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Supplement

Beta-Glucans (1,3/1,6-β-D-glucan)

1,3/1,6-β-glucans bind Dectin-1 receptors on macrophages and dendritic cells, priming innate immune response, enhancing phagocytosis, and activating complement cascade.[1320,1361,1376, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence
Immune SupportHeart HealthInflammationalias: beta glucanalias: yeast beta-glucanalias: oat beta-glucanalias: Wellmune

Composite Rating

3.9/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

100/100

High depth from human/RCT/meta counts

Community Direction

34

Positive Lean • confidence Low

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 24 • mentions 8 • links 214

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Immune Support, Heart Health, Inflammation.[73,122,215, etc.]

Dose guide: Human-study daily dose: 250 mg-10000 mg/day (higher-confidence extraction from PubMed abstracts)..[73,122,215, etc.]

Category: other.[73,122,215, etc.]

Category

Other

Evidence Tier

ROBUST

Daily Guide

Human-study daily dose: 250 mg-10000 mg/day (higher-confidence extraction from PubMed abstracts).

Dosing Guide

Human-study daily dose: 250 mg-10000 mg/day (higher-confidence extraction from PubMed abstracts).[,, etc.]

At-A-Glance Evidence Architecture[1320,1361,1376, etc.]

Clinical Depth

Humans: 355 • RCTs: 105 • Meta: 16

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 279 • Interactions: 738

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

1056 total studies · 42 recent

Timeline

19902026

Top Signal Metrics[1320,1361,1376, etc.]

Animal-only studies

1,884

In vitro / tissue

1,152

Total indexed

1,056

Interaction signals

738

Human studies

355

Safety adverse signals

279

Community Direction Mix[73,122,215, etc.]

Weighted direction score: 34 (Positive Lean)

Evidence Quality Summary[1320,1361,1376, etc.]

≥2 meta-analyses OR (≥5 RCTs AND ≥25 human studies).

Animal-only studies

1,884

In vitro / tissue

1,152

Total indexed

1,056

Interaction signals

738

Human studies

355

Safety adverse signals

279

Randomized trials

105

Meta-analyses

16

Study Type Breakdown

Distribution of evidence by study design strength

Meta-AnalysesLevel 1a16
Randomized TrialsLevel 1b105
Human Studies (other)Level 3-4234
All IndexedAll levels1,056
100

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1320,1361,1376, etc.]

PMID 26001090 • 2015

A systematic review and meta-analysis of beta-glucan consumption on glycemic control in hypercholesterolemic individuals.

International journal of food sciences and nutrition

Open PubMed

PMID 41540766 • 2026 Jan

Adaptogenic Effects of Mushroom Blend Supplementation on Stress, Fatigue, and Sleep: A Randomised, Double-Blind, and Placebo-Controlled Trial.

Brain and behavior

Open PubMed

PMID 38777445 • 2024 Jun

Community Report Frequency[73,122,215, etc.]

Benefit reports: 5

Adverse reports: 2

No-effect reports: 0

Mixed reports: 1

Unclear reports: 0

Signal confidence: 0.22

Top Reported Effects[73,122,215, etc.]

Benefits

  • energy: 1
  • effective: 1

Adverse

  • confusing different types: 1
  • expensive: 1

No Effect

  • insufficient no-effect reports captured: 0

Yeast-derived (Wellmune) for immune support, oat-derived for cholesterol. Two different products with different mechanisms. | Step2: Moderate positive empirical signal; apply a light priority boost.

Reddit evidence: 2 mentions (confidence 0.22) across Biohackers, Supplements.

Amazon signal: 0 products scanned (confidence 0.00).

GNC signal: 0 products scanned (confidence 0.00) [ERROR].

Community Evidence Examples[73,122,215, etc.]

post • r/Biohackers • unclear

Organic Mushrooms Lion’s Mane – 90% fruiting body + 10% mycelium (erinacine A quantified). Does this make sense chemically? I’ve been comparing Lion’s Mane supplements and wanted a sanity check from people who understand extraction chemist…

Open mention

post • r/Biohackers • benefit

What do you think of my stack ? 🧬 supermonkeygodkingemperor's Master Alzheimer's Reversal Protocol 4.0 *(Building on Neuro-Resilience Stack 3.0: Shifting from prevention to active reversal via enhanced neurogenesis, amyloid/tau clearance,…

Open mention

post • r/Supplements • benefit

Best Psyllium Husk Supplement in the UK? Or Safer Alternatives if Lead Levels Are Unclear? Hi everyone, I've been trying to up my fibre intake for heart health and cholesterol management, and psyllium husk keeps coming up as one of the bes…

Retail Signal Examples

amazon

Amazon search for Beta-Glucans (1,3/1,6-β-D-glucan)

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22beta%20glucan%22)%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)
  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22beta%20glucan%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)
  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22beta%20glucan%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%20randomized%20controlled%20trial%5BPublication%20Type%5D

Scientific Evidence Notes[1320,1361,1376, etc.]

1. β-glucan supplementation and URTI: MA of RCTs

META_ANALYSIS • 2019 • Adults

8 RCTs with 3932 subjects.

Outcome: Yeast β-glucan (Wellmune) 250-500 mg/day reduced URTI incidence (−25%), duration, and severity in healthy adults and athletes.[1320,1361,1376, etc.]

Open source
2. Oat β-glucan and cholesterol: EFSA-approved health claim MA

META_ANALYSIS • 2014 • Adults

28 RCTs with 2547 subjects.

Outcome: Oat β-glucan 3 g/day reduced LDL-cholesterol by −0.25 mmol/L (−7%); EFSA-approved health claim for cardiovascular benefit.[1320,1361,1376, etc.]

1320
1361,
1376

Safety and Pitfalls

  • Very safe. Different sources (yeast, oat, mushroom) have different benefits — yeast for immune, oat for cholesterol.[73,122,215, etc.]
  • Potential side effect: bloating[73,122,215, etc.]
  • Potential side effect: gas (oat form)[73,122,215, etc.]
  • Use caution with condition: immunosuppressed patients receiving organ transplants[73,122,215, etc.]
  • Interaction check: immunosuppressants[73,122,215, etc.]
Benefit
5 (63%)
Adverse2 (25%)
No Effect0 (0%)
Mixed1 (13%)

Effect of combination of Beta Glucan and Lactobacillus rhamnosus HerizI on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: A randomized double-blind placebo-controlled clinical trial.

Clinical nutrition ESPEN

Open PubMed

PMID 28251654 • 2017 Sep

Effect of a polysaccharide-rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) in body weight loss: randomised, double-blind, placebo-controlled clinical trial in overweight and obese adults.

Journal of the science of food and agriculture

Open PubMed

PMID 39832981 • 2025 Jan 20

Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: protocol for a randomised, double-blinded, placebo-controlled, parallel-group study.

BMJ open

Open PubMed

PMID 36657917 • 2023 Feb

The separate effects of whole oats and isolated beta-glucan on lipid profile: A systematic review and meta-analysis of randomized controlled trials.

Clinical nutrition ESPEN

Open PubMed

PMID 37960157 • 2023 Oct 24

Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.

Nutrients

Open PubMed

PMID 40746014 • 2025

Yeast Beta-Glucan Enhances Antibody Response Following Influenza Vaccination - A Double-Blind, Randomized, Placebo-Controlled Pilot Trial.

Journal of dietary supplements

Open PubMed

PMID 23340963 • 2013 Dec

Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects.

European journal of nutrition

Open PubMed

PMID 34977959 • 2022 Jun

Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials.

European journal of nutrition

Open PubMed

PMID 31816842 • 2019 Dec 3

Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

Nutrients

Open PubMed

PMID 40516031 • 2026

Impact of non-digestible carbohydrates and prebiotics on immunity, infections, inflammation and vaccine responses: a systematic review of evidence in healthy humans and a discussion of mechanistic proposals.

Critical reviews in food science and nutrition

Open PubMed

PMID 27724985 • 2016 Oct

The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials.

The British journal of nutrition

Open PubMed

PMID 25668347 • 2015 May

Effects of dietary fibre type on blood pressure: a systematic review and meta-analysis of randomized controlled trials of healthy individuals.

Journal of hypertension

Open PubMed

PMID 27273067 • 2016 Nov

A systematic review and meta-analysis of randomized controlled trials of the effect of barley β-glucan on LDL-C, non-HDL-C and apoB for cardiovascular disease risk reduction(i-iv).

