Habit
Any potential polyphenol benefits are offset by dose-dependent alcohol risk.[1329,1386,1438, etc.]
Superscript reference numbers link to the Sources bibliography.
Composite Rating
Blends evidence depth, community direction, safety friction, and completeness.
Evidence Intensity
86/100
High depth from human/RCT/meta counts
Community Direction
0
Mixed / Neutral • confidence Minimal
Safety Friction
27/100
Early signal from adverse/interaction markers
Data Completeness
100%
Studies 24 • mentions 0 • links 35
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Classification: reduce.[1081,1204,1329, etc.]
Best fit: Users interpreting red wine as universally health-protective..[1081,1204,1329, etc.]
Goal alignment: Sleep, Liver Support, Metabolic Health, Longevity.[1081,1204,1329, etc.]
Classification
Reduce
Evidence Tier
HIGH
Best Fit
Users interpreting red wine as universally health-protective.
Primary Focus
Sleep, Liver Support
Clinical Depth
Humans: 94 • RCTs: 7 • Meta: 0
Cohort / Real-World
Cohort signals: 24
Safety Markers
Adverse signals: 3 • Interactions: 0
Freshness, trend, and study timeline for this item
Status
Trend
→ Stable evidence base
Depth
94 total studies · 2 recent
Timeline
Total indexed
94
Human studies
94
In vitro / tissue
87
Cardiometabolic signals
32
Cohort signals
24
Randomized trials
7
Weighted direction score: 0 (Mixed / Neutral)
No directional mention volume was resolved; fallback profile metadata is shown in other sections.
High when replicated human meta-analysis/trial/cohort depth is present for the habit or exposure.
Total indexed
94
Human studies
94
In vitro / tissue
87
Cardiometabolic signals
32
Cohort signals
24
Randomized trials
7
Neuropsych signals
4
Safety adverse signals
3
Sleep signals
1
Animal-only studies
0
Meta-analyses
0
Dependency signals
0
Distribution of evidence by study design strength
Evidence Strength: High
Composite of study volume, RCTs, and meta-analyses
PMID 15674304 • 2005 Mar
Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease.
European journal of clinical nutrition
Open PubMedPMID 9201083 • 1997 Jun
Effects of red wine on 24-hour esophageal pH and pressures in healthy volunteers.
Digestive diseases and sciences
Open PubMedPMID 24970377 • 2014
Advice on lifestyle changes (diet, red wine and physical activity) does not affect internal carotid and middle cerebral artery blood flow velocity in patients with carotid arteriosclerosis in a randomized controlled trial.
Cerebrovascular diseases (Basel, Switzerland)
Open PubMedPMID 24228901 • 2013 Nov 15
A daily glass of red wine associated with lifestyle changes independently improves blood lipids in patients with carotid arteriosclerosis: results from a randomized controlled trial.
Nutrition journal
Open PubMedPMID 16675507 • 2006 Jul
Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption.
Clinical chemistry
Open PubMedPMID 18616675 • 2008 Sep
Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype.
Alcoholism, clinical and experimental research
Open PubMedPMID 19457484 • 2009 Nov
Acute, food-induced moderate elevation of plasma uric acid protects against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans.
Atherosclerosis
Open PubMedPMID 33689041 • 2021 Mar 10
Post-Diagnostic Dietary and Lifestyle Factors and Prostate Cancer Recurrence, Progression, and Mortality.
Current oncology reports
Open PubMedPMID 23511381 • 2013 Aug
Alcohol and plasma triglycerides.
Current opinion in lipidology
Open PubMedPMID 29458056 • 2018 May-Jun
Alcohol and CV Health: Jekyll and Hyde J-Curves.
Progress in cardiovascular diseases
Open PubMedPMID 14621457 • 2003 Aug
Beyond the French paradox: the impact of moderate beverage alcohol and wine consumption in the prevention of cardiovascular disease.
Cardiology clinics
Open PubMedPMID 11408943 • 2001 Jul
Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review).
International journal of molecular medicine
Open PubMedPMID 8942923 • 1996 Dec
Alcohol and preoperative management.
Plastic and reconstructive surgery
Open PubMedPMID 40754514 • 2025 Dec
Association between alcoholic beverage consumption and cerebral small vessel disease burden.
The journal of prevention of Alzheimer's disease
Open PubMedPMID 41515126 • 2025 Dec 19
Diet After Acute Coronary Artery Syndrome.
