Supplement
Essential cofactor for carboxylase enzymes (ACC, PCC, PC, MCC) in fatty acid synthesis, gluconeogenesis, and amino acid catabolism; supports keratin infrastructure for hair and nail growth.[2853,2905,5454, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
27/100
Early depth from human/RCT/meta counts
Community Direction
-16
Caution Lean • confidence High
Safety Friction
0/100
Sparse signal from adverse/interaction markers
Data Completeness
100%
Studies 3 • mentions 8 • links 5
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Skin Hair, Metabolic Health.[2853,2905,5454, etc.]
Dose guide: 2.5-10 mg/day for hair/nails (note: RDA is only 30 mcg).[2853,2905,5454, etc.]
Category
Vitamin
Evidence Tier
EXPLORATORY
Daily Guide
2.5-10 mg/day for hair/nails (note: RDA is only 30 mcg)
Clinical Depth
Humans: 3 • RCTs: 1 • Meta: 0
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 0 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
· Limited trend data
Depth
3 total studies
Timeline
Total indexed
3
Human studies
3
Randomized trials
1
Mechanistic signals
1
Meta-analyses
0
Cohort signals
0
Weighted direction score: -16 (Caution Lean)
Total indexed
3
Human studies
3
Randomized trials
1
Mechanistic signals
1
Meta-analyses
0
Cohort signals
0
Distribution of evidence by study design strength
Evidence Strength: Early
Composite of study volume, RCTs, and meta-analyses
PMID 28879195 • 2017
Biotin supplementation for hair and nail changes: review of clinical evidence
SYSTEMATIC_REVIEW
Open PubMedPMID 8477615 • 1993
Biotin and brittle fingernails: a controlled trial
RCT
Open PubMedPMID 29232858 • 2017
High-dose biotin interference with lab assays: FDA safety alert
MECHANISTIC
Open PubMedBenefit reports: 3
Adverse reports: 4
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 1.00
Benefits
Adverse
No Effect
One of the most overhyped supplements. Benefits only proven in deficiency states. The lab test interference issue is serious and underappreciated. Many get adequate biotin from diet (eggs, nuts, organ meats).
aggregate • adverse
Aggregate community signal: 8 directional mentions (benefit 3, adverse 4, no-effect 0, mixed 1).
Open mentionamazon
Amazon search for Biotin (Vitamin B7, standalone high-dose)
Rating: n/a | Reviews: n/a
Open productEvidence Sources
PUBMED • 2017 • Human evidence curation set
PMID 28879195 from SYSTEMATIC_REVIEW.
Outcome: See linked PubMed abstract for methods and outcomes.[2853,2905,5454, etc.]
Open sourcePUBMED • 1993 • Human evidence curation set
PMID 8477615 from RCT.
Outcome: See linked PubMed abstract for methods and outcomes.[2853,2905,5454, etc.]
Open sourceImported legacy community score: 10.0/10 (manual mapping confidence 1.00).
Legacy community note: The most universally recommended supplement across all health communities. Users frequently report improved energy, mood, and reduced illness frequency. Consistently called "the one supplement everyone should take."
PUBMED • 2017 • Human evidence curation set
PMID 29232858 from MECHANISTIC.
Outcome: See linked PubMed abstract for methods and outcomes.[2853,2905,5454, etc.]
Open source