Supplement
Supports broad cellular function with category-specific mechanisms.[2558,2839,2869, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
10
Mixed / Neutral • confidence Minimal
Safety Friction
99/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 12 • mentions 4 • links 22
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[570,718,942, etc.]
Dose guide: Human-study daily dose: 500 mg-1500 mg/day (higher-confidence extraction from PubMed abstracts)..[570,718,942, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 500 mg-1500 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 64 • RCTs: 18 • Meta: 2
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 31 • Interactions: 7
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
103 total studies · 2 recent
Timeline
Total indexed
103
Human studies
64
Animal-only studies
43
Safety adverse signals
31
In vitro / tissue
30
Randomized trials
18
Weighted direction score: 10 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
103
Human studies
64
Animal-only studies
43
Safety adverse signals
31
In vitro / tissue
30
Randomized trials
18
Interaction signals
7
Meta-analyses
2
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 29018060 • 2018 Feb
Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.
Br J Sports Med
Open PubMedPMID 40425393 • 2025 Jul
Effects of dietary supplements on patients with osteoarthritis: A systematic review and network meta-analysis.
J Integr Med
Open PubMedPMID 28790224 • 2017 Apr
Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial.
Acta Med Indones
Open PubMedPMID 33617972 • 2021 May
Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study.
Osteoarthritis Cartilage
Open PubMedPMID 40507030 • 2025 May 23
Using the Rise and Fall of Oxidative Stress and Inflammation Post-Exercise to Evaluate the Effect of Methylsulfonylmethane Supplementation on Immune Response mRNA.
Nutrients
Open PubMedPMID 33685850 • 2021 Aug
Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticular hyaluronic acid injection. A randomized clinical trial.
J Craniomaxillofac Surg
Open PubMedPMID 34684621 • 2021 Oct 15
The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial.
Nutrients
Open PubMedPMID 26684635 • 2016 Mar
Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial.
Int J Immunopathol Pharmacol
Open PubMedPMID 34884724 • 2021 Nov 29
Nutraceutical Approach to Chronic Osteoarthritis: From Molecular Research to Clinical Evidence.
Int J Mol Sci
Open PubMedPMID 37146985 • 2023 Jul 1
Nutritional Supplements in the Clinical Management of Tendinopathy: A Scoping Review.
J Sport Rehabil
Open PubMedPMID 38138558 • 2023 Dec 13
Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane.
Molecules
Open PubMedPMID 30986309 • 2019 Jun 1
Dietary Ingredients as an Alternative Approach for Mitigating Chronic Musculoskeletal Pain: Evidence-Based Recommendations for Practice and Research in the Military.
Pain Med
Open PubMedBenefit reports: 2
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22methylsulfonylmethane%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22methylsulfonylmethane%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=methylsulfonylmethane
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 500 mg-1500 mg/day (confidence HIGH).
Extracted from 12 dosing mentions across 4 PubMed studies (mg/day).
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$10.00.
Legacy community note: Well-regarded for joint health. Often used in combination with glucosamine and chondroitin. Users with arthritis report pain reduction. Some notice improved hair and skin as bonus effects.
aggregate • benefit
Aggregate community signal: 4 directional mentions (benefit 2, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Msm
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 64, RCTs 18, meta-analyses 2.[2558,2839,2869, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29018060 from Br J Sports Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40425393 from J Integr Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28790224 from Acta Med Indones.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33617972 from Osteoarthritis Cartilage.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40507030 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33685850 from J Craniomaxillofac Surg.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34684621 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26684635 from Int J Immunopathol Pharmacol.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34884724 from Int J Mol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37146985 from J Sport Rehabil.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38138558 from Molecules.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30986309 from Pain Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2558,2839,2869, etc.]
Open source