Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
37
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 24 • mentions 11 • links 341
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials.
Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study.
Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study.
Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials.
Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.
Nutrition supplementation combined with exercise versus exercise alone in treating knee osteoarthritis: a double-blinded, randomised, placebo-controlled trial.
A Randomized, Double-Blind, Placebo-Controlled, Prospective Clinical Trial Evaluating Water-Soluble Chicken Eggshell Membrane for Improvement in Joint Health in Adults with Knee Osteoarthritis.
The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial.
Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens.
Effects of N-acetyl glucosamine and chondroitin sulfate supplementation on knee pain and self-reported knee function in middle-aged and older Japanese adults: a randomized, double-blind, placebo-controlled trial.
The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study.
European journal of physical and rehabilitation medicine
The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial.
Extracted from 2 dosing mentions across 1 PubMed studies (mg/day).
AnalyzeAndOptimize Instagram mentions: 1.
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Legacy community note: Very widely used with mixed experiences. Many elderly users report meaningful joint pain relief. Some studies are less impressive. Glucosamine SULFATE form is strongly preferred. Best results over longer periods (8+ weeks).
My biohacking journey as a middle aged overweight guy 12 months ago I was very unhealthy - 123kg (271lb), cholesterol >8, elevated liver enzymes, hypertension. The typical lazy 40 year old white collar male. Desk job, no exercise, high str…
I feel like it's excessive, what could I cut out? B12 - getting mouth ulcers (aphthas) without it Magnesium - eyelids are twitching without it Glucosamine Chondroitin MSM and collagen - my joints are loud as heck (doc said it's nothing to …
Any recommendations on joint supplements??? Good grief there’s a dang sub for *everything* it seems & took me posting & getting removed a couple times before I was pointed here. *ANYWAY…* I am an almost-43 y/o female cashier that has to be…
Almost 32 year old looking for long term health I am mostly concerned with long term joint pain and gut health, along with boosting my immune system because I have a 2yo in daycare and a 5 month old baby. I want to live long and feel good …
Glucosamine sulfate is a must try with or with out chondroitin sulfate. Some people do okay on the less expensive glucosamine HCl. You might get a CRP blood test looking for high inflammation and vitamin D test. my mother's high CRP came d…
I found a lot more success personally in decreasing inflammatory foods I eat like refined sugars and seed oils compared to supplementing my way out of the problem. Many are expensive like MSM and glucosamine or chondroitin. Only supplement…
1. Glucosamine for knee osteoarthritis: Cochrane review of 43 RCTs
META_ANALYSIS • 2015 • Adults
43 RCTs with 9110 knee OA patients.
Outcome: Glucosamine sulfate (crystalline) reduced pain (SMD −0.47) and improved WOMAC function; non-crystalline and HCl forms showed less consistent benefit.[1342,1359,1360, etc.]
Open source 2. GAIT trial: glucosamine, chondroitin for knee OA pain
RCT • 2006 • Adults
1583 patients in NIH-funded factorial RCT.
Outcome: Combination glucosamine+chondroitin provided significant pain relief in moderate-to-severe OA subgroup (79.2% vs 54.3% placebo) but not overall population.[1342,1359,1360, etc.]
Open source 3. Glucosamine use and mortality: UK Biobank analysis
COHORT • 2020 • Adults
495,077 adults followed over 8 years.
Outcome: Regular glucosamine use associated with 15% lower all-cause mortality (HR 0.85), 18% lower CVD mortality, and reduced CRP levels.[1342,1359,1360, etc.]
Open source 4. PubMed evidence summary: Glucosamine + Chondroitin
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
PMID 25629804 from The Cochrane database of systematic reviews.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 6. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.
PUBMED • 2000 • Human evidence curation set
PMID 10732937 from JAMA.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 7. Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials.
PUBMED • 2019 • Human evidence curation set
PMID 30879253 from Advances in therapy.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 8. Brain gray matter alterations in first episodes of depression: A meta-analysis of whole-brain studies.
PUBMED • 2016 • Human evidence curation set
PMID 26592799 from Neuroscience and biobehavioral reviews.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 9. Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study.
PUBMED • 2025 • Human evidence curation set
PMID 40664872 from Scientific reports.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 10. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study.
PUBMED • 2012 • Human evidence curation set
PMID 21969261 from Journal of the science of food and agriculture.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 11. Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials.
PUBMED • 2018 • Human evidence curation set
PMID 29947998 from Rheumatology international.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 12. Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
PUBMED • 2019 • Human evidence curation set
PMID 31470599 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 13. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.
PUBMED • 2018 • Human evidence curation set
PMID 29018060 from British journal of sports medicine.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 14. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.
PUBMED • 2016 • Human evidence curation set
PMID 26822714 from Nutrition journal.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 15. Nutrition supplementation combined with exercise versus exercise alone in treating knee osteoarthritis: a double-blinded, randomised, placebo-controlled trial.
PUBMED • 2025 • Human evidence curation set
PMID 39982001 from Age and ageing.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 16. A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.
PUBMED • 2022 • Human evidence curation set
PMID 35458170 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 17. A Randomized, Double-Blind, Placebo-Controlled, Prospective Clinical Trial Evaluating Water-Soluble Chicken Eggshell Membrane for Improvement in Joint Health in Adults with Knee Osteoarthritis.
PUBMED • 2019 • Human evidence curation set
PMID 31381494 from Journal of medicinal food.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 18. The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial.
PUBMED • 2021 • Human evidence curation set
PMID 33592868 from Medicine.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 19. Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial.
PUBMED • 2019 • Human evidence curation set
PMID 31221944 from Alternative therapies in health and medicine.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 20. Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens.
PUBMED • 2015 • Human evidence curation set
PMID 24395557 from Annals of the rheumatic diseases.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 21. Glucosamine-containing supplement improves locomotor functions in subjects with knee pain: a randomized, double-blind, placebo-controlled study.
PUBMED • 2015 • Human evidence curation set
PMID 26604721 from Clinical interventions in aging.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 22. Effects of N-acetyl glucosamine and chondroitin sulfate supplementation on knee pain and self-reported knee function in middle-aged and older Japanese adults: a randomized, double-blind, placebo-controlled trial.
PUBMED • 2016 • Human evidence curation set
PMID 26178634 from Aging clinical and experimental research.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 23. The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study.
PUBMED • 2016 • Human evidence curation set
PMID 26937646 from European journal of physical and rehabilitation medicine.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 24. Role of Glucosamine and Chondroitin in the Prevention of Cancer: A Meta-Analysis.
PUBMED • 2023 • Human evidence curation set
PMID 36715012 from Nutrition and cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 25. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial.
PUBMED • 2003 • Human evidence curation set
PMID 12860582 from Archives of internal medicine.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 26. Effects of Oral Chondroitin Sulfate on Osteoarthritis-Related Pain and Joint Structural Changes: Systematic Review and Meta-Analysis.
PUBMED • 2019 • Human evidence curation set
PMID 30859538 from Journal of special operations medicine : a peer reviewed journal for SOF medical professionals.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 27. Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents.
PUBMED • 2015 • Human evidence curation set
PMID 24866892 from The American journal of sports medicine.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 28. Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis.
PUBMED • 2018 • Human evidence curation set
PMID 29713967 from Clinical rheumatology.
Outcome: See linked PubMed abstract for methods and outcomes.[1342,1359,1360, etc.]
Open source 29. [NON-ARTHROPLASTY TREATMENT FOR KNEE OSTEOARTHRITIS].
META_ANALYSIS • 2017 • PubMed indexed study
PMID 28786278 from Harefuah.
Outcome: Study design: META_ANALYSIS. Quality score: 9.1/10.[1342,1359,1360, etc.]
Open source 30. The Safety and Efficacy of Glucosamine and/or Chondroitin in Humans: A Systematic Review.
SYSTEMATIC_REVIEW • 2025 • PubMed indexed study
PMID 40647198 from Nutrients.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.1/10.[1342,1359,1360, etc.]
Open source 31. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation.
SYSTEMATIC_REVIEW • 2009 • PubMed indexed study
PMID 19903416 from Health technology assessment (Winchester, England).
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.1/10.[1342,1359,1360, etc.]
Open source 32. Glucosamine and chondroitin for osteoarthritis?
META_ANALYSIS • 2001 • PubMed indexed study
PMID 11530541 from Bulletin on the rheumatic diseases.
Outcome: Study design: META_ANALYSIS. Quality score: 9.0/10.[1342,1359,1360, etc.]
Open source 33. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.
META_ANALYSIS • 2003 • PubMed indexed study
PMID 12860572 from Archives of internal medicine.
Outcome: Study design: META_ANALYSIS. Quality score: 9.0/10.[1342,1359,1360, etc.]
Open source 34. A potential role for avocado- and soybean-based nutritional supplements in the management of osteoarthritis: a review.
META_ANALYSIS • 2010 • PubMed indexed study
PMID 20631466 from The Physician and sportsmedicine.
Outcome: Study design: META_ANALYSIS. Quality score: 9.0/10.[1342,1359,1360, etc.]
Open source 35. Nutraceuticals in the management of osteoarthritis : a critical review.
META_ANALYSIS • 2012 • PubMed indexed study
PMID 23018608 from Drugs & aging.
