Supplement
Contains bioactive phytochemicals that may modulate stress, immune, and metabolic pathways.[2076,3244,3390, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
10
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 4 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Stress Resilience, Mood, Immune Support, Longevity.[617,760,993, etc.]
Dose guide: Human-study daily dose: 10 mg-500 mg/day (higher-confidence extraction from PubMed abstracts)..[617,760,993, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 10 mg-500 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 1,253 • RCTs: 166 • Meta: 64
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 1,992 • Interactions: 1,769
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
2611 total studies · 2 recent
Timeline
Animal-only studies
5,563
In vitro / tissue
4,672
Total indexed
2,611
Safety adverse signals
1,992
Interaction signals
1,769
Human studies
1,253
Weighted direction score: 10 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
5,563
In vitro / tissue
4,672
Total indexed
2,611
Safety adverse signals
1,992
Interaction signals
1,769
Human studies
1,253
Randomized trials
166
Meta-analyses
64
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 33441476 • 2022 Apr
Efficacy of dietary supplements on improving sleep quality: a systematic review and meta-analysis.
Postgrad Med J
Open PubMedPMID 36159792 • 2022
Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis.
Front Immunol
Open PubMedPMID 33480264 • 2022
Resveratrol supplementation and type 2 diabetes: a systematic review and meta-analysis.
Crit Rev Food Sci Nutr
Open PubMedPMID 33266114 • 2020 Nov 30
A Meta-Analysis of the Impact of Resveratrol Supplementation on Markers of Renal Function and Blood Pressure in Type 2 Diabetic Patients on Hypoglycemic Therapy.
Molecules
Open PubMedPMID 31490554 • 2019 Dec
Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta-analysis.
Ann N Y Acad Sci
Open PubMedPMID 40771814 • 2025
Efficacy and safety of dietary polyphenol supplements for COPD: a systematic review and meta-analysis.
Front Immunol
Open PubMedPMID 32564438 • 2020 Nov
Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial.
J Bone Miner Res
Open PubMedPMID 35240291 • 2022 Jun
Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial.
Complement Ther Med
Open PubMedPMID 37569440 • 2023 Jul 27
Equol and Resveratrol Improve Bone Turnover Biomarkers in Postmenopausal Women: A Clinical Trial.
Int J Mol Sci
Open PubMedPMID 38794742 • 2024 May 16
Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial.
Nutrients
Open PubMedPMID 34656952 • 2021 Nov
Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial.
Clin Nutr
Open PubMedPMID 22055504 • 2011 Nov 2
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.
Cell Metab
Open PubMedPMID 35315418 • 2022 Mar 14
Dietary supplements for treatment of endometriosis: A review.
Acta Biomed
Open PubMedPMID 30816367 • 2019 Feb 28
Health benefits of resveratrol administration.
Acta Biochim Pol
Open PubMedPMID 34696778 • 2021 Oct 25
Prevention of recurrent respiratory infections : Inter-society Consensus.
Ital J Pediatr
Open PubMedBenefit reports: 2
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22resveratrol%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22resveratrol%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=resveratrol
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 10 mg-500 mg/day (confidence HIGH).
Extracted from 5 dosing mentions across 2 PubMed studies (mg/day).
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$25.00.
Legacy community note: Popular in longevity community thanks to David Sinclair. Some debate about whether human doses achieve meaningful sirtuin activation. Users report better skin and energy. Often stacked with NMN.
aggregate • benefit
Aggregate community signal: 4 directional mentions (benefit 2, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Resveratrol
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 1253, RCTs 166, meta-analyses 64.[2076,3244,3390, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 33441476 from Postgrad Med J.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36159792 from Front Immunol.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 33480264 from Crit Rev Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33266114 from Molecules.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31490554 from Ann N Y Acad Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40771814 from Front Immunol.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32564438 from J Bone Miner Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35240291 from Complement Ther Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37569440 from Int J Mol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38794742 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34656952 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2011 • Human evidence curation set
PMID 22055504 from Cell Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35315418 from Acta Biomed.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30816367 from Acta Biochim Pol.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34696778 from Ital J Pediatr.
Outcome: See linked PubMed abstract for methods and outcomes.[2076,3244,3390, etc.]
Open source