Iron-binding glycoprotein that sequester iron from pathogens (bacteriostatic), stimulates innate immunity (NK cells, macrophages), modulates TLR4, and promotes beneficial gut microbiota.[1325,1402,1413, etc.]
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
9
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 24 • mentions 8 • links 213
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Implementation Blueprint
Goal alignment: Immune Support, Gut Health, Inflammation.[549,697,921, etc.]
One of the safest supplements — naturally present in breast milk. Bovine lactoferrin is 69% homologous to human. Apo (iron-free) form preferred for immune function.[549,697,921, etc.]
Potential side effect: mild GI discomfort[549,697,921, etc.]
Potential side effect: constipation (rare, from iron binding)[549,697,921, etc.]
Use caution with condition: cow milk allergy (bovine-derived)[549,697,921, etc.]
Effects of vitamin A supplementation on intestinal barrier function, growth, total parasitic, and specific Giardia spp infections in Brazilian children: a prospective randomized, double-blind, placebo-controlled trial.
Journal of pediatric gastroenterology and nutrition
Probiotics, Prebiotics, Lactoferrin, and Combination Products for Prevention of Mortality and Morbidity in Preterm Infants: A Systematic Review and Network Meta-Analysis.
Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis.
The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial.
Lactoferrin and lysozyme to promote nutritional, clinical and enteric recovery: a protocol for a factorial, blinded, placebo-controlled randomised trial among children with diarrhoea and malnutrition (the Boresha Afya trial).
Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials.
Effect of tablets containing lactoferrin and lactoperoxidase on gingival health in adults: A randomized, double-blind, placebo-controlled clinical trial.
Regulation of faecal biomarkers in inflammatory bowel disease patients treated with oral mastiha (Pistacia lentiscus) supplement: A double-blind and placebo-controlled randomised trial.
Longevity extension (landmark Science paper 2023): 1
Cardiovascular protection: 1
Antioxidant and anti-inflammatory: 1
Blood pressure reduction: 1
Blood sugar regulation: 1
Exercise performance: 1
Neuroprotection: 1
Adverse
No known significant contraindications: 1
No Effect
insufficient no-effect reports captured: 0
Underappreciated immune supplement. Key advantage: improves iron status WITHOUT constipation — excellent for pregnant women and iron-deficient individuals. | Step2: Insufficient empirical signal for a directional adjustment.
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Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Extracted from 5 dosing mentions across 4 PubMed studies (mg/day).
Imported legacy community score: 9.0/10 (heuristic mapping confidence 1.00).
Legacy community note: Exploded in popularity after 2023 Science paper. Longevity community now considers it a core supplement. Users report improved energy, better sleep, and general well-being. Extremely well-tolerated and affordable.
1. Lactoferrin for prevention of neonatal sepsis: Cochrane MA
META_ANALYSIS • 2020 • Adults
12 RCTs with 5425 preterm/low-birth-weight neonates.
Outcome: Lactoferrin significantly reduced late-onset sepsis (RR 0.59) and necrotizing enterocolitis (RR 0.47); one of the best-studied applications.[1325,1402,1413, etc.]
Open source 2. Lactoferrin for iron deficiency anemia in pregnancy: MA
META_ANALYSIS • 2017 • Adults
4 RCTs with 600 pregnant women.
Outcome: Bovine lactoferrin increased hemoglobin and serum iron comparably to ferrous sulfate with fewer GI side effects.[1325,1402,1413, etc.]
Open source 3. Bovine lactoferrin and common cold in healthy adults
RCT • 2013 • Adults
104 healthy adults over 90 days.
Outcome: 200 mg/day lactoferrin reduced total cold episodes by 42% and symptom severity; enhanced sIgA and NK cell counts.[1325,1402,1413, etc.]
Open source 4. PubMed evidence summary: Lactoferrin
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Open source 5. Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and meta-analysis.
PUBMED • 2025 • Human evidence curation set
PMID 39841980 from Biochemistry and cell biology = Biochimie et biologie cellulaire.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 6. Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants.
PUBMED • 2017 • Human evidence curation set
PMID 28658720 from The Cochrane database of systematic reviews.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 7. Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants.
PUBMED • 2020 • Human evidence curation set
PMID 32232984 from The Cochrane database of systematic reviews.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 8. Evidence from systematic reviews of randomized trials on enteral lactoferrin supplementation in preterm neonates.
PUBMED • 2021 • Human evidence curation set
PMID 32721215 from Biochemistry and cell biology = Biochimie et biologie cellulaire.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 9. Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants.
PUBMED • 2015 • Human evidence curation set
PMID 25699678 from The Cochrane database of systematic reviews.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 10. Histologic scoring indices for evaluation of disease activity in Crohn's disease.
PUBMED • 2017 • Human evidence curation set
PMID 28731502 from The Cochrane database of systematic reviews.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 11. Supplementation With Lactoferrin and Lysozyme Ameliorates Environmental Enteric Dysfunction: A Double-Blind, Randomized, Placebo-Controlled Trial.
PUBMED • 2019 • Human evidence curation set
PMID 30829679 from The American journal of gastroenterology.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 12. Randomized, double-blind, placebo-controlled trial of bovine lactoferrin in patients with chronic hepatitis C.
PUBMED • 2006 • Human evidence curation set
PMID 16984383 from Cancer science.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 13. A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants.
PUBMED • 2007 • Human evidence curation set
PMID 17255839 from Journal of pediatric gastroenterology and nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 14. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial.
PUBMED • 2011 • Human evidence curation set
PMID 21224837 from The American journal of gastroenterology.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 15. Effects of vitamin A supplementation on intestinal barrier function, growth, total parasitic, and specific Giardia spp infections in Brazilian children: a prospective randomized, double-blind, placebo-controlled trial.
PUBMED • 2010 • Human evidence curation set
PMID 20038852 from Journal of pediatric gastroenterology and nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 16. Probiotics, Prebiotics, Lactoferrin, and Combination Products for Prevention of Mortality and Morbidity in Preterm Infants: A Systematic Review and Network Meta-Analysis.
PUBMED • 2023 • Human evidence curation set
PMID 37782505 from JAMA pediatrics.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 17. Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis.
PUBMED • 2022 • Human evidence curation set
PMID 35481594 from Advances in nutrition (Bethesda, Md.).
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 18. The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial.
PUBMED • 2020 • Human evidence curation set
PMID 32407710 from The Lancet. Child & adolescent health.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 19. Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: an overview of systematic reviews.
PUBMED • 2021 • Human evidence curation set
PMID 34564844 from The Cochrane database of systematic reviews.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 20. Enteral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates.
PUBMED • 2019 • Human evidence curation set
PMID 31077334 from The Cochrane database of systematic reviews.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 21. Lactoferrin and lysozyme to promote nutritional, clinical and enteric recovery: a protocol for a factorial, blinded, placebo-controlled randomised trial among children with diarrhoea and malnutrition (the Boresha Afya trial).