Outcome: Study design: META_ANALYSIS. Quality score: 9.0/10.[1342,1359,1360, etc.]
Open source 36. The Effects of Glucosamine and Chondroitin Sulfate on Gut Microbial Composition: A Systematic Review of Evidence from Animal and Human Studies.
SYSTEMATIC_REVIEW • 2019 • PubMed indexed study
PMID 30704054 from Nutrients.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.0/10.[1342,1359,1360, etc.]
Open source 37. Randomised controlled trial: nutritional supplements to relieve irritable bowel syndrome symptoms by targeting the gut microbiota.
RCT • 2025 • PubMed indexed study
PMID 40692549 from Journal of nutritional science.
Outcome: Study design: RCT. Quality score: 8.8/10.[1342,1359,1360, etc.]
Open source 38. Efficacy of Conservative Interventions for Musculoskeletal Conditions on Pain and Disability in Active Serving Military Personnel-A Systematic Review.
SYSTEMATIC_REVIEW • 2024 • PubMed indexed study
PMID 36722165 from Military medicine.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.8/10.[1342,1359,1360, etc.]
Open source 39. The effectiveness of treatments for Kashin-Beck disease: a systematic review and network meta-analysis.
SYSTEMATIC_REVIEW • 2019 • PubMed indexed study
PMID 31376086 from Clinical rheumatology.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.7/10.[1342,1359,1360, etc.]
Open source 40. Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study.
RCT • 2020 • PubMed indexed study
PMID 32678677 from Journal of alternative and complementary medicine (New York, N.Y.).
Outcome: Study design: RCT. Quality score: 8.7/10.[1342,1359,1360, etc.]
Open source 41. Nutrition/Dietary Supplements and Chronic Pain in Patients with Cancer and Survivors of Cancer: A Systematic Review and Research Agenda.
SYSTEMATIC_REVIEW • 2021 • PubMed indexed study
PMID 34323435 from Pain physician.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.7/10.[1342,1359,1360, etc.]
Open source 42. Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial.
RCT • 2017 • PubMed indexed study
PMID 28790224 from Acta medica Indonesiana.
Outcome: Study design: RCT. Quality score: 8.6/10.[1342,1359,1360, etc.]
Open source 43. Supplementary methods in the nonsurgical treatment of osteoarthritis.
SYSTEMATIC_REVIEW • 2015 • PubMed indexed study
PMID 25633815 from Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.6/10.[1342,1359,1360, etc.]
Open source 44. A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative.
SYSTEMATIC_REVIEW • 2014 • PubMed indexed study
PMID 24387819 from Seminars in arthritis and rheumatism.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.6/10.[1342,1359,1360, etc.]
Open source 45. Effect of danaparoid sodium on hard exudates in diabetic retinopathy.
RCT • 1997 • PubMed indexed study
PMID 9413466 from Lancet (London, England).
Outcome: Study design: RCT. Quality score: 8.5/10.[1342,1359,1360, etc.]
Open source 46. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence.
SYSTEMATIC_REVIEW • 2006 • PubMed indexed study
PMID 16859534 from Arthritis research & therapy.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.5/10.[1342,1359,1360, etc.]
Open source 47. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT.
RCT • 2010 • PubMed indexed study
PMID 20525840 from Annals of the rheumatic diseases.
Outcome: Study design: RCT. Quality score: 8.3/10.[1342,1359,1360, etc.]
Open source 48. Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans.
RCT • 2015 • PubMed indexed study
PMID 25719429 from PloS one.
Outcome: Study design: RCT. Quality score: 8.2/10.[1342,1359,1360, etc.]
Open source 49. Adding collagen, propolis plus quercetin, bacillus coagulans, hyaluronic acid and chondroitin sulphate to D-mannose avoids symptoms and prevents recurrence in women with recurrent urinary tract infections: a single-blind randomized controlled trial.
RCT • 2025 • PubMed indexed study
PMID 40162673 from Expert review of anti-infective therapy.
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 50. The effects of chondroitin sulfate supplementation on indices of muscle damage induced by eccentric arm exercise.
RCT • 2005 • PubMed indexed study
PMID 16446690 from The Journal of sports medicine and physical fitness.
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 51. Effect of prior aspirin use on stroke severity in the trial of Org 10172 in acute stroke treatment (TOAST).
RCT • 2001 • PubMed indexed study
PMID 11739983 from Stroke.
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 52. Pharmacokinetic Comparison of Chitosan-Derived and Biofermentation-Derived Glucosamine in Nutritional Supplement for Bone Health.
RCT • 2022 • PubMed indexed study
PMID 35956389 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.0/10.[1342,1359,1360, etc.]
Open source 53. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing.
RCT • 2018 • PubMed indexed study
PMID 30122200 from Nutrition research (New York, N.Y.).
Outcome: Study design: RCT. Quality score: 7.9/10.[1342,1359,1360, etc.]
Open source 54. [Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations].
RCT • 2025 • PubMed indexed study
PMID 40561485 from Terapevticheskii arkhiv.
Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]
Open source 55. Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation.
RCT • 2023 • PubMed indexed study
PMID 37735385 from BMC musculoskeletal disorders.
Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]
Open source 56. Bifidobacterium animalis subsp. lactis Probio-M8 enhances chondroitin efficacy for knee osteoarthritis in postmenopausal women via the gut-joint axis.
RCT • 2025 • PubMed indexed study
PMID 41313018 from mSystems.
Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]
Open source 57. Liquid combination of hyaluronan, glucosamine, and chondroitin as a dietary supplement for knee osteoarthritis patients with moderate knee pain: A randomized controlled study.
RCT • 2021 • PubMed indexed study
PMID 34622845 from Medicine.
Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]
Open source 58. Effects of glucosamine and chondroitin sulfate supplementation in addition to resistance exercise training and manual therapy in patients with knee osteoarthritis: A randomized controlled trial.
RCT • 2022 • PubMed indexed study
PMID 36156542 from JPMA. The Journal of the Pakistan Medical Association.
Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]
Open source 59. Oral Bioavailability and Pharmacokinetics of Nonanimal Chondroitin Sulfate and Its Constituents in Healthy Male Volunteers.
RCT • 2019 • PubMed indexed study
PMID 30040242 from Clinical pharmacology in drug development.
Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]
Open source 60. Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial.
RCT • 2021 • PubMed indexed study
PMID 33210408 from Phytotherapy research : PTR.
Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]
Open source 61. Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study.
RCT • 2020 • PubMed indexed study
PMID 33213125 from Reumatismo.
Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]
Open source 62. Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticular hyaluronic acid injection. A randomized clinical trial.
RCT • 2021 • PubMed indexed study
PMID 33685850 from Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.
Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]
Open source 63. The PLE(2)NO self-management and exercise program for knee osteoarthritis: Study Protocol for a Randomized Controlled Trial.
RCT • 2016 • PubMed indexed study
PMID 27267755 from BMC musculoskeletal disorders.
Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]
Open source 64. A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins.
RCT • 2015 • PubMed indexed study
PMID 25732262 from Journal of photochemistry and photobiology. B, Biology.
Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]
Open source 65. Do shrimp-allergic individuals tolerate shrimp-derived glucosamine?
RCT • 2006 • PubMed indexed study
PMID 17083356 from Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 66. Maternal vitamin A supplementation and immunity to malaria in pregnancy in Ghanaian primigravids.
RCT • 2005 • PubMed indexed study
PMID 16359410 from Tropical medicine & international health : TM & IH.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 67. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial.
RCT • 2008 • PubMed indexed study
PMID 18821708 from Arthritis and rheumatism.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 68. Potential effects of chondroitin sulfate on joint swelling: a GAIT report.
RCT • 2008 • PubMed indexed study
PMID 18768335 from Osteoarthritis and cartilage.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 69. Effects of chondroitin sulfate and glucosamine in adult patients with Kaschin-Beck disease.
RCT • 2010 • PubMed indexed study
PMID 20108108 from Clinical rheumatology.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 70. Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee.
RCT • 2010 • PubMed indexed study
PMID 20179981 from Clinical rheumatology.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 71. Danaparoid sodium lowers proteinuria in diabetic nephropathy.
RCT • 1997 • PubMed indexed study
PMID 9071714 from Journal of the American Society of Nephrology : JASN.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 72. [Anti-arthrosis treatments: efficacy and tolerance of chondroitin sulfates (CS 4&6)].
RCT • 1998 • PubMed indexed study
PMID 9856136 from Presse medicale (Paris, France : 1983).
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 73. [Results of the multicenter clinical trial of structum preparation in Russia].
RCT • 2001 • PubMed indexed study
PMID 11806217 from Terapevticheskii arkhiv.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 74. Testing a novel bioactive marine nutraceutical on osteoarthritis patients.
RCT • 2013 • PubMed indexed study
PMID 24189760 from Acta bio-medica : Atenei Parmensis.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 75. Epidermal growth factor and insulin use in corneal preservation. Results of a multi-center trial. The Corneal Preservation Study Group.
RCT • 1994 • PubMed indexed study
PMID 8115156 from Ophthalmology.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 76. [Combined medication ARTRA in the treatment of osteoarthrosis].
RCT • 2005 • PubMed indexed study
PMID 16404866 from Terapevticheskii arkhiv.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 77. Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine in Pain Reduction and Functional Capacity in Osteoarthritis Patients.
