Supplement
Supports broad cellular function with category-specific mechanisms.[2998,3039,3128, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
34
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 15 • mentions 8 • links 26
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Longevity, Metabolic Health, Energy.[20,350,356, etc.]
Dose guide: Human-study daily dose: 2 mg-12 mg/day (higher-confidence extraction from PubMed abstracts)..[20,350,356, etc.]
Category
Other
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 2 mg-12 mg/day (higher-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 270 • RCTs: 65 • Meta: 15
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 288 • Interactions: 260
Freshness, trend, and study timeline for this item
Status
Trend
↑ Growing evidence base
Depth
916 total studies · 4 recent
Timeline
Animal-only studies
1,303
Total indexed
916
In vitro / tissue
575
Safety adverse signals
288
Human studies
270
Interaction signals
260
Weighted direction score: 34 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Animal-only studies
1,303
Total indexed
916
In vitro / tissue
575
Safety adverse signals
288
Human studies
270
Interaction signals
260
Randomized trials
65
Meta-analyses
15
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 34578794 • 2021 Aug 24
Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing.
Nutrients
Open PubMedPMID 35091276 • 2022 Mar
Astaxanthin supplementation mildly reduced oxidative stress and inflammation biomarkers: a systematic review and meta-analysis of randomized controlled trials.
Nutr Res
Open PubMedPMID 33998846 • 2022
Carotenoids supplementation and inflammation: a systematic review and meta-analysis of randomized clinical trials.
Crit Rev Food Sci Nutr
Open PubMedPMID 32755613 • 2020 Nov
The effects of astaxanthin supplementation on obesity, blood pressure, CRP, glycemic biomarkers, and lipid profile: A meta-analysis of randomized controlled trials.
Pharmacol Res
Open PubMedPMID 39127677 • 2024 Aug 10
Effect of astaxanthin supplementation on female fertility and reproductive outcomes: a systematic review and meta-analysis of clinical and animal studies.
J Ovarian Res
Open PubMedPMID 39064656 • 2024 Jul 10
Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 29941810 • 2018 Jun 25
The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.
Nutrients
Open PubMedPMID 37020589 • 2023
Astaxanthin ameliorates inflammation, oxidative stress, and reproductive outcomes in endometriosis patients undergoing assisted reproduction: A randomized, triple-blind placebo-controlled clinical trial.
Front Endocrinol (Lausanne)
Open PubMedPMID 40014233 • 2025 Apr
Astaxanthin (AstaReal(®)) Improved Acute and Chronic Digital Eye Strain in Children: A Randomized Double-Blind Placebo-Controlled Trial.
Adv Ther
Open PubMedPMID 36986186 • 2023 Mar 17
Effects of Astaxanthin, Lutein, and Zeaxanthin on Eye-Hand Coordination and Smooth-Pursuit Eye Movement after Visual Display Terminal Operation in Healthy Subjects: A Randomized, Double-Blind Placebo-Controlled Intergroup Trial.
Nutrients
Open PubMedPMID 39036884 • 2024 Jul
Randomized clinical trial of astaxanthin supplement on serum inflammatory markers and ER stress-apoptosis gene expression in PBMCs of women with PCOS.
J Cell Mol Med
Open PubMedPMID 35880828 • 2022 Sep 2
Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.
Am J Clin Nutr
Open PubMedPMID 29690549 • 2018 Apr 22
Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review.
Nutrients
Open PubMedPMID 38256329 • 2023 Dec 29
Nutritional Supplements for Skin Health-A Review of What Should Be Chosen and Why.
Medicina (Kaunas)
Open PubMedPMID 30322941 • 2018 Oct 23
Prolonging healthy aging: Longevity vitamins and proteins.
Proc Natl Acad Sci U S A
Open PubMedBenefit reports: 5
Adverse reports: 2
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.36
Benefits
Adverse
No Effect
Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 5 mentions (confidence 0.36) across Biohackers, Supplements.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 2 mg-12 mg/day (confidence HIGH).
