Supplement
Adaptogenic herb with stress-response and sleep support potential.[2552,3397,3599, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
100/100
High depth from human/RCT/meta counts
Community Direction
47
Positive Lean • confidence Low
Safety Friction
100/100
High signal from adverse/interaction markers
Data Completeness
100%
Studies 12 • mentions 10 • links 23
Not medical advice. This product is for educational and informational purposes only. It does not diagnose, treat, cure, or prevent any disease and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
FDA disclaimer: These statements have not been evaluated by the Food and Drug Administration. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Not intended for use by pregnant or nursing women, individuals under 18, or those with known medical conditions without physician consultation.
If you are experiencing a medical emergency, call 911 or your local emergency number immediately.
Goal alignment: Stress Resilience, Sleep, Performance.[22,135,203, etc.]
Dose guide: Human-study daily dose: 600 mg/day (moderate-confidence extraction from PubMed abstracts)..[22,135,203, etc.]
Category
Botanical
Evidence Tier
HIGH
Daily Guide
Human-study daily dose: 600 mg/day (moderate-confidence extraction from PubMed abstracts).
Clinical Depth
Humans: 97 • RCTs: 23 • Meta: 4
Cohort / Real-World
Cohort signals: 0
Safety Markers
Adverse signals: 142 • Interactions: 86
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
193 total studies · 1 recent
Timeline
Total indexed
193
Animal-only studies
146
Safety adverse signals
142
In vitro / tissue
137
Human studies
97
Interaction signals
86
Weighted direction score: 47 (Positive Lean)
High when >=2 human meta-analyses, or >=5 human RCTs with substantial human literature volume.
Total indexed
193
Animal-only studies
146
Safety adverse signals
142
In vitro / tissue
137
Human studies
97
Interaction signals
86
Randomized trials
23
Meta-analyses
4
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 36017529 • 2022 Nov
Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials.
Phytother Res
Open PubMedPMID 35311615 • 2022 Jul
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.
World J Biol Psychiatry
Open PubMedPMID 32316411 • 2020 Apr 17
Effects of Ashwagandha (Withania somnifera) on VO(2max): A Systematic Review and Meta-Analysis.
Nutrients
Open PubMedPMID 40746175 • 2025 Dec
Dual impact of Ashwagandha: Significant cortisol reduction but no effects on perceived stress - A systematic review and meta-analysis.
Nutr Health
Open PubMedPMID 31517876 • 2019 Sep
An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.
Medicine (Baltimore)
Open PubMedPMID 26609282 • 2015
Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial.
J Int Soc Sports Nutr
Open PubMedPMID 37740662 • 2023 Nov
Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial.
J Psychopharmacol
Open PubMedPMID 35984870 • 2022 Dec
The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial.
J Med Food
Open PubMedPMID 33338583 • 2021 Mar
Safety of Ashwagandha Root Extract: A Randomized, Placebo-Controlled, study in Healthy Volunteers.
Complement Ther Med
Open PubMedPMID 34553463 • 2021 Dec
Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study.
J Obstet Gynaecol Res
Open PubMedPMID 37603263 • 2023 Sep
Over the Counter Supplements for Memory: A Review of Available Evidence.
CNS Drugs
Open PubMedPMID 35952387 • 2022 Nov 23
Thyroid, Diet, and Alternative Approaches.
J Clin Endocrinol Metab
Open PubMedBenefit reports: 7
Adverse reports: 2
No-effect reports: 0
Mixed reports: 1
Unclear reports: 0
Signal confidence: 0.32
Benefits
Adverse
No Effect
Often recommended for high-stress users with sleep issues. | Step2: Moderate positive empirical signal; apply a light priority boost.
Reddit evidence: 4 mentions (confidence 0.32) across Biohackers, Supplements.
Amazon signal: 0 products scanned (confidence 0.00).
GNC signal: 0 products scanned (confidence 0.00) [BLOCKED].
PerimeterX / captcha block encountered.
Use adverse/interactions PubMed signal counts for screening; perform clinician review before high-dose or multi-drug stack use.
Human-study daily dose signal: 600 mg/day (confidence MEDIUM).
Extracted from 2 dosing mentions across 2 PubMed studies (mg/day).
