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Supplement

Cordyceps

Contains bioactive phytochemicals that may modulate stress, immune, and metabolic pathways.[1585,2980,3424, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence
Stress ResilienceMoodImmune SupportLongevity

Composite Rating

3.7/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

86/100

High depth from human/RCT/meta counts

Community Direction

67

Positive Lean • confidence Low

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 11 • mentions 6 • links 22

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Stress Resilience, Mood, Immune Support, Longevity.[42,256,267, etc.]

Dose guide: Human-study daily dose: 50 mg-1000 mg/day (higher-confidence extraction from PubMed abstracts)..[42,256,267, etc.]

Category: botanical.[42,256,267, etc.]

Category

Botanical

Evidence Tier

HIGH

Daily Guide

Human-study daily dose: 50 mg-1000 mg/day (higher-confidence extraction from PubMed abstracts).

Dosing Guide

Human-study daily dose: 50 mg-1000 mg/day (higher-confidence extraction from PubMed abstracts).[,, etc.]

At-A-Glance Evidence Architecture[1585,2980,3424, etc.]

Clinical Depth

Humans: 57 • RCTs: 11 • Meta: 0

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 155 • Interactions: 142

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

229 total studies · 2 recent

Timeline

20042024

Top Signal Metrics[1585,2980,3424, etc.]

Animal-only studies

845

In vitro / tissue

440

Total indexed

229

Safety adverse signals

155

Interaction signals

142

Human studies

57

Community Direction Mix[42,256,267, etc.]

Weighted direction score: 67 (Positive Lean)

Evidence Quality Summary[1585,2980,3424, etc.]

High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.

Animal-only studies

845

In vitro / tissue

440

Total indexed

229

Safety adverse signals

155

Interaction signals

142

Human studies

57

Randomized trials

11

Meta-analyses

0

Study Type Breakdown

Distribution of evidence by study design strength

Randomized TrialsLevel 1b11
Human Studies (other)Level 3-446
All IndexedAll levels229
86

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1585,2980,3424, etc.]

PMID 38580687 • 2024 Apr 5

A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults.

Sci Rep

Open PubMed

PMID 31623349 • 2019 Oct 3

Rhodiola/Cordyceps-Based Herbal Supplement Promotes Endurance Training-Improved Body Composition But Not Oxidative Stress and Metabolic Biomarkers: A Preliminary Randomized Controlled Study.

Nutrients

Open PubMed

PMID 36374982 • 2022

Efficacy of Cordyceps cicadae (Ascomycota) Mycelium Supplementation for Amelioration of Dry Eye Symptoms: A Randomized, Double-Blind Clinical Pilot Study.

Community Report Frequency[42,256,267, etc.]

Benefit reports: 5

Adverse reports: 1

No-effect reports: 0

Mixed reports: 0

Unclear reports: 0

Signal confidence: 0.28

Top Reported Effects[42,256,267, etc.]

Benefits

  • recovery: 2
  • sleep: 1
  • strength: 1
  • effective: 1
  • energy: 1

Adverse

  • Autoimmune diseases: 1
  • Mushroom allergy: 1
  • Insomnia (stimulating): 1

No Effect

  • insufficient no-effect reports captured: 0

Moderate positive empirical signal; apply a light priority boost.

Reddit evidence: 3 mentions (confidence 0.28) across Supplements, Biohackers.

Amazon signal: 1 products scanned (948 ratings) (confidence 0.79).

GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].

Community Evidence Examples[42,256,267, etc.]

post • r/Supplements • benefit

Severe Erectile Dysfunction Hi everyone please help, I just turned 30/male and for many years now I just can’t get my member up. I’ve done all the tests and I’m generally healthy, active, and very engaged in fitness. I’ve been experimentin…

Open mention

post • r/Biohackers • benefit

Might have destroyed my mind, body and hormones... Don't trust supplement labels. Seeking recovery advice. Male, age 29 Hey everyone, I've been taking AstroFlav Elevated daily at the full serving size of 4 capsules per day for almost 2 yea…

Open mention

post • r/Supplements • unclear

Looking for supplements that would boost immunity by a high degree Looking for supplements that would boost immunity by a high degree. Below are some of the supplements I usually take or planning to take. I take these supplement. Not daily…

Retail Signal Examples

amazon

FlavCity Chocolate Protein Powder, Organic Cocoa with Collagen Peptides, Reishi & Cordyceps Mushrooms - Focus, Skin, Hair & Joint Support - 100% Grass Fed Whey All in One Smoothie, 20 Servings

Rating: 4.2 | Reviews: 948

Open product

Primary Source Links

Evidence Sources

  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22cordyceps%22)%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)
  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22cordyceps%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)
  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22cordyceps%22)%20AND%20animals%5BMeSH%20Terms%5D%20NOT%20humans%5BMeSH%20Terms%5D

Scientific Evidence Notes[1585,2980,3424, etc.]