Extracted from 9 dosing mentions across 5 PubMed studies (mg/day).
Imported legacy community score: 8.0/10 (heuristic mapping confidence 1.00).
Imported legacy monthly cost signal: ~$20.00.
Legacy community note: Well-regarded for skin and eye health. Users report noticeable skin improvements, reduced sunburn susceptibility, and better recovery from exercise. Popular among outdoor athletes and those concerned about skin aging.
post • r/Biohackers • unclear
Has anyone noticed real skin benefits from astaxanthin supplements? Hi everyone, I’ve been reading about astaxanthin, a powerful antioxidant taken as a dietary supplement, and I’m curious about its real effects on the skin. Some studies cl…
Open mentionpost • r/Supplements • unclear
Do NOT buy astaxanthin at WeightWorld. They're lying about the dosage The WeightWorld Astaxanthin bottle states that each capsule contains 18 mg of astaxanthin, but the website lists 18 mg of *Haematococcus pluvialis* algae extract. These …
Open mentionpost • r/Supplements • unclear
Is this supplement stack too much? Adding Astaxanthin & Shilajit 33M, lift daily, generally healthy. On Rosuvastatin for cholesterol (runs in the family). Current stack: - Biotin 5,000 mcg - Vitamin D 10,000 IU + K2 (200 mcg) - Omega-3 (60…
Open mentionpost • r/Biohackers • unclear
Do NOT buy WeightWorld's astaxanthin. They're lying about the dosage The bottle states that each capsule contains 18 mg of astaxanthin, but the website lists 18 mg of *Haematococcus pluvialis* algae extract. These are not the same. *Haemat…
Open mentionpost • r/Supplements • mixed
My current supplement stack (creatine, taurine, PEA, astaxanthin, etc) —major improvement energy, mood, IBS and recovery. Hi everyone, I wanted to share my current supplement stack and what kind of effects I’ve experienced over the past mo…
Open mentionpost • r/Supplements • benefit
Astaxanthin changed my health I’ve been in the supplement space for a few years now, but like a lot of people, I wasn’t always consistent with my own health routine. So, earlier this year, I decided to fix my basics (diet, sleep, exercise …
Open mentionpost • r/Supplements • benefit
I know they provide tangible benefit but I take 12 mg astaxanthin and heliocare for UV ray protection/ skin aging. Are there other solid supplements that are proven to help with these issues that I should consider? Ooos I meant to write li…
Open mentionpost • r/Biohackers • unclear
Thoughts on Astaxanthin supplementation? It's supposed to be the most powerful antioxidant, so would daily supplementation have any meaningful benefits?
Open mentioncomment • r/Biohackers • unclear
I have been taking Astaxanthin daily since 2012. My functional medicine doctor advised taking it together with Lutein for retinal health. I had a spontaneous retinal detachment in 2012 (followed immediately by retinal surgery). Once you ha…
Open mentioncomment • r/Biohackers • unclear
Can you share brand and dosage for each? I’ve taken each inconsistently. The BioAstin astaxanthin and varying lutein brands and doses
Open mentionamazon
Amazon search for Astaxanthin
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 270, RCTs 65, meta-analyses 15.[2998,3039,3128, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34578794 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35091276 from Nutr Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 33998846 from Crit Rev Food Sci Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32755613 from Pharmacol Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39127677 from J Ovarian Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39064656 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29941810 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37020589 from Front Endocrinol (Lausanne).
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40014233 from Adv Ther.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 36986186 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2024 • Human evidence curation set
PMID 39036884 from J Cell Mol Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35880828 from Am J Clin Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29690549 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 38256329 from Medicina (Kaunas).
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 30322941 from Proc Natl Acad Sci U S A.
Outcome: See linked PubMed abstract for methods and outcomes.[2998,3039,3128, etc.]
Open source