Supplement
Activates AMPK-linked pathways and supports glycemic control.[1836,2625,3691, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
1
Mixed / Neutral • confidence Moderate
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 16 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Metabolic Health, Body Composition, Longevity.[67,335,361, etc.]
Dose guide: Human-study daily dose: 500 mg-1500 mg/day (moderate-confidence extraction from PubMed abstracts)..[67,335,361, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 500 mg-1500 mg/day (moderate-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 287 • RCTs: 41 • Meta: 15
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 887 • Interactions: 1,133
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
552 total studies · 4 recent
Timeline
Animal-only studies
3,020
In vitro / tissue
2,127
Interaction signals
1,133
Safety adverse signals
887
Total indexed
552
Human studies
287
Weighted direction score: 1 (Mixed / Neutral)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
3,020
In vitro / tissue
2,127
Interaction signals
1,133
Safety adverse signals
887
Total indexed
552
Human studies
287
Randomized trials
41
Meta-analyses
15
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 32690176 • 2020 Aug
The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials.
Clin Nutr ESPEN
Open PubMedPMID 35988871 • 2022 Sep
A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults.
Pharmacol Res
Open PubMedPMID 37675930 • 2023 Dec
Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose-response meta-analysis of randomized clinical trials.
Phytother Res
Open PubMedPMID 36941490 • 2023 Apr
Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.
Drugs
Open PubMedPMID 27157250 • 2016 Aug
The effects of a nutraceutical combination on plasma lipids and glucose: A systematic review and meta-analysis of randomized controlled trials.
Pharmacol Res
Open PubMedPMID 35623810 • 2022 Jun
Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.
Clin Nutr ESPEN
Open PubMedPMID 33024120 • 2020 Oct 6
Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study).
Nat Commun
Open PubMedPMID 18442638 • 2008 May
Efficacy of berberine in patients with type 2 diabetes mellitus.
Metabolism
Open PubMedPMID 34923903 • 2022 Jan-Dec
Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study.
Gut Microbes
Open PubMedPMID 39998703 • 2025 Feb 25
The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial.
Eur J Nutr
Open PubMedPMID 39107107 • 2024 Aug
Inflammatory markers and noncoding-RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle-aged men with prediabetes.
Physiol Rep
Open PubMedPMID 41305635 • 2025 Nov 16
The Influence of Berberine on Vascular Function Parameters, Among Them VEGF, in Individuals with MAFLD: A Double-Blind, Randomized, Placebo-Controlled Trial.
Nutrients
Open PubMedPMID 38659110 • 2024 Jun
Dietary supplements: clinical cholesterol-lowering efficacy and potential mechanisms of action.
Int J Food Sci Nutr
Open PubMedPMID 36561763 • 2022
Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy.
Front Immunol
Open PubMedPMID 37298967 • 2023 Jun 1
A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention.
Molecules
Open PubMedBenefit reports: 7
Adverse reports: 6
No-effect reports: 0
Mixed reports: 3
Unclear reports: 0
Signal confidence: 0.52
Benefits
Adverse
No Effect
High empirical usage in glucose-management stacks. | Step2: Insufficient empirical signal for a directional adjustment.
Reddit evidence: 13 mentions (confidence 0.52) across Biohackers, Supplements.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 500 mg-1500 mg/day (confidence MEDIUM).
Extracted from 3 dosing mentions across 3 PubMed studies (mg/day).
Imported legacy community score: 9.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$18.00.
Legacy community note: Called "nature's metformin" - extremely popular for blood sugar and weight management. Users show dramatic fasting glucose improvements on bloodwork. GI side effects are the main complaint but usually resolve. Dihydroberberine gaining popularity for better tolerance.
post • r/Biohackers • mixed
Berberine and obesity legit potential or just another supplement hype? I came across this new research paper on arXiv that reviews berberine, a plant compound you see in a lot of herbal supplements, as a possible treatment for obesity. Wha…
Open mentionpost • r/Supplements • benefit
How effective is berberine from slow Hey peeps! So I’m badly wanting to reduce my weight and tummy..but somehow I end up eating more as Im a foodie! Does this berberine really would help me cutting my appetite?
Open mentionpost • r/Supplements • mixed
Can i take berberine with other supplements? I am 26 F, I have pcos and have also been managing pvcs naturally. I used to take berberine and it worked really well to help me lower my A1C. I stopped taking it after my levels were better. I …
Open mentionpost • r/Biohackers • benefit
Is stacking berberine and metformin pushing biohacking too far for weight loss?
Open mentionpost • r/Supplements • adverse
Gut health supplements, berberine, L-Glutamine, oil of oregano? Pre/probiotics Hey there, looking to hear positive or negative experiences with L Glutamine, berberine, oil or oregano and pre or pro biotic for gut health specifically chroni…
Open mentionpost • r/Supplements • unclear
Berberine supplement when you’re on hypertension meds Is there anyone here on hypertension medication that also takes berberine? I (32F) am on losartan+amlo 50/5 mg. On my last bloodwork and check up last month, my Hba1c is fine but my FBS…
Open mentionpost • r/Biohackers • mixed
No supplements help with my quality of life except for berberine? I have been taking berberine for nearly a month now. It reduced gas, bloating, food coma and sugar cravings. On top of that, I feel like a new person as it has helped A LOT …
Open mentionpost • r/Biohackers • benefit
Anyone tried Beneve’s Xcelerate Stack 3 in place of Berberine for weight loss? Stumbled across this Creator on TikTok, who is a pharmacist. Apparently, they have a supplement that can be used in place of berberine that's apparently more ef…
Open mentioncomment • r/Biohackers • unclear
I heard that a lot actually berberine seems super hit or miss depending on the person. Did you try it for blood sugar specifically or something else?
Open mentioncomment • r/Biohackers • benefit
Here's my berberine experiment: [https://www.youtube.com/watch?v=Tvo5V-Eam-8](https://www.youtube.com/watch?v=Tvo5V-Eam-8) Not bad as far as glucose and insulin. But if it would translate into weight loss is strongly dependant on the initi…
Open mentionamazon
Amazon search for Berberine
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
META_ANALYSIS • 2023 • Adults
Type 2 diabetes and metabolic syndrome cohorts.
Outcome: Reduces fasting glucose and HbA1c in many trials.[1836,2625,3691, etc.]
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 287, RCTs 41, meta-analyses 15.[1836,2625,3691, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32690176 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35988871 from Pharmacol Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37675930 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36941490 from Drugs.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2016 • Human evidence curation set
PMID 27157250 from Pharmacol Res.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35623810 from Clin Nutr ESPEN.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 33024120 from Nat Commun.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18442638 from Metabolism.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 34923903 from Gut Microbes.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 39998703 from Eur J Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39107107 from Physiol Rep.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 41305635 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 38659110 from Int J Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36561763 from Front Immunol.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37298967 from Molecules.
Outcome: See linked PubMed abstract for methods and outcomes.[1836,2625,3691, etc.]
Open source