Supplement
Supports broad cellular function with category-specific mechanisms.[2483,3410,3971, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
34/100
Early depth from human/RCT/meta counts
Community Direction
34
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 6 • mentions 7 • links 17
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[65,221,264, etc.]
Dose guide: Follow product label and start with the lowest effective daily serving..[65,221,264, etc.]
Category
Other
Evidence Tier
MEDIUM
Daily Guide
Follow product label and start with the lowest effective daily serving.
Clinical Depth
Humans: 6 • RCTs: 1 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 27 • Interactions: 12
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
26 total studies · 1 recent
Timeline
In vitro / tissue
45
Animal-only studies
38
Safety adverse signals
27
Total indexed
26
Interaction signals
12
Human studies
6
Weighted direction score: 34 (Positive Lean)
Medium when human evidence exists but is limited, or when animal evidence volume is substantial.
In vitro / tissue
45
Animal-only studies
38
Safety adverse signals
27
Total indexed
26
Interaction signals
12
Human studies
6
Randomized trials
1
Meta-analyses
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 35986358 • 2022 Aug 19
A new nutraceutical (Livogen Plus®) improves liver steatosis in adults with non-alcoholic fatty liver disease.
J Transl Med
Open PubMedPMID 38516747 • 2024 Jan
Protective Effect of Black Seed and Lettuce Oils Against Paracetamol-Induced Hepatotoxicity in Rats.
Pak J Biol Sci
Open PubMedPMID 33719073 • 2021 Apr
Amelioration effect of black seed oil against high-fat diet-induced obesity in rats through Nrf2/HO-1 pathway.
J Food Biochem
Open PubMedBenefit reports: 4
Adverse reports: 1
No-effect reports: 0
Mixed reports: 2
Unclear reports: 0
Signal confidence: 0.39
Benefits
Adverse
No Effect
Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 6 mentions (confidence 0.39) across Supplements, Biohackers.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [ERROR].
terminated
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
post • r/Supplements • mixed
Black Seed Oil makes me feel amazing the first time I take it, but that effect is not replicated in the days following? I recently discovered that after taking black seed oil, my depression and anxiety nearly vanishes. It's easier for me t…
Open mentionpost • r/Biohackers • mixed
Black Seed Oil makes me feel amazing the first time I take it, but that effect is not replicated in the days following? I recently discovered that after taking black seed oil, my depression and anxiety nearly vanishes. It's easier for me t…
Open mentionpost • r/Supplements • unclear
Can I take Black seed oil along with Spike protein detox supplements? Hi all, I started the Dr McCullough's spike protein detox diet for covid vaccine injury. What can I take together and which ones should I not take together? I am taking …
amazon
Amazon search for Black Seed Oil
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier MEDIUM; humans 6, RCTs 1, meta-analyses 0.[2483,3410,3971, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35986358 from J Transl Med.
Outcome: See linked PubMed abstract for methods and outcomes.[,, etc.]
PMID 34819725 • 2021
Effects of Nutritional Interventions in Individuals with Chronic Obstructive Lung Disease: A Systematic Review of Randomized Controlled Trials.
Int J Chron Obstruct Pulmon Dis
Open PubMedPMID 26087391 • 2015 Sep 1
Herbal infusions of black seed and wheat germ oil: Their chemical profiles, in vitro bio-investigations and effective formulations as Phyto-Nanoemulsions.
Colloids Surf B Biointerfaces
Open PubMedPMID 31577540 • 2019 Dec 1
Black Seed Oil and Perioperative Serotonin Syndrome: A Case Report.
A A Pract
Open PubMedpost • r/Biohackers • benefit
Very high natural testosterone protocol (with proof) I am a natty 23 year old with a final stage bilateral varicocele disease (lowers testosterone) and managed to get 1015ng/dl total testosterone & 21 ng/dl free testosterone. I was previou…
Open mentionpost • r/Supplements • benefit
Very high natural testosterone protocol (with proof) I am a natty 23 year old with a final stage bilateral varicocele disease (lowers testosterone) and managed to get 1015ng/dl total testosterone & 21 ng/dl free testosterone. I was previou…
Open mentionpost • r/Biohackers • unclear
Doctor wants me to start 17 supplements at once? He is a DO and seems very interested in helping me but I’m quite apprehensive about this bc that’s two oils and 36 pills in total a day. To be fair I have a ton of symptoms from panic attack…
Open mentionpost • r/Biohackers • unclear
Anyone else drink oils daily? EVOO, flaxseed oil, black seed oil – curious to hear your thoughts Hey everyone, I’ve been incorporating oils into my daily routine for the past few months and wanted to share what I’m doing to see if anyone e…
Open mentionpost • r/Supplements • unclear
Feedback supplement stack! Supplement stack feedback! Please read the below. In the picture it is not the full stack and some I take at half serving etc, like vit C lipsomal I take half dose instead of full 2.5g Let me know any feedback, a…
Open mentioncomment • r/Supplements • unclear
It sounds like your body might be building a quick tolerance. . You could try cycling black seed oil with another supplement like saffron, which is also well-regarded for mood. For example, take one on one day and the other on the next.
Open mentioncomment • r/Supplements • unclear
I felt awful when I took it too. I think it’s because I take other meds so I stopped taking the black seed oil.
Open mentionCommunity Sources
PUBMED • 2024 • Human evidence curation set
PMID 38516747 from Pak J Biol Sci.
Outcome: See linked PubMed abstract for methods and outcomes.[2483,3410,3971, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33719073 from J Food Biochem.
Outcome: See linked PubMed abstract for methods and outcomes.[2483,3410,3971, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34819725 from Int J Chron Obstruct Pulmon Dis.
Outcome: See linked PubMed abstract for methods and outcomes.[2483,3410,3971, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26087391 from Colloids Surf B Biointerfaces.
Outcome: See linked PubMed abstract for methods and outcomes.[2483,3410,3971, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31577540 from A A Pract.
Outcome: See linked PubMed abstract for methods and outcomes.[2483,3410,3971, etc.]
Open source