Supplement
Supports broad cellular function with category-specific mechanisms.[1810,2518,2588, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
10
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 4 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[526,674,898, etc.]
Dose guide: Human-study daily dose: 30 mg-80 mg/day (moderate-confidence extraction from PubMed abstracts)..[526,674,898, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 30 mg-80 mg/day (moderate-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 30 mg-80 mg/day (moderate-confidence extraction from PubMed abstracts).[1810,, etc.]
Clinical Depth
Humans: 602 • RCTs: 67 • Meta: 13
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 3,001 • Interactions: 4,080
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
1155 total studies · 5 recent
Timeline
Animal-only studies
10,536
In vitro / tissue
8,131
Interaction signals
4,080
Safety adverse signals
3,001
Total indexed
1,155
Human studies
602
Weighted direction score: 10 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
10,536
In vitro / tissue
8,131
Interaction signals
4,080
Safety adverse signals
3,001
Total indexed
1,155
Human studies
602
Randomized trials
67
Meta-analyses
13
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 40826844 • 2025 Nov-Dec
Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
Indian J Dermatol Venereol Leprol
Open PubMedPMID 40169165 • 2025 Apr 2
Stem cell injections for osteoarthritis of the knee.
Cochrane Database Syst Rev
Open PubMedPMID 30784039 • 2019 Feb 20
Interventions for primary vesicoureteric reflux.
Cochrane Database Syst Rev
Open PubMedBenefit reports: 2
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
aggregate • benefit
Aggregate community signal: 4 directional mentions (benefit 2, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Hyaluronic Acid
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 602, RCTs 67, meta-analyses 13.[1810,2518,2588, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40826844 from Indian J Dermatol Venereol Leprol.
Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]
PMID 40911749 • 2025 Sep 1
Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction.
J Drugs Dermatol
Open PubMedPMID 18050181 • 2007 Dec 15
Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis.
Arthritis Rheum
Open PubMedPMID 38429164 • 2024 May
Laparoscopic application of sodium hyaluronate-carboxymethylcellulose barrier in abdominopelvic surgery: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Systematic Review Protocols-compliant systematic review and meta-analysis.
Surgery
Open PubMedPMID 38931263 • 2024 Jun 17
The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial.
Nutrients
Open PubMedPMID 26362110 • 2015 Dec
The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials.
J Cosmet Dermatol
Open PubMedPMID 38009035 • 2023 Nov
Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test.
Skin Res Technol
Open PubMedPMID 30658483 • 2019 Jan 17
A Randomized, Controlled Trial of Vitamin D Supplementation on Cardiovascular Risk Factors, Hormones, and Liver Markers in Women with Polycystic Ovary Syndrome.
Nutrients
Open PubMedPMID 26840887 • 2016 Sep
Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study.
J Sci Food Agric
Open PubMedPMID 34622845 • 2021 Oct 8
Liquid combination of hyaluronan, glucosamine, and chondroitin as a dietary supplement for knee osteoarthritis patients with moderate knee pain: A randomized controlled study.
Medicine (Baltimore)
Open PubMedPMID 36206809 • 2023 Feb
Oral Supplementation and Systemic Drugs for Skin Aging: A Narrative Review.
Actas Dermosifiliogr
Open PubMedPMID 34696778 • 2021 Oct 25
Prevention of recurrent respiratory infections : Inter-society Consensus.
Ital J Pediatr
Open PubMedPMID 38101929 • 2023 Dec 15
Management of chronic pain associated with temporomandibular disorders: a clinical practice guideline.
BMJ
Open PubMedSearch fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22hyaluronic%20acid%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22hyaluronic%20acid%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=hyaluronic%20acid
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 30 mg-80 mg/day (confidence MEDIUM).
Extracted from 3 dosing mentions across 1 PubMed studies (mg/day).
AnalyzeAndOptimize Instagram mentions: 1.
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$15.00.
Community Sources
PUBMED • 2025 • Human evidence curation set
PMID 40169165 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30784039 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40911749 from J Drugs Dermatol.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2007 • Human evidence curation set
PMID 18050181 from Arthritis Rheum.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38429164 from Surgery.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38931263 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26362110 from J Cosmet Dermatol.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38009035 from Skin Res Technol.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30658483 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26840887 from J Sci Food Agric.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34622845 from Medicine (Baltimore).
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36206809 from Actas Dermosifiliogr.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34696778 from Ital J Pediatr.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38101929 from BMJ.
Outcome: See linked PubMed abstract for methods and outcomes.[1810,2518,2588, etc.]
Open source