Supplement
Supports electrolyte balance, enzymatic activity, and metabolic signaling.[3148,5137,5341, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
24/100
Early depth from human/RCT/meta counts
Community Direction
10
Mixed / Neutral • confidence Minimal
Safety Friction
38/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 3 • mentions 4 • links 13
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Metabolic Health, Energy, Heart Health, Longevity.[553,701,925, etc.]
Dose guide: Follow product label and start with the lowest effective daily serving..[553,701,925, etc.]
Category
Mineral
Evidence Tier
MEDIUM
Daily Guide
Follow product label and start with the lowest effective daily serving.
Clinical Depth
Humans: 6 • RCTs: 0 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 6 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
· Limited trend data
Depth
7 total studies · 2 recent
Timeline
Total indexed
7
Human studies
6
Safety adverse signals
6
Animal-only studies
5
In vitro / tissue
2
Randomized trials
0
Weighted direction score: 10 (Mixed / Neutral)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
Total indexed
7
Human studies
6
Safety adverse signals
6
Animal-only studies
5
In vitro / tissue
2
Randomized trials
0
Meta-analyses
0
Interaction signals
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 30404535 • 2018 Dec
Is there a role for lithium orotate in psychiatry?
Aust N Z J Psychiatry
Open PubMedPMID 38810780 • 2024 Sep 1
Human brain (7)Li-MRI following low-dose lithium dietary supplementation in healthy participants.
J Affect Disord
Open PubMedPMID 40152059 • 2025 Oct
A Survey Exploring People's Experiences With Lithium Bought as a Supplement: Une enquête sur l'expérience des personnes avec le lithium en supplément.
Can J Psychiatry
Open PubMedBenefit reports: 2
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22lithium%20orotate%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22lithium%20orotate%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=lithium%20orotate
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$10.00.
Legacy community note: Gaining popularity in longevity and biohacking communities. Users report calmer mood, better sleep, and improved emotional regulation. Considered an "underground" neuroprotective supplement.
aggregate • benefit
Aggregate community signal: 4 directional mentions (benefit 2, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Lithium Orotate
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 6, RCTs 0, meta-analyses 0.[3148,5137,5341, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30404535 from Aust N Z J Psychiatry.
Outcome: See linked PubMed abstract for methods and outcomes.[3148,5137,5341, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38810780 from J Affect Disord.
Outcome: See linked PubMed abstract for methods and outcomes.[3148,5137,5341, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40152059 from Can J Psychiatry.
Outcome: See linked PubMed abstract for methods and outcomes.[3148,5137,5341, etc.]
Open source