Supplement
Contains bioactive phytochemicals that may modulate stress, immune, and metabolic pathways.[1560,1762,1794, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
87/100
High depth from human/RCT/meta counts
Community Direction
10
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 12 • mentions 4 • links 22
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Stress Resilience, Mood, Immune Support, Longevity.[616,759,991, etc.]
Dose guide: Human-study daily dose: 500 mg-1000 mg/day (higher-confidence extraction from PubMed abstracts)..[616,759,991, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 500 mg-1000 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 80 • RCTs: 9 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 131 • Interactions: 89
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
221 total studies · 2 recent
Timeline
Animal-only studies
503
In vitro / tissue
317
Total indexed
221
Safety adverse signals
131
Interaction signals
89
Human studies
80
Weighted direction score: 10 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
503
In vitro / tissue
317
Total indexed
221
Safety adverse signals
131
Interaction signals
89
Human studies
80
Randomized trials
9
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 17907228 • 2007 Oct 15
Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial.
Arthritis Rheum
Open PubMedPMID 38800991 • 2024 Jul 28
Ganoderma lucidum dry extract supplementation modulates T lymphocyte function in older women.
Br J Nutr
Open PubMedPMID 39241163 • 2024
Efficacy of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Supplementation on Psychological Stress and Selective Fitness Profile Parameters in Female College Students in West Bengal, India.
Int J Med Mushrooms
Open PubMedPMID 17597499 • 2007
Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trial.
Am J Chin Med
Open PubMedPMID 28183232 • 2017 Dec
Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers.
Pharm Biol
Open PubMedPMID 14630595 • 2004 Feb
Ganoderma lucidum ('Lingzhi'); acute and short-term biomarker response to supplementation.
Int J Food Sci Nutr
Open PubMedPMID 36995535 • 2023 Jun
Medicinal Mushroom Supplements in Cancer: A Systematic Review of Clinical Studies.
Curr Oncol Rep
Open PubMedPMID 34444885 • 2021 Aug 7
Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum.
Nutrients
Open PubMedPMID 30989848 • 2019 Mar
[Pharmacokinetics of ganoderic acids].
Zhongguo Zhong Yao Za Zhi
Open PubMedPMID 35889330 • 2022 Jul 12
Medicinal Fungi with Antiviral Effect.
Molecules
Open PubMedPMID 30334243 • 2018 Oct 15
Herb-Drug Interactions in Cancer Care.
Oncology (Williston Park)
Open PubMedPMID 37427574 • 2023 Jul 31
Combined Ganoderma lucidum polysaccharide and ciprofloxacin therapy alleviates Salmonella enterica infection, protects the intestinal barrier, and regulates gut microbiota.
Food Funct
Open PubMedBenefit reports: 2
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 1 products scanned (948 ratings) (confidence 0.79).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22reishi%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22reishi%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=reishi
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Lowest observed monthly cost signal: $89.99 (FlavCity Chocolate Protein Powder, Organic Cocoa with Collagen Peptides, Reishi & Cordyceps Mushrooms - Focus, Skin, Hair & Joint Support - 100% Grass Fed Whey All in One Smoothie, 20 Servings).
Human-study daily dose signal: 500 mg-1000 mg/day (confidence HIGH).
Extracted from 7 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$22.00.
aggregate • benefit
Aggregate community signal: 4 directional mentions (benefit 2, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
FlavCity Chocolate Protein Powder, Organic Cocoa with Collagen Peptides, Reishi & Cordyceps Mushrooms - Focus, Skin, Hair & Joint Support - 100% Grass Fed Whey All in One Smoothie, 20 Servings
Rating: 4.2 | Reviews: 948
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 80, RCTs 9, meta-analyses 0.[1560,1762,1794, etc.]
Open sourcePUBMED • 2007 • Human evidence curation set
PMID 17907228 from Arthritis Rheum.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38800991 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39241163 from Int J Med Mushrooms.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2007 • Human evidence curation set
PMID 17597499 from Am J Chin Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28183232 from Pharm Biol.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2004 • Human evidence curation set
PMID 14630595 from Int J Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36995535 from Curr Oncol Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34444885 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30989848 from Zhongguo Zhong Yao Za Zhi.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35889330 from Molecules.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30334243 from Oncology (Williston Park).
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37427574 from Food Funct.
Outcome: See linked PubMed abstract for methods and outcomes.[1560,1762,1794, etc.]
Open source