Supplement
Supports broad cellular function with category-specific mechanisms.[2210,3851,5444, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
0/100
Sparse depth from human/RCT/meta counts
Community Direction
-9
Mixed / Neutral • confidence Moderate
Safety Friction
44/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 3 • mentions 14 • links 14
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[39,223,314, etc.]
Dose guide: Follow product label and start with the lowest effective daily serving..[39,223,314, etc.]
Category
Other
Evidence Tier
LOW
Daily Guide
Follow product label and start with the lowest effective daily serving.
Clinical Depth
Humans: 0 • RCTs: 0 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 3 • Interactions: 2
Freshness, trend, and study timeline for this item
Status
Trend
· Limited trend data
Depth
3 total studies · 1 recent
Timeline
Total indexed
3
Safety adverse signals
3
Animal-only studies
2
In vitro / tissue
2
Interaction signals
2
Human studies
0
Weighted direction score: -9 (Mixed / Neutral)
Low when evidence is mostly preclinical/in vitro or sparse human literature.
Total indexed
3
Safety adverse signals
3
Animal-only studies
2
In vitro / tissue
2
Interaction signals
2
Human studies
0
Randomized trials
0
Meta-analyses
0
Distribution of evidence by study design strength
PMID 23821590 • 2013 Jul
Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model.
Hum Exp Toxicol
Open PubMedPMID 41642311 • 2026 Feb 5
Serrapeptase After Liposuction for Lipedema: Limited Evidence for Antifibrotic Efficacy.
Aesthetic Plast Surg
Open PubMedPMID 33307341 • 2021 Feb
Vascular Necrosis of the Upper Extremity After Self-Treatment for Peyronie's Disease.
Sex Med
Open PubMedBenefit reports: 5
Adverse reports: 5
No-effect reports: 0
Mixed reports: 4
Unclear reports: 0
Signal confidence: 0.41
Benefits
Adverse
No Effect
Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 7 mentions (confidence 0.41) across Supplements, Biohackers.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
post • r/Supplements • mixed
Serrapeptase: real effects on inflammation and recovery? Hello, I'm interested in serrapeptase for its purported effects on inflammation and tissues. Opinions are very divided and sometimes excessive in both directions. I prefer to see bal…
Open mentionpost • r/Biohackers • unclear
Muscle knots fixed by supplementing with serrapeptase and nattokinase Anecdotal occurrence - has happened twice. I’ve experienced injuries from running long distance both in my hips and lower back. I tried daily stretching, professional sp…
Open mentionpost • r/Supplements • mixed
NAC & Serrapeptase - acid reflux / heart burn side effect? I've been using NAC (Pure Encapsulations 1200mg per day) and Serrapeptase (Doctor's Best 120,000 UI per day) as part of a Candida/SIBO overgrowth protocol. After 1 week, i've been …
amazon
Amazon search for Serrapeptase
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier LOW; humans 0, RCTs 0, meta-analyses 0.[2210,3851,5444, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 23821590 from Hum Exp Toxicol.
Outcome: See linked PubMed abstract for methods and outcomes.[2210,, etc.]
terminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
post • r/Supplements • unclear
Lumbrokinase, Nattokinase & Serrapeptase Supplement I've been taking Serrapeptase on and off for a few years for my sinus issues (I still go back and forth on its usefulness), but, after reading about the benefits of Lumbrokinase and Natto…
Open mentionpost • r/Supplements • unclear
Feedback supplement stack! Supplement stack feedback! Please read the below. In the picture it is not the full stack and some I take at half serving etc, like vit C lipsomal I take half dose instead of full 2.5g Let me know any feedback, a…
Open mentionpost • r/Supplements • benefit
Is there actual evidence arterial plaque could be reduced by supplements? Hello everyone, I've started looking into nattokinase, serrapeptase and other similar compounds for its potential to actually reduce arterial plaque and other fibrot…
Open mentionpost • r/Biohackers • benefit
Can someone explain how to do a proper parasite & biofilm cleanse step by step? Hey guys, I’ve been reading a lot about parasites, biofilm, and full body detox lately. I’ve eaten badly for years and I feel like my body might be full of stu…
Open mentionpost • r/Supplements • mixed
Help to pick the right supplements Hi! I find myself in a tuff place in life and really want to change things up. I dived deep into the supplements world until the point i got a bit overwhelmed by the options and was hoping some of you cou…
Open mentioncomment • r/Supplements • benefit
I’ve done hours and hours of research on serrapeptase and sadly came away believing that it does more harm than good. You can find a safer supplement for anything you could use serrapeptase for. For inflammation, omega 3 and Curcumin are b…
Open mentioncomment • r/Supplements • unclear
Hey! Can you explain a little more what kind of issue you had with the pectoral muscle? And how much serrapeptase do you take? I've been struggling with fibrotic muscle tissue in my pectoral after a shoulder injury and have recently starte…
Open mentionCommunity Sources
PUBMED • 2026 • Human evidence curation set
PMID 41642311 from Aesthetic Plast Surg.
Outcome: See linked PubMed abstract for methods and outcomes.[2210,3851,5444, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33307341 from Sex Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2210,3851,5444, etc.]
Open source