Supplement
Fibrinolytic enzyme from natto fermentation.[1873,1936,3302, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
68/100
Moderate depth from human/RCT/meta counts
Community Direction
18
Positive Lean • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 9 • mentions 4 • links 19
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Heart Health, Longevity.[581,729,953, etc.]
Dose guide: 100-200 mg/day standardized activity units.[581,729,953, etc.]
Category
Enzyme
Evidence Tier
MEDIUM
Daily Guide
100-200 mg/day standardized activity units
Clinical Depth
Humans: 20 • RCTs: 7 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 40 • Interactions: 29
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
53 total studies · 2 recent
Timeline
Total indexed
53
In vitro / tissue
51
Animal-only studies
46
Safety adverse signals
40
Interaction signals
29
Human studies
20
Weighted direction score: 18 (Positive Lean)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
Total indexed
53
In vitro / tissue
51
Animal-only studies
46
Safety adverse signals
40
Interaction signals
29
Human studies
20
Randomized trials
7
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 33843667 • 2021
Nattokinase atherothrombotic prevention study: A randomized controlled trial.
Clin Hemorheol Microcirc
Open PubMedPMID 31070609 • 2019 May 22
The effects of nattokinase supplementation on collagen-epinephrine closure time, prothrombin time and activated partial thromboplastin time in nondiabetic and hypercholesterolemic subjects.
Food Funct
Open PubMedPMID 37836525 • 2023 Sep 30
The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Benefit reports: 2
Adverse reports: 1
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Often used in vascular stacks despite lower certainty evidence. | Step2: Insufficient empirical signal for a directional adjustment.
aggregate • benefit
Aggregate community signal: 4 directional mentions (benefit 2, adverse 1, no-effect 0, mixed 1).
Open mentionamazon
Amazon search for Nattokinase
Rating: n/a | Reviews: n/a
Open productEvidence Sources
RCT • 2021 • Adults
Small human studies.
Outcome: Possible modest vascular marker benefits.[1873,1936,3302, etc.]
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 20, RCTs 7, meta-analyses 0.[1873,1936,3302, etc.]
Open sourceNutrients
PMID 18971533 • 2008 Aug
Effects of nattokinase on blood pressure: a randomized, controlled trial.
Hypertens Res
Open PubMedPMID 19786378 • 2009
Combined nattokinase with red yeast rice but not nattokinase alone has potent effects on blood lipids in human subjects with hyperlipidemia.
Asia Pac J Clin Nutr
Open PubMedPMID 41325794 • 2026 Jan
Nattokinase supplementation for cognitive enhancement in asymptomatic intracranial/carotid stenosis: A randomized controlled trial.
J Stroke Cerebrovasc Dis
Open PubMedPMID 33966563 • 2022
Phosphocalcic metabolism and the role of vitamin D, vitamin K2, and nattokinase supplementation.
Crit Rev Food Sci Nutr
Open PubMedPMID 35883536 • 2022 Jul 13
Biotechnology, Bioengineering and Applications of Bacillus Nattokinase.
Biomolecules
Open PubMedPMID 40573100 • 2025 Jun 12
Fermented Fruits, Vegetables, and Legumes in Metabolic Syndrome: From Traditional Use to Functional Foods and Medical Applications.
Nutrients
Open PubMedReddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22nattokinase%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22nattokinase%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=nattokinase
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$18.00.
Legacy community note: Rapidly growing popularity. Users in cardiovascular communities report improved circulation, reduced leg swelling, and better bloodwork. Some cardiologists are recommending it. Strong following in Japanese health traditions.
Community Sources
PUBMED • 2021 • Human evidence curation set
PMID 33843667 from Clin Hemorheol Microcirc.
Outcome: See linked PubMed abstract for methods and outcomes.[1873,1936,3302, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31070609 from Food Funct.
Outcome: See linked PubMed abstract for methods and outcomes.[1873,1936,3302, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37836525 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1873,1936,3302, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18971533 from Hypertens Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1873,1936,3302, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19786378 from Asia Pac J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1873,1936,3302, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 41325794 from J Stroke Cerebrovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[1873,1936,3302, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 33966563 from Crit Rev Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1873,1936,3302, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35883536 from Biomolecules.
Outcome: See linked PubMed abstract for methods and outcomes.[1873,1936,3302, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40573100 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1873,1936,3302, etc.]
Open source