1. PubMed evidence summary: Cordyceps

PUBMED • Humans + preclinical triage

Counts aggregated from automated literature sweep and tiering rules.

Outcome: Tier HIGH; humans 57, RCTs 11, meta-analyses 0.[1585,2980,3424, etc.]

Open source
2. A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults.

PUBMED • 2024 • Human evidence curation set

PMID 38580687 from Sci Rep.

Outcome: See linked PubMed abstract for methods and outcomes.[, etc.]

1585
2980,
3424

Safety and Pitfalls

  • Elevated adverse/interactions signal in literature; review medications and conditions before use.[42,256,267, etc.]
  • High interaction-signal count detected in literature search.[42,256,267, etc.]
  • Legacy caution group: Autoimmune diseases[42,256,267, etc.]
  • Legacy caution group: Mushroom allergy[42,256,267, etc.]
  • Legacy caution group: Insomnia (stimulating)[42,256,267, etc.]
Benefit
5 (83%)
Adverse1 (17%)
No Effect0 (0%)
Mixed0 (0%)

Int J Med Mushrooms

Open PubMed

PMID 38501161 • 2024 Apr 22

Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise.

Food Funct

Open PubMed

PMID 33078636 • 2021

Effects of Concurrent Training and a Multi-Ingredient Performance Supplement Containing Rhodiola rosea and Cordyceps sinensis on Body Composition, Performance, and Health in Active Men.

J Diet Suppl

Open PubMed

PMID 15118196 • 2004 Apr

Cordyceps Sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performance.

Int J Sport Nutr Exerc Metab

Open PubMed

PMID 37373268 • 2023 Jun 14

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer.

Int J Mol Sci

Open PubMed

PMID 29568244 • 2018

Herbal medicine for sports: a review.

J Int Soc Sports Nutr

Open PubMed

PMID 32545666 • 2020 Jun 12

Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Cordyceps Medicinal Fungus and Its Nutraceutical and Therapeutic Potential.

Molecules

Open PubMed

PMID 36995535 • 2023 Jun

Medicinal Mushroom Supplements in Cancer: A Systematic Review of Clinical Studies.

Curr Oncol Rep

Open PubMed

PMID 35889330 • 2022 Jul 12

Medicinal Fungi with Antiviral Effect.

Molecules

Open PubMed

PerimeterX / captcha block encountered.

Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.

Lowest observed monthly cost signal: $89.99 (FlavCity Chocolate Protein Powder, Organic Cocoa with Collagen Peptides, Reishi & Cordyceps Mushrooms - Focus, Skin, Hair & Joint Support - 100% Grass Fed Whey All in One Smoothie, 20 Servings).

Human-study daily dose signal: 50 mg-1000 mg/day (confidence HIGH).

Extracted from 4 dosing mentions across 3 PubMed studies (mg/day).

Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).

Imported legacy monthly cost signal: ~$25.00.

Legacy community note: Highly regarded among athletes and biohackers. Users report noticeable energy boost and better endurance without jitteriness. Popular pre-workout ingredient.

Open mention

post • r/Biohackers • benefit

I Mapped Every Known Hallmark of Aging to One Protocol — The Result Points to a 140-Year Human Lifespan N=1 Protocol OPTIMIZED v2.4: Pursuing Biological Immortality....(HOMO RHIZOMATICUS) With love, for humanity, forever yours, Optimized\_…