European journal of clinical nutrition

Open PubMed

PMID 35631184 • 2022 May 13

Effects of Oat Beta-Glucan Intake on Lipid Profiles in Hypercholesterolemic Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Nutrients

Open PubMed

PMID 31573387 • 2020 Apr

Soluble and Insoluble Yeast β-Glucan Differentially Affect Upper Respiratory Tract Infection in Marathon Runners: A Double-Blind, Randomized Placebo-Controlled Trial.

Journal of medicinal food

Open PubMed

PMID 30198828 • 2019 Jan

Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects.

Journal of the American College of Nutrition

Open PubMed

PMID 36811560 • 2023 Feb

Galactomannans are the most effective soluble dietary fibers in type 2 diabetes: a systematic review and network meta-analysis.

The American journal of clinical nutrition

Open PubMed

PMID 26690472 • 2015 Dec 10

The Metabolic Effects of Oats Intake in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Nutrients

Open PubMed

PMID 26771637 • 2016 Jan 13

Effect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials.

Nutrients

Open PubMed

PMID 25081694 • 2014

Effect of beta glucan on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: a randomized double-blind placebo-controlled clinical trial.

Asian Pacific journal of cancer prevention : APJCP

Open PubMed

PMID 36435335 • 2023 May

Effect of Oat Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Journal of the Academy of Nutrition and Dietetics

Open PubMed

PMID 18074229 • 2008 Mar

Effect of high beta-glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men--a randomized, double-blinded, placebo-controlled trial.

Plant foods for human nutrition (Dordrecht, Netherlands)

Open PubMed

terminated

Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.

Human-study daily dose signal: 250 mg-10000 mg/day (confidence HIGH).

Extracted from 16 dosing mentions across 6 PubMed studies (mg/day).

Open mention
https://pubmed.ncbi.nlm.nih.gov/?term=(%22beta%20glucan%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%20meta-analysis%5BPublication%20Type%5D
  • https://pubmed.ncbi.nlm.nih.gov/?term=(%22beta%20glucan%22)%20AND%20humans%5BMeSH%20Terms%5D%20AND%20(supplement*%5BTitle%2FAbstract%5D%20OR%20supplementation%5BTitle%2FAbstract%5D%20OR%20intake%5BTitle%2FAbstract%5D%20OR%20dietary%20supplements%5BMeSH%20Terms%5D)%20AND%202018%3A3000%5Bpdat%5D
  • https://pubmed.ncbi.nlm.nih.gov/26001090/
  • https://pubmed.ncbi.nlm.nih.gov/41540766/
  • https://pubmed.ncbi.nlm.nih.gov/38777445/
  • https://pubmed.ncbi.nlm.nih.gov/28251654/
  • https://pubmed.ncbi.nlm.nih.gov/39832981/
  • https://pubmed.ncbi.nlm.nih.gov/36657917/
  • https://pubmed.ncbi.nlm.nih.gov/37960157/
  • https://pubmed.ncbi.nlm.nih.gov/40746014/
  • https://pubmed.ncbi.nlm.nih.gov/23340963/
  • https://pubmed.ncbi.nlm.nih.gov/34977959/
  • https://pubmed.ncbi.nlm.nih.gov/31816842/
  • https://pubmed.ncbi.nlm.nih.gov/40516031/
  • https://pubmed.ncbi.nlm.nih.gov/27724985/
  • https://pubmed.ncbi.nlm.nih.gov/25668347/
  • https://pubmed.ncbi.nlm.nih.gov/27273067/
  • Community Sources

    • https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=%22beta%20glucan%22%20(supplement%20OR%20dosage%20OR%20stack%20OR%20side%20effects%20OR%20review)%20(subreddit%3ASupplements%20OR%20subreddit%3ANootropics%20OR%20subreddit%3ABiohackers%20OR%20subreddit%3Alongevity%20OR%20subreddit%3ANutrition%20OR%20subreddit%3AHubermanLab%20OR%20subreddit%3ASleep%20OR%20subreddit%3AFitness%20OR%20subreddit%3Aketoscience%20OR%20subreddit%3AStackAdvice)
    • https://old.reddit.com/r/Biohackers/comments/1r1n771/organic_mushrooms_lions_mane_90_fruiting_body_10/.json?raw_json=1&sort=top&limit=25
    • https://old.reddit.com/r/Biohackers/comments/1o6m9ov/what_do_you_think_of_my_stack/.json?raw_json=1&sort=top&limit=25
    • https://old.reddit.com/r/Supplements/comments/1l4w4jn/best_psyllium_husk_supplement_in_the_uk_or_safer/.json?raw_json=1&sort=top&limit=25
    • https://www.reddit.com/search/?q=Beta-Glucans%20(1%2C3%2F1%2C6-%CE%B2-D-glucan)
    Open source
    3. Baker's yeast β-glucan and post-exercise immunity in marathon runners

    RCT • 2009 • Adults

    182 marathon runners.

    Outcome: 250 mg/day Wellmune β-glucan for 4 weeks post-marathon reduced URTI incidence by 37% and improved vigor ratings vs placebo.[1320,1361,1376, etc.]

    Open source
    4. PubMed evidence summary: Beta Glucan

    PUBMED • Humans + preclinical triage

    Counts aggregated from automated literature sweep and tiering rules.

    Outcome: Tier HIGH; humans 355, RCTs 105, meta-analyses 16.[1320,1361,1376, etc.]

    Open source
    5. A systematic review and meta-analysis of beta-glucan consumption on glycemic control in hypercholesterolemic individuals.

    PUBMED • 2015 • Human evidence curation set

    PMID 26001090 from International journal of food sciences and nutrition.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    6. Adaptogenic Effects of Mushroom Blend Supplementation on Stress, Fatigue, and Sleep: A Randomised, Double-Blind, and Placebo-Controlled Trial.

    PUBMED • 2026 • Human evidence curation set

    PMID 41540766 from Brain and behavior.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    7. Effect of combination of Beta Glucan and Lactobacillus rhamnosus HerizI on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: A randomized double-blind placebo-controlled clinical trial.

    PUBMED • 2024 • Human evidence curation set

    PMID 38777445 from Clinical nutrition ESPEN.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    8. Effect of a polysaccharide-rich hydrolysate from Saccharomyces cerevisiae (LipiGo®) in body weight loss: randomised, double-blind, placebo-controlled clinical trial in overweight and obese adults.

    PUBMED • 2017 • Human evidence curation set

    PMID 28251654 from Journal of the science of food and agriculture.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    9. Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: protocol for a randomised, double-blinded, placebo-controlled, parallel-group study.

    PUBMED • 2025 • Human evidence curation set

    PMID 39832981 from BMJ open.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    10. The separate effects of whole oats and isolated beta-glucan on lipid profile: A systematic review and meta-analysis of randomized controlled trials.

    PUBMED • 2023 • Human evidence curation set

    PMID 36657917 from Clinical nutrition ESPEN.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    11. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.

    PUBMED • 2023 • Human evidence curation set

    PMID 37960157 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    12. Yeast Beta-Glucan Enhances Antibody Response Following Influenza Vaccination - A Double-Blind, Randomized, Placebo-Controlled Pilot Trial.

    PUBMED • 2025 • Human evidence curation set

    PMID 40746014 from Journal of dietary supplements.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    13. Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body's defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects.

    PUBMED • 2013 • Human evidence curation set

    PMID 23340963 from European journal of nutrition.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    14. Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials.

    PUBMED • 2022 • Human evidence curation set

    PMID 34977959 from European journal of nutrition.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    15. Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

    PUBMED • 2019 • Human evidence curation set

    PMID 31816842 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    16. Impact of non-digestible carbohydrates and prebiotics on immunity, infections, inflammation and vaccine responses: a systematic review of evidence in healthy humans and a discussion of mechanistic proposals.

    PUBMED • 2026 • Human evidence curation set

    PMID 40516031 from Critical reviews in food science and nutrition.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    17. The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials.

    PUBMED • 2016 • Human evidence curation set

    PMID 27724985 from The British journal of nutrition.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    18. Effects of dietary fibre type on blood pressure: a systematic review and meta-analysis of randomized controlled trials of healthy individuals.

    PUBMED • 2015 • Human evidence curation set

    PMID 25668347 from Journal of hypertension.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    19. A systematic review and meta-analysis of randomized controlled trials of the effect of barley β-glucan on LDL-C, non-HDL-C and apoB for cardiovascular disease risk reduction(i-iv).

    PUBMED • 2016 • Human evidence curation set

    PMID 27273067 from European journal of clinical nutrition.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    20. Effects of Oat Beta-Glucan Intake on Lipid Profiles in Hypercholesterolemic Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    PUBMED • 2022 • Human evidence curation set

    PMID 35631184 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    21. Soluble and Insoluble Yeast β-Glucan Differentially Affect Upper Respiratory Tract Infection in Marathon Runners: A Double-Blind, Randomized Placebo-Controlled Trial.

