Supplement
Supports broad cellular function with category-specific mechanisms.[1422,1538,2130, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
50
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 4 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[81,105,111, etc.]
Dose guide: Human-study daily dose: 200 mg-6000 mg/day (higher-confidence extraction from PubMed abstracts)..[81,105,111, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 200 mg-6000 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 123 • RCTs: 23 • Meta: 4
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 1,201 • Interactions: 701
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
706 total studies · 3 recent
Timeline
Animal-only studies
1,310
Safety adverse signals
1,201
Total indexed
706
Interaction signals
701
In vitro / tissue
382
Human studies
123
Weighted direction score: 50 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
1,310
Safety adverse signals
1,201
Total indexed
706
Interaction signals
701
In vitro / tissue
382
Human studies
123
Randomized trials
23
Meta-analyses
4
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 29037431 • 2018 Dec
Effect of Chlorella supplementation on cardiovascular risk factors: A meta-analysis of randomized controlled trials.
Clin Nutr
Open PubMedPMID 35331862 • 2022 Jun
Effect of supplementation with Chlorella vulgaris on lipid profile in adults: A systematic review and dose-response meta-analysis of randomized controlled trials.
Complement Ther Med
Open PubMedPMID 40289965 • 2025 Mar 7
The Role of Chlorella and Spirulina as Adjuvants of Cardiovascular Risk Factor Control: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Nutrients
Open PubMedPMID 39461896 • 2025 Mar 1
The Effect of Algae Supplementation on Anthropometric Indices in Adults: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Nutr Rev
Open PubMedPMID 11347287 • 2001 May-Jun
A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis.
Altern Ther Health Med
Open PubMedPMID 34433510 • 2022 Jul 28
High-intensity interval training with or without chlorella vulgaris supplementation in obese and overweight women: effects on mitochondrial biogenesis, performance and body composition.
Br J Nutr
Open PubMedPMID 38474825 • 2024 Feb 29
Chlorella Supplementation Reduces Blood Lactate Concentration and Increases O(2) Pulse during Submaximal and Maximal Cycling in Young Healthy Adults.
Nutrients
Open PubMedPMID 12874157 • 2003 Jul 22
Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial.
CMAJ
Open PubMedPMID 26275653 • 2015 Aug
A randomized controlled trial of 6-week Chlorella vulgaris supplementation in patients with major depressive disorder.
Complement Ther Med
Open PubMedPMID 22849818 • 2012 Jul 31
Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of natural killer cell activity and early inflammatory response (randomized, double-blinded, placebo-controlled trial).
Nutr J
Open PubMedPMID 38256329 • 2023 Dec 29
Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
Medicina (Kaunas)
Open PubMedPMID 26561078 • 2016
Chlorella vulgaris: A Multifunctional Dietary Supplement with Diverse Medicinal Properties.
Curr Pharm Des
Open PubMedPMID 32878326 • 2020 Aug 31
Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis.
Nutrients
Open PubMedPMID 24402174 • 2014 Jan 7
Astaxanthin: sources, extraction, stability, biological activities and its commercial applications--a review.
Mar Drugs
Open PubMedPMID 23680061 • 2013 May-Jun
Chlorella-induced psychosis.
Psychosomatics
Open PubMedBenefit reports: 3
Adverse reports: 1
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.28
Benefits
Adverse
No Effect
Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 3 mentions (confidence 0.28) across Biohackers, HubermanLab.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 200 mg-6000 mg/day (confidence HIGH).
Extracted from 10 dosing mentions across 5 PubMed studies (mg/day).
post • r/Biohackers • unclear
My daily smoothie (50,000+ ORAC units) 50g of Casein 1 cup of blueberries 1 cup of cranberries 1 cup of kale 1/2 cup of spinach 1 tablespoon of Russian, Siberian wildflower honey A handful of walnuts, almonds, and pumpkin seeds 5g of Creat…
Open mentionpost • r/Biohackers • benefit
My Personal Challenge to Decalcify My Pineal Gland in 30 Days This is based on my personal experience and I'm happy to share. Thirty days ago, I started a method to decalcify my pineal gland after learning that fluoride accumulates there m…
Open mentionpost • r/Biohackers • benefit
Just Got Back from Eudemonia Summit - Here's Everything I Tried Just wrapped up a few days at Eudemonia and wanted to do a full product recap. I tried a ton of stuff, bought way too much, and had some really great conversations with founde…
Open mentionpost • r/HubermanLab • benefit
Just Got Back from Eudemonia Summit - Here's Everything I Tried Just wrapped up a few days at Eudemonia and wanted to do a full product recap. I tried a ton of stuff, bought way too much, and had some really great conversations with founde…
Open mentionamazon
Amazon search for Chlorella
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 123, RCTs 23, meta-analyses 4.[1422,1538,2130, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29037431 from Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35331862 from Complement Ther Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40289965 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39461896 from Nutr Rev.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11347287 from Altern Ther Health Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34433510 from Br J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38474825 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2003 • Human evidence curation set
PMID 12874157 from CMAJ.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26275653 from Complement Ther Med.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2012 • Human evidence curation set
PMID 22849818 from Nutr J.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38256329 from Medicina (Kaunas).
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 26561078 from Curr Pharm Des.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32878326 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24402174 from Mar Drugs.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 23680061 from Psychosomatics.
Outcome: See linked PubMed abstract for methods and outcomes.[1422,1538,2130, etc.]
Open source