Supplement
Supports electrolyte balance, enzymatic activity, and metabolic signaling.[1521,1649,1721, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
1
Mixed / Neutral • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 9 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Metabolic Health, Energy, Heart Health, Longevity.[226,292,309, etc.]
Dose guide: Human-study daily dose: 2 mg/day (early-confidence extraction from PubMed abstracts)..[226,292,309, etc.]
Category
Mineral
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 2 mg/day (early-confidence extraction from PubMed abstracts).
Dosing Guide
Human-study daily dose: 2 mg/day (early-confidence extraction from PubMed abstracts).[1521,, etc.]
Clinical Depth
Humans: 130 • RCTs: 49 • Meta: 7
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 55 • Interactions: 20
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
326 total studies · 2 recent
Timeline
Total indexed
326
Animal-only studies
185
Human studies
130
Safety adverse signals
55
Randomized trials
49
In vitro / tissue
27
Weighted direction score: 1 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
326
Animal-only studies
185
Human studies
130
Safety adverse signals
55
Randomized trials
49
In vitro / tissue
27
Interaction signals
20
Meta-analyses
7
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 37952433 • 2024 Jan
Effects of chromium supplementation on body composition in patients with type 2 diabetes: A dose-response systematic review and meta-analysis of randomized controlled trials.
J Trace Elem Med Biol
Open PubMedPMID 24635480 • 2014 Jun
Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes.
J Clin Pharm Ther
Open PubMedPMID 12664086 • 2003 Apr
Chromium picolinate for reducing body weight: meta-analysis of randomized trials.
Int J Obes Relat Metab Disord
Benefit reports: 4
Adverse reports: 3
No-effect reports: 1
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.20
Benefits
Adverse
No Effect
Insufficient empirical signal for a directional adjustment.
Reddit evidence: 2 mentions (confidence 0.20) across Supplements.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
post • r/Supplements • mixed
chromium picolinate rebound and side effect I started taking chromium a few years ago, and I've been doing several tests, stopping and starting again from time to time, and this supplement has a very noticeable effect on me, the problem is…
Open mentionpost • r/Supplements • unclear
Which of these should I keep/toss I'm trying to cut down on how much I spend on supplements. Currently taking these ones: multivitamin, NAC, quercetin, vitamin C, magnesium glycinate, chromium picolinate, inositol, vitamin D3/K2
Open mentionpost • r/Supplements • benefit
I've been researching this for weeks because the prescription stuff is just not happening financially. Insurance won't cover it and $1000+ monthly is insane, like that's rent money From what I can tell konjac root expands in the stomach fo…
amazon
Amazon search for Chromium Picolinate
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 130, RCTs 49, meta-analyses 7.[1521,1649,1721, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 37952433 from J Trace Elem Med Biol.
Outcome: See linked PubMed abstract for methods and outcomes.
PMID 41067797 • 2025 Oct
Therapeutic effects of chromium supplementation on women with polycystic ovarian syndrome: A systematic review and meta-analysis.
Endocrinol Diabetes Nutr (Engl Ed)
Open PubMedPMID 30383288 • 2018 Nov 1
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment.
Cochrane Database Syst Rev
Open PubMedPMID 33183560 • 2020 Dec
The effect of chromium supplementation on apolipoproteins: A systematic review and meta-analysis of randomized clinical trials.
Clin Nutr ESPEN
Open PubMedPMID 31593637 • 2020 May
The effects of chromium and vitamin D(3) co-supplementation on insulin resistance and tumor necrosis factor-alpha in type 2 diabetes: a randomized placebo-controlled trial.
Appl Physiol Nutr Metab
Open PubMedPMID 30977089 • 2020 Feb
Effects of Chromium and Carnitine Co-supplementation on Body Weight and Metabolic Profiles in Overweight and Obese Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial.
Biol Trace Elem Res
Open PubMedPMID 17109595 • 2006 Dec
The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial.
Diabetes Technol Ther
Open PubMedPMID 17291720 • 2007 Mar
Chromium picolinate supplementation in women: effects on body weight, composition, and iron status.
Nutrition
Open PubMedPMID 15990745 • 2005 Apr
Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus.
Am Heart J
Open PubMedPMID 8644693 • 1996 Jun
Chromium supplementation and resistance training: effects on body composition, strength, and trace element status of men.
Am J Clin Nutr
Open PubMedPMID 34970669 • 2022 Aug 1
Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome.
Adv Nutr
Open PubMedPMID 30513859 • 2018 Dec 3
Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review.
Nutrients
Open PubMedPMID 28835408 • 2018 Jul
Sugar addiction: is it real? A narrative review.
Br J Sports Med
Open PubMedHuman-study daily dose signal: 2 mg/day (confidence LOW).
Extracted from 1 dosing mentions across 1 PubMed studies (mg/day).
Imported legacy community score: 6.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$7.00.
Legacy community note: Moderately popular. Diabetic and weight loss communities report modest benefits. Not dramatic but helpful as part of a blood sugar management stack.
post • r/Supplements • unclear
chromium picolinate on empty stomach? Any ill effects?
Open mentioncomment • r/Supplements • unclear
I also struggle to place "chromium picolinate" in my saily protocol. Specially because my multivitamin already has it on its formula. Sometimes I take it before a long run but I don't notice improvements.
Open mentionCommunity Sources
PUBMED • 2014 • Human evidence curation set
PMID 24635480 from J Clin Pharm Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2003 • Human evidence curation set
PMID 12664086 from Int J Obes Relat Metab Disord.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 41067797 from Endocrinol Diabetes Nutr (Engl Ed).
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30383288 from Cochrane Database Syst Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33183560 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 31593637 from Appl Physiol Nutr Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 30977089 from Biol Trace Elem Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 17109595 from Diabetes Technol Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2007 • Human evidence curation set
PMID 17291720 from Nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2005 • Human evidence curation set
PMID 15990745 from Am Heart J.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 1996 • Human evidence curation set
PMID 8644693 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34970669 from Adv Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30513859 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 28835408 from Br J Sports Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1521,1649,1721, etc.]
Open source