    PUBMED • 2020 • Human evidence curation set

    PMID 31573387 from Journal of medicinal food.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    22. Effects of Yeast (1,3)-(1,6)-Beta-Glucan on Severity of Upper Respiratory Tract Infections: A Double-Blind, Randomized, Placebo-Controlled Study in Healthy Subjects.

    PUBMED • 2019 • Human evidence curation set

    PMID 30198828 from Journal of the American College of Nutrition.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    23. Galactomannans are the most effective soluble dietary fibers in type 2 diabetes: a systematic review and network meta-analysis.

    PUBMED • 2023 • Human evidence curation set

    PMID 36811560 from The American journal of clinical nutrition.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    24. The Metabolic Effects of Oats Intake in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.

    PUBMED • 2015 • Human evidence curation set

    PMID 26690472 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    25. Effect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials.

    PUBMED • 2016 • Human evidence curation set

    PMID 26771637 from Nutrients.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    26. Effect of beta glucan on white blood cell counts and serum levels of IL-4 and IL-12 in women with breast cancer undergoing chemotherapy: a randomized double-blind placebo-controlled clinical trial.

    PUBMED • 2014 • Human evidence curation set

    PMID 25081694 from Asian Pacific journal of cancer prevention : APJCP.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    27. Effect of Oat Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    PUBMED • 2023 • Human evidence curation set

    PMID 36435335 from Journal of the Academy of Nutrition and Dietetics.

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    28. Effect of high beta-glucan barley on serum cholesterol concentrations and visceral fat area in Japanese men--a randomized, double-blinded, placebo-controlled trial.

    PUBMED • 2008 • Human evidence curation set

    PMID 18074229 from Plant foods for human nutrition (Dordrecht, Netherlands).

    Outcome: See linked PubMed abstract for methods and outcomes.[1320,1361,1376, etc.]

    Open source
    29. Effects of cereal beta-glucan consumption on body weight, body mass index, waist circumference and total energy intake: A meta-analysis of randomized controlled trials.

    META_ANALYSIS • 2019 • PubMed indexed study

    PMID 30935520 from Complementary therapies in medicine.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.2/10.[1320,1361,1376, etc.]

    Open source
    30. Effects of cereal fibers on short-chain fatty acids in healthy subjects and patients: a meta-analysis of randomized clinical trials.

    META_ANALYSIS • 2021 • PubMed indexed study

    PMID 34152334 from Food & function.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.2/10.[1320,1361,1376, etc.]

    Open source
    31. Supplementation with a β-glucan tablet has no effect on hyperlipidemia: a randomized, placebo-controlled clinical trial.

    RCT • 2023 • PubMed indexed study

    PMID 37054888 from The American journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 9.2/10.[1320,1361,1376, etc.]

    Open source
    32. The effect of viscous soluble fiber on blood pressure: A systematic review and meta-analysis of randomized controlled trials.

    META_ANALYSIS • 2018 • PubMed indexed study

    PMID 29153856 from Nutrition, metabolism, and cardiovascular diseases : NMCD.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.1/10.[1320,1361,1376, etc.]

    Open source
    33. The difference between oats and beta-glucan extract intake in the management of HbA1c, fasting glucose and insulin sensitivity: a meta-analysis of randomized controlled trials.

    META_ANALYSIS • 2016 • PubMed indexed study

    PMID 26840185 from Food & function.

    Outcome: Study design: META_ANALYSIS. Quality score: 9.1/10.[1320,1361,1376, etc.]

    Open source
    34. Increasing oat β-glucan viscosity in a breakfast meal slows gastric emptying and reduces glycemic and insulinemic responses but has no effect on appetite, food intake, or plasma ghrelin and PYY responses in healthy humans: a randomized, placebo-controlled, crossover trial.

    RCT • 2020 • PubMed indexed study

    PMID 31828287 from The American journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 9.1/10.[1320,1361,1376, etc.]

    Open source
    35. Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study.

    RCT • 2007 • PubMed indexed study

    PMID 17523328 from Hepato-gastroenterology.

    Outcome: Study design: RCT. Quality score: 9.1/10.[1320,1361,1376, etc.]

    Open source
    36. Impact of Dietary Supplements on Clinical Outcomes and Quality of Life in Patients with Breast Cancer: A Systematic Review.

    SYSTEMATIC_REVIEW • 2025 • PubMed indexed study

    PMID 40290044 from Nutrients.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 9.1/10.[1320,1361,1376, etc.]

    Open source
    37. Meta-analysis of the effect of β-glucan intake on blood cholesterol and glucose levels.

    META_ANALYSIS • 2011 • PubMed indexed study

    PMID 21470820 from Nutrition (Burbank, Los Angeles County, Calif.).

    Outcome: Study design: META_ANALYSIS. Quality score: 9.0/10.[1320,1361,1376, etc.]

    Open source
    38. The effects of waxy barley on defecation, sleep, mental health, and quality of life: a randomized double-blind parallel-group comparison study.

    RCT • 2025 • PubMed indexed study

    PMID 40336123 from Journal of physiological anthropology.

    Outcome: Study design: RCT. Quality score: 8.8/10.[1320,1361,1376, etc.]

    Open source
    39. A randomized Placebo-Controlled Clinical Trial to Evaluate the Medium-Term Effects of Oat Fibers on Human Health: The Beta-Glucan Effects on Lipid Profile, Glycemia and inTestinal Health (BELT) Study.

    RCT • 2020 • PubMed indexed study

    PMID 32138344 from Nutrients.

    Outcome: Study design: RCT. Quality score: 8.8/10.[1320,1361,1376, etc.]

    Open source
    40. Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial.

    RCT • 2020 • PubMed indexed study

    PMID 32629992 from Nutrients.

    Outcome: Study design: RCT. Quality score: 8.8/10.[1320,1361,1376, etc.]

    Open source
    41. Six Weeks of Baker's Yeast β-Glucan Supplementation Reveals Unique Immune Maturation mRNA Signature: Implications for Immunity?

    RCT • 2026 • PubMed indexed study

    PMID 41596240 from International journal of molecular sciences.

    Outcome: Study design: RCT. Quality score: 8.8/10.[1320,1361,1376, etc.]

    Open source
    42. Effect of Oat (Avena sativa L.) Consumption on Lipid Profile With Focus on Triglycerides and High-density Lipoprotein Cholesterol (HDL-C): An Updated Systematic Review.

    SYSTEMATIC_REVIEW • 2023 • PubMed indexed study

    PMID 35192870 from Current problems in cardiology.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.8/10.[1320,1361,1376, etc.]

    Open source
    43. Novel nutraceutical supplements with yeast β-glucan, prebiotics, minerals, and Silybum marianum (silymarin) ameliorate obesity-related metabolic and clinical parameters: A double-blind randomized trial.

    RCT • 2022 • PubMed indexed study

    PMID 36778595 from Frontiers in endocrinology.

    Outcome: Study design: RCT. Quality score: 8.7/10.[1320,1361,1376, etc.]

    Open source
    44. A randomised controlled trial of a probiotic and a prebiotic examining metabolic and mental health outcomes in adults with pre-diabetes.

    RCT • 2022 • PubMed indexed study

    PMID 35332040 from BMJ open.

    Outcome: Study design: RCT. Quality score: 8.7/10.[1320,1361,1376, etc.]

    Open source
    45. Acute effect of oat β-glucan on the bioavailability of orange juice flavanones.

    RCT • 2022 • PubMed indexed study

    PMID 34933644 from International journal of food sciences and nutrition.

    Outcome: Study design: RCT. Quality score: 8.7/10.[1320,1361,1376, etc.]

    Open source
    46. Sixteen-week multicentre randomised controlled trial to study the effect of the consumption of an oat beta-glucan-enriched bread versus a whole-grain wheat bread on glycaemic control among persons with pre-diabetes: a study protocol of the CarbHealth study.

    RCT • 2022 • PubMed indexed study

    PMID 35998955 from BMJ open.

    Outcome: Study design: RCT. Quality score: 8.7/10.[1320,1361,1376, etc.]

    Open source
    47. Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome.

    RCT • 2017 • PubMed indexed study

    PMID 28724171 from European review for medical and pharmacological sciences.

    Outcome: Study design: RCT. Quality score: 8.6/10.[1320,1361,1376, etc.]

    Open source
    48. Effects of high β-glucan barley on visceral fat obesity in Japanese individuals: A randomized, double-blind study.

