Supplement
Supports electrolyte balance, enzymatic activity, and metabolic signaling.[1557,2017,2295, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 9 • mentions 2 • links 19
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Metabolic Health, Energy, Heart Health, Longevity.[561,709,933, etc.]
Dose guide: Human-study daily dose: 300 mg-1000 mg/day (higher-confidence extraction from PubMed abstracts)..[561,709,933, etc.]
Category
Mineral
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 300 mg-1000 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 94 • RCTs: 39 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 74 • Interactions: 11
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
120 total studies · 2 recent
Timeline
Total indexed
120
Human studies
94
Safety adverse signals
74
Animal-only studies
45
Randomized trials
39
In vitro / tissue
11
Weighted direction score: 0 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
120
Human studies
94
Safety adverse signals
74
Animal-only studies
45
Randomized trials
39
In vitro / tissue
11
Interaction signals
11
Meta-analyses
1
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 24696187 • 2014 Apr 3
Magnesium supplementation in pregnancy.
Cochrane Database Syst Rev
Open PubMedPMID 14596323 • 2003 Sep
Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study.
Magnes Res
Open PubMedPMID 35253448 • 2022 Mar 15
Effects of Magnesium Citrate, Magnesium Oxide, and Magnesium Sulfate Supplementation on Arterial Stiffness: A Randomized, Double-Blind, Placebo-Controlled Intervention Trial.
J Am Heart Assoc
Open PubMedPMID 34859788 • 2021 Aug 1
Magnesium citrate supplementation decreased blood pressure and HbA1c in normomagnesemic subjects with metabolic syndrome: a 12-week, placebo-controlled, double-blinded pilot trial.
Magnes Res
Open PubMedPMID 21199787 • 2010 Dec
Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep.
Magnes Res
Open PubMedPMID 39770988 • 2024 Dec 18
Comparative Clinical Study on Magnesium Absorption and Side Effects After Oral Intake of Microencapsulated Magnesium (MAGSHAPE(TM) Microcapsules) Versus Other Magnesium Sources.
Nutrients
Open PubMedPMID 32162607 • 2019 Aug 1
Assessment of bioavailability of Mg from Mg citrate and Mg oxide by measuring urinary excretion in Mg-saturated subjects.
Magnes Res
Open PubMedPMID 39077820 • 2024 Jul 1
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
Magnes Res
Open PubMedPMID 30074549 • 2018 Aug
Preventive Therapy of Migraine.
Continuum (Minneap Minn)
Open PubMedBenefit reports: 1
Adverse reports: 1
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
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Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22magnesium%20citrate%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=magnesium%20citrate
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 300 mg-1000 mg/day (confidence HIGH).
Extracted from 10 dosing mentions across 3 PubMed studies (mg/day).
aggregate • unclear
Aggregate community signal: 2 directional mentions (benefit 1, adverse 1, no-effect 0, mixed 0).
Open mentionamazon
Amazon search for Magnesium Citrate
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 94, RCTs 39, meta-analyses 1.[1557,2017,2295, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24696187 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1557,2017,2295, etc.]
Open sourcePUBMED • 2003 • Human evidence curation set
PMID 14596323 from Magnes Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1557,2017,2295, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35253448 from J Am Heart Assoc.
Outcome: See linked PubMed abstract for methods and outcomes.[1557,2017,2295, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34859788 from Magnes Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1557,2017,2295, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 21199787 from Magnes Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1557,2017,2295, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39770988 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1557,2017,2295, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 32162607 from Magnes Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1557,2017,2295, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39077820 from Magnes Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1557,2017,2295, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30074549 from Continuum (Minneap Minn).
Outcome: See linked PubMed abstract for methods and outcomes.[1557,2017,2295, etc.]
Open source