Mucuna Pruriens (Velvet Bean)

MECHANISTIC • 2012 • Adults

Preclinical and clinical review.

Outcome: Mucuna-derived L-DOPA crosses BBB, upregulates dopamine synthesis, shows comparable efficacy to synthetic L-DOPA for Parkinson's symptoms in small clinical studies.[1897,1918,1993, etc.]

PUBMED • Humans + preclinical triage

Counts aggregated from automated literature sweep and tiering rules.

Outcome: Tier MEDIUM; humans 12, RCTs 3, meta-analyses 0.[1897,1918,1993, etc.]

PUBMED • 2017 • Human evidence curation set

PMID 28679598 from Neurology.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2026 • Human evidence curation set

PMID 41269916 from Journal of Parkinson's disease.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2018 • Human evidence curation set

PMID 29352722 from Parkinsonism & related disorders.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2022 • Human evidence curation set

PMID 35939305 from JAMA neurology.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2024 • Human evidence curation set

PMID 38462520 from Internal medicine (Tokyo, Japan).

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2026 • Human evidence curation set

PMID 41575577 from Amino acids.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2020 • Human evidence curation set

PMID 32179240 from Parkinsonism & related disorders.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2019 • Human evidence curation set

PMID 31796973 from Southern medical journal.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2018 • Human evidence curation set

PMID 29427634 from Journal of ethnopharmacology.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2015 • Human evidence curation set

PMID 26366963 from Clinical neuropharmacology.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2025 • Human evidence curation set

PMID 41220013 from The Senior care pharmacist.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]

PUBMED • 2010 • Human evidence curation set

PMID 19207619 from International journal of andrology.

Outcome: See linked PubMed abstract for methods and outcomes.[1897,1918,1993, etc.]