Supplement
Polyphenol with inflammatory pathway modulation.[2869,3365,4056, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
24
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 7 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Joint Health, Heart Health, Longevity.[108,280,301, etc.]
Dose guide: Human-study daily dose: 120 mg-1500 mg/day (higher-confidence extraction from PubMed abstracts)..[108,280,301, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 120 mg-1500 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 1,335 • RCTs: 244 • Meta: 109
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 3,828 • Interactions: 2,931
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
2680 total studies · 3 recent
Timeline
In vitro / tissue
7,533
Animal-only studies
6,212
Safety adverse signals
3,828
Interaction signals
2,931
Total indexed
2,680
Human studies
1,335
Weighted direction score: 24 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
In vitro / tissue
7,533
Animal-only studies
6,212
Safety adverse signals
3,828
Interaction signals
2,931
Total indexed
2,680
Human studies
1,335
Randomized trials
244
Meta-analyses
109
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 29018060 • 2018 Feb
Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.
Br J Sports Med
Open PubMedPMID 36804260 • 2023 Apr
Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
Cytokine
Open PubMedPMID 35935936 • 2022
Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.
Front Immunol
Open PubMedPMID 35311615 • 2022 Jul
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.
World J Biol Psychiatry
Open PubMedPMID 37325651 • 2023
Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis.
Front Immunol
Open PubMedPMID 34017975 • 2021 Jun 25
The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis.
Biosci Rep
Open PubMedPMID 39354480 • 2024 Oct 1
Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial.
Nutr J
Open PubMedPMID 36192751 • 2022 Oct 3
Effects of curcumin and/or coenzyme Q10 supplementation on metabolic control in subjects with metabolic syndrome: a randomized clinical trial.
Nutr J
Open PubMedPMID 38795741 • 2024 Jul
Curcumin supplementation alleviates hepatic fat content associated with modulation of gut microbiota-dependent bile acid metabolism in patients with nonalcoholic simple fatty liver disease: a randomized controlled trial.
Am J Clin Nutr
Open PubMedPMID 34708460 • 2021 Dec
Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple-blind, placebo-controlled clinical trial.
Phytother Res
Open PubMedPMID 37394650 • 2023 Jul
Effect of curcumin on inflammatory biomarkers and iron profile in patients with premenstrual syndrome and dysmenorrhea: A randomized controlled trial.
Physiol Rep
Open PubMedPMID 38794742 • 2024 May 16
Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial.
Nutrients
Open PubMedPMID 31412624 • 2019 Aug 13
Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects.
Molecules
Open PubMedPMID 37513676 • 2023 Jul 23
The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components.
Nutrients
Open PubMedPMID 35315418 • 2022 Mar 14
Dietary supplements for treatment of endometriosis: A review.
Acta Biomed
Open PubMedBenefit reports: 4
Adverse reports: 2
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.36
Benefits
Adverse
No Effect
Users report stronger results with enhanced forms. | Step2: Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 5 mentions (confidence 0.36) across Supplements, Biohackers.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 120 mg-1500 mg/day (confidence HIGH).
Extracted from 5 dosing mentions across 3 PubMed studies (mg/day).
Imported legacy community score: 9.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$20.00.
Legacy community note: One of the most widely used and praised supplements. Users report significant joint pain relief, reduced inflammation markers on bloodwork, and improved mood. Strong consensus that enhanced absorption forms are necessary.
post • r/Supplements • unclear
Anyone take turmeric and Curcumin supplements? Anyone take Turmeric and Curcumin supplements or just Curcumin supplements? I heard they are good for lowering inflammation. I suffer from endometriosis. I am worried to take it because it is …
Open mentionpost • r/Biohackers • unclear
Curcumin supplements I’m going down a rabbit hole looking for the purest turmeric supplement. I’ve been reading that alot of them can be contaminated with lead but haven’t been able to find a clear brand that for sure isn’t. The fresh root…
Open mentionpost • r/Supplements • adverse
Turmeric and Curcumin supplement Any take Turmeric and Curcumin Supplement? I started taking it because i heard it lowers inflammation but i started experiencing stomach pain/ cramping recently while taking it. Is this normal? (I have endo…
Open mentionpost • r/Biohackers • unclear
Efficacy of curcumin/turmeric on inflammation and oxidative stress in prediabetes and type 2 diabetes: a systematic review and dose-response meta-analysis
Open mentionpost • r/Biohackers • unclear
Exploring curcumin's efficacy in the management of periodontal disease: An umbrella review
Open mentionpost • r/Biohackers • unclear
Effect of Pre-Heating on Enhancing the Anti-Digestive and Antioxidant Properties of Curcumin Rice by Self-Emulsifying Technology
Open mentionpost • r/Biohackers • unclear
Synergistic Effects of Curcumin and Antibiotics Against Drug-Sensitive and Multidrug-Resistant Mycobacterium tuberculosis
Open mentionpost • r/Supplements • unclear
My dad is taking all this… Safe? Useless? Good? My dad (50s) has recently become obsessed with supplements and takes a LOT. As someone in the medical field I find it a bit concerning. He claims to have done his research but I think a some …
Open mentioncomment • r/Supplements • unclear
They are the same thing. Curcumin is the scientific way of saying turmeric. Although, curcumin supplements are typically more concentrated and more for inflammation and turmeric is usually just the spice form in capsules which is more for …
Open mentioncomment • r/Supplements • unclear
They are not the same thing Curcumin is a component of turmeric
Open mentionamazon
Amazon search for Curcumin
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
META_ANALYSIS • 2022 • Adults
Human intervention trials.
Outcome: Modest reductions in CRP and pain scores.[2869,3365,4056, etc.]
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 1335, RCTs 244, meta-analyses 109.[2869,3365,4056, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29018060 from Br J Sports Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36804260 from Cytokine.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35935936 from Front Immunol.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35311615 from World J Biol Psychiatry.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37325651 from Front Immunol.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34017975 from Biosci Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39354480 from Nutr J.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36192751 from Nutr J.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38795741 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34708460 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37394650 from Physiol Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38794742 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31412624 from Molecules.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37513676 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35315418 from Acta Biomed.
Outcome: See linked PubMed abstract for methods and outcomes.[2869,3365,4056, etc.]
Open source