RCT • 2019 • PubMed indexed study
PMID 29701488 from Journal of dietary supplements.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 7.0/10.[1342,1359,1360, etc.]
Open source 78. Association of regular glucosamine use with incident dementia: evidence from a longitudinal cohort and Mendelian randomization study.
COHORT • 2023 • PubMed indexed study
PMID 36978077 from BMC medicine.
Outcome: Study design: COHORT. Quality score: 6.4/10.[1342,1359,1360, etc.]
Open source 79. Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction.
COHORT • 2024 • PubMed indexed study
PMID 38180010 from Journal of dietary supplements.
Outcome: Study design: COHORT. Quality score: 6.1/10.[1342,1359,1360, etc.]
Open source 80. Review perspective on advanced nutrachemicals and anterior cruciate ligament rehabilitation.
PUBMED • 2025 • PubMed indexed study
PMID 39438142 from Zeitschrift fur Naturforschung. C, Journal of biosciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1342,1359,1360, etc.]
Open source 81. Dynamic hydrazone crosslinked salecan/chondroitin sulfate hydrogel platform as a promising wound healing Strategy: A comparative study on antibiotic and probiotic delivery.
COHORT • 2024 • PubMed indexed study
PMID 39241931 from International journal of pharmaceutics.
Outcome: Study design: COHORT. Quality score: 5.8/10.[1342,1359,1360, etc.]
Open source 82. Nutraceutical Approach to Chronic Osteoarthritis: From Molecular Research to Clinical Evidence.
PUBMED • 2021 • PubMed indexed study
PMID 34884724 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 83. Glucosamine/Chondroitin and Mortality in a US NHANES Cohort.
COHORT • 2020 • PubMed indexed study
PMID 33219063 from Journal of the American Board of Family Medicine : JABFM.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 84. Biological mechanisms of glycan- and glycosaminoglycan-based nutraceuticals.
PUBMED • 2019 • PubMed indexed study
PMID 31030758 from Progress in molecular biology and translational science.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 85. Comparative Analyses of Pharmaceuticals or Food Supplements Containing Chondroitin Sulfate: Are Their Bioactivities Equivalent?
COHORT • 2019 • PubMed indexed study
PMID 31494830 from Advances in therapy.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 86. Growing a backbone - functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions.
PUBMED • 2020 • PubMed indexed study
PMID 31957773 from Biomaterials science.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 87. European chondroitin sulfate and glucosamine food supplements: A systematic quality and quantity assessment compared to pharmaceuticals.
COHORT • 2019 • PubMed indexed study
PMID 31320062 from Carbohydrate polymers.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 88. [The efficacy and safety of intra-articular application of a combination of sodium hyaluronate and chondroitin sulfate for osteoarthritis of the knee: a multicenter prospective study].
COHORT • 2020 • PubMed indexed study
PMID 32598775 from Terapevticheskii arkhiv.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 89. Medical devices that look like medicines: safety and regulatory concerns for children in Europe.
COHORT • 2020 • PubMed indexed study
PMID 31533915 from Archives of disease in childhood.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Outcome: Study design: COHORT. Quality score: 5.5/10.[1342,1359,1360, etc.]
Open source 95. Specialty supplements and prostate cancer risk in the VITamins and Lifestyle (VITAL) cohort.
COHORT • 2011 • PubMed indexed study
PMID 21598177 from Nutrition and cancer.
Outcome: Study design: COHORT. Quality score: 5.5/10.[1342,1359,1360, etc.]
Open source 96. The NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT).
COHORT • 2008 • PubMed indexed study
PMID 19062354 from Journal of pain & palliative care pharmacotherapy.
Outcome: Study design: COHORT. Quality score: 5.5/10.[1342,1359,1360, etc.]
Open source 97. Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis.
PUBMED • 2025 • PubMed indexed study
PMID 40500442 from Nature.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 98. Multicomponent analysis of dietary supplements containing glucosamine and chondroitin: comparative low- and high-field NMR spectroscopic study.
PUBMED • 2024 • PubMed indexed study
PMID 37819571 from Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 99. Chondroitin Sulfate-Based Nanocapsules as Nanocarriers for Drugs and Nutraceutical Supplements.
PUBMED • 2024 • PubMed indexed study
PMID 38892083 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 100. Sugar as a therapeutic target for the cognitive restoration following traumatic brain injury.
PUBMED • 2019 • PubMed indexed study
PMID 31609736 from Current opinion in neurology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 101. Hyaluronan and chondroitin sulfate in chicken-vegetable bone broth delay osteoporosis progression.
PUBMED • 2024 • PubMed indexed study
PMID 38317402 from Journal of food science.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 102. TMEM165 a new player in proteoglycan synthesis: loss of TMEM165 impairs elongation of chondroitin- and heparan-sulfate glycosaminoglycan chains of proteoglycans and triggers early chondrocyte differentiation and hypertrophy.
PUBMED • 2021 • PubMed indexed study
PMID 34930890 from Cell death & disease.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 103. Chondrogenic differentiation of mesenchymal stem/stromal cells on 3D porous poly (ε-caprolactone) scaffolds: Effects of material alkaline treatment and chondroitin sulfate supplementation.
PUBMED • 2020 • PubMed indexed study
PMID 32107152 from Journal of bioscience and bioengineering.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 104. A nutraceutical formulation combined with sclerofoam-assisted laser treatment ameliorates chronic venous insufficiency.
PUBMED • 2022 • PubMed indexed study
PMID 35435595 from Lasers in medical science.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 105. Cost-Effectiveness Assessment of Different Glucosamines in Patients with Knee Osteoarthritis: A Simulation Model Adapted to Germany.
PUBMED • 2021 • PubMed indexed study
PMID 33858318 from Current aging science.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 106. Development of collagen-poly(caprolactone)-based core-shell scaffolds supplemented with proteoglycans and glycosaminoglycans for ligament repair.
PUBMED • 2021 • PubMed indexed study
PMID 33545824 from Materials science & engineering. C, Materials for biological applications.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 107. Diet in Knee Osteoarthritis-Myths and Facts.
PUBMED • 2025 • PubMed indexed study
PMID 40507141 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]
Outcome: Study design: OTHER. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 109. The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.
PUBMED • 2018 • PubMed indexed study
PMID 29547721 from Molecular cell.
Outcome: Study design: OTHER. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 110. The use of NSAIDs and nutritional supplements in athletes with osteoarthritis: prevalence, benefits, and consequences.
PUBMED • 2005 • PubMed indexed study
PMID 15636778 from Clinics in sports medicine.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 111. When food becomes a drug: nonanabolic nutritional supplement use in athletes.
PUBMED • 2002 • PubMed indexed study
PMID 12435662 from The American journal of sports medicine.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 112. A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part 9.
PUBMED • 2010 • PubMed indexed study
PMID 20547670 from British journal of sports medicine.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 113. Chondroitin Sulfate Safety and Quality.
PUBMED • 2019 • PubMed indexed study
PMID 31013685 from Molecules (Basel, Switzerland).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1342,1359,1360, etc.]
Open source 114. Galactosaminoglycans: Medical Applications and Drawbacks.
PUBMED • 2019 • PubMed indexed study
PMID 31374852 from Molecules (Basel, Switzerland).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1342,1359,1360, etc.]
Open source 115. Thermal and storage stability of nutraceuticals in a milk beverage dietary supplement.
PUBMED • 2007 • PubMed indexed study
PMID 17995798 from Journal of food science.
Outcome: Study design: OTHER. Quality score: 5.0/10.[1342,1359,1360, etc.]
Open source 116. Nutritional supplements for knee osteoarthritis--still no resolution.
PUBMED • 2006 • PubMed indexed study
PMID 16495399 from The New England journal of medicine.
Outcome: Study design: OTHER. Quality score: 5.0/10.[1342,1359,1360, etc.]
Open source 117. Glucosamine and chondroitin for treating symptoms of osteoarthritis: evidence is widely touted but incomplete.
PUBMED • 2000 • PubMed indexed study
PMID 10732941 from JAMA.
Outcome: Study design: OTHER. Quality score: 5.0/10.[1342,1359,1360, etc.]
Open source 118. Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality.
PUBMED • 2016 • PubMed indexed study
PMID 26728196 from Nutrition journal.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.9/10.[1342,1359,1360, etc.]
Open source 119. Changes in Reported Dietary Supplement Use in Cognitively Normal National Alzheimer's Coordinating Center Participants Aged 55 and Older From 2015 to 2019.
PUBMED • 2023 • PubMed indexed study
PMID 37044210 from The Journal of nutrition.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]
Open source 120. Phenome-wide screening of the putative causal determinants of bipolar affective disorder using genetic data.
PUBMED • 2026 • PubMed indexed study
PMID 41481605 from PloS one.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]
Open source 121. Nutritional Supplements in the Clinical Management of Tendinopathy: A Scoping Review.
PUBMED • 2023 • PubMed indexed study
PMID 37146985 from Journal of sport rehabilitation.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 122. Undenatured type II collagen for knee osteoarthritis.
PUBMED • 2025 • PubMed indexed study
PMID 40253594 from Annals of medicine.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 123. Urinary sulfated glycosaminoglycan insufficiency and chondroitin sulfate supplement in urolithiasis.
