Session check

Supplement

Bacopa Monnieri

Nootropic herb with bacosides enhancing cholinergic signaling and neuroprotection.[1688,1723,1797, etc.]

Superscript reference numbers link to the Sources bibliography.

Strong Evidence

CognitiveBrain HealthStress Resiliencealias: bacopaalias: brahmi

Composite Rating

3.3/5

Blends evidence depth, community direction, safety friction, and completeness.

Evidence Intensity

83/100

High depth from human/RCT/meta counts

Community Direction

-2

Mixed / Neutral • confidence Moderate

Safety Friction

100/100

High signal from adverse/interaction markers

Data Completeness

100%

Studies 24 • mentions 13 • links 59

Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.

FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.

If you are experiencing a medical emergency, call 911 or your local emergency number immediately.

Implementation Blueprint

Goal alignment: Cognitive, Brain Health, Stress Resilience.[129,157,259, etc.]

Dose guide: Human-study daily dose: 150 mg-300 mg/day (moderate-confidence extraction from PubMed abstracts)..[129,157,259, etc.]

Category: nootropic.[129,157,259, etc.]

At-A-Glance Evidence Architecture[1688,1723,1797, etc.]

Clinical Depth

Humans: 45 • RCTs: 11 • Meta: 0

Cohort / Real-World

Cohort signals: 0

Safety Markers

Adverse signals: 128 • Interactions: 69

Evidence Tracking

Freshness, trend, and study timeline for this item

Evidence Tracking

Status

New Evidence

Trend

→ Stable evidence base

Depth

101 total studies · 4 recent

Timeline

20062025

Top Signal Metrics[1688,1723,1797, etc.]

Animal-only studies

229

In vitro / tissue

148

Safety adverse signals

128

Total indexed

101

Interaction signals

Human studies

Community Direction Mix[129,157,259, etc.]

Weighted direction score: -2 (Mixed / Neutral)

Evidence Quality Summary[1688,1723,1797, etc.]

≥2 meta-analyses OR (≥5 RCTs AND ≥25 human studies).

Animal-only studies

229

In vitro / tissue

148

Safety adverse signals

128

Total indexed

101

Interaction signals

Human studies

Randomized trials

Meta-analyses

Study Type Breakdown

Distribution of evidence by study design strength

Randomized TrialsLevel 1b11

Human Studies (other)Level 3-434

All IndexedAll levels101

Evidence Strength: High

Composite of study volume, RCTs, and meta-analyses

Top Human Studies[1688,1723,1797, etc.]

PMID 38512715 • 2024 Nov

Neurocognitive effects a combined polyphenolic-rich herbal extract in healthy middle-aged adults - a randomised, double-blind, placebo-controlled study.

Nutritional neuroscience

Open PubMed

PMID 31736428 • 2021 Nov

Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex: a double-blind, placebo-controlled study.

Nutritional neuroscience

Open PubMed

Community Report Frequency[129,157,259, etc.]

Benefit reports: 6

Adverse reports: 6

No-effect reports: 0

Mixed reports: 1

Unclear reports: 0

Signal confidence: 0.47

Top Reported Effects[129,157,259, etc.]

Benefits

reduced: 2
better: 1
energy: 1

Adverse

side effects: 3
anxiety: 2
headache: 1
cramps: 1

No Effect

insufficient no-effect reports captured: 0

Patience required — benefits compound over months. Best with fat for absorption. | Step2: User reports show a high adverse-rate signal at usable volume; downgrade recommendation priority.

Reddit evidence: 8 mentions (confidence 0.47) across Biohackers, Supplements, HubermanLab.

Amazon signal: 0 products scanned (confidence 0.00).

Community Evidence Examples[129,157,259, etc.]

post • r/Biohackers • unclear

Stacking Bacopa, Ginkgo, Lion’s Mane & Rhodiola: why so little effect?

Open mention

post • r/Supplements • adverse

Experiencing Side Effects After Starting Bacopa Monnieri – Demotivation, Headaches, and Vivid Dreams I started taking Bacopa Monnieri about 2 weeks ago (500 mg, Bacosides >20%). During the first few days, everything felt fine. But by the s…

Open mention

post • r/HubermanLab • mixed

Supplements: Bacopa monnieri I grow my own bacopa monnieri plant at my home. I started growing it as a hobby. I crush the leaves and take it along with ghee and honey. I have tried taking it for a couple of weeks now. I have noticed that i…

Retail Signal Examples

amazon

Amazon search for Bacopa Monnieri

Rating: n/a | Reviews: n/a

Open product

Primary Source Links

Evidence Sources

Scientific Evidence Notes[1688,1723,1797, etc.]

1. Bacopa monnieri and cognition: MA of 9 RCTs

META_ANALYSIS • 2014 • Adults

9 RCTs with 518 healthy adults.

Outcome: Bacopa significantly improved attention (speed of attention +17%), cognitive processing, and free recall memory after 12+ weeks; no acute effects.[1688,1723,1797, etc.]

Open source

2. Bacopa monnieri and memory in older Australians: CDRI 08 extract RCT

RCT • 2010 • Adults

98 healthy adults ≥55 years over 12 weeks.

Outcome: 300 mg/day CDRI 08 significantly improved logical memory, paired associates, and delayed recall vs placebo.[1688,1723,1797, etc.]

Implementation Blueprint

At-A-Glance Evidence Architecture[1688,1723,1797, etc.]

Evidence Tracking

Evidence Tracking

Top Signal Metrics[1688,1723,1797, etc.]

Community Direction Mix[129,157,259, etc.]

Evidence Quality Summary[1688,1723,1797, etc.]

Study Type Breakdown

Top Human Studies[1688,1723,1797, etc.]

Community Report Frequency[129,157,259, etc.]

Top Reported Effects[129,157,259, etc.]

Community Evidence Examples[129,157,259, etc.]

Retail Signal Examples

Primary Source Links

Scientific Evidence Notes[1688,1723,1797, etc.]

Safety and Pitfalls