PUBMED • 2024 • Human evidence curation set
PMID 39122384 from BMJ open.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 22. Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials.
PUBMED • 2022 • Human evidence curation set
PMID 35276902 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 23. Enteral Bioactive Factor Supplementation in Preterm Infants: A Systematic Review.
PUBMED • 2020 • Human evidence curation set
PMID 32987621 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 24. Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial.
PUBMED • 2019 • Human evidence curation set
PMID 30525953 from Beneficial microbes.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 25. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial.
PUBMED • 2019 • Human evidence curation set
PMID 30635141 from Lancet (London, England).
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 26. Effects of lactoferrin on infectious diseases in Japanese summer: A randomized, double-blinded, placebo-controlled trial.
PUBMED • 2021 • Human evidence curation set
PMID 32151562 from Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 27. Effect of tablets containing lactoferrin and lactoperoxidase on gingival health in adults: A randomized, double-blind, placebo-controlled clinical trial.
PUBMED • 2019 • Human evidence curation set
PMID 31292969 from Journal of periodontal research.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 28. Regulation of faecal biomarkers in inflammatory bowel disease patients treated with oral mastiha (Pistacia lentiscus) supplement: A double-blind and placebo-controlled randomised trial.
PUBMED • 2019 • Human evidence curation set
PMID 30450689 from Phytotherapy research : PTR.
Outcome: See linked PubMed abstract for methods and outcomes.[1325,1402,1413, etc.]
Open source 29. Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants.
SYSTEMATIC_REVIEW • 2011 • PubMed indexed study
PMID 21975765 from The Cochrane database of systematic reviews.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.5/10.[1325,1402,1413, etc.]
Open source 30. Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants.
SYSTEMATIC_REVIEW • 2010 • PubMed indexed study
PMID 20464748 from The Cochrane database of systematic reviews.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.5/10.[1325,1402,1413, etc.]
Open source 31. New infant formulas for healthy term infants: A randomized, controlled, double-blind, multicenter, non-inferiority design safety study.
RCT • 2025 • PubMed indexed study
PMID 41406156 from PloS one.
Outcome: Study design: RCT. Quality score: 9.4/10.[1325,1402,1413, etc.]
Open source 32. Pharmacological strategies and nutritional supplements for managing dysgeusia among chemotherapy patients: A systematic review.
SYSTEMATIC_REVIEW • 2024 • PubMed indexed study
PMID 38900642 from Clinical nutrition ESPEN.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.4/10.[1325,1402,1413, etc.]
Open source 33. Role of lactoferrin in preventing preterm birth and pregnancy complications: a systematic review and meta-analysis.
META_ANALYSIS • 2023 • PubMed indexed study
PMID 35333034 from Minerva obstetrics and gynecology.
Outcome: Study design: META_ANALYSIS. Quality score: 9.3/10.[1325,1402,1413, etc.]
Open source 34. Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study.
RCT • 2008 • PubMed indexed study
PMID 18727656 from Journal of clinical periodontology.
Outcome: Study design: RCT. Quality score: 9.3/10.[1325,1402,1413, etc.]
Open source 35. Dietary and nutritional interventions in children with cerebral palsy: A systematic literature review.
SYSTEMATIC_REVIEW • 2022 • PubMed indexed study
PMID 35867728 from PloS one.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.3/10.[1325,1402,1413, etc.]
Open source 36. Lactoferrin Supplementation to Prevent Late-Onset Sepsis in Preterm Infants: A Meta-Analysis.
META_ANALYSIS • 2021 • PubMed indexed study
PMID 31529448 from American journal of perinatology.
Outcome: Study design: META_ANALYSIS. Quality score: 9.2/10.[1325,1402,1413, etc.]
Open source 37. Is Lactoferrin More Effective in Reducing Late-Onset Sepsis in Preterm Neonates Fed Formula Than in Those Receiving Mother's Own Milk? Secondary Analyses of Two Multicenter Randomized Controlled Trials.
META_ANALYSIS • 2019 • PubMed indexed study
PMID 31238372 from American journal of perinatology.
Outcome: Study design: META_ANALYSIS. Quality score: 9.2/10.[1325,1402,1413, etc.]
Open source 38. Prophylactic lactoferrin for preventing late-onset sepsis and necrotizing enterocolitis in preterm infants: A PRISMA-compliant systematic review and meta-analysis.
META_ANALYSIS • 2018 • PubMed indexed study
PMID 30170397 from Medicine.
Outcome: Study design: META_ANALYSIS. Quality score: 9.1/10.[1325,1402,1413, etc.]
Open source 39. Evaluation of Bovine Lactoferrin for Prevention of Late-Onset Sepsis in Low-Birth-Weight Infants: A Double-Blind Randomized Controlled Trial.
RCT • 2025 • PubMed indexed study
PMID 40507041 from Nutrients.
Outcome: Study design: RCT. Quality score: 9.1/10.[1325,1402,1413, etc.]
Open source 40. A Systematic Review of Isotopically Measured Iron Absorption in Infants and Children Under 2 Years.
SYSTEMATIC_REVIEW • 2024 • PubMed indexed study
PMID 39599621 from Nutrients.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.1/10.[1325,1402,1413, etc.]
Open source 41. Meta-analysis: efficacy of bovine lactoferrin in Helicobacter pylori eradication.
META_ANALYSIS • 2009 • PubMed indexed study
PMID 19183156 from Alimentary pharmacology & therapeutics.
Outcome: Study design: META_ANALYSIS. Quality score: 9.0/10.[1325,1402,1413, etc.]
Open source 42. Meta-analysis: the effect of supplementation with lactoferrin on eradication rates and adverse events during Helicobacter pylori eradication therapy.
META_ANALYSIS • 2009 • PubMed indexed study
PMID 19298339 from Helicobacter.
Outcome: Study design: META_ANALYSIS. Quality score: 9.0/10.[1325,1402,1413, etc.]
Open source 43. Does Colostrum Bovinum Supplementation Affect Swimming Performance in Endurance-Trained Males? A Randomized Placebo-Controlled Crossover Study.
RCT • 2024 • PubMed indexed study
PMID 39339805 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.9/10.[1325,1402,1413, etc.]
Open source 44. Assessment of food supplements for the prevention of necrotizing enterocolitis in preterm neonates: A systematic review and network meta-analysis.
SYSTEMATIC_REVIEW • 2023 • PubMed indexed study
PMID 37924642 from Computers in biology and medicine.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.8/10.[1325,1402,1413, etc.]
Open source 45. A Randomized, Double-Blind, Controlled Trial to Assess the Effects of Lactoferrin at Two Doses vs. Active Control on Immunological and Safety Parameters in Healthy Adults.
RCT • 2025 • PubMed indexed study
PMID 39465888 from International journal of toxicology.
Outcome: Study design: RCT. Quality score: 8.8/10.[1325,1402,1413, etc.]