PUBMED • 2019 • PubMed indexed study
PMID 30845174 from PloS one.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 124. Basic Emollients for Xerosis Cutis Not Associated With Atopic Dermatitis: A Review of Clinical Studies.
PUBMED • 2025 • PubMed indexed study
PMID 40444760 from International journal of dermatology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 125. Synergistic effects of creatine supplementation and resistance training in the management of knee osteoarthritis: A narrative review.
PUBMED • 2025 • PubMed indexed study
PMID 41243927 from JPMA. The Journal of the Pakistan Medical Association.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 126. Chondroitin Sulfate Enhances Proliferation and Migration via Inducing β-Catenin and Intracellular ROS as Well as Suppressing Metalloproteinases through Akt/NF-κB Pathway Inhibition in Human Chondrocytes.
PUBMED • 2022 • PubMed indexed study
PMID 35297475 from The journal of nutrition, health & aging.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 127. Nutrition, osteoarthritis and cartilage metabolism.
PUBMED • 2019 • PubMed indexed study
PMID 30982220 from Aging clinical and experimental research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 128. Systemic drugs with impact on osteoarthritis.
PUBMED • 2019 • PubMed indexed study
PMID 31726891 from Drug metabolism reviews.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 129. How to Treat Osteoarthritis in Obese Patients?
PUBMED • 2020 • PubMed indexed study
PMID 31241017 from Current rheumatology reviews.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 130. EFFICACY OF HERBAL AND NATURALLY-DERIVED DIETARY SUPPLEMENTS FOR THE MANAGEMENT OF KNEE OSTEOARTHRITIS: A MINI-REVIEW.
PUBMED • 2021 • PubMed indexed study
PMID 34537753 from Wiadomosci lekarskie (Warsaw, Poland : 1960).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 131. Noninterventional Therapies for the Management of Knee Osteoarthritis.
PUBMED • 2019 • PubMed indexed study
PMID 30477045 from The journal of knee surgery.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 132. Natural Product Dietary Supplement Use by Individuals With Rheumatoid Arthritis: A Scoping Review.
PUBMED • 2019 • PubMed indexed study
PMID 29975014 from Arthritis care & research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 133. Biomaterial-engineered intra-articular drug delivery systems for osteoarthritis therapy.
PUBMED • 2019 • PubMed indexed study
PMID 31524006 from Drug delivery.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 134. GAG replenishment therapy for bladder pain syndrome/interstitial cystitis.
PUBMED • 2019 • PubMed indexed study
PMID 30592544 from Neurourology and urodynamics.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 135. Probiotics in human gut microbiota can degrade host glycosaminoglycans.
PUBMED • 2018 • PubMed indexed study
PMID 30006634 from Scientific reports.
Outcome: Study design: OTHER. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 136. Clinical Guide to Obesity and Nonherbal Nutraceuticals in Canine Orthopedic Conditions.
PUBMED • 2022 • PubMed indexed study
PMID 35562213 from The Veterinary clinics of North America. Small animal practice.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 137. Highly purified chondroitin sulfate: a literature review on clinical efficacy and pharmacoeconomic aspects in osteoarthritis treatment.
PUBMED • 2021 • PubMed indexed study
PMID 32638342 from Aging clinical and experimental research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 138. Oligodendrocyte precursor cells synthesize neuromodulatory factors.
PUBMED • 2015 • PubMed indexed study
PMID 25966014 from PloS one.
Outcome: Study design: OTHER. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 139. Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study.
PUBMED • 2018 • PubMed indexed study
PMID 29391578 from Scientific reports.
Outcome: Study design: OTHER. Quality score: 4.7/10.[1342,1359,1360, etc.]
Open source 140. Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane.
PUBMED • 2023 • PubMed indexed study
PMID 38138558 from Molecules (Basel, Switzerland).
Outcome: Study design: OTHER. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 141. Glucosamine and Chondroitin Sulfate: What Has Been Learned Since the Glucosamine/chondroitin Arthritis Intervention Trial.
PUBMED • 2018 • PubMed indexed study
PMID 29771395 from Orthopedics.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 142. Chondroitin sulphate: a focus on osteoarthritis.
PUBMED • 2016 • PubMed indexed study
PMID 27194526 from Glycoconjugate journal.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 145. Natural Products for Promoting Joint Health and Managing Osteoarthritis.
PUBMED • 2018 • PubMed indexed study
PMID 30232562 from Current rheumatology reports.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 146. Preventing urinary tract infections after menopause without antibiotics.
PUBMED • 2017 • PubMed indexed study
PMID 28364867 from Maturitas.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 147. Non-surgical treatments for the management of early osteoarthritis.
PUBMED • 2016 • PubMed indexed study
PMID 27043347 from Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 148. Oral chondroprotection with nutraceuticals made of chondroitin sulphate plus glucosamine sulphate in osteoarthritis.
PUBMED • 2014 • PubMed indexed study
PMID 24815409 from Carbohydrate polymers.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 149. Evidence-Based Evaluation of Complementary Health Approaches for Pain Management in the United States.
PUBMED • 2016 • PubMed indexed study
PMID 27594189 from Mayo Clinic proceedings.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 150. Managing the pain of knee osteoarthritis.
PUBMED • 2014 • PubMed indexed study
PMID 25295768 from The Physician and sportsmedicine.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 151. Complementary and alternative medicine use in dermatology in the United States.
PUBMED • 2014 • PubMed indexed study
PMID 24517329 from Journal of alternative and complementary medicine (New York, N.Y.).
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 152. Dietary interventions for atopic disorders.
PUBMED • 2014 • PubMed indexed study
PMID 23701569 from Current pharmaceutical design.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 153. Inappropriate claims from non-equivalent medications in osteoarthritis: a position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).
PUBMED • 2018 • PubMed indexed study
PMID 29177637 from Aging clinical and experimental research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 154. Can Hyaluronic Acid Combined with Chondroitin Sulfate in Viscosupplementation of Knee Osteoarthritis Improve Pain Symptoms and Mobility?
PUBMED • 2024 • PubMed indexed study
PMID 39062546 from Biomolecules.
Outcome: Study design: OTHER. Quality score: 4.6/10.[1342,1359,1360, etc.]
Open source 155. Osteoarthritis: diagnosis and treatment.
PUBMED • 2012 • PubMed indexed study
PMID 22230308 from American family physician.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 157. Glucosamine and chondroitin sulfate.
PUBMED • 2011 • PubMed indexed study
PMID 21220090 from Rheumatic diseases clinics of North America.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 158. Dietary supplements for osteoarthritis.
PUBMED • 2008 • PubMed indexed study
PMID 18246887 from American family physician.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 159. Nutrition and dietary supplements.
PUBMED • 1999 • PubMed indexed study
PMID 10516985 from Physical medicine and rehabilitation clinics of North America.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 160. Nutripharmaceuticals for osteoarthritis.
PUBMED • 2001 • PubMed indexed study
PMID 11567542 from Best practice & research. Clinical rheumatology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 161. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis.
PUBMED • 2010 • PubMed indexed study
PMID 20232616 from Alternative therapies in health and medicine.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 162. Recent advances in glucosamine and chondroitin supplementation.
PUBMED • 2004 • PubMed indexed study
PMID 15553585 from The journal of knee surgery.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 163. Advances in corneal preservation.
PUBMED • 1990 • PubMed indexed study
PMID 1710084 from Transactions of the American Ophthalmological Society.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 164. Chondroitin and glucosamine in the management of osteoarthritis: an update.
PUBMED • 2013 • PubMed indexed study
PMID 23955063 from Current rheumatology reports.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 165. Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis.
PUBMED • 2007 • PubMed indexed study
PMID 17658908 from Drugs & aging.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 166. Use of glucosamine and chondroitin in persons with osteoarthritis.
PUBMED • 2012 • PubMed indexed study
PMID 22632689 from PM & R : the journal of injury, function, and rehabilitation.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 167. Glucosamine and Chondroitin Supplements and Risk of Colorectal Adenoma and Serrated Polyp.
PUBMED • 2020 • PubMed indexed study
PMID 33055203 from Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
Outcome: Study design: OTHER. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 168. Dietary and viscosupplementation in ankle arthritis.
PUBMED • 2008 • PubMed indexed study
PMID 18692004 from Foot and ankle clinics.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 169. Risk assessment for glucosamine and chondroitin sulfate.
PUBMED • 2007 • PubMed indexed study
PMID 16942821 from Regulatory toxicology and pharmacology : RTP.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 170. Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: what's the evidence?
PUBMED • 2013 • PubMed indexed study
PMID 23186102 from Current medical research and opinion.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 171. Glucosamine and chondroitin for osteoarthritis.
PUBMED • 2008 • PubMed indexed study
PMID 19094424 from The Journal of international medical research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 172. Importance of pharmaceutical composition and evidence from clinical trials and pharmacological studies in determining effectiveness of chondroitin sulphate and other glycosaminoglycans: a critique.
PUBMED • 2009 • PubMed indexed study
PMID 19814857 from The Journal of pharmacy and pharmacology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 173. Metabolism and biochemical/physiological roles of chondroitin sulfates: analysis of endogenous and supplemental chondroitin sulfates in blood circulation.
PUBMED • 2006 • PubMed indexed study
PMID 16779785 from Biomedical chromatography : BMC.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 174. The efficacy of glucosamine and chondroitin sulfate in the treatment of osteoarthritis: are these saccharides drugs or nutraceuticals?
