Supplement

Boron

Supports electrolyte balance, enzymatic activity, and metabolic signaling.[1502,2464,2971, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence

Metabolic HealthEnergyHeart HealthLongevity

Composite Rating

4.0/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

Positive Lean • confidence Low

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 12 • mentions 7 • links 23

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Metabolic Health, Energy, Heart Health, Longevity.[57,132,137, etc.]

Dose guide: Human-study daily dose: 3.25 mg-11.6 mg/day (higher-confidence extraction from PubMed abstracts)..[57,132,137, etc.]

Category: mineral.[57,132,137, etc.]

Safety and Pitfalls

Elevated adverse/interactions signal in literature; review medications and conditions before use.[57,132,137, etc.]
High interaction-signal count detected in literature search.[57,132,137, etc.]
ODS safety note: Ask ODS Join the ODS Email List Consumer Datos en español Health Professional Other Resources Table of Contents Introduction Recommended Intakes Sources of Boron Boron Intakes and Status Boron Deficiency Boron and Health Health Risks from Excessive Boron Interactions with Medications Boron and Healthful Diets References Disclaimer This is a fact sheet intended for health professionals.[57,132,137, etc.]
ODS safety note: Cancer Preliminary evidence suggests that dietary boron intake might affect cancer risk.[57,132,137, etc.]
ODS safety note: Several observational studies found that boron intakes are inversely associated with prostate cancer risk in men and with lung and cervical cancer risk in women [ 1 , 9 , 41-44 ].[57,132,137, etc.]
ODS safety note: For example, in a case control study of 763 women with lung cancer and 838 healthy women, those in the lowest quartile of boron intake (less than 0.78 mg/day) had almost twice the risk of lung cancer of those in the highest quartile (more than 1.25 mg/day) [ 44 ].[57,132,137, etc.]
ODS safety note: An observational study in Turkey evaluated two criteria for prostate cancer risk, prostate size and prostate specific antigen (PSA) levels.[57,132,137, etc.]
ODS safety note: Health Risks from Excessive Boron No data are available on adverse effects of high boron intakes from food or water [ 2 ].[57,132,137, etc.]
ODS safety note: Boron toxicity can also cause headache, hypothermia, restlessness, weariness, renal injury, dermatitis, alopecia, anorexia, and indigestion.[57,132,137, etc.]
ODS safety note: A human health risk assessment of boron (boric acid and borax) in drinking water.[57,132,137, etc.]
ODS interaction note: Ask ODS Join the ODS Email List Consumer Datos en español Health Professional Other Resources Table of Contents Introduction Recommended Intakes Sources of Boron Boron Intakes and Status Boron Deficiency Boron and Health Health Risks from Excessive Boron Interactions with Medications Boron and Healthful Diets References Disclaimer This is a fact sheet intended for health professionals.[57,132,137, etc.]
ODS interaction note: Food and Drug Administration developed Daily Values (DVs) to help consumers compare the nutrient contents of products within the context of a total diet.[57,132,137, etc.]
ODS interaction note: Interactions with Medications Boron is not known to have any clinically relevant interactions with medications.[57,132,137, etc.]
Population caution: Boron Intakes and Status According to data from the Third National Health and Nutrition Examination Survey (NHANES III; 1988–1994) and the Continuing Survey of Food Intakes by Individuals (1994–1996), median dietary boron intakes range from 0.87 to 1.35 mg/day in adults, 1.05 to 1.08 mg/day in pregnant women, and 0.75 to 0.96 mg/day in school-age children [ 2 ].[57,132,137, etc.]
Legacy caution group: Hormone-sensitive cancers without physician guidance[57,132,137, etc.]

At-A-Glance Evidence Architecture[1502,2464,2971, etc.]

Clinical Depth

Humans: 245 • RCTs: 17 • Meta: 0

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 1,701 • Interactions: 4,157

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

Updated

Trend

→ Stable evidence base

Depth

624 total studies

Timeline

19942023

Top Signal Metrics[1502,2464,2971, etc.]

Interaction signals

4,157

Animal-only studies

3,350

In vitro / tissue

1,941

Safety adverse signals

1,701

Total indexed

624

Human studies

245

Community Direction Mix[57,132,137, etc.]

Weighted direction score: 49 (Positive Lean)

Benefit5 (71%)

Adverse1 (14%)

No Effect1 (14%)

Mixed0 (0%)

Evidence Quality Summary[1502,2464,2971, etc.]

High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.

Interaction signals

4,157

Animal-only studies

3,350

In vitro / tissue

1,941

Safety adverse signals

1,701

Total indexed

624

Human studies

245

Randomized trials

Meta-analyses

Study Type Breakdown

Distribution of evidence by study design strength

Randomized TrialsLevel 1b17

Human Studies (other)Level 3-4228

All IndexedAll levels624

100

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1502,2464,2971, etc.]

PMID 12428176 • 2002 Nov

Boron supplementation and activated factor VII in healthy men.

Eur J Clin Nutr

Open PubMed

PMID 35183882 • 2022 May

Possible therapeutic effects of boron citrate and oleoylethanolamide supplementation in patients with COVID-19: A pilot randomized, double-blind, clinical trial.

J Trace Elem Med Biol

Open PubMed

PMID 7889884 • 1994 Nov

Dietary boron, brain function, and cognitive performance.

Environ Health Perspect

Open PubMed

PMID 7889885 • 1994 Nov

Plasma boron and the effects of boron supplementation in males.

