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Supplement

Panax Ginseng (Korean Red Ginseng)

Ginsenosides modulate HPA axis, enhance NO synthesis, improve glucose uptake, and exert neuroprotective/immunomodulatory effects via multiple pathways.[1859,2660,2866, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence
EnergyCognitiveImmune SupportLibidoStress Resiliencealias: Korean ginsengalias: Asian ginsengalias: red ginsengalias: KRG

Composite Rating

2.2/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

40/100

Early depth from human/RCT/meta counts

Community Direction

9

Mixed / Neutral • confidence Minimal

Safety Friction

92/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 6 • mentions 8 • links 19

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Energy, Cognitive, Immune Support, Libido, Stress Resilience.[535,683,907, etc.]

Dose guide: Human-study daily dose: 40 mg-67 mg/day (moderate-confidence extraction from PubMed abstracts)..[535,683,907, etc.]

Category: botanical.[535,683,907, etc.]

Category

Botanical

Evidence Tier

ROBUST

Daily Guide

Human-study daily dose: 40 mg-67 mg/day (moderate-confidence extraction from PubMed abstracts).

Dosing Guide

Human-study daily dose: 40 mg-67 mg/day (moderate-confidence extraction from PubMed abstracts).[, etc.]

At-A-Glance Evidence Architecture[1859,2660,2866, etc.]

Clinical Depth

Humans: 6 • RCTs: 2 • Meta: 0

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 11 • Interactions: 17

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

Established

Trend

→ Stable evidence base

Depth

28 total studies

Timeline

20082022

Top Signal Metrics[1859,2660,2866, etc.]

Animal-only studies

56

In vitro / tissue

50

Total indexed

28

Interaction signals

17

Safety adverse signals

11

Human studies

6

Community Direction Mix[535,683,907, etc.]

Weighted direction score: 9 (Mixed / Neutral)

Evidence Quality Summary[1859,2660,2866, etc.]

Some human evidence or substantial animal evidence.

Animal-only studies

56

In vitro / tissue

50

Total indexed

28

Interaction signals

17

Safety adverse signals

11

Human studies

6

Randomized trials

2

Meta-analyses

0

Study Type Breakdown

Distribution of evidence by study design strength

Randomized TrialsLevel 1b2
Human Studies (other)Level 3-44
All IndexedAll levels28
40

Evidence Strength: Early

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1859,2660,2866, etc.]

PMID 33650944 • 2022 Aug

Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials.

Nutritional neuroscience

Open PubMed

PMID 32893745 • 2020 Nov-Dec

Vitamin E and ginseng supplementation to enhance female sexual function: a randomized, double-blind, placebo-controlled, clinical trial.

Women & health

Open PubMed

PMID 28981384 • 2018 Jan

The Effects of a Korean Ginseng, GINST15, on Hypo-Pituitary-Adrenal and Oxidative Activity Induced by Intense Work Stress.

Community Report Frequency[535,683,907, etc.]

Benefit reports: 4

Adverse reports: 3

No-effect reports: 0

Mixed reports: 1

Unclear reports: 0

Signal confidence: 0.00

Top Reported Effects[535,683,907, etc.]

Benefits

  • Enhanced energy and vitality: 1
  • Improved erectile function: 1
  • Immune system stimulation: 1
  • Cognitive enhancement: 1
  • Anti-fatigue effects: 1
  • Adaptogenic stress support: 1

Adverse

  • Insomnia (stimulating): 1
  • Uncontrolled high blood pressure: 1
  • Those on blood thinners: 1

No Effect

  • insufficient no-effect reports captured: 0

One of the most studied herbs globally. Korean Red form has best evidence. Avoid cheap non-standardized products. | Step2: Insufficient empirical signal for a directional adjustment.

Community Evidence Examples[535,683,907, etc.]

aggregate • benefit

Aggregate community signal: 8 directional mentions (benefit 4, adverse 3, no-effect 0, mixed 1).

Open mention

Retail Signal Examples

amazon

Amazon search for Panax Ginseng (Korean Red Ginseng)

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22korean%20ginseng%22)%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)
  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22korean%20ginseng%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)
  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22korean%20ginseng%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%20randomized%20controlled%20trial%5BPublication%20Type%5D

Scientific Evidence Notes[1859,2660,2866, etc.]

1. Panax ginseng and cognitive function: MA of RCTs

META_ANALYSIS • 2018 • Adults

10 RCTs with 834 subjects.

Outcome: Ginseng significantly improved cognitive composite scores (ES 0.36), reaction time, and working memory in healthy adults and MCI patients.[1859,2660,2866, etc.]

Open source
2. Korean Red Ginseng and erectile dysfunction: MA of 7 RCTs

META_ANALYSIS • 2008 • Adults

7 RCTs with 363 men with ED.

Outcome: KRG 600-1000 mg TID significantly improved IIEF erectile function score (SMD 1.4) and satisfaction vs placebo.[1859,2660,2866, etc.]