Open mention
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22cordyceps%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%20randomized%20controlled%20trial%5BPublication%20Type%5D
  • https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=(%22cordyceps%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%20meta-analysis%5BPublication%20Type%5D
  • https://pubmed.ncbi.nlm.nih.gov/38580687/
  • https://pubmed.ncbi.nlm.nih.gov/31623349/
  • https://pubmed.ncbi.nlm.nih.gov/36374982/
  • https://pubmed.ncbi.nlm.nih.gov/38501161/
  • https://pubmed.ncbi.nlm.nih.gov/33078636/
  • https://pubmed.ncbi.nlm.nih.gov/15118196/
  • https://pubmed.ncbi.nlm.nih.gov/37373268/
  • https://pubmed.ncbi.nlm.nih.gov/29568244/
  • https://pubmed.ncbi.nlm.nih.gov/32545666/
  • https://pubmed.ncbi.nlm.nih.gov/36995535/
  • https://pubmed.ncbi.nlm.nih.gov/35889330/
  • https://pubmed.ncbi.nlm.nih.gov/?term=Cordyceps
  • Community Sources

    • https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22cordyceps%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
    • https://old.reddit.com/r/Supplements/comments/1o29q3i/severe_erectile_dysfunction/.json?raw_json=1&sort=top&limit=25
    • https://old.reddit.com/r/Biohackers/comments/1m5culw/might_have_destroyed_my_mind_body_and_hormones/.json?raw_json=1&sort=top&limit=25
    • https://old.reddit.com/r/Supplements/comments/1nhpidf/looking_for_supplements_that_would_boost_immunity/.json?raw_json=1&sort=top&limit=25
    • https://www.reddit.com/search/?q=Cordyceps
    1585,
    2980,
    3424
    Open source
    3. Rhodiola/Cordyceps-Based Herbal Supplement Promotes Endurance Training-Improved Body Composition But Not Oxidative Stress and Metabolic Biomarkers: A Preliminary Randomized Controlled Study.

    PUBMED • 2019 • Human evidence curation set

    PMID 31623349 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1585,2980,3424, etc.]

    Open source
    4. Efficacy of Cordyceps cicadae (Ascomycota) Mycelium Supplementation for Amelioration of Dry Eye Symptoms: A Randomized, Double-Blind Clinical Pilot Study.

    PUBMED • 2022 • Human evidence curation set

    PMID 36374982 from Int J Med Mushrooms.

    Outcome: See linked PubMed abstract for methods and outcomes.[1585,2980,3424, etc.]

    Open source
    5. Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise.

    PUBMED • 2024 • Human evidence curation set

    PMID 38501161 from Food Funct.

    Outcome: See linked PubMed abstract for methods and outcomes.[1585,2980,3424, etc.]

    Open source
    6. Effects of Concurrent Training and a Multi-Ingredient Performance Supplement Containing Rhodiola rosea and Cordyceps sinensis on Body Composition, Performance, and Health in Active Men.

    PUBMED • 2021 • Human evidence curation set

    PMID 33078636 from J Diet Suppl.

    Outcome: See linked PubMed abstract for methods and outcomes.[1585,2980,3424, etc.]

    Open source
    7. Cordyceps Sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performance.

    PUBMED • 2004 • Human evidence curation set

    PMID 15118196 from Int J Sport Nutr Exerc Metab.

    Outcome: See linked PubMed abstract for methods and outcomes.[1585,2980,3424, etc.]

    Open source
    8. Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer.

    PUBMED • 2023 • Human evidence curation set

    PMID 37373268 from Int J Mol Sci.

    Outcome: See linked PubMed abstract for methods and outcomes.[1585,2980,3424, etc.]

    Open source
    9. Herbal medicine for sports: a review.

    PUBMED • 2018 • Human evidence curation set

    PMID 29568244 from J Int Soc Sports Nutr.

    Outcome: See linked PubMed abstract for methods and outcomes.[1585,2980,3424, etc.]

    Open source
    10. Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Cordyceps Medicinal Fungus and Its Nutraceutical and Therapeutic Potential.

    PUBMED • 2020 • Human evidence curation set

    PMID 32545666 from Molecules.

    Outcome: See linked PubMed abstract for methods and outcomes.[1585,2980,3424, etc.]

    Open source
    11. Medicinal Mushroom Supplements in Cancer: A Systematic Review of Clinical Studies.

    PUBMED • 2023 • Human evidence curation set

    PMID 36995535 from Curr Oncol Rep.

    Outcome: See linked PubMed abstract for methods and outcomes.[1585,2980,3424, etc.]

    Open source
    12. Medicinal Fungi with Antiviral Effect.

    PUBMED • 2022 • Human evidence curation set

    PMID 35889330 from Molecules.

    Outcome: See linked PubMed abstract for methods and outcomes.[1585,2980,3424, etc.]

    Open source