Supplement
Supports broad cellular function with category-specific mechanisms.[1427,1494,1504, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 2 • links 25
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[539,687,911, etc.]
Dose guide: Follow product label and start with the lowest effective daily serving..[539,687,911, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Follow product label and start with the lowest effective daily serving.
Clinical Depth
Humans: 262 • RCTs: 70 • Meta: 2
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 177 • Interactions: 190
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
735 total studies · 6 recent
Timeline
Animal-only studies
1,333
Total indexed
735
In vitro / tissue
539
Human studies
262
Interaction signals
190
Safety adverse signals
177
Weighted direction score: 0 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
1,333
Total indexed
735
In vitro / tissue
539
Human studies
262
Interaction signals
190
Safety adverse signals
177
Randomized trials
70
Meta-analyses
2
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 34213769 • 2022 Jan
Effect of glutamine supplementation on inflammatory markers in critically ill patients supported with enteral or parenteral feeding.
JPEN J Parenter Enteral Nutr
Open PubMedPMID 29138359 • 2017 Nov
Comparative effects of intraduodenal amino acid infusions on food intake and gut hormone release in healthy males.
Physiol Rep
Open PubMedPMID 38193521 • 2024 Dec
Supplementation of L-glutamine enhanced mucosal immunity and improved hormonal status of combat-sport athletes.
J Int Soc Sports Nutr
Open PubMedPMID 38337738 • 2024 Feb 5
Concurrent Ingestion of Alkaline Water and L-Glutamine Enhanced Salivary α-Amylase Activity and Testosterone Concentration in Boxing Athletes.
Nutrients
Open PubMedPMID 39765161 • 2025 Feb
Effects of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on cardiac surgery: A randomized controlled trial.
Clin Nutr
Open PubMedPMID 38892699 • 2024 Jun 5
Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women.
Nutrients
Open PubMedPMID 40914430 • 2025 Dec
Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on inflammation in patients with cardiac surgery: A secondary analysis of a randomized controlled trial.
J Cardiol
Open PubMedPMID 37836400 • 2023 Sep 23
L-Glutamine and Survival of Patients with Locally Advanced Head and Neck Cancer Receiving Chemoradiotherapy.
Nutrients
Open PubMedPMID 35241123 • 2022 Mar 3
Advances in the diagnosis and treatment of sickle cell disease.
J Hematol Oncol
Open PubMedPMID 28835408 • 2018 Jul
Sugar addiction: is it real? A narrative review.
Br J Sports Med
Open PubMedPMID 12241009 • 2002 Jul
Mechanisms of hyperammonemia.
Clin Chem Lab Med
Open PubMedPMID 11366485 • 1998 Nov-Dec
Nutrition know-how.
Posit Aware
Open PubMedPMID 12481981 • 2002 Nov
II. Glutamine and glutamate.
Biomed Pharmacother
Open PubMedPMID 38674821 • 2024 Apr 11
Chilean Market Protein Shakes Composition.
Nutrients
Open PubMedPMID 34709541 • 2021 Dec
The effect of glutamine supplementation on serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients: a case-control study.
Inflammopharmacology
Open PubMedBenefit reports: 1
Adverse reports: 1
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22l-glutamine%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22l-glutamine%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=l-glutamine
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Sentiment Score
-0.3/100
Benefit Mentions
No benefit mentions recorded.
Adverse Mentions
No adverse mentions recorded.
Best Responders
No responder profile recorded.
aggregate • unclear
Aggregate community signal: 2 directional mentions (benefit 1, adverse 1, no-effect 0, mixed 0).
Open mentionamazon
Amazon search for L-glutamine
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 262, RCTs 70, meta-analyses 2.[1427,1494,1504, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34213769 from JPEN J Parenter Enteral Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 29138359 from Physiol Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38193521 from J Int Soc Sports Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38337738 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39765161 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38892699 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40914430 from J Cardiol.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37836400 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35241123 from J Hematol Oncol.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 28835408 from Br J Sports Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2002 • Human evidence curation set
PMID 12241009 from Clin Chem Lab Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 1998 • Human evidence curation set
PMID 11366485 from Posit Aware.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2002 • Human evidence curation set
PMID 12481981 from Biomed Pharmacother.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38674821 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34709541 from Inflammopharmacology.
Outcome: See linked PubMed abstract for methods and outcomes.[1427,1494,1504, etc.]
Open source