Supplement
Supports broad cellular function with category-specific mechanisms.[1962,1972,2298, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
23
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 9 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[48,54,253, etc.]
Dose guide: Follow product label and start with the lowest effective daily serving..[48,54,253, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Follow product label and start with the lowest effective daily serving.
Clinical Depth
Humans: 462 • RCTs: 100 • Meta: 42
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 116 • Interactions: 61
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
737 total studies · 4 recent
Timeline
Total indexed
737
Human studies
462
Animal-only studies
222
In vitro / tissue
152
Safety adverse signals
116
Randomized trials
100
Weighted direction score: 23 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
737
Human studies
462
Animal-only studies
222
In vitro / tissue
152
Safety adverse signals
116
Randomized trials
100
Interaction signals
61
Meta-analyses
42
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 20458757 • 2010 May 14
Systematic review and meta-analysis of Saccharomyces boulardii in adult patients.
World J Gastroenterol
Open PubMedPMID 33295643 • 2020 Dec 8
Probiotics for treating acute infectious diarrhoea.
Cochrane Database Syst Rev
Open PubMedPMID 26756877 • 2016 Mar
Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Children.
J Pediatr Gastroenterol Nutr
Open PubMedBenefit reports: 5
Adverse reports: 2
No-effect reports: 1
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.32
Benefits
Adverse
No Effect
Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 4 mentions (confidence 0.32) across Supplements, Biohackers.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
post • r/Supplements • mixed
Probiotics That Actually Work: A Strain Specific Guide Most probiotics fail because people choose the wrong strain. Forget brands focus on clinically-studied strains for your specific issue. **Target These Strains:** * **Bloating / IBS:** …
Open mentionpost • r/Biohackers • unclear
What to do if the doc prescribed antibiotics? I’m always wondering what the community uses as a substitute for antibiotics? I’ve been dealing with recurring sinus and ear troubles for months. I’m sitting in an urgent care right now and it …
Open mentionpost • r/Biohackers • benefit
Rate My Stack I've taken supplements for a while but pretty new to stacking and this quantity. I think I've pinned down my new routine. Let me know if there is anything I should swap, add, remove, any issues you see, etc. Am I doing too mu…
amazon
Amazon search for Saccharomyces Boulardii
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 462, RCTs 100, meta-analyses 42.[1962,1972,2298, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 20458757 from World J Gastroenterol.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,, etc.]
PMID 38778521 • 2024 Jan-Dec
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes.
Gut Microbes
Open PubMedPMID 32592699 • 2020 Aug
Probiotics Reduce Mortality and Morbidity in Preterm, Low-Birth-Weight Infants: A Systematic Review and Network Meta-analysis of Randomized Trials.
Gastroenterology
Open PubMedPMID 30517196 • 2018
Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis.
PLoS One
Open PubMedPMID 37960315 • 2023 Nov 3
The Effect of Probiotic Supplements on Metabolic Parameters of People with Type 2 Diabetes in Greece-A Randomized, Double-Blind, Placebo-Controlled Study.
Nutrients
Open PubMedPMID 35276991 • 2022 Feb 1
A Four-Probiotics Regimen Combined with A Standard Helicobacter pylori-Eradication Treatment Reduces Side Effects and Increases Eradication Rates.
Nutrients
Open PubMedPMID 39467682 • 2024 Oct 15
[A prospective randomized controlled study on probiotics for the prevention of antibiotic-associated diarrhea in infants and young children].
Zhongguo Dang Dai Er Ke Za Zhi
Open PubMedPMID 38849408 • 2024 Jun 7
Saccharomyces boulardii combined with triple therapy alter the microbiota in the eradication of Helicobacter pylori infection.
Sci Rep
Open PubMedPMID 39592940 • 2024 Nov 26
Effectiveness and safety of vonoprazan and amoxicillin dual regimen with Saccharomyces boulardii supplements on eradication of Helicobacter pylori.
BMC Gastroenterol
Open PubMedPMID 34329947 • 2021 Aug
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial.
EBioMedicine
Open PubMedPMID 24739189 • 2014 Jul
European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014.
J Pediatr Gastroenterol Nutr
Open PubMedPMID 35068121 • 2022 Feb
Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG.
Arch Argent Pediatr
Open PubMedPMID 20208051 • 2010 Mar 15
Probiotics.
Am J Health Syst Pharm
Open PubMedImported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$15.00.
Legacy community note: Popular for skin and joint health. Users report more hydrated skin and reduced joint stiffness. Often stacked with collagen for synergistic beauty benefits. Topical HA also widely used.
post • r/Biohackers • benefit
My rated 10/10 supplement stack by chatGPT for a 32 year old male. What do you guys think? 🧪 💯 10/10 Daily Supplement Stack 🧬 Mitochondrial & Energy Support • NAD+ – 100 mg (SubQ, AM) • PQQ – 40 mg • CoQ10 (Ubiquinol) – 200 mg • TMG (Tr…
Open mentionpost • r/Biohackers • benefit
Can a Probiotic Make You Stronger? What I Found About TWK10 This is not a paid post or advertisement—just an interesting piece of research I found worth sharing..I've always been interested in natural ways to improve endurance, strength, a…
Open mentioncomment • r/Supplements • unclear
**Saccharomyces boulardii** (a beneficial yeast) and **Bifidobacterium lactis HN019** are two of the most clinically supported strains for reducing frequency, improving stool consistency, and regulating bowel movements. Always best to chec…
Open mentionCommunity Sources
PUBMED • 2020 • Human evidence curation set
PMID 33295643 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26756877 from J Pediatr Gastroenterol Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38778521 from Gut Microbes.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32592699 from Gastroenterology.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30517196 from PLoS One.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37960315 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35276991 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39467682 from Zhongguo Dang Dai Er Ke Za Zhi.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38849408 from Sci Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39592940 from BMC Gastroenterol.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34329947 from EBioMedicine.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24739189 from J Pediatr Gastroenterol Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35068121 from Arch Argent Pediatr.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 20208051 from Am J Health Syst Pharm.
Outcome: See linked PubMed abstract for methods and outcomes.[1962,1972,2298, etc.]
Open source