Supplement
Supports membrane fluidity, anti-inflammatory lipid mediators, and triglyceride control.[1382,1698,2201, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
12
Mixed / Neutral • confidence Minimal
Safety Friction
81/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 23 • mentions 6 • links 41
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Heart Health, Longevity, Metabolic Health, Brain Health.[588,589,736, etc.]
Dose guide: 1-3 g/day combined EPA+DHA with meals.[588,589,736, etc.]
Category
Fatty Acid
Evidence Tier
HIGH
Daily Guide
1-3 g/day combined EPA+DHA with meals
Clinical Depth
Humans: 59 • RCTs: 17 • Meta: 5
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 9 • Interactions: 10
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
79 total studies · 5 recent
Timeline
Total indexed
79
Human studies
59
Animal-only studies
23
Randomized trials
17
Interaction signals
10
In vitro / tissue
9
Weighted direction score: 12 (Mixed / Neutral)
Aggregated evidence from 2 mapped records: Omega-3 Epa, Omega-3 Dha.
Total indexed
79
Human studies
59
Animal-only studies
23
Randomized trials
17
Interaction signals
10
In vitro / tissue
9
Safety adverse signals
9
Meta-analyses
5
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 31847055 • 2019 Dec 18
Omega-3 and omega-6 polyunsaturated fatty acids for dry eye disease.
Cochrane Database Syst Rev
Open PubMedPMID 39617283 • 2025 Jul-Aug
Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword.
Prog Cardiovasc Dis
Open PubMedPMID 26229448 • 2015
Aterofisiol(®) in carotid plaque evolution.
Drug Des Devel Ther
Open PubMedBenefit reports: 3
Adverse reports: 2
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
High adherence when capsules are enteric-coated. | Step2: Aggregated empirical signal from 2 mapped records.
aggregate • benefit
Aggregate community signal: 6 directional mentions (benefit 3, adverse 2, no-effect 0, mixed 1).
Open mentionamazon
Amazon search for Omega-3 (EPA + DHA)
Rating: n/a | Reviews: n/a
Open productEvidence Sources
META_ANALYSIS • 2023 • Adults
Large pooled analyses in humans.
Outcome: Improves triglycerides; mixed mortality effects.[1382,1698,2201, etc.]
RCT • 2019 • Adults
High-risk cohorts on statins.
Outcome: Lower major CV event risk in selected groups.[1382,1698,2201, etc.]
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 59, RCTs 17, meta-analyses 5.[, etc.]
PMID 34130033 • 2021 Jun
Methodology for altering omega-3 EPA+DHA and omega-6 linoleic acid as controlled variables in a dietary trial.
Clin Nutr
Open PubMedPMID 31192682 • 2019 Aug 26
Effects of omega-3 fatty acids supplementation on neoadjuvant chemotherapy-induced toxicity in patients with locally advanced breast cancer: a randomized, controlled, double-blinded clinical trial.
Nutr Hosp
Open PubMedPMID 36602145 • 2023 Feb 15
[Parenteral supplementation with EPA/DHA omega-3 fatty acids improves recovery prognosis in critically ill patients].
Nutr Hosp
Open PubMedPMID 33932804 • 2021 May
Type 2 diabetes preventive effects with a 12-months sardine-enriched diet in elderly population with prediabetes: An interventional, randomized and controlled trial.
Clin Nutr
Open PubMedPMID 31555976 • 2020 Sep
EPA and DHA as markers of nutraceutical treatment response in major depressive disorder.
Eur J Nutr
Open PubMedPMID 41311022 • 2026 Mar 1
Re-evaluating omega-3 (EPA/DHA) in cancer prevention and management.
Curr Opin Clin Nutr Metab Care
Open PubMedPMID 41072116 • 2025 Dec
A review of the relationships between reported fish oil supplement use and health outcomes in the UK Biobank.