Imported legacy community score: 10.0/10 (manual mapping confidence 1.00).
Imported legacy monthly cost signal: ~$18.00.
Legacy community note: One of the most popular and praised adaptogens. Users consistently report dramatic stress reduction, better sleep, improved gym performance, and enhanced libido. KSM-66 specifically recommended as the best extract.
post • r/Biohackers • mixed
If you were building a “sexual performance stack” from scratch, what’s in it? I’m curious how this sub would architect this from first principles. Not “take Viagra and call it a day.” I mean if you were optimizing the entire sexual respons…
Open mentionpost • r/Supplements • unclear
Stacking LJ100 Tongkat 200 mg (22% Bioactive Eurypeptides) a day with Ashwagandha KSM 66 and P5P (50mg). Suffering from symptoms of low E2 What's my best bet here? I do enjoy the benefits of Tongkat and have been running it as my daily for…
Open mentionpost • r/Biohackers • benefit
20 Biohacks Ranked by Human Data (Including a Few You Probably Haven’t Tried) Saw a lot of basic "top supplement" lists floating around, so I decided to do one better. I used Gemini 2.5 with a solid prompt focused only on interventions bac…
Open mentionpost • r/Biohackers • benefit
Built a long-term foundational stack after a lot of research. Would love feedback. Hey everyone, I’m 23M and recently went through a rough phase (stress, weight gain, low energy/libido). I’ve since dropped \~30kg, rebuilt my routine, and n…
Open mentionpost • r/Biohackers • benefit
26M - Is this lifestyle & supplement protocol reasonable ? Hi everyone, I’m looking for objective feedback on my current lifestyle, training and supplement protocol, and whether it makes sense long term. The supplement protocol is somethin…
Open mentionpost • r/Biohackers • unclear
Opinions about my stack? 17M Hey everyone 👋🏼 M17, 63kg, 183cm, smoking a pack a day, alcohol occasionally but never getting drunk. Ashwagandha KSM-66 - 600mg/day Vitamin C Liposomal -> 1g/day Siberian Ginseng Extract 10:1 -> 200mg/day Ma…
Open mentionpost • r/Supplements • unclear
PLZZZZ RATE MY STACK 1) vitamin d3 + k2 [ 60kiu/1x week ] 2) zinc + cu [ 13mg elemental ] 3) magnesium glycinate [ 440mg ] 4) caffiene [ 200-400mg daily ] 5) l-theanine [ 400mg daily ] 6) ashwagandha ksm-66 [ 600mg daily ] 7) boron [ 6mg 5…
Open mentionpost • r/Biohackers • unclear
Rate My Stack 20M 1) vitamin d3 + k2 [ 60kiu/1x week ] 2) zinc + cu [ 13mg elemental ] 3) magnesium glycinate [ 440mg ] 4) caffiene [ 200-400mg daily ] 5) l-theanine [ 400mg daily ] 6) ashwagandha ksm-66 [ 600mg daily ] 7) boron [ 6mg 5x a…
Open mentionamazon
Amazon search for Ashwagandha (KSM-66)
Rating: n/a | Reviews: n/a
Open productEvidence Sources
Community Sources
RCT • 2021 • Adults
Moderate-sized human trials.
Outcome: Improves stress metrics and sleep quality in many studies.[2552,3397,3599, etc.]
PUBMED • Humans + preclinical triage
Counts aggregated from automated literature sweep and tiering rules.
Outcome: Tier HIGH; humans 97, RCTs 23, meta-analyses 4.[2552,3397,3599, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 36017529 from Phytother Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35311615 from World J Biol Psychiatry.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2020 • Human evidence curation set
PMID 32316411 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40746175 from Nutr Health.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 31517876 from Medicine (Baltimore).
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2015 • Human evidence curation set
PMID 26609282 from J Int Soc Sports Nutr.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37740662 from J Psychopharmacol.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35984870 from J Med Food.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33338583 from Complement Ther Med.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 34553463 from J Obstet Gynaecol Res.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2023 • Human evidence curation set
PMID 37603263 from CNS Drugs.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35952387 from J Clin Endocrinol Metab.
Outcome: See linked PubMed abstract for methods and outcomes.[2552,3397,3599, etc.]
Open source