Session check

Supplement

Aged Garlic Extract (Allicin)

Organosulfur compounds (allicin, S-allylcysteine) inhibit cholesterol synthesis, provide vasodilation via H₂S/NO pathways, antimicrobial activity, and immunomodulation.[1322,1324,1365, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence

Heart HealthImmune SupportInflammationBlood Sugaralias: AGEalias: Kyolicalias: allicinalias: garlic supplement

Composite Rating

3.8/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

Mixed / Neutral • confidence Minimal

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 24 • mentions 9 • links 113

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Heart Health, Immune Support, Inflammation, Blood Sugar.[506,654,878, etc.]

Dose guide: Human-study daily dose: 1 mg-250 mg/day (higher-confidence extraction from PubMed abstracts)..[506,654,878, etc.]

Category: botanical.[506,654,878, etc.]

At-A-Glance Evidence Architecture[1322,1324,1365, etc.]

Clinical Depth

Humans: 100 • RCTs: 39 • Meta: 5

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 150 • Interactions: 60

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

219 total studies · 8 recent

Timeline

19942025

Top Signal Metrics[1322,1324,1365, etc.]

Animal-only studies

402

In vitro / tissue

244

Total indexed

219

Safety adverse signals

150

Human studies

100

Interaction signals

Community Direction Mix[506,654,878, etc.]

Weighted direction score: 1 (Mixed / Neutral)

Evidence Quality Summary[1322,1324,1365, etc.]

≥2 meta-analyses OR (≥5 RCTs AND ≥25 human studies).

Animal-only studies

402

In vitro / tissue

244

Total indexed

219

Safety adverse signals

150

Human studies

100

Interaction signals

Randomized trials

Meta-analyses

Study Type Breakdown

Distribution of evidence by study design strength

Meta-AnalysesLevel 1a5

Randomized TrialsLevel 1b39

Human Studies (other)Level 3-456

All IndexedAll levels219

100

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1322,1324,1365, etc.]

PMID 29576354 • 2018 Apr

Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial.

Clinical nutrition ESPEN

Open PubMed

PMID 26954484 • 2016 May-Jun

The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial.

Journal of diabetes and its complications

Open PubMed

Community Report Frequency[506,654,878, etc.]

Benefit reports: 4

Adverse reports: 3

No-effect reports: 1

Mixed reports: 1

Unclear reports: 0

Signal confidence: 0.00

Top Reported Effects[506,654,878, etc.]

Benefits

NAD+ elevation: 1
Cellular energy support: 1
Healthy aging: 1
Cardiovascular function: 1
Metabolic health: 1
Neuroprotection: 1

Adverse

Active cancer: 1
Budget-conscious (may prefer niacinamide as cheaper alternative): 1

No Effect

no noticeable effect: 1

Aged garlic extract (Kyolic) is the best-studied form. Food-based garlic adds synergistic benefits. | Step2: Insufficient empirical signal for a directional adjustment.

Reddit evidence: 0 mentions (confidence 0.00).

Community Evidence Examples[506,654,878, etc.]

aggregate • benefit

Aggregate community signal: 9 directional mentions (benefit 4, adverse 3, no-effect 1, mixed 1).

Open mention

Retail Signal Examples

amazon

Amazon search for Aged Garlic Extract (Allicin)

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Scientific Evidence Notes[1322,1324,1365, etc.]

1. Garlic supplementation and blood pressure: MA of 20 RCTs

META_ANALYSIS • 2015 • Adults

20 RCTs with 970 hypertensive subjects.

Outcome: Garlic significantly reduced SBP by −8.3 mmHg and DBP by −5.5 mmHg in hypertensives; Kyolic aged extract most studied.[1322,1324,1365, etc.]

Open source

2. Garlic and total cholesterol: MA of 39 RCTs

META_ANALYSIS • 2013 • Adults

39 RCTs with 2298 subjects.

Outcome: Garlic reduced total cholesterol by −17 mg/dL (−8%) and LDL by −9 mg/dL after 2+ months of supplementation.[1322,1324,1365, etc.]

Implementation Blueprint

At-A-Glance Evidence Architecture[1322,1324,1365, etc.]

Evidence Tracking

Evidence Tracking

Top Signal Metrics[1322,1324,1365, etc.]

Community Direction Mix[506,654,878, etc.]

Evidence Quality Summary[1322,1324,1365, etc.]

Study Type Breakdown

Top Human Studies[1322,1324,1365, etc.]

Community Report Frequency[506,654,878, etc.]

Top Reported Effects[506,654,878, etc.]

Community Evidence Examples[506,654,878, etc.]

Retail Signal Examples

Primary Source Links

Scientific Evidence Notes[1322,1324,1365, etc.]

Safety and Pitfalls