Supplement
Supports broad cellular function with category-specific mechanisms.[2805,3136,3437, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
97/100
High depth from human/RCT/meta counts
Community Direction
58
Positive Lean • confidence Moderate
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 12 • mentions 11 • links 24
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[228,380,401, etc.]
Dose guide: Human-study daily dose: 200 mg/day (moderate-confidence extraction from PubMed abstracts)..[228,380,401, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 200 mg/day (moderate-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 67 • RCTs: 9 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 88 • Interactions: 448
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
159 total studies · 4 recent
Timeline
Animal-only studies
1,073
In vitro / tissue
463
Interaction signals
448
Total indexed
159
Safety adverse signals
88
Human studies
67
Weighted direction score: 58 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
1,073
In vitro / tissue
463
Interaction signals
448
Total indexed
159
Safety adverse signals
88
Human studies
67
Randomized trials
9
Meta-analyses
1
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 39095666 • 2025 Apr
Nonantibiotic prophylaxis for urinary tract infections: a network meta-analysis of randomized controlled trials.
Infection
Open PubMedPMID 36621376 • 2023 Jul
A Randomized Controlled Trial Comparing a New D-Mannose-based Dietary Supplement to Placebo for the Treatment of Uncomplicated Escherichia coli Urinary Tract Infections.
Eur Urol Focus
Open PubMedPMID 38637262 • 2024 May-Jun
Randomized clinical trial of non-antibiotic prophylaxis with d-Mannose plus Proanthocyanidins vs. Proanthocyanidins alone for urinary tract infections and asymptomatic bacteriuria in de novo kidney transplant recipients: The Manotras study.
Nefrologia (Engl Ed)
Open PubMedPMID 40162673 • 2025 Jul
Adding collagen, propolis plus quercetin, bacillus coagulans, hyaluronic acid and chondroitin sulphate to D-mannose avoids symptoms and prevents recurrence in women with recurrent urinary tract infections: a single-blind randomized controlled trial.
Expert Rev Anti Infect Ther
Open PubMedPMID 37374369 • 2023 Jun 17
D-Mannose Plus Saccharomyces boulardii to Prevent Urinary Tract Infections and Discomfort after Cystoscopy: A Single-Center Prospective Randomized Pilot Study.
Medicina (Kaunas)
Open PubMedPMID 31674202 • 2020 Apr
Cranberry, D-mannose and anti-inflammatory agents prevent lower urinary tract symptoms in women undergoing prolapse surgery.
Climacteric
Open PubMedPMID 28608666 • 2017 Aug
[Evaluation of the effects of a natural dietary supplement with cranberry, Noxamicina® and D-mannose in recurrent urinary infections in perimenopausal women].
Minerva Ginecol
Open PubMedPMID 39642888 • 2025 Jan 13
Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity.
Cancer Cell
Open PubMedPMID 36041061 • 2022 Aug 30
D-mannose for preventing and treating urinary tract infections.
Cochrane Database Syst Rev
Open PubMedPMID 35313893 • 2022 Mar 22
Role of D-mannose in urinary tract infections - a narrative review.
Nutr J
Open PubMedPMID 32561190 • 2020 Aug 28
Recurrent urinary tract infections: from pathogenesis to prevention.
Med Clin (Barc)
Open PubMedPMID 30361493 • 2018 Dec
Nonantibiotic prevention and management of recurrent urinary tract infection.
Nat Rev Urol
Open PubMedBenefit reports: 8
Adverse reports: 1
No-effect reports: 0
Mixed reports: 2
Unclear reports: 0
Signal confidence: 0.64
Benefits
Adverse
No Effect
Strong positive empirical sentiment with adequate confidence; boost recommendation priority.
Reddit evidence: 10 mentions (confidence 0.64) across Supplements, herbalism, Ureaplasma, CUTI.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 200 mg/day (confidence MEDIUM).
Extracted from 2 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 9.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$15.00.
Legacy community note: Extremely popular among women with recurrent UTIs. Community reports dramatic reduction in UTI frequency. Often described as "life-changing" by chronic UTI sufferers. Growing mainstream acceptance.
post • r/Supplements • benefit
Fructose Metabolism and the Energy Crisis of Modern Disease: A Research Journey ## The Metabolic Theory of Everything? This post is part personal reflection, part academic deep dive. I’ve spent the past several months exploring why so many…
Open mentionpost • r/herbalism • mixed
Sos!! Antibiotic resistant and reoccurring UTI, Bv, yeast I need help. This is a long story but I started getting yeast and about 18months ago. 4.5 months ago my new partner and I started having sex and then the uti’s joined my other issue…
Open mentionpost • r/Ureaplasma • mixed
I BEAT UREAPLASMA, E FAE AND ECOLI - HOW I DID IT Here is my exact timeline and everything I did. This has been the hardest 6 months of my life. February 3, 2021 - begin white discharge, urinary frequency, urinary retention and vulva pain …
Open mentionpost • r/CUTI • benefit
Gutted to hear my urologist no longer recommends Hiprex 26F, have struggled with UTI’s caused by sex for over four years now. Back when the issue first started, I was taking postcoital Macrobid, which worked well! Eventually, though, I sch…
Open mentionpost • r/TwoXChromosomes • benefit
PSA for UTI-prone women! I used to get horrendous UTIs, and nothing helped. I found something that works for me, so I hope it will work for you, too! I was reading a post on Reddit the other day about a woman who gets debilitating UTI's af…
Open mentionpost • r/preppers • benefit
PSA for women and men who are also prepping for women! Please add the supplement D-mannose to your preps if you are a woman or have any women you want to keep safe! One in five women experience recurrent urinary tract infections, and I ima…
Open mentionpost • r/CUTI • benefit
I finally healed my year long UTI Hi everyone. WOW do UTIs suck. I got this uti over a year ago and initially went on 3 courses of amoxicillin antibiotics since it wouldn't go away. I then started taking D Mannose daily which subsided most…
Open mentionpost • r/Interstitialcystitis • benefit
How I basically cured IC and some things I've learned I've had interstitial cystitis for about 10 years. Started with a UTI I got from my wife, having sex and getting into an argument while she had a bad untreated UTI, and then not finishi…
Open mentioncomment • r/herbalism • benefit
I had a similar time in my life where I was looping through these same 3 infections. I found a "yeast buster tincture" to help a lot taken for a week twice a day to get rid of a yeast infection. Common ingredients for one are Usnea Lichen,…
Open mentioncomment • r/herbalism • unclear
Depending on which kind of infection : Berberine in an alkalic environment or d-mannose from cranberries or a streptomyces (nyastine for example) strain
Open mentionamazon
Amazon search for D-mannose
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 67, RCTs 9, meta-analyses 1.[2805,3136,3437, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39095666 from Infection.
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36621376 from Eur Urol Focus.
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38637262 from Nefrologia (Engl Ed).
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40162673 from Expert Rev Anti Infect Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37374369 from Medicina (Kaunas).
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31674202 from Climacteric.
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2017 • Human evidence curation set
PMID 28608666 from Minerva Ginecol.
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39642888 from Cancer Cell.
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36041061 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35313893 from Nutr J.
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32561190 from Med Clin (Barc).
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30361493 from Nat Rev Urol.
Outcome: See linked PubMed abstract for methods and outcomes.[2805,3136,3437, etc.]
Open source