Open source 46. Bovine lactoferrin for the prevention of COVID-19 infection in health care personnel: a double-blinded randomized clinical trial (LF-COVID).
RCT • 2023 • PubMed indexed study
PMID 36474100 from Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
Outcome: Study design: RCT. Quality score: 8.8/10.[1325,1402,1413, etc.]
Open source 47. Immunomodulatory effects of fucoidan in recreationally active adult males undertaking 3-weeks of intensified training.
RCT • 2023 • PubMed indexed study
PMID 38247026 from Journal of sports sciences.
Outcome: Study design: RCT. Quality score: 8.8/10.[1325,1402,1413, etc.]
Open source 48. Effects of Long-Term Supplementation of Bovine Colostrum on Iron Homeostasis, Oxidative Stress, and Inflammation in Female Athletes: A Placebo-Controlled Clinical Trial.
RCT • 2022 • PubMed indexed study
PMID 36615842 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.8/10.[1325,1402,1413, etc.]
Open source 49. Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review.
SYSTEMATIC_REVIEW • 2023 • PubMed indexed study
PMID 37661669 from The Turkish journal of pediatrics.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.8/10.[1325,1402,1413, etc.]
Open source 50. ELFIN, the United Kingdom preterm lactoferrin trial: interpretation and future questions (1).
RCT • 2021 • PubMed indexed study
PMID 32830532 from Biochemistry and cell biology = Biochimie et biologie cellulaire.
Outcome: Study design: RCT. Quality score: 8.7/10.[1325,1402,1413, etc.]
Open source 51. Effect of bovine lactoferrin on prevention of late-onset sepsis in infants <1500 g: a pooled analysis of individual patient data from two randomized controlled trials.
RCT • 2021 • PubMed indexed study
PMID 32931708 from Biochemistry and cell biology = Biochimie et biologie cellulaire.
Outcome: Study design: RCT. Quality score: 8.7/10.[1325,1402,1413, etc.]
Open source 52. The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review.
SYSTEMATIC_REVIEW • 2022 • PubMed indexed study
PMID 34133812 from Reviews in medical virology.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.7/10.[1325,1402,1413, etc.]
Open source 53. Nutritional interventions to reduce rates of infection, necrotizing enterocolitis and mortality in very preterm infants.
SYSTEMATIC_REVIEW • 2020 • PubMed indexed study
PMID 31645057 from Pediatric research.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.7/10.[1325,1402,1413, etc.]
Open source 54. Protocol for the Lactoferrin Infant Feeding Trial (LIFT): a randomised trial of adding lactoferrin to the feeds of very-low birthweight babies prior to hospital discharge.
RCT • 2018 • PubMed indexed study
PMID 30282685 from BMJ open.
Outcome: Study design: RCT. Quality score: 8.6/10.[1325,1402,1413, etc.]
Open source 55. Effects of short-term supplementation with bovine lactoferrin and/or immunoglobulins on body mass and metabolic measures: a randomised controlled trial.
RCT • 2017 • PubMed indexed study
PMID 27592680 from International journal of food sciences and nutrition.
Outcome: Study design: RCT. Quality score: 8.6/10.[1325,1402,1413, etc.]
Open source 56. The Lacuna Trial: a double-blind randomized controlled pilot trial of lactoferrin supplementation in the very preterm infant.
RCT • 2016 • PubMed indexed study
PMID 26938920 from Journal of perinatology : official journal of the California Perinatal Association.
Outcome: Study design: RCT. Quality score: 8.6/10.[1325,1402,1413, etc.]
Open source 57. Growth and tolerance of formula with lactoferrin in infants through one year of age: double-blind, randomized, controlled trial.
RCT • 2015 • PubMed indexed study
PMID 26547414 from BMC pediatrics.
Outcome: Study design: RCT. Quality score: 8.6/10.[1325,1402,1413, etc.]
Open source 58. Oral supplementation with bovine whey-derived Ig-rich fraction and lactoferrin improves SCORAD and DLQI in atopic dermatitis.
RCT • 2017 • PubMed indexed study
PMID 28012820 from Journal of dermatological science.
Outcome: Study design: RCT. Quality score: 8.6/10.[1325,1402,1413, etc.]
Open source 59. The effect of 14 weeks of vitamin D3 supplementation on antimicrobial peptides and proteins in athletes.
RCT • 2016 • PubMed indexed study
PMID 25861808 from Journal of sports sciences.
Outcome: Study design: RCT. Quality score: 8.6/10.[1325,1402,1413, etc.]
Open source 60. Influence of 4 weeks of bovine colostrum supplementation on neutrophil and mucosal immune responses to prolonged cycling.
RCT • 2015 • PubMed indexed study
PMID 25727914 from Scandinavian journal of medicine & science in sports.
Outcome: Study design: RCT. Quality score: 8.6/10.[1325,1402,1413, etc.]
Open source 61. Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children.
RCT • 2013 • PubMed indexed study
PMID 22939927 from The Journal of pediatrics.
Outcome: Study design: RCT. Quality score: 8.5/10.[1325,1402,1413, etc.]
Open source 62. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial.
RCT • 2009 • PubMed indexed study
PMID 19809023 from JAMA.
Outcome: Study design: RCT. Quality score: 8.5/10.[1325,1402,1413, etc.]
Open source 63. Effect of lactoferrin supplementation on the effectiveness and tolerability of a 7-day quadruple therapy after failure of a first attempt to cure Helicobacter pylori infection.
RCT • 2007 • PubMed indexed study
PMID 17392649 from Medical science monitor : international medical journal of experimental and clinical research.
Outcome: Study design: RCT. Quality score: 8.5/10.[1325,1402,1413, etc.]
Open source 64. Gut Balance, a synbiotic supplement, increases fecal Lactobacillus paracasei but has little effect on immunity in healthy physically active individuals.
RCT • 2012 • PubMed indexed study
PMID 22572834 from Gut microbes.
Outcome: Study design: RCT. Quality score: 8.5/10.[1325,1402,1413, etc.]
Open source 65. The clinical efficacy of a bovine lactoferrin/whey protein Ig-rich fraction (Lf/IgF) for the common cold: a double blind randomized study.
RCT • 2013 • PubMed indexed study
PMID 23642947 from Complementary therapies in medicine.
Outcome: Study design: RCT. Quality score: 8.5/10.[1325,1402,1413, etc.]
Open source 66. Effect of kangaroo mother care in low birth weight infants on human milk intake: a randomized controlled trial.
RCT • 2025 • PubMed indexed study
PMID 39947481 from The American journal of clinical nutrition.
Outcome: Study design: RCT. Quality score: 8.4/10.[1325,1402,1413, etc.]
Open source 67. Efficacy of Bovine Lactoferrin Supplementation in Preventing Late-onset Sepsis in low Birth Weight Neonates: A Randomized Placebo-Controlled Clinical Trial.
RCT • 2015 • PubMed indexed study
PMID 26224129 from Journal of tropical pediatrics.
