Supplement
Supports broad cellular function with category-specific mechanisms.[3397,3686,3807, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
7
Mixed / Neutral • confidence Moderate
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 11 • links 27
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[167,179,396, etc.]
Dose guide: Human-study daily dose: 10000 mg/day (early-confidence extraction from PubMed abstracts)..[167,179,396, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 10000 mg/day (early-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 840 • RCTs: 151 • Meta: 41
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 584 • Interactions: 770
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
1224 total studies · 8 recent
Timeline
Animal-only studies
3,536
In vitro / tissue
1,715
Total indexed
1,224
Human studies
840
Interaction signals
770
Safety adverse signals
584
Weighted direction score: 7 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
3,536
In vitro / tissue
1,715
Total indexed
1,224
Human studies
840
Interaction signals
770
Safety adverse signals
584
Randomized trials
151
Meta-analyses
41
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 39332623 • 2025 Mar
Therapeutic management in women with a diminished ovarian reserve: a systematic review and meta-analysis of randomized controlled trials.
Fertil Steril
Open PubMedPMID 40611279 • 2025 Jul 3
The effectiveness of nutritional supplements in improving polycystic ovary syndrome in women: a systematic review and network meta-analysis.
Reprod Biol Endocrinol
Open PubMedPMID 38824654 • 2024 Oct 1
Alcohol intake and endogenous sex hormones in women: Meta-analysis of cohort studies and Mendelian randomization.
Cancer
Open PubMedPMID 35460091 • 2022 Jun
Dehydroepiandrosterone status and efficacy of dehydroepiandrosterone supplementation for bone health in anorexia nervosa: A systematic review and meta-analysis.
Int J Eat Disord
Open PubMedPMID 39722805 • 2024
Different supplements improve insulin resistance, hormonal functions, and oxidative stress on overweight and obese women with polycystic ovary syndrome: a systematic review and meta-analysis.
Front Endocrinol (Lausanne)
Open PubMedPMID 32675010 • 2020 Aug 28
Effects of dehydroepiandrosterone (DHEA) supplementation on the lipid profile: A systematic review and dose-response meta-analysis of randomized controlled trials.
Nutr Metab Cardiovasc Dis
Open PubMedPMID 31517876 • 2019 Sep
An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.
Medicine (Baltimore)
Open PubMedPMID 33137599 • 2021 Jan
Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial.
Phytomedicine
Open PubMedPMID 33562394 • 2021 Feb 7
Effects of Vitamin D Supplementation on Surrogate Markers of Fertility in PCOS Women: A Randomized Controlled Trial.
Nutrients
Open PubMedPMID 35857132 • 2022 Dec
Efficacy of multi-strain probiotic along with dietary and lifestyle modifications on polycystic ovary syndrome: a randomised, double-blind placebo-controlled study.
Eur J Nutr
Open PubMedPMID 38010274 • 2024 Jun
Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress.
Stress Health
Open PubMedPMID 40260281 • 2025
Flaxseed intervention and reproductive endocrine profiles in patients with polycystic ovary syndrome: an open-labeled randomized controlled clinical trial.
Front Endocrinol (Lausanne)
Open PubMedPMID 40522647 • 2025 Aug 26
Adrenal Insufficiency in Adults: A Review.
JAMA
Open PubMedPMID 38184959 • 2024 Mar
Nutritional supplements and IVF: an evidence-based approach.
Reprod Biomed Online
Open PubMedPMID 36121077 • 2023
Dehydroepiandrosterone (DHEA): Pharmacological Effects and Potential Therapeutic Application.
Mini Rev Med Chem
Open PubMedBenefit reports: 5
Adverse reports: 3
No-effect reports: 1
Mixed reports: 2
Unclear reports: 0
Signal confidence: 0.65
Benefits
Adverse
No Effect
Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 9 mentions (confidence 0.65) across NootropicsDepot, MMA, estrogel, DebateVaccines.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 10000 mg/day (confidence LOW).
Extracted from 1 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 6.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$10.00.
Legacy community note: Used more cautiously than other supplements due to hormonal effects. Popular among anti-aging physicians. Users over 50 report improved energy and well-being. Blood testing before and during use is strongly recommended.
post • r/NootropicsDepot • benefit
⚠️ NEW PRODUCT RELEASES ARE COMING 7/25/24 | One Mystery Product, Magnesium Glycerophosphate Capsules & Powder, Magnesium Pidolate Capsules & Powder, TauroMAG Capsules & Powder, & DHEA Tablets ⚠️ [NEW PRODUCT RELEASES ARE COMING 7\/25\/24 …
Open mentionpost • r/MMA • mixed
According to this study, DHEA does nothing for strength/conditioning or testosterone levels. Nothing close to TRT which Hendo had used to knock people out. TRT was way worse as PED. "***In middle-aged men, no statistically significant effe…
Open mentionpost • r/estrogel • adverse
There is no such thing as Power's "DHT Mutants", just patients who need abiraterone to lower their DHEA Powers love to talk about "DHT mutants", for transwomen with a high DHT despite good or high doses of E, and sometimes proper AA treatm…
Open mentionpost • r/DebateVaccines • unclear
Using published scientific research to show that the vaccine does cause autism. **A positive association found between autism prevalence and childhood vaccination uptake across the U.S. population** ''The reason for the rapid rise of autis…
Open mentionpost • r/PCOS • benefit
Reserch: Effects of a ketogenic diet in overweight women with polycystic ovary syndrome. Hey, y'all does anyone have the full research article on this? It's a small sample size but I would love to know the methodology, particularly the ”ke…
Open mentionpost • r/tressless • adverse
5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? [https://academic.oup.com/jcem/article/86/3/1324/2847799](https://academic.oup.com/jcem/…
Open mentionpost • r/trt • benefit
Not Feeling Great on TRT? A Guide If you’ve just started TRT (Testosterone Replacement Therapy) and don’t feel great, it can be pretty disheartening. You’ve just started on a journey that you’d hoped would bring vitality, energy, libido, m…
Open mentionpost • r/AsianBeauty • mixed
I did some research on hormonal acne and essential oils. ETA: I am NOT advocating trying these methods without consulting a medical professional. PLEASE SPEAK WITH A PROFESSIONAL FIRST. This is important because a) what you think is hormon…
Open mentioncomment • r/MMA • unclear
DHEA is used as a masking agent.
Open mentioncomment • r/MMA • benefit
100%. 7-keto DHEA, as OP as has pointed out has no anabolic benefits. The only reason to use it is a) you're a goof and think because it works in rats it'll work in humans for increasing metabolism or b) you're a cheat and you're trying to…
Open mentionamazon
Amazon search for Dhea
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 840, RCTs 151, meta-analyses 41.[3397,3686,3807, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39332623 from Fertil Steril.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40611279 from Reprod Biol Endocrinol.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38824654 from Cancer.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35460091 from Int J Eat Disord.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39722805 from Front Endocrinol (Lausanne).
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32675010 from Nutr Metab Cardiovasc Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31517876 from Medicine (Baltimore).
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33137599 from Phytomedicine.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33562394 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35857132 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38010274 from Stress Health.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40260281 from Front Endocrinol (Lausanne).
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40522647 from JAMA.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38184959 from Reprod Biomed Online.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36121077 from Mini Rev Med Chem.
Outcome: See linked PubMed abstract for methods and outcomes.[3397,3686,3807, etc.]
Open source