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Supplement

Magnesium Threonate

Supports electrolyte balance, enzymatic activity, and metabolic signaling.[4250,5801]

Superscript reference numbers link to the Sources bibliography.

Early Research
Metabolic HealthEnergyHeart HealthLongevity

Composite Rating

1.9/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

0/100

Sparse depth from human/RCT/meta counts

Community Direction

33

Positive Lean • confidence Minimal

Safety Friction

14/100

Early signal from adverse/interaction markers

Data Completeness

100%

Studies 1 • mentions 3 • links 11

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Metabolic Health, Energy, Heart Health, Longevity.[562,710,934, etc.]

Dose guide: Follow product label and start with the lowest effective daily serving..[562,710,934, etc.]

Category: mineral.[562,710,934, etc.]

Category

Mineral

Evidence Tier

LOW

Daily Guide

Follow product label and start with the lowest effective daily serving.

Dosing Guide

Follow product label and start with the lowest effective daily serving.[4250,]

At-A-Glance Evidence Architecture[4250,5801]

Clinical Depth

Humans: 0 • RCTs: 0 • Meta: 0

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 1 • Interactions: 0

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

Established

Trend

· Limited trend data

Depth

1 total studies

Timeline

20222022

Top Signal Metrics[4250,5801]

Animal-only studies

2

Total indexed

1

Safety adverse signals

1

Human studies

0

In vitro / tissue

0

Randomized trials

0

Community Direction Mix[562,710,934, etc.]

Weighted direction score: 33 (Positive Lean)

Benefit2 (67%)

Evidence Quality Summary[4250,5801]

Low when evidence is mostly preclinical/in vitro or sparse human literature.

Animal-only studies

2

Total indexed

1

Safety adverse signals

1

Human studies

0

In vitro / tissue

0

Randomized trials

0

Meta-analyses

0

Interaction signals

0

Study Type Breakdown

Distribution of evidence by study design strength

All IndexedAll levels1

Top Human Studies[4250,5801]

PMID 34730480 • 2022 Dec

Elevation of brain magnesium with Swiss chard and buckwheat extracts in an animal model of reduced magnesium dietary intake.

Nutr Neurosci

Open PubMed

Community Report Frequency[562,710,934, etc.]

Benefit reports: 2

Adverse reports: 1

No-effect reports: 0

Mixed reports: 0

Unclear reports: 0

Signal confidence: 0.00

Top Reported Effects[562,710,934, etc.]

Benefits

  • Enhanced cognitive function and memory: 1
  • Improved learning capacity: 1
  • May slow age-related cognitive decline: 1
  • Better sleep quality: 1
  • Neuroprotection: 1

Adverse

  • Those primarily seeking muscle/cramp relief (glycinate better): 1
  • Budget-conscious (more expensive): 1

No Effect

  • insufficient no-effect reports captured: 0

Insufficient empirical signal for a directional adjustment.

Reddit evidence: 0 mentions (confidence 0.00).

Amazon signal: 0 products scanned (confidence 0.00).

Community Evidence Examples[562,710,934, etc.]

aggregate • benefit

Aggregate community signal: 3 directional mentions (benefit 2, adverse 1, no-effect 0, mixed 0).

Open mention

Retail Signal Examples

amazon

Amazon search for Magnesium Threonate

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22magnesium%20threonate%22)%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)
  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22magnesium%20threonate%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)
  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22magnesium%20threonate%22)%20AND%20animals%5BMeSH%20Terms%5D%20NOT%20humans%5BMeSH%20Terms%5D

Scientific Evidence Notes[4250,5801]

1. PubMed evidence summary: Magnesium Threonate

PUBMED • Humans + preclinical triage

Counts aggregated from automated literature sweep and tiering rules.

Outcome: Tier LOW; humans 0, RCTs 0, meta-analyses 0.[4250,5801]

Open source
2. Elevation of brain magnesium with Swiss chard and buckwheat extracts in an animal model of reduced magnesium dietary intake.

PUBMED • 2022 • Human evidence curation set

PMID 34730480 from Nutr Neurosci.

Outcome: See linked PubMed abstract for methods and outcomes.[4250,5801]

5801

Safety and Pitfalls

  • Lower safety signal in literature, but monitor for individual response.[562,710,934, etc.]
  • Legacy caution group: Those primarily seeking muscle/cramp relief (glycinate better)[562,710,934, etc.]
  • Legacy caution group: Budget-conscious (more expensive)[562,710,934, etc.]
Adverse1 (33%)
No Effect0 (0%)
Mixed0 (0%)

GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].

PerimeterX / captcha block encountered.

Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22magnesium%20threonate%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)

Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22magnesium%20threonate%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)

Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=magnesium%20threonate

Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.

Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).

Imported legacy monthly cost signal: ~$30.00.

Legacy community note: Highly praised in nootropic and longevity communities. Users report clearer thinking, better memory recall, and improved sleep. More expensive than glycinate but users feel the cognitive benefit justifies cost.

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22magnesium%20threonate%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%20randomized%20controlled%20trial%5BPublication%20Type%5D
  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22magnesium%20threonate%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%20meta-analysis%5BPublication%20Type%5D
  • https://pubmed.ncbi.nlm.nih.gov/34730480/
  • https://pubmed.ncbi.nlm.nih.gov/?term=Magnesium%20Threonate
  • Community Sources

    • https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22magnesium%20threonate%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
    • https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22magnesium%20threonate%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
    • https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=magnesium%20threonate
    • https://www.reddit.com/search/?q=Magnesium%20Threonate
    Open source