Outcome: Study design: RCT. Quality score: 8.4/10.[1325,1402,1413, etc.]
Open source 68. Effects of a Novel High-Quality Protein Infant Formula on Energetic Efficiency and Tolerance: A Randomized Trial.
RCT • 2022 • PubMed indexed study
PMID 35666855 from Journal of pediatric gastroenterology and nutrition.
Outcome: Study design: RCT. Quality score: 8.3/10.[1325,1402,1413, etc.]
Open source 69. Intervention and Mechanisms of Alanyl-glutamine for Inflammation, Nutrition, and Enteropathy: A Randomized Controlled Trial.
RCT • 2020 • PubMed indexed study
PMID 32826717 from Journal of pediatric gastroenterology and nutrition.
Outcome: Study design: RCT. Quality score: 8.3/10.[1325,1402,1413, etc.]
Open source 70. Bovine Lactoferrin Supplementation Does Not Disrupt Microbiota Development in Preterm Infants Receiving Probiotics.
RCT • 2020 • PubMed indexed study
PMID 32404742 from Journal of pediatric gastroenterology and nutrition.
Outcome: Study design: RCT. Quality score: 8.3/10.[1325,1402,1413, etc.]
Open source 71. Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial.
RCT • 2009 • PubMed indexed study
PMID 19861543 from Cancer prevention research (Philadelphia, Pa.).
Outcome: Study design: RCT. Quality score: 8.3/10.[1325,1402,1413, etc.]
Open source 72. Effects of pentasa-combined probiotics on the microflora structure and prognosis of patients with inflammatory bowel disease.
RCT • 2019 • PubMed indexed study
PMID 31418411 from The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
Outcome: Study design: RCT. Quality score: 8.3/10.[1325,1402,1413, etc.]
Open source 73. Enteral lactoferrin to prevent infection for very preterm infants: the ELFIN RCT.
RCT • 2018 • PubMed indexed study
PMID 30574860 from Health technology assessment (Winchester, England).
Outcome: Study design: RCT. Quality score: 8.2/10.[1325,1402,1413, etc.]
Open source 74. Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women.
RCT • 2022 • PubMed indexed study
PMID 35545875 from Journal of cosmetic dermatology.
Outcome: Study design: RCT. Quality score: 8.2/10.[1325,1402,1413, etc.]
Open source 75. Lipid-Based Nutrient Supplements During Pregnancy and Lactation Did Not Affect Human Milk Oligosaccharides and Bioactive Proteins in a Randomized Trial.
RCT • 2017 • PubMed indexed study
PMID 28794206 from The Journal of nutrition.
Outcome: Study design: RCT. Quality score: 8.2/10.[1325,1402,1413, etc.]
Open source 76. Effects of probiotics supplementation and circuit training on immune responses among sedentary young males.
RCT • 2018 • PubMed indexed study
PMID 28677946 from The Journal of sports medicine and physical fitness.
Outcome: Study design: RCT. Quality score: 8.2/10.[1325,1402,1413, etc.]
Open source 77. Effect of probiotics (Lactobacillus plantarum 299 plus Bifidobacterium Cure21) in patients with poor ileal pouch function: a randomised controlled trial.
RCT • 2016 • PubMed indexed study
PMID 27150635 from Scandinavian journal of gastroenterology.
Outcome: Study design: RCT. Quality score: 8.2/10.[1325,1402,1413, etc.]
Open source 78. A Patented Dietary Supplement (Hydroxy-Methyl-Butyrate, Carnosine, Magnesium, Butyrate, Lactoferrin) Is a Promising Therapeutic Target for Age-Related Sarcopenia through the Regulation of Gut Permeability: A Randomized Controlled Trial.
RCT • 2024 • PubMed indexed study
PMID 38732615 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 79. Preventing Sepsis in Preterm Infants with Bovine Lactoferrin: A Randomized Trial Exploring Immune and Antioxidant Effects.
RCT • 2025 • PubMed indexed study
PMID 41097231 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 80. Effect of Lactoferrin on Clinical Outcomes of Hospitalized Patients with COVID-19: The LAC Randomized Clinical Trial.
RCT • 2023 • PubMed indexed study
PMID 36904283 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 81. Concurrent Ingestion of Alkaline Water and L-Glutamine Enhanced Salivary α-Amylase Activity and Testosterone Concentration in Boxing Athletes.
RCT • 2024 • PubMed indexed study
PMID 38337738 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 82. Recombinant human lactoferrin ingestion attenuates indomethacin-induced enteropathy in vivo in healthy volunteers.
RCT • 2003 • PubMed indexed study
PMID 14647223 from European journal of clinical nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 83. Absorption of iron from recombinant human lactoferrin in young US women.
RCT • 2006 • PubMed indexed study
PMID 16469988 from The American journal of clinical nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 84. Helicobacter pylori eradication: a randomized prospective study of triple therapy versus triple therapy plus lactoferrin and probiotics.
RCT • 2007 • PubMed indexed study
PMID 17313499 from The American journal of gastroenterology.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 85. Gastric digestion of bovine lactoferrin in vivo in adults.
RCT • 2001 • PubMed indexed study
PMID 11481401 from The Journal of nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 86. Efficacy of rice-based oral rehydration solution containing recombinant human lactoferrin and lysozyme in Peruvian children with acute diarrhea.
RCT • 2007 • PubMed indexed study
PMID 17255841 from Journal of pediatric gastroenterology and nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 87. A new chance of preventing winter diseases by the administration of synbiotic formulations.
RCT • 2008 • PubMed indexed study
PMID 18685511 from Journal of clinical gastroenterology.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 88. Breast milk immune factors in Bangladeshi women supplemented postpartum with retinol or beta-carotene.
RCT • 1999 • PubMed indexed study
PMID 10232636 from The American journal of clinical nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1325,1402,1413, etc.]
Open source 89. Early Effect of Supplemented Infant Formulae on Intestinal Biomarkers and Microbiota: A Randomized Clinical Trial.
RCT • 2020 • PubMed indexed study
PMID 32443684 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.0/10.[1325,1402,1413, etc.]
Open source 90. Reducing Iron Content in Infant Formula from 8 to 2 mg/L Does Not Increase the Risk of Iron Deficiency at 4 or 6 Months of Age: A Randomized Controlled Trial.
RCT • 2020 • PubMed indexed study
PMID 33374970 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.0/10.[1325,1402,1413, etc.]
Open source 91. Probiotic Lactobacillus casei: Effective for Managing Childhood Diarrhea by Altering Gut Microbiota and Attenuating Fecal Inflammatory Markers.
RCT • 2019 • PubMed indexed study
PMID 31126062 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.0/10.[1325,1402,1413, etc.]
Open source 92. Bioavailability of a Novel Form of Microencapsulated Bovine Lactoferrin and Its Effect on Inflammatory Markers and the Gut Microbiome: A Pilot Study.