PUBMED • 2005 • PubMed indexed study
PMID 16170388 from Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 175. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease.
PUBMED • 1998 • PubMed indexed study
PMID 9600024 from Alternative medicine review : a journal of clinical therapeutic.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 176. What about supplements for osteoarthritis? A critical and evidenced-based review.
PUBMED • 2011 • PubMed indexed study
PMID 21518314 from International journal of rheumatic diseases.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 177. Sulfur in human nutrition and applications in medicine.
PUBMED • 2002 • PubMed indexed study
PMID 11896744 from Alternative medicine review : a journal of clinical therapeutic.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 178. Chondroitin sulphate: a complex molecule with potential impacts on a wide range of biological systems.
PUBMED • 2009 • PubMed indexed study
PMID 19114230 from Complementary therapies in medicine.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 179. Chondroprotective agents: glucosamine and chondroitin.
PUBMED • 2003 • PubMed indexed study
PMID 12911236 from Foot and ankle clinics.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 180. Quality of different chondroitin sulfate preparations in relation to their therapeutic activity.
PUBMED • 2009 • PubMed indexed study
PMID 19814858 from The Journal of pharmacy and pharmacology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 181. Prevention of recurrent urinary tract infections in women.
PUBMED • 2013 • PubMed indexed study
PMID 23766394 from Drug and therapeutics bulletin.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 182. Nutritional factors and osteoarthritis: recent developments.
PUBMED • 2005 • PubMed indexed study
PMID 16093847 from Current opinion in rheumatology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 183. Herbs and dietary supplement use in patients with stage 5 chronic kidney disease.
PUBMED • 2006 • PubMed indexed study
PMID 16538934 from Nephrology nursing journal : journal of the American Nephrology Nurses' Association.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 184. Clinical review of chondroitin sulfate in osteoarthritis.
PUBMED • 2008 • PubMed indexed study
PMID 18674931 from Osteoarthritis and cartilage.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 185. Supplemental conditionally essential nutrients in cardiovascular disease therapy.
PUBMED • 2006 • PubMed indexed study
PMID 16407731 from The Journal of cardiovascular nursing.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 186. A review of evidence-based medicine for glucosamine and chondroitin sulfate use in knee osteoarthritis.
PUBMED • 2009 • PubMed indexed study
PMID 19111223 from Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 187. Selected CAM therapies for arthritis-related pain: the evidence from systematic reviews.
PUBMED • 2004 • PubMed indexed study
PMID 14668651 from The Clinical journal of pain.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 188. Complementary and alternative modalities to relieve osteoarthritis symptoms.
PUBMED • 2012 • PubMed indexed study
PMID 22373747 from The American journal of nursing.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 189. Naturocetic (glucosamine and chondroitin sulfate) compounds as structure-modifying drugs in the treatment of osteoarthritis.
PUBMED • 2003 • PubMed indexed study
PMID 12960496 from Current opinion in rheumatology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 190. Alternative therapies for traditional disease states: osteoarthritis.
PUBMED • 2003 • PubMed indexed study
PMID 12562155 from American family physician.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 191. Determining the efficacy of glucosamine and chondroitin for osteoarthritis.
PUBMED • 2001 • PubMed indexed study
PMID 11416939 from The Nurse practitioner.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 192. Evidence of nutriceutical effectiveness in the treatment of osteoarthritis.
PUBMED • 2000 • PubMed indexed study
PMID 11123100 from Current rheumatology reports.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 193. Nutraceuticals: do they work and when should we use them?
PUBMED • 2006 • PubMed indexed study
PMID 16483910 from Best practice & research. Clinical rheumatology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 194. The utility of nutraceuticals in the treatment of osteoarthritis.
PUBMED • 2007 • PubMed indexed study
PMID 17437663 from Current rheumatology reports.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 195. Glucosamine for osteoarthritis: part I, review of the clinical evidence.
PUBMED • 2004 • PubMed indexed study
PMID 15344672 from Medicine and health, Rhode Island.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 196. Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people.
PUBMED • 2019 • PubMed indexed study
PMID 31241413 from Journal of psychopharmacology (Oxford, England).
Outcome: Study design: OTHER. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 197. Fucosylated chondroitin sulfate from Isostichopus badionotus alleviates metabolic syndromes and gut microbiota dysbiosis induced by high-fat and high-fructose diet.
PUBMED • 2019 • PubMed indexed study
PMID 30465844 from International journal of biological macromolecules.
Outcome: Study design: OTHER. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 198. Benefits of Circulating Human Metabolites from Fish Cartilage Hydrolysate on Primary Human Dermal Fibroblasts, an Ex Vivo Clinical Investigation for Skin Health Applications.
PUBMED • 2022 • PubMed indexed study
PMID 36501057 from Nutrients.
Outcome: Study design: OTHER. Quality score: 4.5/10.[1342,1359,1360, etc.]
Open source 199. Structural modulation of gut microbiota by chondroitin sulfate and its oligosaccharide.
PUBMED • 2016 • PubMed indexed study
PMID 27164502 from International journal of biological macromolecules.
Outcome: Study design: OTHER. Quality score: 4.4/10.[1342,1359,1360, etc.]
Open source 200. Glucosamine and Chondroitin Use and Mortality Among Adults in the United States from 1999 to 2014.
PUBMED • 2023 • PubMed indexed study
PMID 36971848 from Journal of integrative and complementary medicine.
Outcome: Study design: OTHER. Quality score: 4.3/10.[1342,1359,1360, etc.]
Open source 201. Chondrocyte autophagy mediated by T-2 toxin via AKT/TSC/Rheb/mTOR signaling pathway and protective effect of CSA-SeNP.
PUBMED • 2024 • PubMed indexed study
PMID 38815737 from Osteoarthritis and cartilage.
Outcome: Study design: OTHER. Quality score: 4.3/10.[1342,1359,1360, etc.]
Open source 202. Specialty supplement use and biologic measures of oxidative stress and DNA damage.
PUBMED • 2013 • PubMed indexed study
PMID 23917455 from Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
Outcome: Study design: OTHER. Quality score: 4.3/10.[1342,1359,1360, etc.]
Open source 203. Association between use of specialty dietary supplements and C-reactive protein concentrations.
PUBMED • 2012 • PubMed indexed study
PMID 23139249 from American journal of epidemiology.
Outcome: Study design: OTHER. Quality score: 4.3/10.[1342,1359,1360, etc.]
Open source 204. A Novel Sprayable Fibrinogen/Glycosaminoglycans/Collagen-Based Bioink for Skin Wound Healing Applied by a Handheld Dual-Head Airbrush.
PUBMED • 2026 • PubMed indexed study
PMID 40708386 from Advanced healthcare materials.
Outcome: Study design: OTHER. Quality score: 4.3/10.[1342,1359,1360, etc.]
Open source 205. Interventions to improve locomotive syndrome: a systematic review and meta-analysis of randomized controlled trials.
META_ANALYSIS • 2023 • PubMed indexed study
PMID 37346825 from Nagoya journal of medical science.
Outcome: Study design: META_ANALYSIS. Quality score: 10.0/10.[1342,1359,1360, etc.]
Open source 206. Milk-Fat Globule Membrane Plus Glucosamine Improves Joint Function and Physical Performance: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.
RCT • 2019 • PubMed indexed study
PMID 31257264 from Journal of nutritional science and vitaminology.
Outcome: Study design: RCT. Quality score: 10.0/10.[1342,1359,1360, etc.]
Open source 207. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
RCT • 2021 • PubMed indexed study
PMID 32981536 from The British journal of nutrition.
Outcome: Study design: RCT. Quality score: 10.0/10.[1342,1359,1360, etc.]
Open source 208. A Dietary Supplement in the Management of Patients with Lumbar Osteochondrosis: A Randomized, Double-Blinded, Placebo-Controlled Study.
RCT • 2024 • PubMed indexed study
PMID 39203831 from Nutrients.
Outcome: Study design: RCT. Quality score: 9.9/10.[1342,1359,1360, etc.]
Open source 209. Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review.
SYSTEMATIC_REVIEW • 2023 • PubMed indexed study
PMID 36902359 from International journal of molecular sciences.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.8/10.[1342,1359,1360, etc.]
Open source 210. Prevalence of Glucosamine and Omega-3 Fatty Acid Use and Characteristics of Users among Mid-Age Women: Analysis of a Nationally Representative Sample of 10,638 Women.
RCT • 2016 • PubMed indexed study
PMID 27273353 from The journal of nutrition, health & aging.
Outcome: Study design: RCT. Quality score: 9.7/10.[1342,1359,1360, etc.]
Open source 211. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.
RCT • 2013 • PubMed indexed study
PMID 24274358 from Nutrition journal.
Outcome: Study design: RCT. Quality score: 9.6/10.[1342,1359,1360, etc.]
Open source 212. Effect of Polyglucosamine on Weight Loss and Metabolic Parameters in Overweight and Obesity: A Systemic Review and Meta-Analysis.
META_ANALYSIS • 2020 • PubMed indexed study
PMID 32784736 from Nutrients.
Outcome: Study design: META_ANALYSIS. Quality score: 9.5/10.[1342,1359,1360, etc.]
