Supplement
Betulinic acid (from birch substrate), melanin complex, and β-glucans provide potent antioxidant activity (highest ORAC of any food), activate NK cells, and inhibit NF-κB inflammatory signaling.[2055,3311,4001, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
39/100
Early depth from human/RCT/meta counts
Community Direction
-21
Caution Lean • confidence Moderate
Safety Friction
0/100
Sparse signal from adverse/interaction markers
Data Completeness
100%
Studies 3 • mentions 9 • links 5
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Immune Support, Inflammation, Longevity.[2055,3311,4001, etc.]
Dose guide: 500-1500 mg extract daily (hot water extraction preferred).[2055,3311,4001, etc.]
Category
Botanical
Evidence Tier
EXPLORATORY
Daily Guide
500-1500 mg extract daily (hot water extraction preferred)
Clinical Depth
Humans: 3 • RCTs: 1 • Meta: 1
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 0 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
· Limited trend data
Depth
3 total studies
Timeline
Total indexed
3
Human studies
3
Randomized trials
1
Meta-analyses
1
Mechanistic signals
1
Cohort signals
0
Weighted direction score: -21 (Caution Lean)
Total indexed
3
Human studies
3
Randomized trials
1
Meta-analyses
1
Mechanistic signals
1
Cohort signals
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 33818810 • 2021
Inonotus obliquus bioactive compounds: systematic review
SYSTEMATIC_REVIEW
Open PubMedPMID 31126049 • 2019
Chaga mushroom extract and inflammation in IBD patients: pilot study
RCT
Open PubMedPMID 21820502 • 2011
Chaga antioxidant capacity and melanin complexes: review
MECHANISTIC
Open PubMedBenefit reports: 3
Adverse reports: 4
No-effect reports: 1
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.40
Benefits
Adverse
No Effect
Highest antioxidant food by ORAC testing. However, very limited human data and HIGH oxalate content is a real concern. Sustainability of wild harvesting is also an issue.
Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).
Legacy community note: Popular for skin and joint health. Users report more hydrated skin and reduced joint stiffness. Often stacked with collagen for synergistic beauty benefits. Topical HA also widely used.
aggregate • adverse
Aggregate community signal: 9 directional mentions (benefit 3, adverse 4, no-effect 1, mixed 1).
Open mentionamazon
Amazon search for Chaga Mushroom (Inonotus obliquus)
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • 2021 • Human evidence curation set
PMID 33818810 from SYSTEMATIC_REVIEW.
Outcome: See linked PubMed abstract for methods and outcomes.[2055,3311,4001, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31126049 from RCT.
Outcome: See linked PubMed abstract for methods and outcomes.[2055,3311,4001, etc.]
Open sourcePUBMED • 2011 • Human evidence curation set
PMID 21820502 from MECHANISTIC.
Outcome: See linked PubMed abstract for methods and outcomes.[2055,3311,4001, etc.]
Open source