough but i figured why not start doi…
Open mentionpost • r/Biohackers • benefit
Urolithin A reduces cardiovascular disease biomarkers in humans sup y'all as part of my 2026 goals i want to get my longevity stack dialed in. i've had pomella (pomegranate extract) in my drawer for a while, which provides precursors for y…
Open mentionpost • r/Supplements • benefit
Endurance athletes prepping for a race, what supplements do you think are game changers for performance and recovery? I will be participating in a few endurance races over the next 2 mos. Hyrox and Spartan DEKA for those familiar. They wil…
Open mentionpost • r/Biohackers • benefit
Just Got Back from Eudemonia Summit - Here's Everything I Tried Just wrapped up a few days at Eudemonia and wanted to do a full product recap. I tried a ton of stuff, bought way too much, and had some really great conversations with founde…
Open mentioncomment • r/Supplements • adverse
This aligns perfectly with the emerging 'Metabolic Theory' of mental health. We used to think anxiety was just a neurotransmitter issue (Serotonin/GABA). Now we are realizing it is often a **bio-energetic** issue. If neurons in the emotion…
Open mentioncomment • r/Biohackers • benefit
# Abstract The increasing focus on longevity and cellular health has brought into the spotlight two key compounds, urolithin A (UroA) and spermidine, for their promising roles in autophagy and mitophagy. Urolithin A, a natural metabolite d…
Open mentionCommunity Sources
PUBMED • 2022 • Human evidence curation set
PMID 36175997 from BMC Med.
Outcome: See linked PubMed abstract for methods and outcomes.[3837,4062,4318, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37743489 from BMC Med.
Outcome: See linked PubMed abstract for methods and outcomes.[3837,4062,4318, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35021194 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3837,4062,4318, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 41174221 from Nat Aging.
Outcome: See linked PubMed abstract for methods and outcomes.[3837,4062,4318, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39487653 from J Int Soc Sports Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3837,4062,4318, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34030963 from Trends Mol Med.
Outcome: See linked PubMed abstract for methods and outcomes.[3837,4062,4318, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33236953 from Am J Physiol Gastrointest Liver Physiol.
Outcome: See linked PubMed abstract for methods and outcomes.[3837,4062,4318, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39060742 from Sports Med.
Outcome: See linked PubMed abstract for methods and outcomes.[3837,4062,4318, etc.]
Open source