Supplement
Supports broad cellular function with category-specific mechanisms.[2915,3280,3930, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
17/100
Early depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
48/100
Moderate signal from adverse/interaction markers
Data Completeness
100%
Studies 3 • mentions 2 • links 13
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[560,708,932, etc.]
Dose guide: Follow product label and start with the lowest effective daily serving..[560,708,932, etc.]
Category
Other
Evidence Tier
LOW
Daily Guide
Follow product label and start with the lowest effective daily serving.
Clinical Depth
Humans: 3 • RCTs: 0 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 4 • Interactions: 2
Freshness, trend, and study timeline for this item
Status
Trend
· Limited trend data
Depth
11 total studies
Timeline
Total indexed
11
Animal-only studies
10
In vitro / tissue
4
Safety adverse signals
4
Human studies
3
Interaction signals
2
Weighted direction score: 0 (Mixed / Neutral)
Low when evidence is mostly preclinical/in vitro or sparse human literature.
Total indexed
11
Animal-only studies
10
In vitro / tissue
4
Safety adverse signals
4
Human studies
3
Interaction signals
2
Randomized trials
0
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 33560149 • 2022
Maca Root (Lepidium meyenii) Extract Increases the Expression of MMP-1 and Stimulates Migration of Triple-Negative Breast Cancer Cells.
Nutr Cancer
Open PubMedPMID 30981185 • 2019 Jun
Screening for CYP3A4 inhibition and induction coupled to parallel artificial membrane permeability assay (PAMPA) for prediction of botanical-drug interactions: The case of açaí and maca.
Phytomedicine
Open PubMedPMID 29313251 • 2018 Jun
Unintentional and Sequential Lead Exposure from a Ceramic Mug and Maca (Lepidium meyenii).
Benefit reports: 1
Adverse reports: 1
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22maca%20root%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
aggregate • unclear
Aggregate community signal: 2 directional mentions (benefit 1, adverse 1, no-effect 0, mixed 0).
Open mentionamazon
Amazon search for Maca Root
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier LOW; humans 3, RCTs 0, meta-analyses 0.[2915,3280,3930, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 33560149 from Nutr Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
J Med Toxicol
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22maca%20root%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=maca%20root
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Community Sources
PUBMED • 2019 • Human evidence curation set
PMID 30981185 from Phytomedicine.
Outcome: See linked PubMed abstract for methods and outcomes.[2915,3280,3930, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29313251 from J Med Toxicol.
Outcome: See linked PubMed abstract for methods and outcomes.[2915,3280,3930, etc.]
Open source