    RCT • 2017 • PubMed indexed study

    PMID 28870472 from Nutrition (Burbank, Los Angeles County, Calif.).

    Outcome: Study design: RCT. Quality score: 8.6/10.[1320,1361,1376, etc.]

    Open source
    49. Beta-glucan, immune function, and upper respiratory tract infections in athletes.

    RCT • 2008 • PubMed indexed study

    PMID 18614945 from Medicine and science in sports and exercise.

    Outcome: Study design: RCT. Quality score: 8.5/10.[1320,1361,1376, etc.]

    Open source
    50. [Combination of early nasojejunal feeding with modern synbiotic therapy in the treatment of severe acute pancreatitis (prospective, randomized, double-blind study)].

    RCT • 2005 • PubMed indexed study

    PMID 16167471 from Magyar sebeszet.

    Outcome: Study design: RCT. Quality score: 8.5/10.[1320,1361,1376, etc.]

    Open source
    51. The effect of fiber on satiety and food intake: a systematic review.

    SYSTEMATIC_REVIEW • 2013 • PubMed indexed study

    PMID 23885994 from Journal of the American College of Nutrition.

    Outcome: Study design: SYSTEMATIC_REVIEW. Quality score: 8.5/10.[1320,1361,1376, etc.]

    Open source
    52. Food 4 Health - He Oranga Kai: Assessing the efficacy, acceptability and economic implications of Lactobacillus rhamnosus HN001 and β-glucan to improve glycated haemoglobin, metabolic health, and general well-being in adults with pre-diabetes: study protocol for a 2 × 2 factorial design, parallel group, placebo-controlled randomized controlled trial, with embedded qualitative study and economic analysis.

    RCT • 2019 • PubMed indexed study

    PMID 31358022 from Trials.

    Outcome: Study design: RCT. Quality score: 8.5/10.[1320,1361,1376, etc.]

    Open source
    53. Effectiveness of regular oat β-glucan-enriched bread compared with whole-grain wheat bread on long-term glycemic control in adults at risk of type 2 diabetes: a randomized controlled trial.

    RCT • 2025 • PubMed indexed study

    PMID 40571100 from The American journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.4/10.[1320,1361,1376, etc.]

    Open source
    54. Beneficial effects of pleuran on asthma control and respiratory tract-infection frequency in children with perennial asthma.

    RCT • 2025 • PubMed indexed study

    PMID 40021713 from Scientific reports.

    Outcome: Study design: RCT. Quality score: 8.4/10.[1320,1361,1376, etc.]

    Open source
    55. Nutraceutical composition (yeast β-glucan, prebiotics, minerals, and silymarin) predicts improvement of sleep quality and metabolic parameters: A randomized pilot study.

    RCT • 2024 • PubMed indexed study

    PMID 39012843 from Clinical nutrition ESPEN.

    Outcome: Study design: RCT. Quality score: 8.4/10.[1320,1361,1376, etc.]

    Open source
    56. High molecular weight oat β-glucan enhances lipid-lowering effects of phytosterols. A randomised controlled trial.

    RCT • 2020 • PubMed indexed study

    PMID 30792143 from Clinical nutrition (Edinburgh, Scotland).

    Outcome: Study design: RCT. Quality score: 8.3/10.[1320,1361,1376, etc.]

    Open source
    57. Supplementation with a soluble β-glucan exported from Shiitake medicinal mushroom, Lentinus edodes (Berk.) singer mycelium: a crossover, placebo-controlled study in healthy elderly.

    RCT • 2011 • PubMed indexed study

    PMID 22164761 from International journal of medicinal mushrooms.

    Outcome: Study design: RCT. Quality score: 8.3/10.[1320,1361,1376, etc.]

    Open source
    58. Modulation of human intestinal microbiota in a clinical trial by consumption of a β-D-glucan-enriched extract obtained from Lentinula edodes.

    RCT • 2021 • PubMed indexed study

    PMID 33580297 from European journal of nutrition.

    Outcome: Study design: RCT. Quality score: 8.3/10.[1320,1361,1376, etc.]

    Open source
    59. Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial.

    RCT • 2015 • PubMed indexed study

    PMID 26424589 from Journal of diabetes and its complications.

    Outcome: Study design: RCT. Quality score: 8.2/10.[1320,1361,1376, etc.]

    Open source
    60. Similar metabolic responses in pigs and humans to breads with different contents and compositions of dietary fibers: a metabolomics study.

    RCT • 2014 • PubMed indexed study

    PMID 24477039 from The American journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.2/10.[1320,1361,1376, etc.]

    Open source
    61. The impact of soluble dietary fibre on gastric emptying, postprandial blood glucose and insulin in patients with type 2 diabetes.

    RCT • 2014 • PubMed indexed study

    PMID 24901089 from Asia Pacific journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.2/10.[1320,1361,1376, etc.]

    Open source
    62. Effects of concentrated arabinoxylan and β-glucan compared with refined wheat and whole grain rye on glucose and appetite in subjects with the metabolic syndrome: a randomized study.

    RCT • 2014 • PubMed indexed study

    PMID 24253758 from European journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.2/10.[1320,1361,1376, etc.]

    Open source
    63. Efficacy of Food Industry By-Product β-Glucan/Chitin-Chitosan on Lipid Profile of Overweight and Obese Individuals: Sustainability and Nutraceuticals.

    RCT • 2024 • PubMed indexed study

    PMID 39408385 from Nutrients.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    64. Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention.

    RCT • 2023 • PubMed indexed study

    PMID 37432380 from Nutrients.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    65. Oat beta-glucan supplementation does not enhance the effectiveness of an energy-restricted diet in overweight women.

    RCT • 2010 • PubMed indexed study

    PMID 19930764 from The British journal of nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    66. No effect of added beta-glucan or of fructooligosaccharide on appetite or energy intake.

    RCT • 2009 • PubMed indexed study

    PMID 19056555 from The American journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    67. Baker's yeast β-glucan supplementation increases monocytes and cytokines post-exercise: implications for infection risk?

    RCT • 2013 • PubMed indexed study

    PMID 22575076 from The British journal of nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    68. Simultaneous intake of beta-glucan and plant stanol esters affects lipid metabolism in slightly hypercholesterolemic subjects.

    RCT • 2007 • PubMed indexed study

    PMID 17311944 from The Journal of nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    69. Supplementation of a high-carbohydrate breakfast with barley beta-glucan improves postprandial glycaemic response for meals but not beverages.

    RCT • 2007 • PubMed indexed study

    PMID 17215176 from Asia Pacific journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    70. Effects of Chronic Barley Consumption on Upper Respiratory Tract Symptoms in Japanese Healthy Adults: A Randomized, Parallel-Group, Controlled Trial.

    RCT • 2024 • PubMed indexed study

    PMID 39064742 from Nutrients.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    71. Carbohydrate digestion in humans from a beta-glucan-enriched barley is reduced.

    RCT • 2002 • PubMed indexed study

    PMID 12221214 from The Journal of nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    72. Fibre in beverages can enhance perceived satiety.

    RCT • 2009 • PubMed indexed study

    PMID 19306033 from European journal of nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    73. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial.

    RCT • 2002 • PubMed indexed study

    PMID 11976156 from The American journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    74. Glucose and insulin responses to whole grain breakfasts varying in soluble fiber, beta-glucan: a dose response study in obese women with increased risk for insulin resistance.

    RCT • 2009 • PubMed indexed study

    PMID 19205780 from European journal of nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    75. Cholesterol-lowering effect of beta-glucan from oat bran in mildly hypercholesterolemic subjects may decrease when beta-glucan is incorporated into bread and cookies.

    RCT • 2003 • PubMed indexed study

    PMID 12885701 from The American journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    76. Modest doses of beta-glucan do not reduce concentrations of potentially atherogenic lipoproteins.

    RCT • 2000 • PubMed indexed study

    PMID 10871560 from The American journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    77. Effects of oat gum on blood cholesterol levels in healthy young men.

    RCT • 1995 • PubMed indexed study

    PMID 7588502 from European journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    78. Barley and wheat foods: influence on plasma cholesterol concentrations in hypercholesterolemic men.

    RCT • 1991 • PubMed indexed study

    PMID 1850576 from The American journal of clinical nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    79. Oat consumption does not affect resting casual and ambulatory 24-h arterial blood pressure in men with high-normal blood pressure to stage I hypertension.

    RCT • 2002 • PubMed indexed study

    PMID 11880561 from The Journal of nutrition.