Open source 213. Glucosamine supplementation contributes to reducing the risk of type 2 diabetes: Evidence from Mendelian randomization combined with a meta-analysis.
META_ANALYSIS • 2025 • PubMed indexed study
PMID 40300556 from The Journal of international medical research.
Outcome: Study design: META_ANALYSIS. Quality score: 9.3/10.[1342,1359,1360, etc.]
Open source 214. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee.
RCT • 2002 • PubMed indexed study
PMID 11934964 from Rheumatology (Oxford, England).
Outcome: Study design: RCT. Quality score: 9.3/10.[1342,1359,1360, etc.]
Open source 215. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.
RCT • 2002 • PubMed indexed study
PMID 12374520 from Archives of internal medicine.
Outcome: Study design: RCT. Quality score: 9.3/10.[1342,1359,1360, etc.]
Open source 216. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial.
RCT • 2001 • PubMed indexed study
PMID 11214126 from Lancet (London, England).
Outcome: Study design: RCT. Quality score: 9.3/10.[1342,1359,1360, etc.]
Open source 217. Sulodexide for Diabetic-Induced Disabilities: A Systematic Review and Meta-Analysis.
META_ANALYSIS • 2021 • PubMed indexed study
PMID 33502688 from Advances in therapy.
Outcome: Study design: META_ANALYSIS. Quality score: 9.2/10.[1342,1359,1360, etc.]
Open source 218. Sulodexide for the Symptoms and Signs of Chronic Venous Disease: A Systematic Review and Meta-analysis.
META_ANALYSIS • 2020 • PubMed indexed study
PMID 31989486 from Advances in therapy.
Outcome: Study design: META_ANALYSIS. Quality score: 9.2/10.[1342,1359,1360, etc.]
Open source 219. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions.
RCT • 2023 • PubMed indexed study
PMID 36918892 from Nutrition journal.
Outcome: Study design: RCT. Quality score: 9.1/10.[1342,1359,1360, etc.]
Open source 220. Does Salt Form Matter? A Pilot Randomized, Double-Blind, Crossover Pharmacokinetic Comparison of Crystalline and Regular Glucosamine Sulfate in Healthy Volunteers.
RCT • 2025 • PubMed indexed study
PMID 40806074 from Nutrients.
Outcome: Study design: RCT. Quality score: 9.1/10.[1342,1359,1360, etc.]
Open source 221. Glucosamine supplementation after anterior cruciate ligament reconstruction in athletes: a randomized placebo-controlled trial.
RCT • 2015 • PubMed indexed study
PMID 25630243 from Research in sports medicine (Print).
Outcome: Study design: RCT. Quality score: 9.0/10.[1342,1359,1360, etc.]
Open source 222. [Effect of dietary supplements and whey protein on muscle mass and strength of the operated limb after anterior cruciate ligament reconstruction: a systematic review].
SYSTEMATIC_REVIEW • 2023 • PubMed indexed study
PMID 37346024 from Voprosy pitaniia.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.8/10.[1342,1359,1360, etc.]
Open source 223. A systematic review of possible interactions for herbal medicines and dietary supplements used concomitantly with disease-modifying or symptom-alleviating multiple sclerosis drugs.
SYSTEMATIC_REVIEW • 2021 • PubMed indexed study
PMID 33624893 from Phytotherapy research : PTR.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.7/10.[1342,1359,1360, etc.]
Open source 224. Conditional Recommendations for Specific Dietary Ingredients as an Approach to Chronic Musculoskeletal Pain: Evidence-Based Decision Aid for Health Care Providers, Participants, and Policy Makers.
SYSTEMATIC_REVIEW • 2019 • PubMed indexed study
PMID 30986301 from Pain medicine (Malden, Mass.).
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.7/10.[1342,1359,1360, etc.]
Open source 225. TAME trial: a multi-arm phase II randomised trial of four novel interventions for malnutrition enteropathy in Zambia and Zimbabwe - a study protocol.
RCT • 2019 • PubMed indexed study
PMID 31727642 from BMJ open.
Outcome: Study design: RCT. Quality score: 8.7/10.[1342,1359,1360, etc.]
Open source 226. Acute effects of a dietary non-starch polysaccharide supplement on cognitive performance in healthy middle-aged adults.
RCT • 2015 • PubMed indexed study
PMID 24621069 from Nutritional neuroscience.
Outcome: Study design: RCT. Quality score: 8.6/10.[1342,1359,1360, etc.]
Open source 227. Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: A systematic review.
SYSTEMATIC_REVIEW • 2018 • PubMed indexed study
PMID 29446485 from Journal of oral rehabilitation.
Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.6/10.[1342,1359,1360, etc.]
Open source 228. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial.
RCT • 2004 • PubMed indexed study
PMID 15501201 from The American journal of medicine.
Outcome: Study design: RCT. Quality score: 8.5/10.[1342,1359,1360, etc.]
Open source 229. Amiprilose hydrochloride for rheumatoid arthritis.
RCT • 1989 • PubMed indexed study
PMID 2672925 from Annals of internal medicine.
Outcome: Study design: RCT. Quality score: 8.5/10.[1342,1359,1360, etc.]
Open source 230. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial.
RCT • 2010 • PubMed indexed study
PMID 20606148 from JAMA.
Outcome: Study design: RCT. Quality score: 8.5/10.[1342,1359,1360, etc.]
Open source 231. Evaluation of the effect of the administration of a glucosamine‑containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double‑blind placebo‑controlled study.
RCT • 2018 • PubMed indexed study
PMID 30132529 from Molecular medicine reports.
Outcome: Study design: RCT. Quality score: 8.4/10.[1342,1359,1360, etc.]
Open source 232. Effect of oral glucosamine on joint structure in individuals with chronic knee pain: a randomized, placebo-controlled clinical trial.
RCT • 2014 • PubMed indexed study
PMID 24616448 from Arthritis & rheumatology (Hoboken, N.J.).
Outcome: Study design: RCT. Quality score: 8.4/10.[1342,1359,1360, etc.]
Open source 233. Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials.
RCT • 2008 • PubMed indexed study
PMID 17681803 from Osteoarthritis and cartilage.
Outcome: Study design: RCT. Quality score: 8.3/10.[1342,1359,1360, etc.]
Open source 234. Association of Mucin-Degrading Gut Microbiota and Dietary Patterns with Colonic Transit Time in Constipation: A Secondary Analysis of a Randomized Clinical Trial.
RCT • 2024 • PubMed indexed study
PMID 39796573 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 235. Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects.
RCT • 2006 • PubMed indexed study
PMID 17065354 from Diabetes.
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 236. The effect of glucosamine supplementation on people experiencing regular knee pain.
RCT • 2003 • PubMed indexed study
PMID 12547742 from British journal of sports medicine.
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 237. Effect of glycomacropeptide fractions on cholecystokinin and food intake.
RCT • 2010 • PubMed indexed study
PMID 20205966 from The British journal of nutrition.
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 238. The effect of glucosamine on Serum HDL cholesterol and apolipoprotein AI levels in people with diabetes.
RCT • 2007 • PubMed indexed study
PMID 17682119 from Diabetes care.
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 239. The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics.
RCT • 2002 • PubMed indexed study
PMID 12190996 from Diabetes, obesity & metabolism.
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 240. The effect of short chain fatty acid supplementation on membrane electrolyte transport and blood pressure.
RCT • 1990 • PubMed indexed study
PMID 2283638 from Journal of human hypertension.
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 241. Post-prandial glycaemic reduction by an alpha-glucosidase inhibitor in type 2 diabetic patients with therapeutically attained basal normoglycaemia.
RCT • 1991 • PubMed indexed study
PMID 1842749 from Diabetes research (Edinburgh, Scotland).
Outcome: Study design: RCT. Quality score: 8.1/10.[1342,1359,1360, etc.]
Open source 242. Impact of Glucosamine Supplementation on Gut Health.
RCT • 2021 • PubMed indexed study
PMID 34202877 from Nutrients.
Outcome: Study design: RCT. Quality score: 8.0/10.[1342,1359,1360, etc.]
Open source 243. Impact of dietary supplementation of glycocalyx precursors on vascular function in type 2 diabetes.
RCT • 2024 • PubMed indexed study
PMID 39480270 from Journal of applied physiology (Bethesda, Md. : 1985).
Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]
Open source 244. Effects of 4-month treatment with glycocalyx dietary supplement on endothelial glycocalyx and vascular function after COVID-19 infection.
RCT • 2025 • PubMed indexed study
PMID 40270280 from European journal of clinical investigation.
Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]
Open source 245. A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial.
RCT • 2008 • PubMed indexed study
PMID 18279523 from Nutrition journal.
Outcome: Study design: RCT. Quality score: 7.8/10.[1342,1359,1360, etc.]
Open source 246. Sulodexide in the Treatment of Patients with Early Stages of COVID-19: A Randomized Controlled Trial.
RCT • 2021 • PubMed indexed study
PMID 33677827 from Thrombosis and haemostasis.
Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]
Open source 247. Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: A randomized controlled pilot trial.
RCT • 2020 • PubMed indexed study
PMID 32444040 from Complementary therapies in medicine.
Outcome: Study design: RCT. Quality score: 7.7/10.[1342,1359,1360, etc.]
