Supplement
Contains bioactive phytochemicals that may modulate stress, immune, and metabolic pathways.[2607,3262,3538, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
10
Mixed / Neutral • confidence Minimal
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 14 • mentions 4 • links 24
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Stress Resilience, Mood, Immune Support, Longevity.[498,646,869, etc.]
Dose guide: Human-study daily dose: 500 mg/day (moderate-confidence extraction from PubMed abstracts)..[498,646,869, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 500 mg/day (moderate-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 500 mg/day (moderate-confidence extraction from PubMed abstracts).[,, etc.]
Clinical Depth
Humans: 104 • RCTs: 18 • Meta: 12
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 236 • Interactions: 117
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
309 total studies · 1 recent
Timeline
Animal-only studies
367
Total indexed
309
Safety adverse signals
236
In vitro / tissue
233
Interaction signals
117
Human studies
104
Weighted direction score: 10 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
367
Total indexed
309
Safety adverse signals
236
In vitro / tissue
233
Interaction signals
117
Human studies
104
Randomized trials
18
Meta-analyses
12
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 32048383 • 2020 Jul
Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials.
Phytother Res
Open PubMedPMID 27000311 • 2016 Mar 22
Dietary supplements for dysmenorrhoea.
Cochrane Database Syst Rev
Open PubMedPMID 40037045 • 2025 Jun 15
Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies.
Food Chem
Open PubMedBenefit reports: 2
Adverse reports: 1
No-effect reports: 1
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 0 mentions (confidence 0.00).
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
aggregate • benefit
Aggregate community signal: 4 directional mentions (benefit 2, adverse 1, no-effect 1, mixed 0).
Open mentionamazon
Amazon search for Fenugreek
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 104, RCTs 18, meta-analyses 12.[2607,3262,3538, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32048383 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,, etc.]
PMID 32421208 • 2020 May 18
Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants.
Cochrane Database Syst Rev
Open PubMedPMID 36992660 • 2023 May
Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis.
Phytother Res
Open PubMedPMID 36470549 • 2023 Jan
Effects of fenugreek supplementation on the components of metabolic syndrome: A systematic review and dose-response meta-analysis of randomized clinical trials.
Pharmacol Res
Open PubMedPMID 33025616 • 2020 Dec
Efficacy of a novel extract of fenugreek seeds in alleviating vasomotor symptoms and depression in perimenopausal women: A randomized, double-blinded, placebo-controlled study.
J Food Biochem
Open PubMedPMID 36921902 • 2023 May
Effectiveness of lactation cookies on human milk production rates: a randomized controlled trial.
Am J Clin Nutr
Open PubMedPMID 36199177 • 2023 Jan
The effects of fenugreek seed extract supplementation in patients with Alzheimer's disease: A randomized, double-blind, placebo-controlled trial.
Phytother Res
Open PubMedPMID 32147060 • 2020 Mar
The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial.
Complement Ther Med
Open PubMedPMID 30889454 • 2019 Jun
Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double-blinded, randomized, controlled trial.
Nutrition
Open PubMedPMID 32441668 • 2020 May 22
Efficacy of fenugreek seed extract on men's psychological and physical health: a randomized placebo-controlled double-blind clinical trial.
J Complement Integr Med
Open PubMedPMID 33150931 • 2021 Jun 1
Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review.
Adv Nutr
Open PubMedPMID 35081820 • 2023
The effects of dietary supplements and natural products targeting glucose levels: an overview.
Crit Rev Food Sci Nutr
Open PubMedSearch fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22fenugreek%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
Fallback search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=comments&t=all&limit=16&q=%22fenugreek%22%20(supplement%20OR%20capsule%20OR%20powder%20OR%20experience%20OR%20results%20OR%20side%20effects)
Broad search failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=new&t=all&limit=16&q=fenugreek
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 500 mg/day (confidence MEDIUM).
Extracted from 3 dosing mentions across 3 PubMed studies (mg/day).
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$14.00.
Legacy community note: Popular in testosterone and fitness communities. Users report improved libido and energy. The maple syrup smell is a well-known side effect. Blood sugar benefits appreciated by metabolic health community.
Community Sources
PUBMED • 2016 • Human evidence curation set
PMID 27000311 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40037045 from Food Chem.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32421208 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36992660 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36470549 from Pharmacol Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33025616 from J Food Biochem.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36921902 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36199177 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32147060 from Complement Ther Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30889454 from Nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32441668 from J Complement Integr Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33150931 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 35081820 from Crit Rev Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2607,3262,3538, etc.]
Open source