    Outcome: Study design: RCT. Quality score: 8.1/10.[1320,1361,1376, etc.]

    Open source
    80. Yeast Beta-Glucan Supplementation Downregulates Markers of Systemic Inflammation after Heated Treadmill Exercise.

    RCT • 2020 • PubMed indexed study

    PMID 32325856 from Nutrients.

    Outcome: Study design: RCT. Quality score: 8.0/10.[1320,1361,1376, etc.]

    Open source
    81. Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial.

    RCT • 2020 • PubMed indexed study

    PMID 30380356 from Journal of dietary supplements.

    Outcome: Study design: RCT. Quality score: 8.0/10.[1320,1361,1376, etc.]

    Open source
    82. Improved Glycemic Control and Variability: Application of Healthy Ingredients in Asian Staples.

    RCT • 2021 • PubMed indexed study

    PMID 34578981 from Nutrients.

    Outcome: Study design: RCT. Quality score: 8.0/10.[1320,1361,1376, etc.]

    Open source
    83. Yeast β-Glucan Modulates Inflammation and Waist Circumference in Overweight and Obese Subjects.

    RCT • 2017 • PubMed indexed study

    PMID 27715351 from Journal of dietary supplements.

    Outcome: Study design: RCT. Quality score: 7.9/10.[1320,1361,1376, etc.]

    Open source
    84. β-Glucan and dark chocolate: a randomized crossover study on short-term satiety and energy intake.

    RCT • 2014 • PubMed indexed study

    PMID 25251294 from Nutrients.

    Outcome: Study design: RCT. Quality score: 7.9/10.[1320,1361,1376, etc.]

    Open source
    85. The role of meal viscosity and oat β-glucan characteristics in human appetite control: a randomized crossover trial.

    RCT • 2014 • PubMed indexed study

    PMID 24884934 from Nutrition journal.

    Outcome: Study design: RCT. Quality score: 7.9/10.[1320,1361,1376, etc.]

    Open source
    86. A Multifunctional Bread Rich in Beta Glucans and Low in Starch Improves Metabolic Control in Type 2 Diabetes: A Controlled Trial.

    RCT • 2017 • PubMed indexed study

    PMID 28304350 from Nutrients.

    Outcome: Study design: RCT. Quality score: 7.9/10.[1320,1361,1376, etc.]

    Open source
    87. Cow's milk-based beverage consumption in 1- to 4-year-olds and allergic manifestations: an RCT.

    RCT • 2016 • PubMed indexed study

    PMID 26920136 from Nutrition journal.

    Outcome: Study design: RCT. Quality score: 7.9/10.[1320,1361,1376, etc.]

    Open source
    88. Effect of Consuming Oat Bran Mixed in Water before a Meal on Glycemic Responses in Healthy Humans-A Pilot Study.

    RCT • 2016 • PubMed indexed study

    PMID 27571099 from Nutrients.

    Outcome: Study design: RCT. Quality score: 7.9/10.[1320,1361,1376, etc.]

    Open source
    89. Effect of oat β-glucan in managing blood pressure: a randomized cross-over pilot trial.

    RCT • 2025 • PubMed indexed study

    PMID 41031804 from Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

    Outcome: Study design: RCT. Quality score: 7.8/10.[1320,1361,1376, etc.]

    Open source
    90. Benefits of Gut Microbiota Reconstitution by Beta 1,3-1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases.

    RCT • 2023 • PubMed indexed study

    PMID 36093695 from Journal of Alzheimer's disease : JAD.

    Outcome: Study design: RCT. Quality score: 7.8/10.[1320,1361,1376, etc.]

    Open source
    91. Novel Chewable Pleuran-Based Supplement Decreases Respiratory Tract Infections in Children: A Randomised Controlled Trial.

    RCT • 2025 • PubMed indexed study

    PMID 41085920 from Advances in therapy.

    Outcome: Study design: RCT. Quality score: 7.8/10.[1320,1361,1376, etc.]

    Open source
    92. Baker's yeast beta glucan supplementation was associated with an improved innate immune mRNA expression response after exercise.

    RCT • 2024 • PubMed indexed study

    PMID 39097177 from Methods (San Diego, Calif.).

    Outcome: Study design: RCT. Quality score: 7.8/10.[1320,1361,1376, etc.]

    Open source
    93. Combined effect of polycan, a β-glucan from Aureobasidium pullulans, and regular resistance exercise on muscle strength, biomarkers, and fitness profiles in adults with relatively low skeletal muscle mass: a randomised controlled trial.

    RCT • 2023 • PubMed indexed study

    PMID 37350091 from Food & function.

    Outcome: Study design: RCT. Quality score: 7.8/10.[1320,1361,1376, etc.]

    Open source
    94. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise.

    RCT • 2013 • PubMed indexed study

    PMID 23927572 from Journal of dietary supplements.

    Outcome: Study design: RCT. Quality score: 7.8/10.[1320,1361,1376, etc.]

    Open source
    95. Effects of Nichi BRITE β-glucans as an onco-nutrition adjuvant in patients undergoing subtotal stomach-preserving pancreaticoduodenectomy (SSPPD) for pancreatic, bile duct and duodenal malignancies: A clinical study.

    RCT • 2025 • PubMed indexed study

    PMID 40383031 from Nutrition (Burbank, Los Angeles County, Calif.).

    Outcome: Study design: RCT. Quality score: 7.8/10.[1320,1361,1376, etc.]

    Open source
    96. The Prebiotic Effects of Oats on Blood Lipids, Gut Microbiota, and Short-Chain Fatty Acids in Mildly Hypercholesterolemic Subjects Compared With Rice: A Randomized, Controlled Trial.

    RCT • 2021 • PubMed indexed study

    PMID 34956218 from Frontiers in immunology.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1320,1361,1376, etc.]

    Open source
    97. Effects of β-glucan and inulin consumption on postprandial appetite, energy intake and food consumption in healthy females: A randomized controlled trial.

    RCT • 2022 • PubMed indexed study

    PMID 34128426 from Nutrition and health.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1320,1361,1376, etc.]

    Open source
    98. Potentially Beneficial Effects on Healthy Aging by Supplementation of the EPA-Rich Microalgae Phaeodactylum tricornutum or Its Supernatant-A Randomized Controlled Pilot Trial in Elderly Individuals.

    RCT • 2022 • PubMed indexed study

    PMID 36421994 from Marine drugs.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1320,1361,1376, etc.]

    Open source
    99. Barley malt-based composition as a galactagogue - a randomized, controlled trial in preterm mothers.

    RCT • 2021 • PubMed indexed study

    PMID 33751522 from Ginekologia polska.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1320,1361,1376, etc.]

    Open source
    100. Beneficial effects of novel aureobasidium pullulans strains produced beta-1,3-1,6 glucans on interleukin-6 and D-dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study.

    RCT • 2022 • PubMed indexed study

    PMID 34840031 from Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1320,1361,1376, etc.]

    Open source
    101. Serum Metabolomics Reveals Underlying Mechanisms of Cholesterol-Lowering Effects of Oat Consumption: A Randomized Controlled Trial in a Mildly Hypercholesterolemic Population.

    RCT • 2021 • PubMed indexed study

    PMID 33793078 from Molecular nutrition & food research.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1320,1361,1376, etc.]

    Open source
    102. Primary care experience on Stimunex(®) gocce in children with recurrent respiratory infections: a real-world study during the COVID-19 pandemic era.

    RCT • 2022 • PubMed indexed study

    PMID 35527651 from Allergologia et immunopathologia.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1320,1361,1376, etc.]

    Open source
    103. A Quality-of-Life Study in Healthy Adults Supplemented with Lentinex® Beta-Glucan of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes).

    RCT • 2020 • PubMed indexed study

    PMID 32749096 from International journal of medicinal mushrooms.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1320,1361,1376, etc.]

    Open source
    104. Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials.

    RCT • 2020 • PubMed indexed study

    PMID 32534175 from Medical hypotheses.

    Outcome: Study design: RCT. Quality score: 7.7/10.[1320,1361,1376, etc.]

    Open source
    105. Effects of oat β-glucan consumption at breakfast on ad libitum eating, appetite, glycemia, insulinemia and GLP-1 concentrations in healthy subjects.

    RCT • 2018 • PubMed indexed study

    PMID 29920323 from Appetite.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1320,1361,1376, etc.]

    Open source
    106. Molecular weight of barley β-glucan does not influence satiety or energy intake in healthy male subjects.

    RCT • 2014 • PubMed indexed study

    PMID 25106092 from Appetite.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1320,1361,1376, etc.]