RCT • 2018 • PubMed indexed study
PMID 30126153 from Nutrients.
Outcome: Study design: RCT. Quality score: 7.9/10.[1325,1402,1413, etc.]
Open source 93. Vitamin D₃ Supplementation Reduces the Symptoms of Upper Respiratory Tract Infection during Winter Training in Vitamin D-Insufficient Taekwondo Athletes: A Randomized Controlled Trial.
RCT • 2018 • PubMed indexed study
PMID 30223447 from International journal of environmental research and public health.
Outcome: Study design: RCT. Quality score: 7.9/10.[1325,1402,1413, etc.]
Open source 94. Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial.
RCT • 2016 • PubMed indexed study
PMID 27801789 from Nutrients.
Outcome: Study design: RCT. Quality score: 7.9/10.[1325,1402,1413, etc.]
Open source 95. Resveratrol in Hepatitis C Patients Treated with Pegylated-Interferon-α-2b and Ribavirin Reduces Sleep Disturbance.
RCT • 2017 • PubMed indexed study
PMID 28820468 from Nutrients.
Outcome: Study design: RCT. Quality score: 7.9/10.[1325,1402,1413, etc.]
Open source 96. Influence of bovine lactoferrin on feeding intolerance and intestinal permeability in preterm infants: a randomized controlled trial.
RCT • 2024 • PubMed indexed study
PMID 39565449 from European journal of pediatrics.
Outcome: Study design: RCT. Quality score: 7.8/10.[1325,1402,1413, etc.]
Open source 97. Mechanisms affecting the gut of preterm infants in enteral feeding trials: a nested cohort within a randomised controlled trial of lactoferrin.
RCT • 2023 • PubMed indexed study
PMID 36396443 from Archives of disease in childhood. Fetal and neonatal edition.
Outcome: Study design: RCT. Quality score: 7.8/10.[1325,1402,1413, etc.]
Open source 98. Evaluation of a Multimodal Stress Management and Comprehensive Lifestyle Modification Program on Quality of Life and Gastrointestinal Symptoms in Patients with Crohn's Disease: A Randomized Controlled Pilot Trial with 9-Month Follow-Up.
RCT • 2024 • PubMed indexed study
PMID 38350430 from Digestion.
Outcome: Study design: RCT. Quality score: 7.8/10.[1325,1402,1413, etc.]
Open source 99. Randomised clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment.
RCT • 2019 • PubMed indexed study
PMID 30565745 from Mycoses.
Outcome: Study design: RCT. Quality score: 7.7/10.[1325,1402,1413, etc.]
Open source 100. Lactoferrin for iron-deficiency anemia in children with inflammatory bowel disease: a clinical trial.
RCT • 2022 • PubMed indexed study
PMID 35681097 from Pediatric research.
Outcome: Study design: RCT. Quality score: 7.7/10.[1325,1402,1413, etc.]
Open source 101. Randomized Controlled Trial of Bovine Lactoferrin for Prevention of Sepsis and Neurodevelopment Impairment in Infants Weighing Less Than 2000 Grams.
RCT • 2020 • PubMed indexed study
PMID 32037149 from The Journal of pediatrics.
Outcome: Study design: RCT. Quality score: 7.7/10.[1325,1402,1413, etc.]
Open source 102. Cytokine responses to symbiotic and lactoferrin combination in very low birth weight neonates: a randomized control trial.
RCT • 2020 • PubMed indexed study
PMID 31984696 from Archivos argentinos de pediatria.
Outcome: Study design: RCT. Quality score: 7.7/10.[1325,1402,1413, etc.]
Open source 103. THE EFFECT OF ENTERAL LACTOFERRIN SUPPLEMENTATION IN PREVENTION OF MORBIDITY ASSOCIATED WITH IMMATURE DIGESTIVE TRACT IN PREMATURE INFANTS: PROSPECTIVE COHORT STUDY.
RCT • 2022 • PubMed indexed study
PMID 35271478 from Georgian medical news.
Outcome: Study design: RCT. Quality score: 7.7/10.[1325,1402,1413, etc.]
Open source 104. Effects of exercise in hot and humid conditions and bovine colostrum on salivary immune markers.
RCT • 2020 • PubMed indexed study
PMID 33077128 from Journal of thermal biology.
Outcome: Study design: RCT. Quality score: 7.7/10.[1325,1402,1413, etc.]
Open source 105. Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial.
RCT • 2019 • PubMed indexed study
PMID 29338568 from The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
Outcome: Study design: RCT. Quality score: 7.7/10.[1325,1402,1413, etc.]
Open source 106. Change of some oxidative stress parameters after supplementation with whey protein isolate in patients with type 2 diabetes.
RCT • 2020 • PubMed indexed study
PMID 32065880 from Nutrition (Burbank, Los Angeles County, Calif.).
Outcome: Study design: RCT. Quality score: 7.7/10.[1325,1402,1413, etc.]
Open source 107. A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway.
RCT • 2019 • PubMed indexed study
PMID 30611996 from Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
Outcome: Study design: RCT. Quality score: 7.7/10.[1325,1402,1413, etc.]
Open source 108. Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial.
RCT • 2014 • PubMed indexed study
PMID 24709463 from Early human development.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 109. Dietary Supplementation with a Combination of Lactoferrin, Fish Oil, and Enterococcus faecium WB2000 for Treating Dry Eye: A Rat Model and Human Clinical Study.
RCT • 2016 • PubMed indexed study
PMID 26795265 from The ocular surface.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 110. Lactoferrin and lysozyme to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for a randomized controlled trial.
RCT • 2017 • PubMed indexed study
PMID 29110675 from Trials.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 111. A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics.
RCT • 2015 • PubMed indexed study
PMID 25163639 from The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 112. Effect of bovine lactoferrin from iron-fortified formulas on diarrhea and respiratory tract infections of weaned infants in a randomized controlled trial.
RCT • 2016 • PubMed indexed study
PMID 26602290 from Nutrition (Burbank, Los Angeles County, Calif.).
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 113. Iron metabolism in infants: influence of bovine lactoferrin from iron-fortified formula.
RCT • 2015 • PubMed indexed study
PMID 25592008 from Nutrition (Burbank, Los Angeles County, Calif.).
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 114. Bovine Lactoferrin Enhances TLR7-Mediated Responses in Plasmacytoid Dendritic Cells in Elderly Women: Results From a Nutritional Intervention Study With Bovine Lactoferrin, GOS and Vitamin D.
RCT • 2018 • PubMed indexed study
PMID 30515164 from Frontiers in immunology.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 115. Antibiotic treatment to prevent postextraction complications: a monocentric, randomized clinical trial. Preliminary outcomes.
RCT • 2017 • PubMed indexed study
PMID 28569454 from Minerva stomatologica.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 116. Administration of a multistrain probiotic product (VSL#3) to women in the perinatal period differentially affects breast milk beneficial microbiota in relation to mode of delivery.
