Supplement
Triterpenoid saponins (asiaticoside, madecassoside) promote collagen synthesis, increase GABA and acetylcholine, enhance BDNF expression, strengthen venous walls, and modulate cortisol.[1356,1686,1688, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
46/100
Moderate depth from human/RCT/meta counts
Community Direction
9
Mixed / Neutral • confidence Minimal
Safety Friction
88/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 7 • mentions 8 • links 20
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Cognitive, Skin Hair, Stress Resilience, Mobility.[513,661,885, etc.]
Dose guide: Human-study daily dose: 68 mg-160 mg/day (moderate-confidence extraction from PubMed abstracts)..[513,661,885, etc.]
Category
Botanical
Evidence Tier
EMERGING
Daily Guide
Human-study daily dose: 68 mg-160 mg/day (moderate-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 7 • RCTs: 3 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 14 • Interactions: 9
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
13 total studies
Timeline
In vitro / tissue
14
Safety adverse signals
14
Total indexed
13
Animal-only studies
11
Interaction signals
9
Human studies
7
Weighted direction score: 9 (Mixed / Neutral)
Some human evidence or substantial animal evidence.
In vitro / tissue
14
Safety adverse signals
14
Total indexed
13
Animal-only studies
11
Interaction signals
9
Human studies
7
Randomized trials
3
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Moderate
Composite of study volume, RCTs, and meta-analyses
PMID 30456780 • 2019 Aug
Effects of a topical lotion containing aminophylline, caffeine, yohimbe, l-carnitine, and gotu kola on thigh circumference, skinfold thickness, and fat mass in sedentary females.
Journal of cosmetic dermatology
Open PubMedPMID 17324660 • 2007 Mar
Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults.
Journal of the American Dietetic Association
Open PubMedPMID 16729760 • 2006
[Efficiency of includes of bioactive substances in diet of patient with hepatic encephalopathy].
Voprosy pitaniia
Open PubMedPMID 34315377 • 2021
The Safety and Efficacy of Botanicals with Nootropic Effects.
Current neuropharmacology
Open PubMedPMID 30889210 • 2019
16S rRNA gene profiling and genome reconstruction reveal community metabolic interactions and prebiotic potential of medicinal herbs used in neurodegenerative disease and as nootropics.
PloS one
Open PubMedPMID 10711131 • 1999 May-Jun
Dietary supplements used in the treatment of depression, anxiety, and sleep disorders.
Lippincott's primary care practice
Open PubMedPMID 31884466 • 2020
Screening of Nutraceuticals and Plant Extracts for Inhibition of Amyloid-β Fibrillation.
Journal of Alzheimer's disease : JAD
Open PubMedBenefit reports: 4
Adverse reports: 3
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Classic Ayurvedic brain and skin herb. Best evidence for chronic venous insufficiency and wound healing. Also shows cognitive and anxiolytic promise. | Step2: Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
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Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22gotu%20kola%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=gotu%20kola
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 68 mg-160 mg/day (confidence MEDIUM).
Extracted from 3 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 8.0/10 (heuristic mapping confidence 0.92).
Legacy community note: Highly respected nootropic. Users consistently report improved memory after 2-3 months. GI side effects are the main complaint. Fat-soluble bacosides require fat for absorption.
aggregate • benefit
Aggregate community signal: 8 directional mentions (benefit 4, adverse 3, no-effect 0, mixed 1).
Open mentionamazon
Amazon search for Gotu Kola (Centella asiatica)
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
SYSTEMATIC_REVIEW • 2017 • Adults
8 studies with 320 subjects.
Outcome: Gotu kola improved working memory, attention, and mood (reduced anxiety) in elderly and healthy adults; asiaticoside may enhance hippocampal neurogenesis.[1356,1686,1688, etc.]
Open sourceMETA_ANALYSIS • 2013 • Adults
8 RCTs with 498 CVI patients.
Outcome: TTFCA (60-120 mg/day) significantly improved leg heaviness, edema, and venous distensibility in chronic venous insufficiency.[1356,1686,1688, etc.]
Open sourceRCT • 2006 • Adults
44 post-surgical patients.
Outcome: Asiaticoside cream significantly improved wound healing, reduced hypertrophic scar formation, and increased collagen remodeling.[1356,1686,1688, etc.]
Open sourcePUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 7, RCTs 3, meta-analyses 0.[1356,1686,1688, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30456780 from Journal of cosmetic dermatology.
Outcome: See linked PubMed abstract for methods and outcomes.[1356,1686,1688, etc.]
Open sourcePUBMED • 2007 • Human evidence curation set
PMID 17324660 from Journal of the American Dietetic Association.
Outcome: See linked PubMed abstract for methods and outcomes.[1356,1686,1688, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 16729760 from Voprosy pitaniia.
Outcome: See linked PubMed abstract for methods and outcomes.[1356,1686,1688, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34315377 from Current neuropharmacology.
Outcome: See linked PubMed abstract for methods and outcomes.[1356,1686,1688, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30889210 from PloS one.
Outcome: See linked PubMed abstract for methods and outcomes.[1356,1686,1688, etc.]
Open sourcePUBMED • 1999 • Human evidence curation set
PMID 10711131 from Lippincott's primary care practice.
Outcome: See linked PubMed abstract for methods and outcomes.[1356,1686,1688, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31884466 from Journal of Alzheimer's disease : JAD.
Outcome: See linked PubMed abstract for methods and outcomes.[1356,1686,1688, etc.]
Open source