Nutrients
Open PubMedPMID 35654336 • 2022 Sep-Oct
The history, science, and art of wine and the case for health benefits: perspectives of an oenophilic cardiovascular pathologist.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
Open PubMedPMID 16922819 • 2006 Sep
Alcohol is bad for blood pressure.
Clinical and experimental pharmacology & physiology
Open PubMedPMID 10370878 • 1999
Wine and migraine: compatibility or incompatibility?
Drugs under experimental and clinical research
Open PubMedPMID 11442298 • 2001 Jun
Alzheimer's disease: insights from epidemiology.
Aging (Milan, Italy)
Open PubMedPMID 30076269 • 2019 Jan
Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study.
Journal of neurology, neurosurgery, and psychiatry
Open PubMedPMID 18088206 • 2008 Jan
Lifestyle-related factors in predementia and dementia syndromes.
Expert review of neurotherapeutics
Open PubMedPMID 23579938 • 2010
Focus on: The cardiovascular system: what did we learn from the French (Paradox)?
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism
Open PubMedPMID 12074969 • 2002 May
Wine flavonoids protect against LDL oxidation and atherosclerosis.
Annals of the New York Academy of Sciences
Open PubMedPMID 21745730 • 2011 Sep
The role of diet in the prevention of type 2 diabetes.
Nutrition, metabolism, and cardiovascular diseases : NMCD
Open PubMedBenefit reports: 0
Adverse reports: 0
No-effect reports: 0
Mixed reports: 0
Unclear reports: 0
Signal confidence: 0.00
Benefits
Adverse
No Effect
Community confidence 0.00 with mentions: benefit 0, adverse 0, no-effect 0.
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Fallback search fetch failed: Failed to fetch after retries: https://old.reddit.com/search.json?raw_json=1&sort=relevance&t=year&limit=12&q=frequent%20red%20wine%20intake
aggregate • unclear
No directional first-hand mentions captured in the current community corpus; source links are retained for traceability.
Open mentionEvidence Sources
Community Sources
PUBMED • Human lifestyle/habit literature
Counts from structured habit/exposure PubMed query set.
Outcome: Humans 94, RCT 7, meta 0, cohort 24, sleep signals 1, cardiometabolic signals 32.[1329,1386,1438, etc.]
Open sourcePUBMED • 2005 • Human evidence curation set
PMID 15674304 from European journal of clinical nutrition.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2014 • Human evidence curation set
PMID 24970377 from Cerebrovascular diseases (Basel, Switzerland).
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 24228901 from Nutrition journal.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 1997 • Human evidence curation set
PMID 9201083 from Digestive diseases and sciences.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 16675507 from Clinical chemistry.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18616675 from Alcoholism, clinical and experimental research.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2009 • Human evidence curation set
PMID 19457484 from Atherosclerosis.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2021 • Human evidence curation set
PMID 33689041 from Current oncology reports.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2013 • Human evidence curation set
PMID 23511381 from Current opinion in lipidology.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2018 • Human evidence curation set
PMID 29458056 from Progress in cardiovascular diseases.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2003 • Human evidence curation set
PMID 14621457 from Cardiology clinics.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11408943 from International journal of molecular medicine.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 1996 • Human evidence curation set
PMID 8942923 from Plastic and reconstructive surgery.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 40754514 from The journal of prevention of Alzheimer's disease.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2025 • Human evidence curation set
PMID 41515126 from Nutrients.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2022 • Human evidence curation set
PMID 35654336 from Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2006 • Human evidence curation set
PMID 16922819 from Clinical and experimental pharmacology & physiology.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 1999 • Human evidence curation set
PMID 10370878 from Drugs under experimental and clinical research.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2001 • Human evidence curation set
PMID 11442298 from Aging (Milan, Italy).
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2019 • Human evidence curation set
PMID 30076269 from Journal of neurology, neurosurgery, and psychiatry.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2008 • Human evidence curation set
PMID 18088206 from Expert review of neurotherapeutics.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2010 • Human evidence curation set
PMID 23579938 from Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2002 • Human evidence curation set
PMID 12074969 from Annals of the New York Academy of Sciences.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open sourcePUBMED • 2011 • Human evidence curation set
PMID 21745730 from Nutrition, metabolism, and cardiovascular diseases : NMCD.
Outcome: See linked PubMed abstract for methods and outcomes.[1329,1386,1438, etc.]
Open source