Supplement
Supports broad cellular function with category-specific mechanisms.[2182,2852,2981, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
10
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 11 • mentions 4 • links 21
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[601,747,974, etc.]
Dose guide: Human-study daily dose: 30 mg/day (moderate-confidence extraction from PubMed abstracts)..[601,747,974, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 30 mg/day (moderate-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 30 mg/day (moderate-confidence extraction from PubMed abstracts).[2182,, etc.]
Clinical Depth
Humans: 203 • RCTs: 29 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 726 • Interactions: 3,077
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
515 total studies · 3 recent
Timeline
Animal-only studies
5,785
In vitro / tissue
3,229
Interaction signals
3,077
Safety adverse signals
726
Total indexed
515
Human studies
203
Weighted direction score: 10 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
5,785
In vitro / tissue
3,229
Interaction signals
3,077
Safety adverse signals
726
Total indexed
515
Human studies
203
Randomized trials
29
Meta-analyses
1
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 33539192 • 2021 Apr
Phosphatidylserine for the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.
J Altern Complement Med
Open PubMedPMID 36558392 • 2022 Dec 8
A Magtein(®), Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults.
Nutrients
Open PubMedPMID 23495677 • 2014 Apr
The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial.
Benefit reports: 2
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
aggregate • benefit
Aggregate community signal: 4 directional mentions (benefit 2, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Phosphatidylserine
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 203, RCTs 29, meta-analyses 1.[2182,2852,2981, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33539192 from J Altern Complement Med.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
J Hum Nutr Diet
PMID 39317299 • 2025 Jan 15
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial.
J Affect Disord
Open PubMedPMID 38173190 • 2024 Apr
Phosphatidylserine enriched with polyunsaturated n-3 fatty acid supplementation for attention-deficit hyperactivity disorder in children and adolescents with epilepsy: A randomized placebo-controlled trial.
Epilepsia Open
Open PubMedPMID 36014880 • 2022 Aug 17
Water-Soluble Tomato Concentrate, a Potential Antioxidant Supplement, Can Attenuate Platelet Apoptosis and Oxidative Stress in Healthy Middle-Aged and Elderly Adults: A Randomized, Double-Blinded, Crossover Clinical Trial.
Nutrients
Open PubMedPMID 29576358 • 2018 Apr
A lecithin phosphatidylserine and phosphatidic acid complex (PAS) reduces symptoms of the premenstrual syndrome (PMS): Results of a randomized, placebo-controlled, double-blind clinical trial.
Clin Nutr ESPEN
Open PubMedPMID 37603263 • 2023 Sep
Over the Counter Supplements for Memory: A Review of Available Evidence.
CNS Drugs
Open PubMedPMID 40077790 • 2025 Mar 6
Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.
Nutrients
Open PubMedPMID 32370748 • 2020 May 5
Regulation of efferocytosis as a novel cancer therapy.
Cell Commun Signal
Open PubMedPMID 28870843 • 2018 Oct
Phosphatidylserine: A cancer cell targeting biomarker.
Semin Cancer Biol
Open PubMedPerimeterX / captcha block encountered.
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Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=phosphatidylserine
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 30 mg/day (confidence MEDIUM).
Extracted from 2 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$22.00.
Legacy community note: Respected in nootropic and cortisol-management communities. Athletes use it for cortisol control. Elderly report memory improvements. Often part of comprehensive brain health stacks.
Community Sources
PUBMED • 2022 • Human evidence curation set
PMID 36558392 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2182,2852,2981, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 23495677 from J Hum Nutr Diet.
Outcome: See linked PubMed abstract for methods and outcomes.[2182,2852,2981, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39317299 from J Affect Disord.
Outcome: See linked PubMed abstract for methods and outcomes.[2182,2852,2981, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38173190 from Epilepsia Open.
Outcome: See linked PubMed abstract for methods and outcomes.[2182,2852,2981, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36014880 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2182,2852,2981, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29576358 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[2182,2852,2981, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37603263 from CNS Drugs.
Outcome: See linked PubMed abstract for methods and outcomes.[2182,2852,2981, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40077790 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2182,2852,2981, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32370748 from Cell Commun Signal.
Outcome: See linked PubMed abstract for methods and outcomes.[2182,2852,2981, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 28870843 from Semin Cancer Biol.
Outcome: See linked PubMed abstract for methods and outcomes.[2182,2852,2981, etc.]
Open source