1859,
2660,
2866

Safety and Pitfalls

  • May cause insomnia if taken in evening. Cycle 8 weeks on / 2 weeks off.[535,683,907, etc.]
  • Potential side effect: insomnia[535,683,907, etc.]
  • Potential side effect: headache[535,683,907, etc.]
  • Potential side effect: GI upset[535,683,907, etc.]
  • Use caution with condition: hormone-sensitive cancers (theoretical)[535,683,907, etc.]
  • Interaction check: anticoagulants (warfarin)[535,683,907, etc.]
  • Interaction check: MAOIs[535,683,907, etc.]
  • Interaction check: insulin/diabetes meds (additive)[535,683,907, etc.]
  • Legacy caution group: Insomnia (stimulating)[535,683,907, etc.]
  • Legacy caution group: Uncontrolled high blood pressure[535,683,907, etc.]
  • Legacy caution group: Those on blood thinners[535,683,907, etc.]
Benefit
4 (50%)
Adverse3 (38%)
No Effect0 (0%)
Mixed1 (13%)

Journal of medicinal food

Open PubMed

PMID 32481563 • 2020 May 28

Effects of Ginseng Ingestion on Salivary Testosterone and DHEA Levels in Healthy Females: An Exploratory Study.

Nutrients

Open PubMed

PMID 32112899 • 2020 May 23

Korean red ginseng attenuates hyperglycemia-induced renal inflammation and fibrosis via accelerated autophagy and protects against diabetic kidney disease.

Journal of ethnopharmacology

Open PubMed

PMID 33081281 • 2020 Oct 16

Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model.

Molecules (Basel, Switzerland)

Open PubMed

Reddit evidence: 0 mentions (confidence 0.00).

Amazon signal: 0 products scanned (confidence 0.00).

GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].

PerimeterX / captcha block encountered.

Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22korean%20ginseng%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)

Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22korean%20ginseng%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)

Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=korean%20ginseng

Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.

Human-study daily dose signal: 40 mg-67 mg/day (confidence MEDIUM).

Extracted from 3 dosing mentions across 2 PubMed studies (mg/day).

Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).

Legacy community note: Widely used and respected. Men particularly appreciate the sexual health benefits and energy boost. Some find it too stimulating and prefer American ginseng.

https://pubmed.ncbi.nlm.nih.gov/?term=(%22korean%20ginseng%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%20meta-analysis%5BPublication%20Type%5D
  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22korean%20ginseng%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%202018%3A3000%5Bpdat%5D
  • https://pubmed.ncbi.nlm.nih.gov/33650944/
  • https://pubmed.ncbi.nlm.nih.gov/32893745/
  • https://pubmed.ncbi.nlm.nih.gov/28981384/
  • https://pubmed.ncbi.nlm.nih.gov/32481563/
  • https://pubmed.ncbi.nlm.nih.gov/32112899/
  • https://pubmed.ncbi.nlm.nih.gov/33081281/
  • https://pubmed.ncbi.nlm.nih.gov/29929234/
  • https://pubmed.ncbi.nlm.nih.gov/18754850/
  • https://pubmed.ncbi.nlm.nih.gov/27396868/
  • https://pubmed.ncbi.nlm.nih.gov/?term=Panax%20Ginseng%20(Korean%20Red%20Ginseng)
  • Community Sources

    • https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22korean%20ginseng%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
    • https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22korean%20ginseng%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
    • https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=korean%20ginseng
    • https://www.reddit.com/search/?q=Panax%20Ginseng%20(Korean%20Red%20Ginseng)
    Open source
    3. Ginseng and fasting blood glucose: MA of RCTs

    META_ANALYSIS • 2016 • Adults

    16 RCTs with 770 subjects.

    Outcome: Panax ginseng reduced fasting blood glucose by −0.31 mmol/L and HOMA-IR in diabetic/prediabetic populations.[1859,2660,2866, etc.]

    Open source
    4. PubMed evidence summary: Korean Ginseng

    PUBMED • Humans + preclinical triage

    Counts aggregated from automated literature sweep and tiering rules.

    Outcome: Tier MEDIUM; humans 6, RCTs 2, meta-analyses 0.[1859,2660,2866, etc.]

    Open source
    5. Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials.

    PUBMED • 2022 • Human evidence curation set

    PMID 33650944 from Nutritional neuroscience.

    Outcome: See linked PubMed abstract for methods and outcomes.[1859,2660,2866, etc.]

    Open source
    6. Vitamin E and ginseng supplementation to enhance female sexual function: a randomized, double-blind, placebo-controlled, clinical trial.

    PUBMED • 2020 • Human evidence curation set

    PMID 32893745 from Women & health.

    Outcome: See linked PubMed abstract for methods and outcomes.[1859,2660,2866, etc.]

    Open source
    7. The Effects of a Korean Ginseng, GINST15, on Hypo-Pituitary-Adrenal and Oxidative Activity Induced by Intense Work Stress.

    PUBMED • 2018 • Human evidence curation set

    PMID 28981384 from Journal of medicinal food.

    Outcome: See linked PubMed abstract for methods and outcomes.[1859,2660,2866, etc.]

    Open source
    8. Effects of Ginseng Ingestion on Salivary Testosterone and DHEA Levels in Healthy Females: An Exploratory Study.

    PUBMED • 2020 • Human evidence curation set

    PMID 32481563 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1859,2660,2866, etc.]

    Open source
    9. Korean red ginseng attenuates hyperglycemia-induced renal inflammation and fibrosis via accelerated autophagy and protects against diabetic kidney disease.

    PUBMED • 2020 • Human evidence curation set

    PMID 32112899 from Journal of ethnopharmacology.

    Outcome: See linked PubMed abstract for methods and outcomes.[1859,2660,2866, etc.]

    Open source
    10. Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model.

    PUBMED • 2020 • Human evidence curation set

    PMID 33081281 from Molecules (Basel, Switzerland).

    Outcome: See linked PubMed abstract for methods and outcomes.[1859,2660,2866, etc.]

    Open source