Open source 248. Effect of glucosamine on intraocular pressure: a randomized clinical trial.
RCT • 2017 • PubMed indexed study
PMID 27768119 from Eye (London, England).
Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]
Open source 249. Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial.
RCT • 2016 • PubMed indexed study
PMID 26684635 from International journal of immunopathology and pharmacology.
Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]
Open source 250. Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women.
RCT • 2017 • PubMed indexed study
PMID 27801550 from Molecular nutrition & food research.
Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]
Open source 251. Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis.
RCT • 2018 • PubMed indexed study
PMID 28862770 from Oral diseases.
Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]
Open source 252. A clinical trial comparing Lanconone® with ibuprofen for rapid relief in acute joint pain.
RCT • 2016 • PubMed indexed study
PMID 27052991 from Trials.
Outcome: Study design: RCT. Quality score: 7.6/10.[1342,1359,1360, etc.]
Open source 253. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals.
RCT • 2004 • PubMed indexed study
PMID 15135147 from Osteoarthritis and cartilage.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 254. Oral polymeric N-acetyl-D-glucosamine and osteoarthritis.
RCT • 2001 • PubMed indexed study
PMID 11432083 from The Journal of the American Osteopathic Association.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 255. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study.
RCT • 2011 • PubMed indexed study
PMID 22001199 from Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 256. Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis.
RCT • 2009 • PubMed indexed study
PMID 19756416 from Advances in therapy.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 257. A clinical study on glucosamine sulfate versus combination of glucosamine sulfate and NSAIDs in mild to moderate knee osteoarthritis.
RCT • 2012 • PubMed indexed study
PMID 22577354 from TheScientificWorldJournal.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 258. The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: a preliminary study.
RCT • 2001 • PubMed indexed study
PMID 12171689 from The Journal of dermatological treatment.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 259. Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351].
RCT • 2007 • PubMed indexed study
PMID 17974032 from BMC complementary and alternative medicine.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 260. No effect of 6-month intake of glucosamine sulfate on Modic changes or high intensity zones in the lumbar spine: sub-group analysis of a randomized controlled trial.
RCT • 2012 • PubMed indexed study
PMID 22900984 from Journal of negative results in biomedicine.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 261. Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial.
RCT • 2009 • PubMed indexed study
PMID 18848470 from Osteoarthritis and cartilage.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 262. Efficacy of a progressive walking program and glucosamine sulphate supplementation on osteoarthritic symptoms of the hip and knee: a feasibility trial.
RCT • 2010 • PubMed indexed study
PMID 20152042 from Arthritis research & therapy.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 263. Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles.
RCT • 2013 • PubMed indexed study
PMID 22821424 from Inflammopharmacology.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 264. Effects of glucosamine administration on patients with rheumatoid arthritis.
RCT • 2007 • PubMed indexed study
PMID 16953394 from Rheumatology international.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 265. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies.
RCT • 2004 • PubMed indexed study
PMID 15021442 from Menopause (New York, N.Y.).
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 266. Effect of treatment based on syndrome differentiation by Chinese medicine on post-traumatic elbow arthritis.
RCT • 2010 • PubMed indexed study
PMID 20694783 from Chinese journal of integrative medicine.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 267. Clinical efficacy and safety of Gubitong Recipe () in treating osteoarthritis of knee joint.
RCT • 2009 • PubMed indexed study
PMID 20082253 from Chinese journal of integrative medicine.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 268. [Use of the immunopotentiator N-acetyl-glucosamine-N-acetylmuramyl dipeptide during triple anti-Helicobacter pylori therapy].
RCT • 2012 • PubMed indexed study
PMID 23479993 from Terapevticheskii arkhiv.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 269. Postprandial glycemic control, hormonal effects and carbohydrate malabsorption during long-term administration of the alpha-glucosidase inhibitor miglitol.
RCT • 1990 • PubMed indexed study
PMID 2292349 from Digestion.
Outcome: Study design: RCT. Quality score: 7.5/10.[1342,1359,1360, etc.]
Open source 270. No Associations Between Glucosamine Supplementation and Dementia or Parkinson's Disease: Findings From a Large Prospective Cohort Study.
COHORT • 2024 • PubMed indexed study
PMID 37158699 from The journals of gerontology. Series A, Biological sciences and medical sciences.
Outcome: Study design: COHORT. Quality score: 6.8/10.[1342,1359,1360, etc.]
Open source 271. Association between glucosamine use and albuminuria in the UK: a cohort and Mendelian randomisation study.
COHORT • 2025 • PubMed indexed study
PMID 41271412 from BMJ open.
Outcome: Study design: COHORT. Quality score: 6.8/10.[1342,1359,1360, etc.]
Open source 272. Variation in Plasma Levels of Glucosamine With Chronic Dosing: A Possible Reason for Inconsistent Clinical Outcomes in Osteoarthritis.
RCT • 2020 • PubMed indexed study
PMID 32713600 from Clinical therapeutics.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.7/10.[1342,1359,1360, etc.]
Open source 273. Complementary medicine use and its cost in Australians with type 2 diabetes: the Fremantle Diabetes Study Phase II.
RCT • 2020 • PubMed indexed study
PMID 31314167 from Internal medicine journal.
Outcome: Study design: CONTROLLED_TRIAL. Quality score: 6.7/10.[1342,1359,1360, etc.]
Open source 274. Dietary glucosamine supplement use and lower surgery risk in individuals with inflammatory bowel disease: a prospective Cohort Study.
COHORT • 2025 • PubMed indexed study
PMID 40437330 from European journal of nutrition.
Outcome: Study design: COHORT. Quality score: 6.4/10.[1342,1359,1360, etc.]
Open source 275. Association of habitual glucosamine use with risk of microvascular complications among individuals with type 2 diabetes: a prospective cohort study in UK biobank.
COHORT • 2025 • PubMed indexed study
PMID 40169583 from Nutrition & diabetes.
Outcome: Study design: COHORT. Quality score: 6.4/10.[1342,1359,1360, etc.]
Open source 276. The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study.
COHORT • 2021 • PubMed indexed study
PMID 34010361 from PloS one.
Outcome: Study design: COHORT. Quality score: 6.3/10.[1342,1359,1360, etc.]
Open source 277. Patterns of dietary supplement use among older men and women in the UK: findings from the Hertfordshire Cohort Study.
COHORT • 2012 • PubMed indexed study
PMID 22499447 from The journal of nutrition, health & aging.
Outcome: Study design: COHORT. Quality score: 6.1/10.[1342,1359,1360, etc.]
Open source 278. Regular Glucosamine Use May Have Different Roles in the Risk of Site-Specific Cancers: Findings from a Large Prospective Cohort.
COHORT • 2023 • PubMed indexed study
PMID 36716122 from Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
Outcome: Study design: COHORT. Quality score: 6.1/10.[1342,1359,1360, etc.]
Open source 279. Glucosamine Use Is Associated with a Higher Risk of Cardiovascular Diseases in Patients with Osteoarthritis: Results from a Large Study in 685,778 Subjects.
PUBMED • 2022 • PubMed indexed study
PMID 36145069 from Nutrients.
Outcome: Study design: OTHER. Quality score: 6.0/10.[1342,1359,1360, etc.]
Open source 280. Regular glucosamine supplementation and risk of age-related chronic diseases: evidence from a propensity score-matched cohort study.
COHORT • 2025 • PubMed indexed study
PMID 40879960 from Aging clinical and experimental research.
Outcome: Study design: COHORT. Quality score: 5.8/10.[1342,1359,1360, etc.]
Open source 281. Association Between Glucosamine Use and the Risk of Incident Heart Failure: The UK Biobank Cohort Study and Mendelian Randomization Analysis.
COHORT • 2023 • PubMed indexed study
PMID 37422736 from Mayo Clinic proceedings.
Outcome: Study design: COHORT. Quality score: 5.8/10.[1342,1359,1360, etc.]
Open source 282. Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study.
COHORT • 2020 • PubMed indexed study
PMID 32253185 from Annals of the rheumatic diseases.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 283. Nutraceutical and Dietary Strategies for Up-Regulating Macroautophagy.
PUBMED • 2022 • PubMed indexed study
PMID 35216170 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 284. Associations of habitual glucosamine supplementation with incident gout: a large population based cohort study.
COHORT • 2022 • PubMed indexed study
PMID 36175979 from Biology of sex differences.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 285. Assessment of pharmacy students' knowledge, attitude, and practice toward herbal dietary supplements.
COHORT • 2022 • PubMed indexed study
PMID 33048645 from Journal of American college health : J of ACH.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 286. Targeting Sirt1, AMPK, Nrf2, CK2, and Soluble Guanylate Cyclase with Nutraceuticals: A Practical Strategy for Preserving Bone Mass.
PUBMED • 2022 • PubMed indexed study
PMID 35563167 from International journal of molecular sciences.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 287. The role of type 2 diabetes in the association between habitual glucosamine use and dementia: a prospective cohort study.
COHORT • 2022 • PubMed indexed study
PMID 36514123 from Alzheimer's research & therapy.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 288. Comparative Anticoagulant and Thrombin Generation Inhibitory Profile of Heparin, Sulodexide and Its Components.
COHORT • 2020 • PubMed indexed study
PMID 33030036 from Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 289. Recurrent retinal vein thrombosis: prevention with Aspirin, Pycnogenol®, ticlopidine, or sulodexide.