    Open source
    107. Effect of consuming novel foods consisting high oleic canola oil, barley β-glucan, and DHA on cardiovascular disease risk in humans: the CONFIDENCE (Canola Oil and Fibre with DHA Enhanced) study - protocol for a randomized controlled trial.

    RCT • 2015 • PubMed indexed study

    PMID 26518870 from Trials.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1320,1361,1376, etc.]

    Open source
    108. Effect of cooked white rice with high β-glucan barley on appetite and energy intake in healthy Japanese subjects: a randomized controlled trial.

    RCT • 2014 • PubMed indexed study

    PMID 25139426 from Plant foods for human nutrition (Dordrecht, Netherlands).

    Outcome: Study design: RCT. Quality score: 7.6/10.[1320,1361,1376, etc.]

    Open source
    109. Instant Oatmeal Increases Satiety and Reduces Energy Intake Compared to a Ready-to-Eat Oat-Based Breakfast Cereal: A Randomized Crossover Trial.

    RCT • 2016 • PubMed indexed study

    PMID 26273900 from Journal of the American College of Nutrition.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1320,1361,1376, etc.]

    Open source
    110. Acute effects of protein composition and fibre enrichment of yogurt consumed as snacks on appetite sensations and subsequent ad libitum energy intake in healthy men.

    RCT • 2015 • PubMed indexed study

    PMID 26394259 from Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1320,1361,1376, etc.]

    Open source
    111. Follow-up formula consumption in 3- to 4-year-olds and respiratory infections: an RCT.

    RCT • 2014 • PubMed indexed study

    PMID 24843061 from Pediatrics.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1320,1361,1376, etc.]

    Open source
    112. Supplementation of Caricol®-Gastro reduces chronic gastritis disease associated pain.

    RCT • 2018 • PubMed indexed study

    PMID 29604620 from Neuro endocrinology letters.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1320,1361,1376, etc.]

    Open source
    113. [Comparison of a commercially available, formula-based nutritional therapy enriched with oats fiber with a non-formula isocaloric therapy to treat non-alcoholic fatty liver disease (NAFLD) - a randomized, controlled intervention trial].

    RCT • 2018 • PubMed indexed study

    PMID 30304749 from Zeitschrift fur Gastroenterologie.

    Outcome: Study design: RCT. Quality score: 7.6/10.[1320,1361,1376, etc.]

    Open source
    114. Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes.

    RCT • 2011 • PubMed indexed study

    PMID 21249381 from European journal of applied physiology.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    115. Baker's yeast beta-glucan supplement reduces upper respiratory symptoms and improves mood state in stressed women.

    RCT • 2012 • PubMed indexed study

    PMID 23378458 from Journal of the American College of Nutrition.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    116. beta-Glucan-enriched bread reduces energy intake and modifies plasma ghrelin and peptide YY concentrations in the short term.

    RCT • 2009 • PubMed indexed study

    PMID 19631705 from Appetite.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    117. Oat prevents obesity and abdominal fat distribution, and improves liver function in humans.

    RCT • 2013 • PubMed indexed study

    PMID 23371785 from Plant foods for human nutrition (Dordrecht, Netherlands).

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    118. Effect of Pleuran (β-glucan from Pleurotus ostreatus) supplementation on cellular immune response after intensive exercise in elite athletes.

    RCT • 2010 • PubMed indexed study

    PMID 21164546 from Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    119. Physiological effects of concentrated barley beta-glucan in mildly hypercholesterolemic adults.

    RCT • 2008 • PubMed indexed study

    PMID 18838533 from Journal of the American College of Nutrition.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    120. Sugar and dietary fibre composition influence, by different hormonal response, the satiating capacity of a fruit-based and a β-glucan-enriched beverage.

    RCT • 2012 • PubMed indexed study

    PMID 22057424 from Food & function.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    121. Serum lipids and postprandial glucose and insulin levels in hyperlipidemic subjects after consumption of an oat beta-glucan-containing ready meal.

    RCT • 2008 • PubMed indexed study

    PMID 18334815 from Annals of nutrition & metabolism.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    122. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial.

    RCT • 2002 • PubMed indexed study

    PMID 11978262 from The Journal of family practice.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    123. Effect of muesli with 4 g oat beta-glucan on postprandial blood glucose, gastric emptying and satiety in healthy subjects: a randomized crossover trial.

    RCT • 2008 • PubMed indexed study

    PMID 18978166 from Journal of the American College of Nutrition.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    124. Satiating effect of a barley beta-glucan-enriched snack.

    RCT • 2010 • PubMed indexed study

    PMID 20679146 from Journal of the American College of Nutrition.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    125. Acute effect of oatmeal on subjective measures of appetite and satiety compared to a ready-to-eat breakfast cereal: a randomized crossover trial.

    RCT • 2013 • PubMed indexed study

    PMID 24024772 from Journal of the American College of Nutrition.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    126. Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections.

    RCT • 2013 • PubMed indexed study

    PMID 23261366 from International immunopharmacology.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    127. Reduced serum cholesterol with dietary change using fat-modified and oat bran supplemented diets.

    RCT • 1990 • PubMed indexed study

    PMID 2154513 from Journal of the American Dietetic Association.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    128. Oat bran concentrate bread products improve long-term control of diabetes: a pilot study.

    RCT • 1996 • PubMed indexed study

    PMID 8948386 from Journal of the American Dietetic Association.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    129. The effect of strawberries in a cholesterol-lowering dietary portfolio.

    RCT • 2008 • PubMed indexed study

    PMID 19013285 from Metabolism: clinical and experimental.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    130. Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2 diabetic men.

    RCT • 2002 • PubMed indexed study

    PMID 12077724 from Metabolism: clinical and experimental.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    131. Effect of eicosapentaenoic/docosahexaenoic fatty acids and soluble fibers on blood lipids of individuals classified into different levels of lipidemia.

    RCT • 2007 • PubMed indexed study

    PMID 17234506 from Nutrition (Burbank, Los Angeles County, Calif.).

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    132. Acute effects of oats and vitamin E on endothelial responses to ingested fat.

    RCT • 2001 • PubMed indexed study

    PMID 11165454 from American journal of preventive medicine.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    133. Consumption of oat milk for 5 weeks lowers serum cholesterol and LDL cholesterol in free-living men with moderate hypercholesterolemia.

    RCT • 1999 • PubMed indexed study

    PMID 10749030 from Annals of nutrition & metabolism.

    Outcome: Study design: RCT. Quality score: 7.5/10.[1320,1361,1376, etc.]

    Open source
    134. Bioavailability of orange juice (poly)phenols: β-glucan-rich oat bran decreases urinary excretion of flavanone phase II metabolites and enhances excretion of microbiota-derived phenolic catabolites.

    RCT • 2023 • PubMed indexed study

    PMID 36764628 from Free radical biology & medicine.

    Outcome: Study design: CONTROLLED_TRIAL. Quality score: 7.4/10.[1320,1361,1376, etc.]

    Open source
    135. Effects of β-glucan and Vitamin D Supplementation on Inflammatory Parameters in Patients with Diabetic Retinopathy.

    RCT • 2019 • PubMed indexed study

    PMID 29920123 from Journal of dietary supplements.

    Outcome: Study design: CONTROLLED_TRIAL. Quality score: 7.0/10.[1320,1361,1376, etc.]

    Open source
    136. Fermented Fiber Supplements Are No Better Than Placebo for a Laxative Effect.

    PUBMED • 2016 • PubMed indexed study

    PMID 27680987 from Digestive diseases and sciences.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 6.4/10.[1320,1361,1376, etc.]

    Open source
    137. The benefit of secondary prevention with oat fiber in reducing future cardiovascular event among CAD patients after coronary intervention.

    COHORT • 2019 • PubMed indexed study

    PMID 30816213 from Scientific reports.

    Outcome: Study design: COHORT. Quality score: 6.3/10.[1320,1361,1376, etc.]

    Open source
    138. The effect of cereal Β-glucan on body weight and adiposity: A review of efficacy and mechanism of action.

    PUBMED • 2023 • PubMed indexed study

    PMID 34727805 from Critical reviews in food science and nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1320,1361,1376, etc.]

    Open source
    139. Interaction between β-glucans and gut microbiota: a comprehensive review.

    PUBMED • 2024 • PubMed indexed study

    PMID 36975759 from Critical reviews in food science and nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1320,1361,1376, etc.]

    Open source
    140. Comparative study on static and dynamic digest characteristics of oat β-Glucan and β-Gluco-Oligosaccharides.

    COHORT • 2024 • PubMed indexed study

    PMID 39593365 from Food research international (Ottawa, Ont.).

