Supplement
Polysaccharopeptides PSK and PSP activate NK cells, enhance TLR-2 signaling, increase dendritic cell maturation, promote beneficial gut microbiota, and have direct anti-tumor activity.[1720,2160,2304, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
45/100
Moderate depth from human/RCT/meta counts
Community Direction
14
Mixed / Neutral • confidence Moderate
Safety Friction
0/100
Sparse signal from adverse/interaction markers
Data Completeness
100%
Studies 3 • mentions 8 • links 5
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Immune Support, Gut Health.[1720,2160,2304, etc.]
Dose guide: 1-3 g extract daily (standardized PSP/PSK), or 3-9 g dried mushroom powder.[1720,2160,2304, etc.]
Category
Botanical
Evidence Tier
PRELIMINARY
Daily Guide
1-3 g extract daily (standardized PSP/PSK), or 3-9 g dried mushroom powder
Dosing Guide
1-3 g extract daily (standardized PSP/PSK), or 3-9 g dried mushroom powder[1720,,]
Clinical Depth
Humans: 3 • RCTs: 2 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 0 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
· Limited trend data
Depth
3 total studies
Timeline
Total indexed
3
Human studies
3
Randomized trials
2
Meta-analyses
1
Cohort signals
0
Mechanistic signals
0
Weighted direction score: 14 (Mixed / Neutral)
Total indexed
3
Human studies
3
Randomized trials
2
Meta-analyses
1
Cohort signals
0
Mechanistic signals
0
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 17106715 • 2007
PSK (turkey tail) as adjuvant in colorectal/gastric cancer: MA
META_ANALYSIS
Open PubMedPMID 24788984 • 2014
Turkey tail and gut microbiome in healthy volunteers: phase I study
RCT
Open PubMedPMID 23221935 • 2012
Turkey tail polysaccharides and immune function in breast cancer patients
RCT
Open PubMedBenefit reports: 4
Adverse reports: 2
No-effect reports: 1
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.40
Benefits
Adverse
No Effect
One of the most studied medicinal mushrooms. PSK is an approved cancer adjuvant in Japan. Quality hot-water extract preferred.
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Legacy community note: Respected in nootropic and cortisol-management communities. Athletes use it for cortisol control. Elderly report memory improvements. Often part of comprehensive brain health stacks.
aggregate • benefit
Aggregate community signal: 8 directional mentions (benefit 4, adverse 2, no-effect 1, mixed 1).
Open mentionamazon
Amazon search for Turkey Tail Mushroom (Trametes versicolor)
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • 2007 • Human evidence curation set
PMID 17106715 from META_ANALYSIS.
Outcome: See linked PubMed abstract for methods and outcomes.[1720,2160,2304, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24788984 from RCT.
Outcome: See linked PubMed abstract for methods and outcomes.[1720,2160,2304, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 23221935 from RCT.
Outcome: See linked PubMed abstract for methods and outcomes.[1720,2160,2304, etc.]
Open source