RCT • 2015 • PubMed indexed study
PMID 25836922 from Pharmacological research.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 117. Lactobacilli vaginal colonisation after oral consumption of Respecta(®) complex: a randomised controlled pilot study.
RCT • 2015 • PubMed indexed study
PMID 25855055 from Archives of gynecology and obstetrics.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 118. Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactoferrin Counteracts This Effect.
RCT • 2018 • PubMed indexed study
PMID 29198543 from The Journal of pediatrics.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 119. Gut-targeted immunonutrition boosting natural killer cell activity using Saccharomyces boulardii lysates in immuno-compromised healthy elderly subjects.
RCT • 2014 • PubMed indexed study
PMID 24059806 from Rejuvenation research.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 120. Evaluation of the effect of blackcurrant products on gut microbiota and on markers of risk for colon cancer in humans.
RCT • 2014 • PubMed indexed study
PMID 23674271 from Phytotherapy research : PTR.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 121. Summary Protocol for a Multi-Centre Randomised Controlled Trial of Enteral Lactoferrin Supplementation in Newborn Very Preterm Infants (ELFIN).
RCT • 2018 • PubMed indexed study
PMID 29890513 from Neonatology.
Outcome: Study design: RCT. Quality score: 7.6/10.[1325,1402,1413, etc.]
Open source 122. Impact of lactoferrin supplementation on growth and prevalence of Giardia colonization in children.
RCT • 2008 • PubMed indexed study
PMID 18462105 from Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 123. Bovine lactoferrin prevents invasive fungal infections in very low birth weight infants: a randomized controlled trial.
RCT • 2012 • PubMed indexed study
PMID 22184648 from Pediatrics.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 124. Effects of lactoferrin-containing formula in the prevention of enterovirus and rotavirus infection and impact on serum cytokine levels: a randomized trial.
RCT • 2011 • PubMed indexed study
PMID 21880194 from Chang Gung medical journal.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 125. Efficacy and safety of oral lactoferrin supplementation in combination with rHuEPO-beta for the treatment of anemia in advanced cancer patients undergoing chemotherapy: open-label, randomized controlled study.
RCT • 2010 • PubMed indexed study
PMID 20647390 from The oncologist.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 126. Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study.
RCT • 2009 • PubMed indexed study
PMID 19639462 from Acta obstetricia et gynecologica Scandinavica.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 127. Inflammatory responses improve with milk ribonuclease-enriched lactoferrin supplementation in postmenopausal women.
RCT • 2010 • PubMed indexed study
PMID 20473630 from Inflammation research : official journal of the European Histamine Research Society ... [et al.].
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 128. Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women.
RCT • 2009 • PubMed indexed study
PMID 19172341 from Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 129. The effect of caloric supplementation on selected milk protective factors in undernourished Guatemalan mothers.
RCT • 1993 • PubMed indexed study
PMID 8233728 from Pediatric research.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 130. Long-term enteral immunonutrition containing lactoferrin in tube-fed bedridden patients: immunological and nutritional status.
RCT • 2012 • PubMed indexed study
PMID 23204157 from Journal of the American College of Nutrition.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 131. Human milk feeding prevents retinopathy of prematurity (ROP) in preterm VLBW neonates.
RCT • 2013 • PubMed indexed study
PMID 23809355 from Early human development.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 132. Influence of lactoferrin on iron absorption from human milk in infants.
RCT • 1994 • PubMed indexed study
PMID 8134189 from Pediatric research.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 133. Evaluation of Helicobacter Pylori eradication in pediatric patients by triple therapy plus lactoferrin and probiotics compared to triple therapy alone.
RCT • 2012 • PubMed indexed study
PMID 23114016 from Italian journal of pediatrics.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 134. Helicobacter pylori infection in clinical practice: probiotics and a combination of probiotics + lactoferrin improve compliance, but not eradication, in sequential therapy.
RCT • 2012 • PubMed indexed study
PMID 22759324 from Helicobacter.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 135. Iron, zinc, copper and selenium status of breast-fed infants and infants fed trace element fortified milk-based infant formula.
RCT • 1994 • PubMed indexed study
PMID 8025391 from Acta paediatrica (Oslo, Norway : 1992).
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 136. The effect of caloric supplementation on levels of milk IgA antibodies and their avidities in undernourished Guatemalan mothers.
RCT • 1995 • PubMed indexed study
PMID 8525980 from Advances in experimental medicine and biology.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 137. [Effect of transcranial electrostimulation on clinical and laboratory characteristics in patients with gastric ulcer].
RCT • 2009 • PubMed indexed study
PMID 19708562 from Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury.
Outcome: Study design: RCT. Quality score: 7.5/10.[1325,1402,1413, etc.]
Open source 138. Influence of oral administration mode on the efficacy of commercial bovine Lactoferrin against iron and inflammatory homeostasis disorders.
RCT • 2020 • PubMed indexed study
PMID 32274616 from Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.7/10.[1325,1402,1413, etc.]
Open source 139. Dietary supplementation with green tea extract promotes enhanced human leukocyte activity.
RCT • 2015 • PubMed indexed study
PMID 26259232 from Journal of complementary & integrative medicine.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.6/10.[1325,1402,1413, etc.]
Open source 140. Effect of lactoferrin on taste and smell abnormalities induced by chemotherapy: a proteome analysis.
RCT • 2018 • PubMed indexed study
PMID 30182113 from Food & function.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.6/10.[1325,1402,1413, etc.]
Open source 141. Efficacy and tolerability of oral lactoferrin supplementation in mild to moderate acne vulgaris: an exploratory study.
RCT • 2011 • PubMed indexed study
PMID 21303195 from Current medical research and opinion.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.5/10.[1325,1402,1413, etc.]
Open source 142. Digestive Profiles of Human Milk, Recombinant Human and Bovine Lactoferrin: Comparing the Retained Intact Protein and Peptide Release.
COHORT • 2024 • PubMed indexed study
PMID 39064803 from Nutrients.
Outcome: Study design: COHORT. Quality score: 6.1/10.[1325,1402,1413, etc.]
Open source 143. Subclinical Mastitis in a European Multicenter Cohort: Prevalence, Impact on Human Milk (HM) Composition, and Association with Infant HM Intake and Growth.
COHORT • 2019 • PubMed indexed study
PMID 31905959 from Nutrients.
Outcome: Study design: COHORT. Quality score: 6.0/10.[1325,1402,1413, etc.]
Open source 144. Concentration of Lactoferrin in Human Milk and Its Variation during Lactation in Different Chinese Populations.
COHORT • 2018 • PubMed indexed study
PMID 30189612 from Nutrients.
Outcome: Study design: COHORT. Quality score: 5.9/10.[1325,1402,1413, etc.]
Open source 145. Lactoferrin Supplementation in Preventing and Protecting from SARS-CoV-2 Infection: Is There Any Role in General and Special Populations? An Updated Review of Literature.
PUBMED • 2024 • PubMed indexed study
PMID 39408576 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1325,1402,1413, etc.]
