Supplement
Contains bioactive phytochemicals that may modulate stress, immune, and metabolic pathways.[2389,2601,2683, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
89/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 11 • mentions 2 • links 21
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Stress Resilience, Mood, Immune Support, Longevity.[586,734,958, etc.]
Dose guide: Human-study daily dose: 3 mg-250 mg/day (higher-confidence extraction from PubMed abstracts)..[586,734,958, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 3 mg-250 mg/day (higher-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 3 mg-250 mg/day (higher-confidence extraction from PubMed abstracts).[,, etc.]
Clinical Depth
Humans: 31 • RCTs: 10 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 42 • Interactions: 24
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
81 total studies · 2 recent
Timeline
In vitro / tissue
97
Animal-only studies
96
Total indexed
81
Safety adverse signals
42
Human studies
31
Interaction signals
24
Weighted direction score: 0 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
In vitro / tissue
97
Animal-only studies
96
Total indexed
81
Safety adverse signals
42
Human studies
31
Interaction signals
24
Randomized trials
10
Meta-analyses
1
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 36513474 • 2022 Dec
What is the efficacy of dietary, nutraceutical, and probiotic interventions for the management of gastroesophageal reflux disease symptoms? A systematic literature review and meta-analysis.
Clin Nutr ESPEN
Open PubMedPMID 39599665 • 2024 Nov 14
Olive Leaf Extract Supplementation Improves Postmenopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Parallel Study on Postmenopausal Women.
Nutrients
Open PubMedPMID 37375586 • 2023 Jun 9
Benefit reports: 1
Adverse reports: 1
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22olive%20leaf%20extract%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
aggregate • unclear
Aggregate community signal: 2 directional mentions (benefit 1, adverse 1, no-effect 0, mixed 0).
Open mentionamazon
Amazon search for Olive Leaf Extract
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 31, RCTs 10, meta-analyses 1.[2389,2601,2683, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36513474 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.
Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial.
Nutrients
PMID 39993475 • 2025 May
Oleuropein Supplementation Increases Resting Skeletal Muscle Fractional Pyruvate Dehydrogenase Activity but Does Not Influence Whole-Body Metabolism: A Randomized, Double-Blind, and Placebo-Controlled Trial in Healthy, Older Males.
J Nutr
Open PubMedPMID 33034707 • 2021 Jun
The effect of olive leaf extract on cardiovascular health markers: a randomized placebo-controlled clinical trial.
Eur J Nutr
Open PubMedPMID 26951205 • 2017 Jun
Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial.
Eur J Nutr
Open PubMedPMID 25379688 • 2014 Nov 5
Antihypertensive potential of combined extracts of olive leaf, green coffee bean and beetroot: a randomized, double-blind, placebo-controlled crossover trial.
Nutrients
Open PubMedPMID 38256329 • 2023 Dec 29
Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
Medicina (Kaunas)
Open PubMedPMID 27548217 • 2016 Aug 19
Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions.
Nutrients
Open PubMedPMID 29099642 • 2018 Mar
Oleuropein Is Responsible for the Major Anti-Inflammatory Effects of Olive Leaf Extract.
J Med Food
Open PubMedPMID 31035323 • 2019 Apr 28
Olive Leaf Extract (OleaVita) Suppresses Inflammatory Cytokine Production and NLRP3 Inflammasomes in Human Placenta.
Nutrients
Open PubMedFallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22olive%20leaf%20extract%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=olive%20leaf%20extract
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 3 mg-250 mg/day (confidence HIGH).
Extracted from 9 dosing mentions across 4 PubMed studies (mg/day).
Community Sources
PUBMED • 2024 • Human evidence curation set
PMID 39599665 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2389,2601,2683, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37375586 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2389,2601,2683, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39993475 from J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2389,2601,2683, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33034707 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2389,2601,2683, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 26951205 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2389,2601,2683, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 25379688 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2389,2601,2683, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38256329 from Medicina (Kaunas).
Outcome: See linked PubMed abstract for methods and outcomes.[2389,2601,2683, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 27548217 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2389,2601,2683, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29099642 from J Med Food.
Outcome: See linked PubMed abstract for methods and outcomes.[2389,2601,2683, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31035323 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2389,2601,2683, etc.]
Open source