Supplement
Supports broad cellular function with category-specific mechanisms.[2506,2531,2633, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
50
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 4 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[105,208,230, etc.]
Dose guide: Human-study daily dose: 15200 mg/day (early-confidence extraction from PubMed abstracts)..[105,208,230, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 15200 mg/day (early-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 312 • RCTs: 62 • Meta: 20
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 339 • Interactions: 212
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
1012 total studies · 2 recent
Timeline
Total indexed
1,012
Animal-only studies
838
In vitro / tissue
362
Safety adverse signals
339
Human studies
312
Interaction signals
212
Weighted direction score: 50 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
1,012
Animal-only studies
838
In vitro / tissue
362
Safety adverse signals
339
Human studies
312
Interaction signals
212
Randomized trials
62
Meta-analyses
20
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 35988871 • 2022 Sep
A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults.
Pharmacol Res
Open PubMedPMID 37778464 • 2023 Oct
Comparative effects of nutraceuticals on body weight in adults with overweight or obesity: A systematic review and network meta-analysis of 111 randomized clinical trials.
Pharmacol Res
Open PubMedPMID 32967062 • 2021 Feb
Spirulina supplementation and anthropometric indices: A systematic review and meta-analysis of controlled clinical trials.
Phytother Res
Open PubMedPMID 26433766 • 2016 Aug
A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations.
Clin Nutr
Open PubMedPMID 31780031 • 2019 Dec
Effects of Spirulina supplementation on obesity: A systematic review and meta-analysis of randomized clinical trials.
Complement Ther Med
Open PubMedPMID 33908048 • 2021 Aug
Spirulina supplementation and oxidative stress and pro-inflammatory biomarkers: A systematic review and meta-analysis of controlled clinical trials.
Clin Exp Pharmacol Physiol
Open PubMedPMID 40877830 • 2025 Aug 28
Effects of spirulina (Arthrospira) platensis supplementation on inflammation, physical and mental quality of life, and anthropometric measures in patients with relapsing-remitting multiple sclerosis (RRMS): a triple-blinded, randomized, placebo-controlled trial.
Nutr J
Open PubMedPMID 37739734 • 2023 Oct
The effects of spirulina supplementation on serum iron and ferritin, anemia parameters, and fecal occult blood in adults with ulcerative colitis: A randomized, double-blinded, placebo-controlled trial.
Clin Nutr ESPEN
Open PubMedPMID 38655258 • 2024
Effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19: a randomized controlled trial.
Front Immunol
Open PubMedPMID 36861852 • 2023 Jul
The effects of spirulina intake on clinical and metabolic parameters in Alzheimer's disease: A randomized, double-blind, controlled trial.
Phytother Res
Open PubMedPMID 35394687 • 2022 Dec
Spirulina supplementation prevents exercise-induced lipid peroxidation, inflammation and skeletal muscle damage in elite rugby players.
J Hum Nutr Diet
Open PubMedPMID 33715648 • 2022 Jan 28
Spirulina supplementation during gradual weight loss in competitive wrestlers.
Br J Nutr
Open PubMedPMID 38256329 • 2023 Dec 29
Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
Medicina (Kaunas)
Open PubMedPMID 27259333 • 2016 Aug
The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview.
Arch Toxicol
Open PubMedPMID 26262693 • 2015 Jul 1
NUTRITIONAL AND TOXICOLOGICAL ASPECTS OF SPIRULINA (ARTHROSPIRA).
Nutr Hosp
Open PubMedBenefit reports: 3
Adverse reports: 1
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.22
Benefits
Adverse
No Effect
Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 2 mentions (confidence 0.22) across Supplements, Biohackers.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 15200 mg/day (confidence LOW).
Extracted from 1 dosing mentions across 1 PubMed studies (mg/day).
post • r/Supplements • benefit
How effective spirulina is in gaining weight for a skinny guy? Guys! So I wanna know if spirulina is worth taking for weight gain. Though it suggests that it is used for fat loss but I have seen skinny guys taking it.. I am underweight.. u…
Open mentionpost • r/Supplements • unclear
Hi all, are there any supplements can contain clorella, spirulina barley grass and having moringa would be great too I have repeatedly seen experts mention that a combination of these 3 or 4 are great for preventing dementia. So I am askin…
Open mentionpost • r/Biohackers • unclear
My daily smoothie (50,000+ ORAC units) 50g of Casein 1 cup of blueberries 1 cup of cranberries 1 cup of kale 1/2 cup of spinach 1 tablespoon of Russian, Siberian wildflower honey A handful of walnuts, almonds, and pumpkin seeds 5g of Creat…
Open mentioncomment • r/Supplements • unclear
IMO, it's worth consuming if it makes you more energetic. That's what a lot of our customers report when they take spirulina for the first time. But to gain weight... gotta pick something with more calories that makes you feel less full
Open mentioncomment • r/Supplements • benefit
Not very. (Although it would still be of benefit.) Spirulina is more commonly used for aid in weight loss. Spirulina is not a fattenning food, gram for gram, when compared with other dry foods.
Open mentioncomment • r/Supplements • unclear
Chlorella and spirulina are great for detoxing, as they are able to take fat-soluble toxins and make them water-soluble in order to be transported in the blood and excreted. This is important as the brain is very fatty, and most toxins are…
Open mentionamazon
Amazon search for Spirulina
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 312, RCTs 62, meta-analyses 20.[2506,2531,2633, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35988871 from Pharmacol Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37778464 from Pharmacol Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 32967062 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26433766 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31780031 from Complement Ther Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33908048 from Clin Exp Pharmacol Physiol.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40877830 from Nutr J.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37739734 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38655258 from Front Immunol.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36861852 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35394687 from J Hum Nutr Diet.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 33715648 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38256329 from Medicina (Kaunas).
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 27259333 from Arch Toxicol.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26262693 from Nutr Hosp.
Outcome: See linked PubMed abstract for methods and outcomes.[2506,2531,2633, etc.]
Open source