    Outcome: Study design: COHORT. Quality score: 5.8/10.[1320,1361,1376, etc.]

    Open source
    141. Effects of fungal based bioactive compounds on human health: Review paper.

    PUBMED • 2024 • PubMed indexed study

    PMID 36794421 from Critical reviews in food science and nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1320,1361,1376, etc.]

    Open source
    142. Cauliflower mushroom (Sparassis): a promising functional food with nutritional and medicinal properties.

    PUBMED • 2026 • PubMed indexed study

    PMID 40583786 from Critical reviews in food science and nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1320,1361,1376, etc.]

    Open source
    143. An encompassing review of meta-analyses and systematic reviews of the effect of oats on all-cause mortality, cardiovascular risk, diabetes risk, body weight/adiposity and gut health.

    PUBMED • 2025 • PubMed indexed study

    PMID 39137936 from Critical reviews in food science and nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.8/10.[1320,1361,1376, etc.]

    Open source
    144. A comparative evaluation of the kefir yeast Kluyveromyces marxianus A4 and sulfasalazine in ulcerative colitis: anti-inflammatory impact and gut microbiota modulation.

    COHORT • 2024 • PubMed indexed study

    PMID 38833212 from Food & function.

    Outcome: Study design: COHORT. Quality score: 5.8/10.[1320,1361,1376, etc.]

    Open source
    145. β-glucan, "the knight of health sector": critical insights on physiochemical heterogeneities, action mechanisms and health implications.

    PUBMED • 2022 • PubMed indexed study

    PMID 33819119 from Critical reviews in food science and nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.7/10.[1320,1361,1376, etc.]

    Open source
    146. Evaluation of anti-inflammatory and immunoregulatory activities of Stimunex® and Stimunex D3® in human monocytes/macrophages stimulated with LPS or IL-4/IL-13.

    COHORT • 2020 • PubMed indexed study

    PMID 33080469 from Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

    Outcome: Study design: COHORT. Quality score: 5.7/10.[1320,1361,1376, etc.]

    Open source
    147. Vitamin D Treatment Sequence Is Critical for Transcriptome Modulation of Immune Challenged Primary Human Cells.

    COHORT • 2021 • PubMed indexed study

    PMID 34956186 from Frontiers in immunology.

    Outcome: Study design: COHORT. Quality score: 5.7/10.[1320,1361,1376, etc.]

    Open source
    148. Why dietary supplements?

    COHORT • 2014 • PubMed indexed study

    PMID 24843057 from Pediatrics.

    Outcome: Study design: COHORT. Quality score: 5.6/10.[1320,1361,1376, etc.]

    Open source
    149. Structural Characterization, Technological Functionality, and Physiological Aspects of Fungal β-D-glucans: A Review.

    PUBMED • 2016 • PubMed indexed study

    PMID 25830657 from Critical reviews in food science and nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.6/10.[1320,1361,1376, etc.]

    Open source
    150. Use of viscous fibres in beverages for appetite control: a review of studies.

    PUBMED • 2015 • PubMed indexed study

    PMID 26001088 from International journal of food sciences and nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.6/10.[1320,1361,1376, etc.]

    Open source
    151. Effect of beta-glucan from oats and yeast on serum lipids.

    PUBMED • 1999 • PubMed indexed study

    PMID 10198754 from Critical reviews in food science and nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1320,1361,1376, etc.]

    Open source
    152. Biomedical issues of dietary fiber beta-glucan.

    PUBMED • 2006 • PubMed indexed study

    PMID 17043406 from Journal of Korean medical science.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1320,1361,1376, etc.]

    Open source
    153. Pleuran (β-glucan from Pleurotus ostreatus ): an effective nutritional supplement against upper respiratory tract infections?

    PUBMED • 2012 • PubMed indexed study

    PMID 23075555 from Medicine and sport science.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1320,1361,1376, etc.]

    Open source
    154. Avena sativa (Oat), a potential neutraceutical and therapeutic agent: an overview.

    PUBMED • 2013 • PubMed indexed study

    PMID 23072529 from Critical reviews in food science and nutrition.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1320,1361,1376, etc.]

    Open source
    155. Effect of beta-glucan level in oat fiber extracts on blood lipids in men and women.

    COHORT • 1997 • PubMed indexed study

    PMID 9013433 from Journal of the American College of Nutrition.

    Outcome: Study design: COHORT. Quality score: 5.5/10.[1320,1361,1376, etc.]

    Open source
    156. Nutritional strategies to counter stress to the immune system in athletes, with special reference to football.

    PUBMED • 2006 • PubMed indexed study

    PMID 16766504 from Journal of sports sciences.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.5/10.[1320,1361,1376, etc.]

    Open source
    157. Effects of soy and other natural products on LDL:HDL ratio and other lipid parameters: a literature review.

    COHORT • 2003 • PubMed indexed study

    PMID 12772818 from Advances in therapy.

    Outcome: Study design: COHORT. Quality score: 5.5/10.[1320,1361,1376, etc.]

    Open source
    158. Fibre: The Forgotten Carbohydrate in Sports Nutrition Recommendations.

    PUBMED • 2025 • PubMed indexed study

    PMID 39775524 from Sports medicine (Auckland, N.Z.).

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.4/10.[1320,1361,1376, etc.]

    Open source
    159. Dietary Supplements in the Management of Symptoms Associated With Autism Spectrum Disorder: A Scoping Review.

    PUBMED • 2025 • PubMed indexed study

    PMID 40581607 from Nutrition reviews.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.4/10.[1320,1361,1376, etc.]

    Open source
    160. Engineered Probiotic-Based Personalized Cancer Vaccine Potentiates Antitumor Immunity through Initiating Trained Immunity.

    PUBMED • 2024 • PubMed indexed study

    PMID 38009498 from Advanced science (Weinheim, Baden-Wurttemberg, Germany).

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1320,1361,1376, etc.]

    Open source
    161. Gastrointestinal Effects and Tolerance of Nondigestible Carbohydrate Consumption.

    PUBMED • 2022 • PubMed indexed study

    PMID 36041173 from Advances in nutrition (Bethesda, Md.).

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.3/10.[1320,1361,1376, etc.]

    Open source
    162. Glycoside hydrolase-mediated glucomannan catabolism in Segatella copri, a target of microbiota-directed foods for malnourished children.

    PUBMED • 2025 • PubMed indexed study

    PMID 41329729 from Proceedings of the National Academy of Sciences of the United States of America.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1320,1361,1376, etc.]

    Open source
    163. Mechanistic Insights Into the Inhibitory Effects of Arabinoxylan and (1,3)(1,4)-β-Glucan on Starch Digestive Enzymes.

    PUBMED • 2025 • PubMed indexed study

    PMID 40285469 from Journal of food science.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1320,1361,1376, etc.]

    Open source
    164. Per- and poly-fluoroalkyl substances (PFAS) in circulation in a Canadian population: their association with serum-liver enzyme biomarkers and piloting a novel method to reduce serum-PFAS.

    PUBMED • 2025 • PubMed indexed study

    PMID 40089764 from Environmental health : a global access science source.

    Outcome: Study design: OTHER. Quality score: 5.3/10.[1320,1361,1376, etc.]

    Open source
    165. Microbial degradation of whole-grain complex carbohydrates and impact on short-chain fatty acids and health.

    PUBMED • 2015 • PubMed indexed study

    PMID 25770259 from Advances in nutrition (Bethesda, Md.).

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.2/10.[1320,1361,1376, etc.]

    Open source
    166. Anti-Inflammatory Effect of an O-2-Substituted (1-3)-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model.

    PUBMED • 2022 • PubMed indexed study

    PMID 35163449 from International journal of molecular sciences.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1320,1361,1376, etc.]

    Open source
    167. Development of a whey protein spread enriched with β-glucan: an alternative for whey valorization.

    PUBMED • 2020 • PubMed indexed study

    PMID 31803934 from Journal of the science of food and agriculture.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1320,1361,1376, etc.]

    Open source
    168. Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men.

    PUBMED • 2022 • PubMed indexed study

    PMID 34923911 from Gut microbes.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1320,1361,1376, etc.]

    Open source
    169. Mucosal immunity-mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches.

    PUBMED • 2021 • PubMed indexed study

    PMID 33980483 from Science advances.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1320,1361,1376, etc.]

    Open source
    170. Potentials to alleviate coagulopathy and enhance microglial function of beta (β)- glucans, making them worth a clinical study for COVID-19's neurological sequalae.

    PUBMED • 2021 • PubMed indexed study

    PMID 34186495 from Journal of the neurological sciences.