Prostaglandins Leukot Essent Fatty Acids
Open PubMedPMID 30480773 • 2018 Nov 15
Omega-3 fatty acid addition during pregnancy.
Cochrane Database Syst Rev
Open PubMedPMID 38924283 • 2024 Sep
The effects of omega-3, DHA, EPA, Souvenaid® in Alzheimer's disease: A systematic review and meta-analysis.
Neuropsychopharmacol Rep
Open PubMedPMID 16855961 • 2006 Jul 19
Polyunsaturated fatty acid supplementation for schizophrenia.
Cochrane Database Syst Rev
Open PubMedPMID 26432510 • 2015 Dec
Analysis of hospital cost outcome of DHA-rich fish-oil supplementation in pregnancy: Evidence from a randomized controlled trial.
Prostaglandins Leukot Essent Fatty Acids
Open PubMedPMID 23702094 • 2013 May 23
Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial.
BMC Pediatr
Open PubMedPMID 31595295 • 2019 Dec 1
Effects of oily fish intake on cardiometabolic markers in healthy 8- to 9-y-old children: the FiSK Junior randomized trial.
Am J Clin Nutr
Open PubMedPMID 32155883 • 2020 Mar 6
The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial.
Nutrients
Open PubMedPMID 31963702 • 2020 Jan 18
Microencapsulated Tuna Oil Results in Higher Absorption of DHA in Toddlers.
Nutrients
Open PubMedPMID 10913225 • 2000 Jun
Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition.
Prostaglandins Leukot Essent Fatty Acids
Open PubMedPMID 31811955 • 2020 Jan
Influence of sociodemographic, lifestyle and genetic characteristics on maternal DHA and other polyunsaturated fatty acid status in pregnancy: A systematic review.
Prostaglandins Leukot Essent Fatty Acids
Open PubMedPMID 29040821 • 2018 May
Dietary Intake and Omega-3 DHA Status in Pregnant Women Who Are Overweight.
J Obstet Gynecol Neonatal Nurs
Open PubMedPMID 35956403 • 2022 Aug 7
Consumption of Omega-3 and Maintenance and Incidence of Depressive Episodes: The ELSA-Brasil Study.
Nutrients
Open PubMedPMID 38943596 • 2024 Jul 10
Omega-3 Long-Chain Polyunsaturated Fatty Acids in Nonseafood and Estimated Intake in the USA: Quantitative Analysis by Covalent Adduct Chemical Ionization Mass Spectrometry.
J Agric Food Chem
Open PubMedReddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22omega-3%20epa%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22omega-3%20epa%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=omega-3%20epa
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use. | Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Imported legacy community score: 9.0/10 (manual mapping confidence 1.00).
Imported legacy monthly cost signal: ~$15.00.
Legacy community note: Overwhelmingly positive. Users consistently report reduced joint pain, improved mood, better skin, and improved bloodwork markers. One of the most universally recommended supplements across all health communities.
Community Sources
PUBMED • 2019 • Human evidence curation set
PMID 31847055 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39617283 from Prog Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26229448 from Drug Des Devel Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34130033 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31192682 from Nutr Hosp.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36602145 from Nutr Hosp.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33932804 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31555976 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 41311022 from Curr Opin Clin Nutr Metab Care.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 41072116 from Prostaglandins Leukot Essent Fatty Acids.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30480773 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38924283 from Neuropsychopharmacol Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 16855961 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26432510 from Prostaglandins Leukot Essent Fatty Acids.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 23702094 from BMC Pediatr.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31595295 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32155883 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31963702 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2000 • Human evidence curation set
PMID 10913225 from Prostaglandins Leukot Essent Fatty Acids.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31811955 from Prostaglandins Leukot Essent Fatty Acids.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29040821 from J Obstet Gynecol Neonatal Nurs.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35956403 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38943596 from J Agric Food Chem.
Outcome: See linked PubMed abstract for methods and outcomes.[1382,1698,2201, etc.]
Open source