Open source 146. Lactoferrin for the postoperative management of term neonates after gastrointestinal surgery.
PUBMED • 2023 • PubMed indexed study
PMID 37233609 from The Cochrane database of systematic reviews.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1325,1402,1413, etc.]
Open source 147. Lactoferrin: Properties and Potential Uses in the Food Industry.
PUBMED • 2025 • PubMed indexed study
PMID 40003872 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1325,1402,1413, etc.]
Open source 148. Exploring the Therapeutic Potential of Bovine Colostrum for Cancer Therapies.
PUBMED • 2025 • PubMed indexed study
PMID 40869257 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1325,1402,1413, etc.]
Open source 149. Role of nutrient supplements in children with post-COVID condition: a retrospective preliminary observation and narrative review.
COHORT • 2025 • PubMed indexed study
PMID 40241147 from Italian journal of pediatrics.
Outcome: Study design: COHORT. Quality score: 5.8/10.[1325,1402,1413, etc.]
Open source 150. Determination of Bovine Lactoferrin in Powdered Infant Formula and Adult Nutritionals by Heparin Affinity Extraction and Reverse-Phase High-Performance Liquid Chromatography/Ultraviolet Detection (HPLC/UV): Single-Laboratory Validation, First Action 2021.10.
COHORT • 2024 • PubMed indexed study
PMID 38704865 from Journal of AOAC International.
Outcome: Study design: COHORT. Quality score: 5.8/10.[1325,1402,1413, etc.]
Open source 151. Exclusive Human Milk Diet for Extremely Premature Infants: A Novel Fortification Strategy That Enhances the Bioactive Properties of Fresh, Frozen, and Pasteurized Milk Specimens.
COHORT • 2023 • PubMed indexed study
PMID 37071630 from Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
Outcome: Study design: COHORT. Quality score: 5.8/10.[1325,1402,1413, etc.]
Open source 152. Clinical Applications of Bovine Colostrum in GastrointestinaI Disorders: Mechanisms, Evidence, and Therapeutic Potential.
PUBMED • 2025 • PubMed indexed study
PMID 41226709 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1325,1402,1413, etc.]
Open source 153. Lactoferrin: Structure, function, denaturation and digestion.
PUBMED • 2019 • PubMed indexed study
PMID 28933602 from Critical reviews in food science and nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1325,1402,1413, etc.]
Open source 154. The role of iron in host-microbiota crosstalk and its effects on systemic glucose metabolism.
PUBMED • 2022 • PubMed indexed study
PMID 35986176 from Nature reviews. Endocrinology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1325,1402,1413, etc.]
Open source 155. Clinical aspects of the use of lactoferrin in dentistry.
PUBMED • 2021 • PubMed indexed study
PMID 33662566 from Journal of oral biosciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1325,1402,1413, etc.]
Open source 156. Lactoferrin as a Potent Natural Supplement Exhibiting a Synergistic Effect with Drugs in Antimicrobial and Anticancer Therapies.
PUBMED • 2021 • PubMed indexed study
PMID 34635039 from Current protein & peptide science.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1325,1402,1413, etc.]
Open source 157. Recent perspective on cow's milk allergy and dairy nutrition.
PUBMED • 2022 • PubMed indexed study
PMID 33983082 from Critical reviews in food science and nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1325,1402,1413, etc.]
Open source 158. The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria.
PUBMED • 2019 • PubMed indexed study
PMID 31547574 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1325,1402,1413, etc.]
Open source 159. Short- and Long-Term Implications of Human Milk Microbiota on Maternal and Child Health.
PUBMED • 2021 • PubMed indexed study
PMID 34769296 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1325,1402,1413, etc.]
Open source 160. Dietary and Protective Factors to Halt or Mitigate Progression of Autoimmunity, COVID-19 and Its Associated Metabolic Diseases.
PUBMED • 2021 • PubMed indexed study
PMID 33808574 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1325,1402,1413, etc.]
Open source 161. Nutraceuticals in the Prevention of Viral Infections, including COVID-19, among the Pediatric Population: A Review of the Literature.
PUBMED • 2021 • PubMed indexed study
PMID 33671104 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1325,1402,1413, etc.]
Open source 162. Human milk immunomodulatory proteins are related to development of infant body composition during the first year of lactation.
COHORT • 2021 • PubMed indexed study
PMID 32438370 from Pediatric research.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1325,1402,1413, etc.]
Open source 163. Bovine colostrum: an emerging nutraceutical.
COHORT • 2015 • PubMed indexed study
PMID 25781716 from Journal of complementary & integrative medicine.
Outcome: Study design: COHORT. Quality score: 5.6/10.[1325,1402,1413, etc.]
Open source 164. Lactoferrin and prematurity: a promising milk protein?
PUBMED • 2017 • PubMed indexed study
PMID 28085488 from Biochemistry and cell biology = Biochimie et biologie cellulaire.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.6/10.[1325,1402,1413, etc.]
Open source 165. Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis.
PUBMED • 2017 • PubMed indexed study
PMID 28914813 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.6/10.[1325,1402,1413, etc.]
Open source 166. Bovine lactoferrin: benefits and mechanism of action against infections.
PUBMED • 2006 • PubMed indexed study
PMID 16936799 from Biochemistry and cell biology = Biochimie et biologie cellulaire.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1325,1402,1413, etc.]
Open source 167. Supplementation of an adapted formula with bovine lactoferrin. 2. Effects on serum iron, ferritin and zinc levels.
COHORT • 1992 • PubMed indexed study
PMID 1392356 from Acta paediatrica (Oslo, Norway : 1992).
Outcome: Study design: COHORT. Quality score: 5.5/10.[1325,1402,1413, etc.]
Open source 168. Interaction between Dietary Lactoferrin and Gut Microbiota in Host Health.
PUBMED • 2024 • PubMed indexed study
PMID 38557058 from Journal of agricultural and food chemistry.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.4/10.[1325,1402,1413, etc.]
Open source 169. The Multifaceted Roles of Bovine Lactoferrin: Molecular Structure, Isolation Methods, Analytical Characteristics, and Biological Properties.
PUBMED • 2023 • PubMed indexed study
PMID 38091520 from Journal of agricultural and food chemistry.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.4/10.[1325,1402,1413, etc.]
Open source 170. Diarrhea and Coronavirus Disease 2019 Infection.
PUBMED • 2023 • PubMed indexed study
PMID 36813431 from Gastroenterology clinics of North America.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.4/10.[1325,1402,1413, etc.]
Open source 171. Probiotics, Prebiotics, and Lactoferrin-Implications for Preterm Mortality and Morbidity.
PUBMED • 2023 • PubMed indexed study
PMID 37782507 from JAMA pediatrics.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1325,1402,1413, etc.]
Open source 172. Short communication: The biological value of transition milk: analyses of immunoglobulin G, IGF-I and lactoferrin in primiparous and multiparous dairy cows.