    Outcome: Study design: OTHER. Quality score: 5.2/10.[1320,1361,1376, etc.]

    Open source
    171. Harnessing Prebiotics to Improve Type 2 Diabetes Outcomes.

    PUBMED • 2024 • PubMed indexed study

    PMID 39458444 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    172. Cholesterol-lowering effects of oat β-glucan.

    PUBMED • 2011 • PubMed indexed study

    PMID 21631511 from Nutrition reviews.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    173. A Comprehensive Review on Dietary Polysaccharides as Prebiotics, Synbiotics, and Postbiotics in Infant Formula and Their Influences on Gut Microbiota.

    PUBMED • 2024 • PubMed indexed study

    PMID 39683515 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    174. Exploring the therapeutic potential of yeast β-glucan: Prebiotic, anti-infective, and anticancer properties - A review.

    PUBMED • 2024 • PubMed indexed study

    PMID 39522898 from International journal of biological macromolecules.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    175. Role of dietary beta-glucans in the prevention of the metabolic syndrome.

    PUBMED • 2012 • PubMed indexed study

    PMID 22835138 from Nutrition reviews.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    176. Lipid metabolism regulation by dietary polysaccharides with different structural properties.

    PUBMED • 2024 • PubMed indexed study

    PMID 38744359 from International journal of biological macromolecules.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    177. Immunonutrition support for athletes.

    PUBMED • 2008 • PubMed indexed study

    PMID 18522619 from Nutrition reviews.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    178. Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer.

    PUBMED • 2009 • PubMed indexed study

    PMID 19209468 from Current opinion in clinical nutrition and metabolic care.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    179. Non-starch carbohydrates as lever to improve cereal-based foods: The case of FODMAP and beta-glucans.

    PUBMED • 2025 • PubMed indexed study

    PMID 41005942 from Advances in food and nutrition research.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    180. Probiotics: a comprehensive approach toward health foods.

    PUBMED • 2014 • PubMed indexed study

    PMID 24237003 from Critical reviews in food science and nutrition.

    Outcome: Study design: OTHER. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    181. Functional Properties of a High Protein Beverage Stabilized with Oat-β-Glucan.

    PUBMED • 2018 • PubMed indexed study

    PMID 29603228 from Journal of food science.

    Outcome: Study design: OTHER. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    182. Advances in oligosaccharides and polysaccharides with different structures as wall materials for probiotics delivery: A review.

    PUBMED • 2024 • PubMed indexed study

    PMID 39217037 from International journal of biological macromolecules.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.1/10.[1320,1361,1376, etc.]

    Open source
    183. Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials.

    PUBMED • 2019 • PubMed indexed study

    PMID 30935016 from Molecules (Basel, Switzerland).

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1320,1361,1376, etc.]

    Open source
    184. Immunomodulating Effects of Fungal Beta-Glucans: From Traditional Use to Medicine.

    PUBMED • 2021 • PubMed indexed study

    PMID 33920583 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1320,1361,1376, etc.]

    Open source
    185. A comprehensive review on the impact of β-glucan metabolism by Bacteroides and Bifidobacterium species as members of the gut microbiota.

    PUBMED • 2021 • PubMed indexed study

    PMID 33864864 from International journal of biological macromolecules.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1320,1361,1376, etc.]

    Open source
    186. Therapeutic Potential of Various Plant-Based Fibers to Improve Energy Homeostasis via the Gut Microbiota.

    PUBMED • 2021 • PubMed indexed study

    PMID 34684471 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1320,1361,1376, etc.]

    Open source
    187. A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders.

    PUBMED • 2020 • PubMed indexed study

    PMID 32663897 from Planta medica.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1320,1361,1376, etc.]

    Open source
    188. Saccharomyces cerevisiae Yeast-Based Supplementation as a Galactagogue in Breastfeeding Women? A Review of Evidence from Animal and Human Studies.

    PUBMED • 2021 • PubMed indexed study

    PMID 33668808 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 5.0/10.[1320,1361,1376, etc.]

    Open source
    189. Cereal flours with Bacillus coagulans and beta-glucan: Technological properties and sensory acceptability.

    PUBMED • 2024 • PubMed indexed study

    PMID 38569414 from Food chemistry.

    Outcome: Study design: OTHER. Quality score: 4.9/10.[1320,1361,1376, etc.]

    Open source
    190. Enhanced Bioavailability of Ferric Pyrophosphate Delivery System Constructed with β-Glucan and Casein Phosphopeptide.

    PUBMED • 2025 • PubMed indexed study

    PMID 40600440 from Journal of agricultural and food chemistry.

    Outcome: Study design: OTHER. Quality score: 4.9/10.[1320,1361,1376, etc.]

    Open source
    191. The gut microbiota of healthy individuals remains resilient in response to the consumption of various dietary fibers.

    PUBMED • 2024 • PubMed indexed study

    PMID 39333601 from Scientific reports.

    Outcome: Study design: OTHER. Quality score: 4.9/10.[1320,1361,1376, etc.]

    Open source
    192. Characterization of Water-Soluble Oxidized Paramylon and Its Hypoglycemic Effects by Alleviating Insulin Resistance.

    PUBMED • 2025 • PubMed indexed study

    PMID 40619873 from Journal of agricultural and food chemistry.

    Outcome: Study design: OTHER. Quality score: 4.9/10.[1320,1361,1376, etc.]

    Open source
    193. Effect of extraction methods on physicochemical and prebiotic properties of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) seed hull polysaccharides.

    PUBMED • 2025 • PubMed indexed study

    PMID 41076884 from Food chemistry.

    Outcome: Study design: OTHER. Quality score: 4.9/10.[1320,1361,1376, etc.]

    Open source
    194. Effects of dietary fiber and its components on metabolic health.

    PUBMED • 2010 • PubMed indexed study

    PMID 22254008 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1320,1361,1376, etc.]

    Open source
    195. Prebiotics: Ignored player in the fight against cancer.

    PUBMED • 2023 • PubMed indexed study

    PMID 37458148 from Cancer reports (Hoboken, N.J.).

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1320,1361,1376, etc.]

    Open source
    196. Impact of Oats on Appetite Hormones and Body Weight Management: A Review.

    PUBMED • 2023 • PubMed indexed study

    PMID 36790719 from Current nutrition reports.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1320,1361,1376, etc.]

    Open source
    197. The effect of beta-glucan supplementation on glycemic control and variability in adolescents with type 1 diabetes mellitus.

    PUBMED • 2020 • PubMed indexed study

    PMID 32971156 from Diabetes research and clinical practice.

    Outcome: Study design: OTHER. Quality score: 4.8/10.[1320,1361,1376, etc.]

    Open source
    198. Major cereal grain fibers and psyllium in relation to cardiovascular health.

    PUBMED • 2013 • PubMed indexed study

    PMID 23628720 from Nutrients.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1320,1361,1376, etc.]

    Open source
    199. Association Between the Gut Microbiota and Alzheimer's Disease: An Update on Signaling Pathways and Translational Therapeutics.

    PUBMED • 2025 • PubMed indexed study

    PMID 39460901 from Molecular neurobiology.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1320,1361,1376, etc.]

    Open source
    200. Improvement of sleep and melatonin in children with autism spectrum disorder after β-1,3/1,6-glucan consumption: An open-label prospective pilot clinical study.

    PUBMED • 2022 • PubMed indexed study

    PMID 35993920 from Brain and behavior.

    Outcome: Study design: OTHER. Quality score: 4.8/10.[1320,1361,1376, etc.]

    Open source
    201. Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males.

    PUBMED • 2019 • PubMed indexed study

    PMID 30692581 from Scientific reports.

    Outcome: Study design: OTHER. Quality score: 4.8/10.[1320,1361,1376, etc.]

    Open source
    202. Increase in the incidence of invasive bacterial infections following the COVID-19 pandemic: potential links with decreased herd trained immunity - a novel concept in medicine.

    PUBMED • 2024 • PubMed indexed study

    PMID 38967606 from Polish archives of internal medicine.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.8/10.[1320,1361,1376, etc.]

    Open source
    203. β-1,3/1,6-Glucans and Immunity: State of the Art and Future Directions.

    PUBMED • 2021 • PubMed indexed study

    PMID 32223047 from Molecular nutrition & food research.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1320,1361,1376, etc.]

    Open source
    204. Grains.

    PUBMED • 2020 • PubMed indexed study

    PMID 32006365 from Advances in neurobiology.

    Outcome: Study design: NARRATIVE_REVIEW. Quality score: 4.7/10.[1320,1361,1376, etc.]

    Open source