COHORT • 2019 • PubMed indexed study
PMID 30964246 from Minerva cardioangiologica.
Outcome: Study design: COHORT. Quality score: 5.7/10.[1342,1359,1360, etc.]
Open source 290. Glucosamine use and risk of colorectal cancer: results from the Cancer Prevention Study II Nutrition Cohort.
COHORT • 2018 • PubMed indexed study
PMID 29411204 from Cancer causes & control : CCC.
Outcome: Study design: COHORT. Quality score: 5.6/10.[1342,1359,1360, etc.]
Open source 291. Self-reported medication and herb/supplement use by women with and without fibromyalgia.
COHORT • 2009 • PubMed indexed study
PMID 19445618 from Journal of women's health (2002).
Outcome: Study design: COHORT. Quality score: 5.5/10.[1342,1359,1360, etc.]
Open source 292. Sweet solution: sugars to the rescue.
PUBMED • 2002 • PubMed indexed study
PMID 12186848 from The Journal of cell biology.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1342,1359,1360, etc.]
Open source 293. Tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation.
PUBMED • 2024 • PubMed indexed study
PMID 38225221 from Cell death & disease.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 294. Glucosamine and Silibinin Alter Cartilage Homeostasis through Glycosylation and Cellular Stresses in Human Chondrocyte Cells.
PUBMED • 2024 • PubMed indexed study
PMID 38732122 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 295. GlcNac produced by the gut microbiome enhances host influenza resistance by modulating NK cells.
PUBMED • 2023 • PubMed indexed study
PMID 37953509 from Gut microbes.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 296. Usage patterns, health, and nutritional status of long-term multiple dietary supplement users: a cross-sectional study.
COHORT • 2007 • PubMed indexed study
PMID 17958896 from Nutrition journal.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 297. Plasma Glutaminyl-Peptide Cyclotransferase Mediates Glucosamine-Metabolism-Driven Protection Against Hypertension: A Mendelian Randomization Study.
PUBMED • 2024 • PubMed indexed study
PMID 39596173 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 298. Effects of Modified Glucosamine on the Chondrogenic Potential of Circulating Stem Cells under Experimental Inflammation.
PUBMED • 2023 • PubMed indexed study
PMID 37373540 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 299. Protective role of N-acetylcysteine and Sulodexide on endothelial cells exposed on patients' serum after SARS-CoV-2 infection.
PUBMED • 2023 • PubMed indexed study
PMID 38188630 from Frontiers in cellular and infection microbiology.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 300. Genomic, probiotic, and metabolic potentials of Liquorilactobacillus nagelii AGA58, a novel bacteriocinogenic motile strain isolated from lactic acid-fermented shalgam.
PUBMED • 2023 • PubMed indexed study
PMID 36384719 from Journal of bioscience and bioengineering.
Outcome: Study design: OTHER. Quality score: 5.3/10.[1342,1359,1360, etc.]
Open source 301. Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank.
PUBMED • 2019 • PubMed indexed study
PMID 31088786 from BMJ (Clinical research ed.).
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 302. The effect of glucosamine and glucosamine caramel on quality and consumer acceptability of regular and reduced salt breakfast sausages.
PUBMED • 2021 • PubMed indexed study
PMID 32980721 from Meat science.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 303. A LC-MS/MS method to simultaneously profile 14 free monosaccharides in biofluids.
PUBMED • 2022 • PubMed indexed study
PMID 35114473 from Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 304. Potential Analysis and Preparation of Chitosan Oligosaccharides as Oral Nutritional Supplements of Cancer Adjuvant Therapy.
PUBMED • 2019 • PubMed indexed study
PMID 30791594 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 305. MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses.
PUBMED • 2019 • PubMed indexed study
PMID 31461653 from Cell reports.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 306. Study of the Pollen Grain Metabolome under Deposition of Nitrogen and Phosphorus in Taxus baccata L. and Juniperus communis L.
PUBMED • 2022 • PubMed indexed study
PMID 36430583 from International journal of molecular sciences.
Outcome: Study design: OTHER. Quality score: 5.2/10.[1342,1359,1360, etc.]
Open source 307. Optimizing the Preoperative Preparation of Sarcopenic Older People: The Role of Prehabilitation and Nutritional Supplementation before Knee Arthroplasty.
PUBMED • 2024 • PubMed indexed study
PMID 39458460 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 308. A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals.
PUBMED • 2011 • PubMed indexed study
PMID 21218504 from Diabetes/metabolism research and reviews.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 309. Nutritional Strategies for Chronic Craniofacial Pain and Temporomandibular Disorders: Current Clinical and Preclinical Insights.
PUBMED • 2024 • PubMed indexed study
PMID 39275184 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 310. Glutamine in the fetus and critically ill low birth weight neonate: metabolism and mechanism of action.
PUBMED • 2001 • PubMed indexed study
PMID 11533317 from The Journal of nutrition.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 311. Prevalence of drug-herb and drug-supplement interactions in older adults: a cross-sectional survey.
COHORT • 2018 • PubMed indexed study
PMID 30249608 from The British journal of general practice : the journal of the Royal College of General Practitioners.
Outcome: Study design: CROSS_SECTIONAL. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 312. Sulodexide Slows Down the Senescence of Aortic Endothelial Cells Exposed to Serum from Patients with Peripheral Artery Diseases.
PUBMED • 2018 • PubMed indexed study
PMID 29587258 from Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
Outcome: Study design: OTHER. Quality score: 5.1/10.[1342,1359,1360, etc.]
Open source 313. Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration.
PUBMED • 2022 • PubMed indexed study
PMID 35565950 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1342,1359,1360, etc.]
Open source 314. Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review.
PUBMED • 2020 • PubMed indexed study
PMID 32878230 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1342,1359,1360, etc.]
Open source 315. Nutraceutical Strategies for Suppressing NLRP3 Inflammasome Activation: Pertinence to the Management of COVID-19 and Beyond.
PUBMED • 2020 • PubMed indexed study
PMID 33375692 from Nutrients.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1342,1359,1360, etc.]
Open source 316. Glucosamine supplementation attenuates progression of metabolic dysfunction-associated steatotic liver disease and related comorbidities.
PUBMED • 2025 • PubMed indexed study
PMID 40020645 from Clinical nutrition (Edinburgh, Scotland).
Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]
Open source 317. Glucosamine induces hepatic FGF21 expression by activating the Akt/mTOR/p70S6K axis and driving PGC-1α activity.
PUBMED • 2025 • PubMed indexed study
PMID 40240774 from Scientific reports.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]
Open source 318. Genetic Variance in Heparan Sulfation Is Associated With Salt Sensitivity.
PUBMED • 2024 • PubMed indexed study
PMID 39247955 from Hypertension (Dallas, Tex. : 1979).
Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]
Open source 319. Metabolic brain imaging with glucosamine CEST MRI: in vivo characterization and first insights.
PUBMED • 2023 • PubMed indexed study
PMID 38086821 from Scientific reports.
Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]
Open source 320. There seems to be similar improvement in pain and mouth opening limitation when comparing glucosamine supplements with a placebo or ibuprofen in patients with temporomandibular joint osteoarthritis.
PUBMED • 2018 • PubMed indexed study
PMID 29801932 from Journal of the American Dental Association (1939).
Outcome: Study design: OTHER. Quality score: 4.9/10.[1342,1359,1360, etc.]
Open source 321. Conjugated linoleic acid and glucosamine supplements may prevent bone loss in aging by regulating the RANKL/RANK/OPG pathway.
PUBMED • 2023 • PubMed indexed study
PMID 37932498 from Molecular biology reports.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 322. Glucosamine and lower mortality and cancer incidence: Selection bias in the observational studies.
PUBMED • 2022 • PubMed indexed study
PMID 36029480 from Pharmacoepidemiology and drug safety.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 323. Effects of Glucosamine in the Temporomandibular Joint Osteoarthritis: A Review.
PUBMED • 2024 • PubMed indexed study
PMID 38213156 from Current rheumatology reviews.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 324. Biological activities of glucosamine and its related substances.
PUBMED • 2012 • PubMed indexed study
PMID 22361198 from Advances in food and nutrition research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 325. Glucosamine Use, Inflammation, and Genetic Susceptibility, and Incidence of Type 2 Diabetes: A Prospective Study in UK Biobank.
PUBMED • 2020 • PubMed indexed study
PMID 31988063 from Diabetes care.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 326. A review on the biological activities and the nutraceutical potential of chitooligosaccharides.
PUBMED • 2025 • PubMed indexed study
PMID 39637700 from Carbohydrate research.
Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 327. Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome.
PUBMED • 2019 • PubMed indexed study
PMID 30944389 from Scientific reports.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 328. Enhanced Antiarthritic Efficacy by Nanoparticles of (-)-Epigallocatechin Gallate-Glucosamine-Casein.
PUBMED • 2019 • PubMed indexed study
PMID 31117504 from Journal of agricultural and food chemistry.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]
Open source 329. Sulodexide reduces glucose induced senescence in human retinal endothelial cells.
PUBMED • 2021 • PubMed indexed study
PMID 34075143 from Scientific reports.
Outcome: Study design: OTHER. Quality score: 4.8/10.[1342,1359,1360, etc.]