Environ Health Perspect

Open PubMed

PMID 36808295 • 2023 Nov

A Comparison of Boron Supplement and Tamsulosin as Medical Expulsive Therapy for Urinary Stones After Extracorporeal Shock Wave Lithotripsy: a Randomized Controlled Clinical Trial.

Biol Trace Elem Res

Open PubMed

PMID 25906949 • 2015 May

Effects of boron supplementation on the severity and duration of pain in primary dysmenorrhea.

Complement Ther Clin Pract

Open PubMed

PMID 32540741 • 2020 Dec

Pivotal role of boron supplementation on bone health: A narrative review.

J Trace Elem Med Biol

Open PubMed

PMID 35010952 • 2021 Dec 24

Nutrition, Physical Activity, and Dietary Supplementation to Prevent Bone Mineral Density Loss: A Food Pyramid.

Nutrients

Open PubMed

PMID 30909645 • 2019 Mar 24

The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review.

Nutrients

Open PubMed

PMID 29546541 • 2018 Nov

The Physiological Role of Boron on Health.

Biol Trace Elem Res

Open PubMed

PMID 36868314 • 2023 May 1

Biological and behavioral predictors of relative energy intake after acute exercise.

Appetite

Open PubMed

PMID 35771339 • 2023 May

Boron-Containing Compounds for Prevention, Diagnosis, and Treatment of Human Metabolic Disorders.

Biol Trace Elem Res

Open PubMed

Community Report Frequency[57,132,137, etc.]

Benefit reports: 5

Adverse reports: 1

No-effect reports: 1

Mixed reports: 0

Unclear reports: 0

Signal confidence: 0.32

Top Reported Effects[57,132,137, etc.]

Benefits

better: 1
effective: 1
worked: 1
energy: 1
focus: 1
works: 1
improvement: 1

Adverse

Hormone-sensitive cancers without physician guidance: 1

No Effect

no noticeable effect: 1

Moderate positive empirical signal; apply a light priority boost.

Reddit evidence: 4 mentions (confidence 0.32) across Biohackers, Supplements.

Amazon signal: 0 products scanned (confidence 0.00).

GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].

PerimeterX / captcha block encountered.

Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.

ODS fact sheet linked for safety review.

Human-study daily dose signal: 3.25 mg-11.6 mg/day (confidence HIGH).

Extracted from 5 dosing mentions across 3 PubMed studies (mg/day).

Imported legacy community score: 7.0/10 (heuristic mapping confidence 1.00).

Imported legacy monthly cost signal: ~$7.00.

Legacy community note: Popular in men's health and testosterone optimization communities. Users report improved libido and energy. Budget-friendly and easy to stack. Often considered an underrated mineral.

Community Evidence Examples[57,132,137, etc.]

post • r/Biohackers • unclear

Why isn’t Boron as a supplement more popular/talked about? It’s relatively cheap to supplement with it - wondering why it’s not more popular. As the current article shows, boron has been proven to be an important trace mineral because it (…

Open mention

post • r/Biohackers • benefit

The only 2 supplements that work for libido & erections I have literally tried every single supplement that got the hype for boosting testosterone, libido, better erections...i have spent 2000$+ experimenting for the past 3 years, and i'm …

Open mention

post • r/Biohackers • unclear

should i put my 45yo dad on trt?i need advice should i ask doctor for TRT? is there any natural way increase testosterone supplements boron etc? Total Testosterone---- 431 ng/dl free T--- 4.22pg/ml he wont exercise or anything and depresse…

Open mention

post • r/Biohackers • benefit

Boron Supplementation is a Good Idea! I'm not as into supplementation and biohacking as some people are, and don't have a complex stack of pills. I take some magnesium glycinate (some days), a multivitamin (some days), and every day I take…

Open mention

post • r/Supplements • benefit

Just got my blood test results — low boron levels. What effects can I expect from supplementing boron? Hey everyone, I recently got my blood work done and noticed that my boron levels are quite low. I’ve been reading a bit about how boron …

Open mention

post • r/Supplements • unclear

Considering Adding Boron and/or L-Theanine to My Supplement Routine As of now, I take Vitamin K2+D3 and Omega 3/Fish Oil in the morning. Most nights I take Magnesium Glycinate, and on the nights I don’t, I take Magnesium Citrate. I’ve been…

Open mention

post • r/Biohackers • unclear

Is this a good supplement if I need Calcium, Zinc copper and Boron?

Open mention

post • r/Supplements • unclear

Boron’s tangible effect on libido I am aware boron has been found to increase the amount of free testosterone available, although I also know this doesn’t always correlate to libido. But what I have noticed for me personally is in the firs…

Open mention

comment • r/Biohackers • unclear

Boron levels: not great, not terrible

Open mention

comment • r/Biohackers • unclear

Because most people find the topic boron.....

Open mention

Retail Signal Examples

amazon

Amazon search for Boron

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Community Sources

Scientific Evidence Notes[1502,2464,2971, etc.]

1. PubMed evidence summary: Boron

PUBMED • Humans + preclinical triage

Counts aggregated from automated literature sweep and tiering rules.

Outcome: Tier HIGH; humans 245, RCTs 17, meta-analyses 0.[1502,2464,2971, etc.]

Open source

2. Boron supplementation and activated factor VII in healthy men.

PUBMED • 2002 • Human evidence curation set

PMID 12428176 from Eur J Clin Nutr.