PUBMED • 2023 • PubMed indexed study
PMID 37329844 from Animal : an international journal of animal bioscience.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1325,1402,1413, etc.]
Open source 173. Post Covid telogen effluvium: the diagnostic value of serum ferritin biomarker and the preventive value of dietary supplements. a case control study.
COHORT • 2024 • PubMed indexed study
PMID 38844670 from Archives of dermatological research.
Outcome: Study design: CASE_CONTROL. Quality score: 5.3/10.[1325,1402,1413, etc.]
Open source 174. Impact of a Functional Dairy Powder and Its Primary Component on the Growth of Pathogenic and Probiotic Gut Bacteria and Human Coronavirus 229E.
PUBMED • 2024 • PubMed indexed study
PMID 39273301 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1325,1402,1413, etc.]
Open source 175. Prevention of Age-Related-Increases in the Risks of Incident Functional Disability and Dementia by Home-Delivered Functional Dairy Product Consumption in Japanese Older Adults.
PUBMED • 2024 • PubMed indexed study
PMID 39218696 from Journal of nutritional science and vitaminology.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1325,1402,1413, etc.]
Open source 176. Valpalf(®): A New Nutraceutical Formulation Containing Bovine Lactoferrin That Exhibits Potentiated Biological Activity.
PUBMED • 2024 • PubMed indexed study
PMID 39201246 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1325,1402,1413, etc.]
Open source 177. Clinical applications of bioactive milk components.
PUBMED • 2015 • PubMed indexed study
PMID 26011900 from Nutrition reviews.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.2/10.[1325,1402,1413, etc.]
Open source 178. Early optimal nutrition improves neurodevelopmental outcomes for very preterm infants.
PUBMED • 2014 • PubMed indexed study
PMID 24938866 from Nutrition reviews.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.2/10.[1325,1402,1413, etc.]
Open source 179. Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin.
PUBMED • 2021 • PubMed indexed study
PMID 32841570 from Biochemistry and cell biology = Biochimie et biologie cellulaire.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1325,1402,1413, etc.]
Open source 180. Fermented goat's milk modulates immune response during iron deficiency anemia recovery.
PUBMED • 2022 • PubMed indexed study
PMID 34329496 from Journal of the science of food and agriculture.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1325,1402,1413, etc.]
Open source 181. Dose escalation study of bovine lactoferrin in preterm infants: getting the dose right.
PUBMED • 2021 • PubMed indexed study
PMID 32846100 from Biochemistry and cell biology = Biochimie et biologie cellulaire.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1325,1402,1413, etc.]
Open source 182. Genetic diversity and iron metabolism of Staphylococcus hominis isolates originating from bovine quarter milk, rectal feces, and teat apices.
PUBMED • 2022 • PubMed indexed study
PMID 36270870 from Journal of dairy science.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1325,1402,1413, etc.]
Open source 183. Nutritional roles of lactoferrin.
PUBMED • 2009 • PubMed indexed study
PMID 19318940 from Current opinion in clinical nutrition and metabolic care.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 184. Bovine Colostrum in Pediatric Nutrition and Health.
PUBMED • 2024 • PubMed indexed study
PMID 39770926 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 185. Assessment of Supplementation with Different Biomolecules in the Prevention and Treatment of COVID-19.
PUBMED • 2024 • PubMed indexed study
PMID 39339670 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 186. Mineral-binding milk proteins and peptides; occurrence, biochemical and technological characteristics.
PUBMED • 2000 • PubMed indexed study
PMID 11242452 from The British journal of nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 187. Featured Prebiotic Agent: The Roles and Mechanisms of Direct and Indirect Prebiotic Activities of Lactoferrin and Its Application in Disease Control.
PUBMED • 2023 • PubMed indexed study
PMID 37375663 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 188. Occurrence, structure, biochemical properties and technological characteristics of lactoferrin.
PUBMED • 2000 • PubMed indexed study
PMID 11242441 from The British journal of nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 189. Iron requirements, absorption and metabolism in infancy and childhood.
PUBMED • 2007 • PubMed indexed study
PMID 17414503 from Current opinion in clinical nutrition and metabolic care.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 190. Deoxynivalenol exposure-related male reproductive toxicity in mammals: Molecular mechanisms, detoxification and future directions.
PUBMED • 2025 • PubMed indexed study
PMID 40252554 from Environment international.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 191. Effects of whey protein supplements on metabolism: evidence from human intervention studies.
PUBMED • 2011 • PubMed indexed study
PMID 21912246 from Current opinion in clinical nutrition and metabolic care.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 192. Iron and its relation to immunity and infectious disease.
PUBMED • 2001 • PubMed indexed study
PMID 11160594 from The Journal of nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 193. Revealing the Potency of Growth Factors in Bovine Colostrum.
PUBMED • 2024 • PubMed indexed study
PMID 39064802 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 194. Microbiota-Modulating Strategies in Neonates Undergoing Surgery for Congenital Gastrointestinal Conditions: A Narrative Review.
PUBMED • 2025 • PubMed indexed study
PMID 40647338 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 195. Diarrhea in enterally fed patients: blame the diet?
PUBMED • 2013 • PubMed indexed study
PMID 23799327 from Current opinion in clinical nutrition and metabolic care.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 196. The Role of Lactoferrin in Modulating Inflammation and Preventing Preterm Birth: A Narrative Review.
PUBMED • 2025 • PubMed indexed study
PMID 41097241 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
PMID 11242454 from The British journal of nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 198. Oral rehydration solutions in non-cholera diarrhea: a review.
PUBMED • 2009 • PubMed indexed study
PMID 19550407 from The American journal of gastroenterology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 199. Iron, zinc, folate and vitamin B12 nutritional status and milk composition of low-income Brazilian mothers.
PUBMED • 1989 • PubMed indexed study
PMID 2661218 from European journal of clinical nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 200. Science and Faith to Understand Milk Bioactivity for Infants.
PUBMED • 2024 • PubMed indexed study
PMID 38892610 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 201. Air Pollution-Associated Rhinitis: Exploring the Preventive Role of Nutritional Supplements Against Particulate Matter-Induced Inflammation.
PUBMED • 2025 • PubMed indexed study
PMID 40077699 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1325,1402,1413, etc.]
Open source 202. A Global Review on Short Peptides: Frontiers and Perspectives.
PUBMED • 2021 • PubMed indexed study
PMID 33467522 from Molecules (Basel, Switzerland).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1325,1402,1413, etc.]
Open source 203. Exploring the Potential of Human Milk and Formula Milk on Infants' Gut and Health.
PUBMED • 2022 • PubMed indexed study
PMID 36079814 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1325,1402,1413, etc.]
Open source 204. Milk Proteins-Their Biological Activities and Use in Cosmetics and Dermatology.
PUBMED • 2021 • PubMed indexed study
PMID 34071375 from Molecules (Basel, Switzerland).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1325,1402,1413, etc.]