Supplement
Supports broad cellular function with category-specific mechanisms.[1646,2642,2917, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
74/100
Moderate depth from human/RCT/meta counts
Community Direction
10
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 10 • mentions 4 • links 20
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
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Goal alignment: Longevity, Metabolic Health, Energy.[610,756,984, etc.]
Dose guide: Human-study daily dose: 100 mg-450 mg/day (higher-confidence extraction from PubMed abstracts)..[610,756,984, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 100 mg-450 mg/day (higher-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 100 mg-450 mg/day (higher-confidence extraction from PubMed abstracts).[1646,, etc.]
Clinical Depth
Humans: 39 • RCTs: 6 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 134 • Interactions: 96
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
119 total studies · 2 recent
Timeline
In vitro / tissue
322
Animal-only studies
277
Safety adverse signals
134
Total indexed
119
Interaction signals
96
Human studies
39
Weighted direction score: 10 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
In vitro / tissue
322
Animal-only studies
277
Safety adverse signals
134
Total indexed
119
Interaction signals
96
Human studies
39
Randomized trials
6
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 40024751 • 2025
Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study.
J Nutr Sci Vitaminol (Tokyo)
Open PubMedPMID 35998039 • 2022 Oct 10
A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals.
JCI Insight
Open PubMedPMID 36082508 • 2023 Sep 1
Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial.
Benefit reports: 2
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
aggregate • benefit
Aggregate community signal: 4 directional mentions (benefit 2, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Pterostilbene
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 39, RCTs 6, meta-analyses 0.[1646,2642,2917, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40024751 from J Nutr Sci Vitaminol (Tokyo).
Outcome: See linked PubMed abstract for methods and outcomes.[1646,, etc.]
Hepatology
PMID 27293386 • 2016
Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men.
J Int Soc Sports Nutr
Open PubMedPMID 37671486 • 2023 Jan-Dec
A Short-Term Safety Evaluation of Silbinol(®)- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.
J Evid Based Integr Med
Open PubMedPMID 15931573 • 2005 May
Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers.
Planta Med
Open PubMedPMID 37068054 • 2023 Dec 1
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions.
J Gerontol A Biol Sci Med Sci
Open PubMedPMID 29315906 • 2018 Jan
Antiobesity molecular mechanisms of action: Resveratrol and pterostilbene.
Biofactors
Open PubMedPMID 32064876 • 2020 Nov 18
Occurrence, Bioavailability, Anti-inflammatory, and Anticancer Effects of Pterostilbene.
J Agric Food Chem
Open PubMedPMID 37486219 • 2024 Nov
Antiobesity pathways of pterostilbene and resveratrol: a comprehensive insight.
Crit Rev Food Sci Nutr
Open PubMedPerimeterX / captcha block encountered.
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Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22pterostilbene%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=pterostilbene
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 100 mg-450 mg/day (confidence HIGH).
Extracted from 5 dosing mentions across 3 PubMed studies (mg/day).
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$25.00.
Legacy community note: Increasingly chosen over resveratrol by sophisticated biohackers due to pharmacokinetic advantages. Often combined with NR (Elysium Basis product). Some concern about LDL increase at high doses.
Community Sources
PUBMED • 2022 • Human evidence curation set
PMID 35998039 from JCI Insight.
Outcome: See linked PubMed abstract for methods and outcomes.[1646,2642,2917, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36082508 from Hepatology.
Outcome: See linked PubMed abstract for methods and outcomes.[1646,2642,2917, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 27293386 from J Int Soc Sports Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1646,2642,2917, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37671486 from J Evid Based Integr Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1646,2642,2917, etc.]
Open sourcePUBMED • 2005 • Human evidence curation set
PMID 15931573 from Planta Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1646,2642,2917, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37068054 from J Gerontol A Biol Sci Med Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[1646,2642,2917, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29315906 from Biofactors.
Outcome: See linked PubMed abstract for methods and outcomes.[1646,2642,2917, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32064876 from J Agric Food Chem.
Outcome: See linked PubMed abstract for methods and outcomes.[1646,2642,2917, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 37486219 from Crit Rev Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1646,2642,2917, etc.]
Open source