Supplement
Contains bioactive phytochemicals that may modulate stress, immune, and metabolic pathways.[2241,2634,3063, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
94/100
High depth from human/RCT/meta counts
Community Direction
-20
Caution Lean • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 12 • mentions 3 • links 22
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Stress Resilience, Mood, Immune Support, Longevity.[550,698,922, etc.]
Dose guide: Human-study daily dose: 1000 mg/day (moderate-confidence extraction from PubMed abstracts)..[550,698,922, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 1000 mg/day (moderate-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 33 • RCTs: 6 • Meta: 3
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 50 • Interactions: 40
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
67 total studies · 4 recent
Timeline
Total indexed
67
In vitro / tissue
61
Animal-only studies
52
Safety adverse signals
50
Interaction signals
40
Human studies
33
Weighted direction score: -20 (Caution Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
67
In vitro / tissue
61
Animal-only studies
52
Safety adverse signals
50
Interaction signals
40
Human studies
33
Randomized trials
6
Meta-analyses
3
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 40014460 • 2025 Mar
Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.
Neuropsychopharmacol Rep
Open PubMedPMID 32614129 • 2020 Dec
Effects of Melissa officinalis (Lemon Balm) on cardio-metabolic outcomes: A systematic review and meta-analysis.
Phytother Res
Open PubMedPMID 38575930 • 2024 Apr 4
Effects of Melissa officinalis (lemon balm) consumption on serum lipid profile: a meta-analysis of randomized controlled trials.
BMC Complement Med Ther
Open PubMedPMID 37131158 • 2023 May 2
The effects of melissa officinalis on depression and anxiety in type 2 diabetes patients with depression: a randomized double-blinded placebo-controlled clinical trial.
BMC Complement Med Ther
Open PubMedPMID 27261994 • 2016 Jun
Lemon balm: A promising herbal therapy for patients with borderline hyperlipidemia-A randomized double-blind placebo-controlled clinical trial.
Complement Ther Med
Open PubMedPMID 38580720 • 2024 Apr 5
Effect of a nutraceutical combination on sleep quality among people with impaired sleep: a randomised, placebo-controlled trial.
Sci Rep
Open PubMedPMID 30045422 • 2018
The effects of Melissa officinalis (lemon balm) in chronic stable angina on serum biomarkers of oxidative stress, inflammation and lipid profile.
Asia Pac J Clin Nutr
Open PubMedPMID 33751522 • 2021
Barley malt-based composition as a galactagogue - a randomized, controlled trial in preterm mothers.
Ginekol Pol
Open PubMedPMID 24199972 • 2013 Nov
Valerian/lemon balm use for sleep disorders during menopause.
Complement Ther Clin Pract
Open PubMedPMID 33475068 • 2021 Sep 14
Nutraceuticals for Sleep Disorders.
Comb Chem High Throughput Screen
Open PubMedPMID 40054227 • 2025 May
Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials.
Sleep Med
Open PubMedPMID 34315377 • 2021
The Safety and Efficacy of Botanicals with Nootropic Effects.
Curr Neuropharmacol
Open PubMedBenefit reports: 1
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22lemon%20balm%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22lemon%20balm%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=lemon%20balm
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 1000 mg/day (confidence MEDIUM).
Extracted from 2 dosing mentions across 2 PubMed studies (mg/day).
Imported legacy community score: 6.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$10.00.
Legacy community note: Appreciated for mild, reliable calming effects. Often used as tea or extract before bed. Favored by those who want gentle anxiety relief without prescription medications.
aggregate • unclear
Aggregate community signal: 3 directional mentions (benefit 1, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Lemon Balm
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 33, RCTs 6, meta-analyses 3.[2241,2634,3063, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40014460 from Neuropsychopharmacol Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32614129 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38575930 from BMC Complement Med Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37131158 from BMC Complement Med Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 27261994 from Complement Ther Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38580720 from Sci Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30045422 from Asia Pac J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33751522 from Ginekol Pol.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 24199972 from Complement Ther Clin Pract.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33475068 from Comb Chem High Throughput Screen.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40054227 from Sleep Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34315377 from Curr Neuropharmacol.
Outcome: See linked PubMed abstract for methods and outcomes.[2241,2634,3063, etc.]
Open source