Supplement
Contains bioactive phytochemicals that may modulate stress, immune, and metabolic pathways.[2969,3374,3863, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
77/100
High depth from human/RCT/meta counts
Community Direction
33
Positive Lean • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 11 • mentions 3 • links 21
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Stress Resilience, Mood, Immune Support, Longevity.[499,647,870, etc.]
Dose guide: Human-study daily dose: 100 mg-200 mg/day (higher-confidence extraction from PubMed abstracts)..[499,647,870, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 100 mg-200 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 61 • RCTs: 5 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 157 • Interactions: 214
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
125 total studies · 5 recent
Timeline
In vitro / tissue
435
Animal-only studies
414
Interaction signals
214
Safety adverse signals
157
Total indexed
125
Human studies
61
Weighted direction score: 33 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
In vitro / tissue
435
Animal-only studies
414
Interaction signals
214
Safety adverse signals
157
Total indexed
125
Human studies
61
Randomized trials
5
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 29541713 • 2018 Apr 25
Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients.
Food Funct
Open PubMedPMID 31434498 • 2019 Jan-Dec
Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial.
Clin Appl Thromb Hemost
Open PubMedPMID 34809689 • 2021 Nov 22
Effect of fermented Rhus verniciflua stokes extract on liver function parameters in healthy Korean adults: a double-blind randomized controlled trial.
Trials
Open PubMedPMID 36304817 • 2022
Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study.
J Nutr Sci
Open PubMedPMID 41683255 • 2026 Jan 28
The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial.
Nutrients
Open PubMedPMID 38062873 • 2024 Mar
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.
Aging Cell
Open PubMedPMID 40440029 • 2025 Jun
Supplement and nutraceutical therapy in traumatic brain injury.
Nutr Neurosci
Open PubMedPMID 40208387 • 2025 Apr 10
Fisetin: hormesis accounts for many of its chemoprotective effects.
Biogerontology
Open PubMedPMID 33353228 • 2020 Dec 18
Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease: A Systematic Review.
Molecules
Open PubMedPMID 34836005 • 2021 Oct 23
Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature.
Nutrients
Open PubMedPMID 40563513 • 2025 Jun 16
Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration.
Biomolecules
Open PubMedBenefit reports: 2
Adverse reports: 1
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22fisetin%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22fisetin%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=fisetin
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 100 mg-200 mg/day (confidence HIGH).
Extracted from 7 dosing mentions across 4 PubMed studies (mg/day).
Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$25.00.
Legacy community note: Extremely popular in longevity/biohacking community. Many users follow intermittent high-dose senolytic protocols. Considered one of the most promising anti-aging supplements available. Strawberry source makes it feel natural and safe.
aggregate • benefit
Aggregate community signal: 3 directional mentions (benefit 2, adverse 1, no-effect 0, mixed 0).
Open mentionamazon
Amazon search for Fisetin
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 61, RCTs 5, meta-analyses 0.[2969,3374,3863, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29541713 from Food Funct.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31434498 from Clin Appl Thromb Hemost.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34809689 from Trials.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36304817 from J Nutr Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open sourcePUBMED • 2026 • Human evidence curation set
PMID 41683255 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38062873 from Aging Cell.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40440029 from Nutr Neurosci.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40208387 from Biogerontology.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33353228 from Molecules.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34836005 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40563513 from Biomolecules.
Outcome: See linked PubMed abstract for methods and outcomes.[2969,3374,3863, etc.]
Open source